Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Grigoriadis G and Stewart AG | Human monocytes maintained in culture acquire functional responsiveness to platelet-activating factor that is independent of increases in protein tyrosine phosphorylation. | 1997 | Clin. Exp. Pharmacol. Physiol. | pmid:9269528 |
Gaumond F et al. | Differential signaling pathways in platelet-activating factor-induced proliferation and interleukin-6 production by rat vascular smooth muscle cells. | 1997 | J. Cardiovasc. Pharmacol. | pmid:9269943 |
Klouche M et al. | Endocytosis, storage, and release of IgE by human platelets: differences in patients with type I allergy and nonatopic subjects. | 1997 | J. Allergy Clin. Immunol. | pmid:9275146 |
Chen D and Chen W | Changes of distribution of platelet activating factor in the lung of rats with hypoxic pulmonary hypertension. | 1996 | Chin. Med. J. | pmid:9275354 |
Cheng D and Chen W | Effects of ginkgolide B on isobaric hypoxic pulmonary hypertension in rats. | 1996 | Chin. Med. J. | pmid:9275375 |
Ren G and Ye R | [Changes in urinary excretion of platelet activating factor and its significance in patients with primary nephrotic syndrome]. | 1996 | Zhonghua Nei Ke Za Zhi | pmid:9275622 |
Yamashita A et al. | Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells. | 1997 | J. Biochem. | pmid:9276665 |
Bkaily G et al. | The use of confocal microscopy in the investigation of cell structure and function in the heart, vascular endothelium and smooth muscle cells. | 1997 | Mol. Cell. Biochem. | pmid:9278244 |
Kume K and Shimizu T | Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. | 1997 | J. Biol. Chem. | pmid:9278453 |
Oh SO et al. | Platelet-activating factor in plasma of patients with sickle cell disease in steady state. | 1997 | J. Lab. Clin. Med. | pmid:9280146 |
RodrÃguez Roisin R | [Platelet activating factor and bronchial asthma. Is it relevant?]. | 1997 | Arch. Bronconeumol. | pmid:9280556 |
Kintner DB et al. | Hyperglycemic damage to mitochondrial membranes during cerebral ischemia: amelioration by platelet-activating factor antagonist BN 50739. | 1997 | J. Neurochem. | pmid:9282946 |
Roudebush WE et al. | Evidence for the presence of the platelet-activating factor receptor in the CFW mouse preimplantation two-cell-stage embryo. | 1997 | Biol. Reprod. | pmid:9282993 |
Xie XQ et al. | Differential scanning calorimetry and small angle x-ray diffraction study of the interaction of (R)-PAF, (R)-ET-18-OME and (R)-Lyso-PAF with model membranes. | 1997 | Life Sci. | pmid:9284084 |
Bastos da Silva M et al. | Combined effect of Web 2086 (Paf antagonist) and ketoprofen (Nsaid) on Paf-induced ex vivo platelet aggregation in bovine. | 1997 | Zentralbl Veterinarmed A | pmid:9284631 |
Edwards CM et al. | Effects of the co-polymer surfactant, Pluronic F-68, on platelet aggregation in human whole blood. | 1997 | Artif Cells Blood Substit Immobil Biotechnol | pmid:9285052 |
Karzai W and Reinhart K | Immune modulation and sepsis. | 1997 | Int. J. Clin. Pract. | pmid:9287265 |
Partrick DA et al. | Nitric oxide attenuates platelet-activating factor priming for elastase release in human neutrophils via a cyclic guanosine monophosphate-dependent pathway. | 1997 | Surgery | pmid:9288123 |
Van de Weerdt ML et al. | Effect of platelet-activating factor on bovine pulmonary function. | 1997 | Vet. Rec. | pmid:9290195 |
Partrick DA et al. | Lipid mediators up-regulate CD11b and prime for concordant superoxide and elastase release in human neutrophils. | 1997 | J Trauma | pmid:9291376 |
Bozza PT et al. | Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation. | 1997 | J. Exp. Med. | pmid:9294145 |
Perico N et al. | Platelet-activating factor mediates angiotensin II-induced proteinuria in isolated perfused rat kidney. | 1997 | J. Am. Soc. Nephrol. | pmid:9294830 |
Albert DH et al. | ABT-491, a highly potent and selective PAF antagonist, inhibits nasal vascular permeability associated with experimental allergic rhinitis in brown Norway rats. | 1997 | Inflamm. Res. | pmid:9297547 |
