Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Malabsorption Syndromes D008286 16 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Thrombasthenia D013915 4 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Shock, Traumatic D012774 4 associated lipids
Hemorrhagic Fever, American D006478 2 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Arthus Reaction D001183 8 associated lipids
Thrombocytosis D013922 4 associated lipids
Toxemia D014115 3 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Klebsiella Infections D007710 7 associated lipids
Ascites D001201 25 associated lipids
Albuminuria D000419 18 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Hyperinsulinism D006946 27 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Parkinson Disease D010300 53 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Bronchial Diseases D001982 3 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Tangier Disease D013631 8 associated lipids
Heart Arrest D006323 13 associated lipids
Cystitis D003556 23 associated lipids
Cholecystitis D002764 8 associated lipids
HIV Infections D015658 20 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Medulloblastoma D008527 22 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Hypertension, Portal D006975 12 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Dyslexia D004410 3 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Namm DH and High JA Thrombin-induced formation of a polar lipid material within platelets that possesses platelet-activating activity. 1980 Thromb. Res. pmid:7209881
Tencé V et al. Release, purification, and characterization of platelet-activating factor (PAF). 1980 Biochimie pmid:17941181
Bussolino F and Benveniste J Pharmacological modulation of platelet-activating factor (PAF) release from rabbit leucocytes. I. Role of cAMP. 1980 Immunology pmid:6159308
Bussolino F and Camussi G Effect of prostacyclin on platelet-activating factor induced rabbit and platelet aggregation. 1980 Prostaglandins pmid:6258196
Vargaftig BB et al. Platelet-tissue interaction: role of platelet-activating factor (PAF-acether). 1980 Agents Actions pmid:7270336
Godfroid JJ et al. Platelet activating factor (PAF-acether): total synthesis of 1-O-octadecyl 2-O-acetyl sn-glycero-3-phosphoryl choline. 1980 FEBS Lett. pmid:7409144
Clark PO et al. Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils. 1980 Biochim. Biophys. Acta pmid:7357030
[Do you know PAF?]. 1980 Nouv Presse Med pmid:7367260
Farr RS et al. Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF). 1980 Clin. Immunol. Immunopathol. pmid:7371225
McManus LM et al. Pathobiology of the intravenous infusion of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), in the rabbit. 1980 J. Immunol. pmid:7373056
Cusack NJ Platelet-activating factor. 1980 Nature pmid:7374771
Pirotzky E et al. [Release of platelet activating factor (P.A.F.-acether) by isolated perfused rat kidney]. 1980 C. R. Acad. Sci., D, Sci. Nat. pmid:6772322
Chignard M et al. Platelet-activating factor (PAF-acether) secretion from platelets: effect of aggregating agents. 1980 Br. J. Haematol. pmid:6778498
Vargaftig BB et al. One, two, three or more pathways for platelet aggregation. 1980 Acta Med. Scand. Suppl. pmid:6779505
Arnoux B et al. Release of platelet-activating factor (PAF-acether) from alveolar macrophages by the calcium ionophore A23187 and phagocytosis. 1980 Eur. J. Clin. Invest. pmid:6788561
Halonen M et al. Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. 1980 Am. Rev. Respir. Dis. pmid:7458063
Kirchmaier CM et al. A platelet stimulating fraction in human and animal tissues. 1980 Artery pmid:6971084
Shaw JO and Henson PM The binding of rabbit basophil-derived platelet-activating factor to rabbit platelets. 1980 Am. J. Pathol. pmid:6987890
Vargaftig BB et al. Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives. 1980 Eur. J. Pharmacol. pmid:6995139
Polonsky J et al. Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl platelet-activating factor, from leukocytes: chemical ionization mass spectrometry of phospholipids. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6938950
Colwell JA et al. Platelet adhesion and aggregation in diabetes mellitus. 1979 Metab. Clin. Exp. pmid:122293
Benveniste J et al. [Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine]. 1979 C. R. Acad. Sci., D, Sci. Nat. pmid:121258
pmid:
pmid:3360596
Kelesidis T et al. The Role of Platelet-Activating Factor in Chronic Inflammation, Immune Activation, and Comorbidities Associated with HIV Infection. AIDS Rev pmid:26616844
pmid:9870780