Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ohishi S | [Evaluation of time course and inter-relationship of inflammatory mediators in experimental inflammatory reaction]. | 2000 | Yakugaku Zasshi | pmid:10825809 |
Li SH et al. | Effects of platelet-activating factor antagonist SRI 63-441 on endotoxin-induced changes in rat mesenteric microcirculation. | 1991 | Yao Xue Xue Bao | pmid:1887797 |
Han GQ et al. | [The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim]. | 1989 | Yao Xue Xue Bao | pmid:2609983 |
Fang J and Zheng QY | [Inhibitory effect of esculentoside A on platelet activating factor released from calcimycin induced rat peritoneal macrophages]. | 1991 | Yao Xue Xue Bao | pmid:1823713 |
Han GQ et al. | [Neolignans from Piper hancei Maxim]. | 1986 | Yao Xue Xue Bao | pmid:3776545 |
Cheng NN et al. | [The composition of phospholipid and biosynthesis of platelet-activating factor in earthworm (Eisenia foetida)]. | 1992 | Yao Xue Xue Bao | pmid:1299136 |
Ju DW et al. | [Leflunomide inhibits PAF induced DNA synthesis in rabbit synovial cells and PAF production from rat peritoneal macrophages]. | 1994 | Yao Xue Xue Bao | pmid:8042517 |
Hu JH et al. | [Effects of calcimycin on platelet adhesion to cultured bovine cerebral microvascular endothelial cells and its antagonism by drugs]. | 1994 | Yao Xue Xue Bao | pmid:7976350 |
Ma Y et al. | [PAF antagonistic benzofuran neolignans from Piper kadsura]. | 1993 | Yao Xue Xue Bao | pmid:8237383 |
Ju DW et al. | Effect of platelet activating factor antagonist WEB 2086 on the production of TNF from murine peritoneal macrophages. | 1993 | Yao Xue Xue Bao | pmid:8009983 |
Zeng GQ et al. | Effects of dauricine and tetrandrine on [3H] WEB 2086 specific binding to bovine anterior cerebral arterial smooth muscle cells in vitro. | 1993 | Yao Xue Xue Bao | pmid:8285049 |
Ma Y et al. | [Studies on PAF antagonistic bicyclo(3,2,1) octanoid neolignans from Piper kadsura]. | 1993 | Yao Xue Xue Bao | pmid:8368081 |
Nie ZG and Wang WJ | [Effect of ginkgolide B on platelet-activating factor induced activation of rat polymorphonuclear leukocytes]. | 2003 | Yao Xue Xue Bao | pmid:12778742 |
Peng SY et al. | [Effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes]. | 2010 | Yao Xue Xue Bao | pmid:21351565 |
Zhang LL et al. | [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. | 2007 | Yao Xue Xue Bao | pmid:17520822 |
Zang BX et al. | [Antagonistic effect of myricetin on platelet activing factor]. | 2003 | Yao Xue Xue Bao | pmid:14991995 |
Nie ZG et al. | [Effects of ginkgolide B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes]. | 2004 | Yao Xue Xue Bao | pmid:15491096 |
Ou-Yang XY et al. | [Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation]. | 2005 | Yao Xue Xue Bao | pmid:16011257 |
Peng SY et al. | Effect of ginkgolide B on the platelet-activating factor induced changes of chemotaxis and cytoskeleton of macrophages. | 2006 | Yao Xue Xue Bao | pmid:16671547 |
Mao YJ et al. | [Effect of ginkgolide B on the function of rat aorta smooth cells and U937 cells stimulated by oxLDL]. | 2006 | Yao Xue Xue Bao | pmid:16683525 |