O'Brien JG et al. | Effects of tranexamic acid and aprotinin on PAF-induced vascular permeability in normal, thrombocytopenic or neutropenic rats. | 1997 | Inflamm. Res. | pmid:9297553 |
Stewart A et al. | The regulation by phosphorylation of 'priming' of phospholipase A2 activity in the neutrophil model system, differentiated HL60 cells. | 1997 | Br. J. Pharmacol. | pmid:9298523 |
Manabe H et al. | Anti-inflammatory and bronchodilator properties of KF19514, a phosphodiesterase 4 and 1 inhibitor. | 1997 | Eur. J. Pharmacol. | pmid:9298930 |
Marr KA et al. | Effect of antigen challenge on the activation of peripheral blood neutrophils from horses with chronic obstructive pulmonary disease. | 1997 May-Jun | Res. Vet. Sci. | pmid:9300544 |
Kimura M et al. | Effects of fluvastatin on leukocyte-endothelial cell adhesion in hypercholesterolemic rats. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9301630 |
Herbert JM et al. | Pharmacological evidence for the putative existence of two different subtypes of PAF receptors on platelets and leukocytes; studies with yangambin. | 1997 | J Lipid Mediat Cell Signal | pmid:9302650 |
Bialasiewicz P et al. | Altered intracellular calcium signalling after PAF stimulations in polymorphonuclear leukocytes from asthmatic patients. | 1997 | J Lipid Mediat Cell Signal | pmid:9302652 |
Balsa D et al. | Effect of endotoxin and platelet-activating factor on rat vascular permeability: role of vasoactive mediators. | 1997 | J Lipid Mediat Cell Signal | pmid:9302653 |
Ablett JM et al. | Influence of antigen challenge on platelet responsiveness in horses with chronic obstructive pulmonary disease. | 1997 | Equine Vet. J. | pmid:9306066 |
Oh-ishi S | [Analysis of chemical mediators involved in acute inflammatory reaction with the rat pleurisy model]. | 1997 | Nippon Yakurigaku Zasshi | pmid:9306414 |
Tailor A et al. | Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: an intravital microscopy study. | 1997 | J. Leukoc. Biol. | pmid:9307068 |
Cortijo J et al. | Pharmacological activity of PF-904 in guinea pig in vivo, and on human bronchus and neutrophils in vitro. | 1997 | Eur. J. Pharmacol. | pmid:9311663 |
Teixeira MM et al. | Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin. | 1997 | J. Clin. Invest. | pmid:9312163 |
Cepinskas G et al. | Transendothelial neutrophil migration. Role of neutrophil-derived proteases and relationship to transendothelial protein movement. | 1997 | Circ. Res. | pmid:9314844 |
Wan S et al. | Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. | 1997 | Chest | pmid:9315800 |
Nakao A et al. | cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells. | 1997 | Am. J. Physiol. | pmid:9321918 |
Shimizu T and Mutoh H | Structure and regulation of platelet activating factor receptor gene. | 1997 | Adv. Exp. Med. Biol. | pmid:9321953 |
Mori M et al. | Localization of platelet-activating factor receptor in the rat brain. | 1997 | Adv. Exp. Med. Biol. | pmid:9321976 |
Erickson KL et al. | Alteration of platelet activating factor-induced macrophage tumoricidal response, IA expression, and signal transduction by N-3 fatty acids. | 1997 | Adv. Exp. Med. Biol. | pmid:9321978 |
Muguruma K et al. | The central role of PAF in necrotizing enterocolitis development. | 1997 | Adv. Exp. Med. Biol. | pmid:9321979 |
Aoki Y et al. | A simple, rapid and specific radioreceptor assay for platelet-activating factor. | 1997 | Adv. Exp. Med. Biol. | pmid:9321990 |
Si Y et al. | The change in plasma PAF activity before and after delivery. | 1997 | Adv. Exp. Med. Biol. | pmid:9322006 |
Murray J et al. | Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. | 1997 | Blood | pmid:9326245 |
DeLano FA et al. | Attenuation of oxygen free radical formation and tissue injury during experimental inflammation by P-selectin blockade. | 1997 | Microcirculation | pmid:9329011 |
