| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shukla SD | Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin. | 1985 | Arch. Biochem. Biophys. | pmid:3875314 |
| Moore TL and Weiss TD | Mediators of inflammation. | 1985 | Semin. Arthritis Rheum. | pmid:3936177 |
| Shen TY et al. | The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. | 1985 | Int J Tissue React | pmid:2997065 |
| Sánchez Crespo M et al. | Synthesis of platelet-activating factor from human polymorphonuclear leukocytes: regulation and pharmacological approaches. | 1985 | Int J Tissue React | pmid:2997066 |
| Proll MA et al. | Phosphatidate and monooleylphosphatidate inhibition of fibroblast adenylate cyclase is mediated by the inhibitory coupling protein, Ni. | 1985 | Mol. Pharmacol. | pmid:2997592 |
| MacIntyre DE et al. | Endogenous and pharmacological mechanisms for the regulation of human platelet cytosolic free Ca2+. | 1985 | Nouv Rev Fr Hematol | pmid:2997706 |
| Lachachi H et al. | Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2998370 |
| Hemmendinger S et al. | [Physiology of the interactions of blood and the blood vessel wall. Role of pharmacologically active lipids]. | 1985 | Arch Mal Coeur Vaiss | pmid:3938941 |
| Hwang SB et al. | trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. | 1985 | J. Biol. Chem. | pmid:2999126 |
| Iñarrea P et al. | Synthesis of PAF-acether and blood volume changes in gram-negative sepsis. | 1985 | Immunopharmacology | pmid:3886598 |
| Lellouch-Tubiana A et al. | Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) to guinea-pigs. | 1985 | Br J Exp Pathol | pmid:3890915 |
| Weber N and Mangold HK | Semi-synthetic preparation of 1-O-[1'-14C]hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) using plant cell cultures. | 1985 | J. Lipid Res. | pmid:3891896 |
| Hanahan DJ and Weintraub ST | Platelet-activating factor isolation, identification, and assay. | 1985 | Methods Biochem Anal | pmid:3894881 |
| Lad PM et al. | Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2990462 |
| Billah MM et al. | Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human neutrophils via phospholipase A2. | 1985 | J. Biol. Chem. | pmid:3922982 |
| Ostermann G et al. | Platelet-stimulating and membranolytic properties of racemic PAF-acether and analogues. | 1985 | Biomed. Biochim. Acta | pmid:4004829 |
| Satouchi K et al. | Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004866 |
| Detsouli A et al. | Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether. | 1985 | Br. J. Pharmacol. | pmid:4005486 |
| Korth R et al. | Unsaturated 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholines (unsaturated platelet-activating factor): aggregation of human platelets after incubation with indomethacin, creatinephosphate/creatinephosphokinase, xylocain and hirudine, and serotonin release after incubation with indomethacin. | 1985 | Chem. Phys. Lipids | pmid:4006034 |
| Shigenobu K et al. | Platelet activating factor analogues: lack of correlation between their activities to produce hypotension and endothelium-mediated vasodilation. | 1985 | J. Pharmacobio-dyn. | pmid:4009403 |
| Saeki S et al. | Effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on cardiac function in perfused guinea-pig heart. | 1985 | Life Sci. | pmid:4010479 |
| Nunn B et al. | Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers. | 1985 | Antimicrob. Agents Chemother. | pmid:4015075 |
| Weintraub ST et al. | Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4015656 |
| Yousufzai SY and Abdel-Latif AA | Effects of platelet-activating factor on the release of arachidonic acid and prostaglandins by rabbit iris smooth muscle. Inhibition by calcium channel antagonists. | 1985 | Biochem. J. | pmid:3927898 |
| MacIntyre DE et al. | Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets. | 1985 | FEBS Lett. | pmid:2981715 |
| Imbs AB et al. | [Synthesis of a fluorescently-labeled platelet activating factor]. | 1985 | Bioorg. Khim. | pmid:4062993 |
| Tokumura A et al. | Gas chromatographic-mass spectrometric analysis of biologically active phospholipids having an sn-2-acetyl group. | 1985 | J. Chromatogr. | pmid:4066848 |
| Meloni Bruneri LH and Barbieri D | [Platelet aggregation after the reduction of nitro-blue tetrazolium by eosinophils]. | 1985 | Sangre (Barc) | pmid:4071355 |
| Söling HD et al. | Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. | 1985 | Adv. Enzyme Regul. | pmid:4072796 |
| Mushayakarara EC and Mantsch HH | Thermotropic phase behavior of the platelet-activating factor: an infrared spectroscopic study. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4075223 |
| Zimmerman GA et al. | Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. | 1985 | J. Clin. Invest. | pmid:4077977 |
| Young JM et al. | Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse. | 1985 | Prostaglandins | pmid:4081060 |
| Is there a case for PAF-acether antagonists? Institut Pasteur, Paris, 21 June 1985. Abstracts. | 1985 | Prostaglandins | pmid:4081064 | |
| Morley J et al. | Platelets in asthma. | 1985 | Lancet | pmid:2863708 |
| Cox CP | Activation of washed chicken thrombocytes by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (platelet-activating factor). | 1985 | Comp Biochem Physiol A Comp Physiol | pmid:2864195 |
| Dewald B and Baggiolini M | Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985075 |
| Peach MJ et al. | Mechanisms of endothelium-dependent vascular smooth muscle relaxation. | 1985 | Biochem. Pharmacol. | pmid:2988558 |
| Braquet M et al. | Leukocytic functions in burn-injured patients. | 1985 | Prostaglandins | pmid:2989978 |
| O'Neill C et al. | Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. | 1985 | Ann. N. Y. Acad. Sci. | pmid:2409860 |
| Sage SO and Rink TJ | Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets. | 1985 | FEBS Lett. | pmid:2410292 |
| Grandel KE et al. | Association of platelet-activating factor with primary acquired cold urticaria. | 1985 | N. Engl. J. Med. | pmid:2410790 |
| Bussolino F et al. | Alkyl-ether phosphoglycerides influence calcium fluxes into human endothelial cells. | 1985 | J. Immunol. | pmid:2411812 |
| Johnson HM and Torres BA | Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2412225 |
| Fjellner B and Hägermark O | Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. | 1985 | Acta Derm. Venereol. | pmid:2416164 |
| Snyder F | Chemical and biochemical aspects of platelet activating factor: a novel class of acetylated ether-linked choline-phospholipids. | 1985 Jan-Mar | Med Res Rev | pmid:2984489 |
| Kozubski W and Stańczyk L | [Platelet aggregation in patients with migraine during the pain attack and in the pain-free period]. | 1985 Jul-Aug | Neurol. Neurochir. Pol. | pmid:4094642 |
| Bette-Bobillo P et al. | Synthesis and characterization of a radioiodinated, photoreactive and physiologically active analogue of platelet activating factor. | 1985 Jun-Jul | Chem. Phys. Lipids | pmid:4042252 |
| Leprán I and Lefer AM | Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. | 1985 Mar-Apr | Basic Res. Cardiol. | pmid:4039929 |
| Feuerstein G et al. | Thyrotropin-releasing hormone blocks the hypotensive effects of platelet-activating factor in the unanesthetized guinea pig. | 1985 Mar-Apr | J. Cardiovasc. Pharmacol. | pmid:2581089 |
| Masugi F et al. | Role of acetyl glyceryl ether phosphorylcholine in blood pressure regulation in rats. | 1985 Sep-Oct | Hypertension | pmid:4030044 |