| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Satoh K et al. | [Endothelial injury as an initiating factor: vascular endothelial cell injury and biosynthesis of PAF]. | 1988 | Nippon Rinsho | pmid:3404682 |
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| Itoh M and Takeuchi T | [Mechanism of the formation of ischemic gastric injury induced by oxygen radicals in rats]. | 1990 | Nippon Naika Gakkai Zasshi | pmid:2175336 |
| Ogiwara T and Sato N | [Stress and etiology of peptic ulcers]. | 1995 | Nippon Naika Gakkai Zasshi | pmid:7658116 |
| Kawatake H and Kawakami Y | [Pulmonary thromboembolism and IgE]. | 1993 | Nippon Naika Gakkai Zasshi | pmid:8360566 |
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| Yano S | [Drug therapy of asthma by antiallergic agents]. | 1992 | Nippon Naika Gakkai Zasshi | pmid:1383362 |
| Ozaki Y et al. | Potentiation of neutrophil biosynthesis of platelet-activating factor by cytochalasin B: evaluation of acetyltransferase activity. | 1987 | Nippon Ketsueki Gakkai Zasshi | pmid:3687329 |
| Ozaki Y et al. | Acetyltransferase activity and production of platelet-activating factor by human neutrophils activated with various stimuli. | 1989 | Nippon Ketsueki Gakkai Zasshi | pmid:2515707 |
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| Narita S et al. | [Effects of anti-PAF agents on nasal response after allergen challenge in guinea pigs]. | 1992 | Nippon Jibiinkoka Gakkai Kaiho | pmid:1357119 |
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| Shirasaki H and Asakura K | [Detection of platelet-activating factor in nasal lavage fluid from patients with pollinosis and experimental animals with nasal allergy]. | 1990 | Nippon Jibiinkoka Gakkai Kaiho | pmid:2352050 |
| Ohtani N and Asano G | [Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65]. | 1996 | Nippon Ika Daigaku Zasshi | pmid:8987363 |
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| Kioka K et al. | [Changes in production of platelet activating factor by adherent hepatocytes of mice with experimental liver failure]. | 1989 | Nihon Shokakibyo Gakkai Zasshi | pmid:2770018 |
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| Idei H et al. | [Role of platelet activating factor on the formation of ischemic colitis]. | 1995 | Nihon Shokakibyo Gakkai Zasshi | pmid:7474465 |
| Nogami M et al. | [Effects of a PAF antagonist CV-3988 on the acute gastric erosions of rats by water-immersion stress]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3404759 |
| Boku S | [A role of platelet activating factor in experimental hemorrhagic enteritis induced by Clostridium difficile toxin]. | 1994 | Nihon Shokakibyo Gakkai Zasshi | pmid:7933638 |
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| Nogami M et al. | [Effects of a platelet activating factor (PAF) antagonist CV-3988 on acute gastric erosions in rats by water immersion and restrained stress, and by ethanol]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3210345 |
| Yoshikawa T et al. | [Role of polymorphonuclear leukocytes and oxygen-derived free radicals in the formation of gastric mucosal lesions induced by platelet-activating factor]. | 1989 | Nihon Shokakibyo Gakkai Zasshi | pmid:2547098 |
| Kume K et al. | [Study of platelet activating factor by using mouse ontogenic technology]. | 1996 | Nihon Rinsho Meneki Gakkai Kaishi | pmid:9081720 |
| Matsumoto K et al. | [Platelet activating factor and tumor necrosis factor-alpha in bronchoalveolar lavage fluid of patients with ARDS]. | 1993 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8315901 |
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| Tsukagoshi H and Kurosawa M | [Effect of Asthremedin on bronchial hyperresponsiveness (BHR) to histamine induced by intravenous administration of platelet activating factor (PAF) in guinea pigs]. | 1993 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8391092 |
| Ono S et al. | [Lung 3H-thymidine incorporation in monocrotaline (MCT)-treated rats--role of platelet-activating factor (PAF)]. | 1994 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8084100 |
| Ono S et al. | [Possible involvement of vascular endothelium-derived relaxing factor induced by platelet-activating factor (PAF) on human pulmonary artery after contraction in vitro]. | 1989 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:2615107 |
| Shimizu K et al. | [Actions of platelet activating factor in pulmonary circulation--experimental investigation using rabbit blood vessel smooth muscle preparations]. | 1987 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3444152 |
| Misawa M and Takata T | [Effects of platelet activating factor on the bronchial musculature and vasculature in dogs]. | 1988 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3241511 |
| Inui K | [Participation of platelet activating factor in the pulmonary injury during cardiopulmonary bypass]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:8473789 |