Weber C and Springer TA | Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. | 1997 | J. Clin. Invest. | pmid:9329974 |
Ohkuni H et al. | Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. | 1997 | Adv. Exp. Med. Biol. | pmid:9331745 |
Knight D et al. | Adenosine A3 receptor stimulation inhibits migration of human eosinophils. | 1997 | J. Leukoc. Biol. | pmid:9335316 |
Getting SJ et al. | Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9336316 |
Greiff L et al. | Effects of topical platelet activating factor on the guinea-pig tracheobronchial mucosa in vivo. | 1997 | Acta Physiol. Scand. | pmid:9338520 |
Ohashi Y et al. | Platelet activating factor compromises airway epithelial defense functions. | 1997 | J. Allergy Clin. Immunol. | pmid:9338547 |
Hirashima Y et al. | Elevation of platelet activating factor, inflammatory cytokines, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage. | 1997 | Neurochem. Res. | pmid:9342729 |
Francescangeli E et al. | Activities of enzymes involved in the metabolism of platelet-activating factor in neural cell cultures during proliferation and differentiation. | 1997 | Neurochem. Res. | pmid:9342735 |
Bastos da Silva M et al. | Morphological alterations of blood platelets induced by platelet activating factor (PAF) and partial inhibition by ketoprofen in calves. | 1997 Sep-Oct | Vet. Res. | pmid:9342825 |
Rezaul K et al. | Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345263 |
Iwamoto S et al. | The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345277 |
Bastos da Silva MB et al. | The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. | 1997 | Vet. Res. Commun. | pmid:9345719 |
Million M et al. | Effects of neuropeptide FF on intestinal motility and temperature changes induced by endotoxin and platelet-activating factor. | 1997 | Eur. J. Pharmacol. | pmid:9346330 |
Aspey BS et al. | Effects of combined glutamate and platelet-activating factor inhibition on the outcome of focal cerebral ischaemia - an initial screening study. | 1997 | Metab Brain Dis | pmid:9346472 |
Bzeizi KI et al. | Primary graft dysfunction after liver transplantation: from pathogenesis to prevention. | 1997 | Liver Transpl Surg | pmid:9346727 |
Denham W et al. | Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis. | 1997 | Gastroenterology | pmid:9352880 |
Howarth PH | Mediators of nasal blockage in allergic rhinitis. | 1997 | Allergy | pmid:9353555 |
Nagaoka H et al. | 2-(3-Pyridyl)thiazolidine-4-carboxamides. 1. Novel orally active antagonists of platelet-activating factor (PAF). | 1997 | Chem. Pharm. Bull. | pmid:9353894 |
Liu B et al. | Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating-factor receptor lacking cytoplasmic C-terminal tail. | 1997 | Biochem. J. | pmid:9355758 |
Silomon M et al. | Role of platelet-activating factor in hepatocellular Ca2+ alterations during hemorrhagic shock. | 1997 | J. Surg. Res. | pmid:9356229 |
Wang H et al. | Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: effect of cycloheximide. | 1997 | Pediatr. Res. | pmid:9357930 |
May JA et al. | Platelet responses to several agonists and combinations of agonists in whole blood: a placebo controlled comparison of the effects of a once daily dose of plain aspirin 300 mg, plain aspirin 75 mg and enteric coated aspirin 300 mg, in man. | 1997 | Thromb. Res. | pmid:9361371 |
Radonjic-Lazovic G and Roudebush WE | The effect of short- vs. long-term platelet-activating factor exposure on mouse preimplantation embryo development. | 1995 | Early Pregnancy | pmid:9363251 |
Hershkowitz M and Adunsky A | Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct dementia patients. | 1996 Nov-Dec | Neurobiol. Aging | pmid:9363797 |
Kishimoto S et al. | Comparison of platelet-activating factor receptor mRNA levels in peripheral blood eosinophils from normal subjects and atopic asthmatic patients. | 1997 | Int. Arch. Allergy Immunol. | pmid:9363928 |
Manna SK et al. | Hamycin inhibits IL-8-induced biologic response by modulating its receptor in human polymorphonuclear neutrophils. | 1997 | J. Immunol. | pmid:9366432 |
