| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yang HQ et al. | PMS777, a new cholinesterase inhibitor with anti-platelet activated factor activity, regulates amyloid precursor protein processing in vitro. | 2009 | Neurochem. Res. | pmid:18758955 |
| Steel HC et al. | Posaconazole attenuates leukotriene B4 release and uptake of calcium by chemoattractant-activated human neutrophils: a potential strategy to control neutrophil-mediated inflammation. | 2009 | J. Antimicrob. Chemother. | pmid:19744985 |
| Fité-Mora R | Torsade de pointes associated with rupatadine. | 2009 | Rev Esp Cardiol | pmid:19268083 |
| Kim DD et al. | Independent regulation of periarteriolar and perivenular nitric oxide mechanisms in the in vivo hamster cheek pouch microvasculature. | 2009 | Microcirculation | pmid:19235626 |
| Musio S et al. | Anaphylaxis to a self-peptide in the absence of mast cells or histamine. | 2009 | Lab. Invest. | pmid:19188909 |
| Welch EJ et al. | Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation. | 2009 | Mol. Pharmacol. | pmid:18931035 |
| McIntyre TM et al. | The emerging roles of PAF acetylhydrolase. | 2009 | J. Lipid Res. | pmid:18838739 |
| Rehse K et al. | New 1H-pyrazole-4-carboxamides with antiplatelet activity. | 2009 | Arch. Pharm. (Weinheim) | pmid:19051198 |
| Ereso AQ et al. | Lipoxin a(4) attenuates microvascular fluid leak during inflammation. | 2009 | J. Surg. Res. | pmid:19524267 |
| Detopoulou P et al. | Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure. | 2009 | Clin. Biochem. | pmid:18955040 |
| Giannattasio G et al. | Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. | 2009 | Biochim. Biophys. Acta | pmid:19130898 |
| Khodoun M et al. | Peanuts can contribute to anaphylactic shock by activating complement. | 2009 | J. Allergy Clin. Immunol. | pmid:19121857 |
| Plager DA et al. | Pimecrolimus reduces eosinophil activation associated with calcium mobilization. | 2009 | Int. Arch. Allergy Immunol. | pmid:19127068 |
| Kordan W et al. | Effect of platelet-activating factor on motility, plasmalemma integrity, the process of capacitation and acrosome reaction of fresh and cryopreserved boar spermatozoa. | 2009 | Pol J Vet Sci | pmid:19645346 |
| Poisson C et al. | Caveolae facilitate but are not essential for platelet-activating factor-mediated calcium mobilization and extracellular signal-regulated kinase activation. | 2009 | J. Immunol. | pmid:19620302 |
| Jeong YI et al. | The novel role of platelet-activating factor in protecting mice against lipopolysaccharide-induced endotoxic shock. | 2009 | PLoS ONE | pmid:19652714 |
| Keck M et al. | Pathophysiology of burns. | 2009 | Wien Med Wochenschr | pmid:19652939 |
| Tung JP et al. | Respiratory burst function of ovine neutrophils. | 2009 | BMC Immunol. | pmid:19422720 |
| Penna C et al. | Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor. | 2009 | Acta Physiol (Oxf) | pmid:19432589 |
| Dutra PM et al. | Stimulation of Leishmania tropica protein kinase CK2 activities by platelet-activating factor (PAF). | 2009 | Acta Trop. | pmid:19433049 |
| Cheng L et al. | HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19389802 |
| Di Leo E et al. | Treatment of acquired cold urticaria with rupatadine. | 2009 | Allergy | pmid:19392988 |
| Chang W et al. | Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells. | 2009 | Exp. Lung Res. | pmid:19415549 |
| Yamamura K et al. | Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. | 2009 | Int. Arch. Allergy Immunol. | pmid:19494504 |
| Dorfman AL et al. | The effect of oxygen and light on the structure and function of the neonatal rat retina. | 2009 | Doc Ophthalmol | pmid:18483821 |
| Zhang X et al. | Effect of baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis. | 2009 | Pancreas | pmid:19657312 |
| Guo CJ et al. | The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist. | 2008 Sep-Oct | J Asian Nat Prod Res | pmid:19003620 |
