Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Malabsorption Syndromes D008286 16 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Thrombasthenia D013915 4 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Shock, Traumatic D012774 4 associated lipids
Hemorrhagic Fever, American D006478 2 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Arthus Reaction D001183 8 associated lipids
Thrombocytosis D013922 4 associated lipids
Toxemia D014115 3 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Klebsiella Infections D007710 7 associated lipids
Ascites D001201 25 associated lipids
Albuminuria D000419 18 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Hyperinsulinism D006946 27 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Parkinson Disease D010300 53 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Bronchial Diseases D001982 3 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Tangier Disease D013631 8 associated lipids
Heart Arrest D006323 13 associated lipids
Cystitis D003556 23 associated lipids
Cholecystitis D002764 8 associated lipids
HIV Infections D015658 20 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Medulloblastoma D008527 22 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Hypertension, Portal D006975 12 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Dyslexia D004410 3 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Benveniste J Platelet-activating factor (PAF-acether): present status. 1981 Agents Actions pmid:6176101
Hanahan DJ et al. Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues. 1981 Biochem. Biophys. Res. Commun. pmid:7236259
Stimler NP et al. Anaphylactic actions of platelet-activating factor. 1981 Am. J. Pathol. pmid:6975043
Benveniste J et al. Platelet-activating factor (PAF-acether): molecular aspects of its release and pharmacological actions. 1981 Int. Arch. Allergy Appl. Immunol. pmid:7030966
Chignard M et al. [Platelet aggregation and platelet activating factor (author's transl)]. 1980 Oct-Dec J Pharmacol pmid:7206730
Camussi G et al. Platelet-activating factor (PAF), a mediator of platelet aggregation. Effect of corticosteroids on PAF-induced platelet aggregation. 1980 Oct-Dec Minerva Nefrol pmid:7254682
Suzuki K et al. The influence of 2-mercaptoethanol on von Willebrand factor and bovine platelet aggregating factor. 1980 Feb 1-15 Thromb. Res. pmid:6966083
Check WA A new age in asthma research: study of chemical mediators. 1980 Aug 22-29 JAMA pmid:6104737
Tencé V et al. Release, purification, and characterization of platelet-activating factor (PAF). 1980 Biochimie pmid:17941181
Halonen M et al. Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. 1980 Am. Rev. Respir. Dis. pmid:7458063