Saeed SA et al. | Anti-thrombotic and anti-inflammatory activities of protopine. | 1997 | Pharmacol. Res. | pmid:9368908 |
Snyder F | CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor. | 1997 | Biochim. Biophys. Acta | pmid:9370322 |
Nagase T et al. | Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9372685 |
Tetta C et al. | Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. | 1997 | Am. J. Kidney Dis. | pmid:9372980 |
Garland A et al. | Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. | 1997 | Am. J. Physiol. | pmid:9374740 |
Miyahara T et al. | Role of circulating blood components and thromboxane in anaphylactic vasoconstriction in isolated canine lungs. | 1997 | J. Appl. Physiol. | pmid:9375313 |
Bazan HE et al. | Platelet-activating factor induces cyclooxygenase-2 gene expression in corneal epithelium. Requirement of calcium in the signal transduction pathway. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9375567 |
Mori M et al. | Localization of platelet-activating factor receptor messenger RNA in the rat eye. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9375587 |
Okada S et al. | Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9376127 |
Mantovani A | The interplay between primary and secondary cytokines. Cytokines involved in the regulation of monocyte recruitment. | 1997 | Drugs | pmid:9378074 |
Kagoshima M et al. | Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. | 1997 | Pharmacology | pmid:9380772 |
Kozai T et al. | Platelet activating factor causes hyperconstriction at the inflammatory coronary lesions in pigs in vivo. | 1997 | Coron. Artery Dis. | pmid:9383603 |
Wang HG et al. | Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9384519 |
Sapir T et al. | Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. | 1997 | EMBO J. | pmid:9384577 |
Yu P et al. | [A study on changes and its mechanisms of intestinal mucosal permeability after severe burn]. | 1996 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:9387456 |
Zhou X et al. | [Monocellular quantitative study on the adhesive ability of eosinophils in the course of eosinophils activation]. | 1996 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:9387483 |
Cheng D et al. | [The level of platelet activating factor in blood of rats with hypoxic pulmonary hypertension]. | 1996 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:9389027 |
Cheng D and Chen W | [The role of platelet activating factor in chronic pulmonary hypertension]. | 1996 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:9389061 |
Hu DH and Ma CT | [Effect of platelet activating factor on TxA2, PGI2 and Ca(2+)-ATPase activity in the intra-pulmonary artery smooth muscle cells]. | 1996 | Sheng Li Xue Bao | pmid:9389196 |
Bellamy MC et al. | Changes in inflammatory mediators during orthotopic liver transplantation. | 1997 | Br J Anaesth | pmid:9389852 |
Nathan N et al. | Cytokine and lipid mediator blood concentrations after coronary artery surgery. | 1997 | Anesth. Analg. | pmid:9390587 |
Im SY et al. | Involvement of nuclear factor-kappa B in platelet-activating factor-mediated tumor necrosis factor-alpha expression. | 1997 | Eur. J. Immunol. | pmid:9394802 |
Negro Alvarez JM et al. | Platelet-activating factor antagonists. | 1997 Sep-Oct | Allergol Immunopathol (Madr) | pmid:9395010 |
Elzi DJ et al. | Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9398641 |
el-Shazly AE et al. | Mechanisms involved in activation of human eosinophil exocytosis by substance P: an in vitro model of sensory neuroimmunomodulation. | 1997 Aug-Dec | Immunol. Invest. | pmid:9399104 |
Erickson KL et al. | Induction and modulation of macrophage Ia antigen expression by platelet-activating factor. | 1997 | J. Leukoc. Biol. | pmid:9400826 |
Bix GJ and Clark GD | Elvax as a slow-release delivery agent for a platelet-activating factor receptor agonist and antagonist. | 1997 | J. Neurosci. Methods | pmid:9402559 |