| Kurdiumov IN et al. | [Cerebrovascular and antiaggregative effects of GABA-docosahexaenoyldopamine conjugate]. | 2008 Jul-Aug | Eksp Klin Farmakol | pmid:18819437 |
| Chamogeorgakis TP et al. | Effect of N-acetyl-L-cysteine on lung ischaemia reperfusion injury in a porcine experimental model. | 2008 Jan-Feb | ANZ J Surg | pmid:18199211 |
| Kikuchi M et al. | Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. | 2008 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18502110 |
| Steel HC et al. | Comparison of the anti-inflammatory activities of imidazole antimycotics in relation to molecular structure. | 2008 | Chem Biol Drug Des | pmid:18924285 |
| Penna C et al. | The platelet activating factor triggers preconditioning-like cardioprotective effect via mitochondrial K-ATP channels and redox-sensible signaling. | 2008 | J. Physiol. Pharmacol. | pmid:18441387 |
| Bang UC et al. | Pharmacological approach to acute pancreatitis. | 2008 | World J. Gastroenterol. | pmid:18494044 |
| Zheng HL et al. | [Role of platelet-activating factor in progesterone synthesis and vascular endothelial growth factor expression in rat luteal cells]. | 2008 | Sheng Li Xue Bao | pmid:18425318 |
| Di Y et al. | [Effect of ginkgolide B on plasma levels of interleukin-12 and PAF in severe acute pancreatitis in rats]. | 2008 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21141514 |
| Ogura M et al. | Platelet-activating factor (PAF) induced cytokine production and otitis media with effusion (OME) in the rat middle ear. | 2008 | Auris Nasus Larynx | pmid:17997066 |
| Rastogi P et al. | Tryptase activates calcium-independent phospholipase A2 and releases PGE2 in airway epithelial cells. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18790994 |
| Belayev L et al. | LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. | 2008 | Exp. Neurol. | pmid:18793637 |
| Chu W et al. | Flavonoids from Chinese Viscum coloratum produce cytoprotective effects against ischemic myocardial injuries: inhibitory effect of flavonoids on PAF-induced Ca2+ overload. | 2008 | Phytother Res | pmid:17724771 |
| Morita K et al. | Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signalling in spinal cord in mice. | 2008 | Pain | pmid:18353555 |
| Simonenko VB et al. | [Losartan for the correction of thrombocyte activity in patients suffering from arterial hypertension with metabolic syndrome]. | 2008 | Klin Med (Mosk) | pmid:18326282 |
| Kudriavtseva IuA et al. | [Sorption and contact-activating properties of the <biograft-artery> anastomosis zone: effect of suture material (communication II)]. | 2008 | Angiol Sosud Khir | pmid:19156039 |
| Ibe BO et al. | Mechanisms by which S-albuterol induces human bronchial smooth muscle cell proliferation. | 2008 | Int. Arch. Allergy Immunol. | pmid:18362475 |
| Tiemann U | The role of platelet-activating factor in the mammalian female reproductive tract. | 2008 | Reprod. Domest. Anim. | pmid:18363604 |
| Ibe BO et al. | Platelet-activating factor stimulates ovine foetal pulmonary vascular smooth muscle cell proliferation: role of nuclear factor-kappa B and cyclin-dependent kinases. | 2008 | Cell Prolif. | pmid:18336468 |
| Lu J et al. | Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18356536 |
| Egea L et al. | Increased production of the ether-lipid platelet-activating factor in intestinal epithelial cells infected by Salmonella enteritidis. | 2008 | Biochim. Biophys. Acta | pmid:18442488 |
| Tsoukatos DC et al. | Platelet-activating factor acetylhydrolase and transacetylase activities in human aorta and mammary artery. | 2008 | J. Lipid Res. | pmid:18587071 |
| Ryan SD et al. | Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons. | 2008 | J. Lipid Res. | pmid:18550892 |
| LeBlanc CJ et al. | Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs. | 2008 | Am. J. Vet. Res. | pmid:18380580 |