| Masugi F et al. | [Kidney medulla and hypertension, with special reference to antihypertensive lipids]. | 1983 | Nihon Jinzo Gakkai Shi | pmid:6663856 |
| Komatsu H et al. | Platelet-activating factor induces cell growth through tyrosine phosphorylation pathway in cultured rat mesangial cells. | 1995 | Nihon Jinzo Gakkai Shi | pmid:8583698 |
| Suzuki S et al. | [Effect of a specific antagonist of platelet-activating factor, FR-900452, on proteinuria and urinary thromboxane excretion in aminonucleoside nephrotic rats]. | 1988 | Nihon Jinzo Gakkai Shi | pmid:3244194 |
| Hirano T and Manabe T | "Cocktail" therapy for acute pancreatitis: combined therapy of protease inhibitor, xanthine oxidase inhibitor and platelet activating factor antagonist in rat caerulein-induced pancreatis. | 1992 | Nihon Geka Hokan | pmid:1306981 |
| Fukuoka T | [An experimental study on shock after temporary hepatic inflow occlusion and platelet activating factor (PAF)]. | 1990 | Nihon Geka Gakkai Zasshi | pmid:2263243 |
| Fukuoka T et al. | [Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver]. | 1992 | Nihon Geka Gakkai Zasshi | pmid:1287460 |
| Fukuoka T et al. | [Effect of a platelet activating factor (PAF) antagonist on the hepatic afferent vascular occlusion]. | 1988 | Nihon Geka Gakkai Zasshi | pmid:3412312 |
| Onuki Y et al. | [Experimental studies on the relation of platelet activating factor (PAF) to high mortality in sublethal endotoxemia after massive hepatectomy and effects of its antagonist]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:8332121 |
| Ono S | [Clinical and experimental studies of septic DIC in surgical patients, in terms of its characteristic features and pathogenesis]. | 1994 | Nihon Geka Gakkai Zasshi | pmid:7877583 |
| Koltai M et al. | Platelet-activating factor in septic shock. | 1993 | New Horiz | pmid:7922397 |
| Ayala A and Chaudry IH | Platelet activating factor and its role in trauma, shock, and sepsis. | 1996 | New Horiz | pmid:8774801 |
| Szabó C | Alterations in nitric oxide production in various forms of circulatory shock. | 1995 | New Horiz | pmid:7535648 |
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| Green PG et al. | Modulation of bradykinin-induced plasma extravasation in the rat knee joint by sympathetic co-transmitters. | 1993 | Neuroscience | pmid:8095706 |
| Grassi S et al. | Platelet-activating factor and group I metabotropic glutamate receptors interact for full development and maintenance of long-term potentiation in the rat medial vestibular nuclei. | 1999 | Neuroscience | pmid:10579215 |
| Grassi S and Pettorossi VE | Role of nitric oxide in long-term potentiation of the rat medial vestibular nuclei. | 2000 | Neuroscience | pmid:11068144 |
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| Green PG et al. | Neurogenic and non-neurogenic mechanisms of plasma extravasation in the rat. | 1993 | Neuroscience | pmid:8450970 |
| Yue TL et al. | Characterization of platelet-activating factor-induced elevation of cytosolic free-calcium level in neurohybrid NCB-20 cells. | 1991 | Neuroscience | pmid:2057061 |
| Moriguchi S et al. | Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region. | 2010 | Neuroscience | pmid:20074623 |
| Catalán RE et al. | Platelet-activating factor inhibits (Na+,K+) ATPase activity in rat brain. | 1994 | Neurosci. Res. | pmid:8008253 |
| Boetkjaer A et al. | Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. | 2007 | Neurosci. Lett. | pmid:17881124 |
| Ezoulin MJ et al. | Differential effect of PMS777, a new type of acetylcholinesterase inhibitor, and galanthamine on oxidative injury induced in human neuroblastoma SK-N-SH cells. | 2005 | Neurosci. Lett. | pmid:16095823 |
| Lalouette F et al. | Presence of specific platelet-activating factor binding-sites in neuroblastoma N1E-115 cells. | 1995 | Neurosci. Lett. | pmid:7777190 |
| Lustig HS et al. | Comparative neurotoxic potential of glutamate, endothelins, and platelet-activating factor in cerebral cortical cultures. | 1992 | Neurosci. Lett. | pmid:1357601 |
| Brodie C | Platelet activating factor induces nerve growth factor production by rat astrocytes. | 1995 | Neurosci. Lett. | pmid:7783948 |
| Giménez R and Aguilar J | Cytidine (5') diphosphocholine-induced decrease in cerebral platelet activating factor is due to inactivation of its synthesizing enzyme cholinephosphotransferase in aged rats. | 2001 | Neurosci. Lett. | pmid:11165772 |
| Green PG et al. | Trypsin enhances sympathetic neuron-dependent plasma extravasation in the rat knee joint. | 1993 | Neurosci. Lett. | pmid:8233065 |
| Tabuchi S et al. | Lipid mediators modulate NMDA receptor currents in a Xenopus oocyte expression system. | 1997 | Neurosci. Lett. | pmid:9406868 |
| Liu T et al. | Cytokine-induced neutrophil chemoattractant mRNA expressed in cerebral ischemia. | 1993 | Neurosci. Lett. | pmid:8152586 |
| Teather LA and Wurtman RJ | Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes. | 2003 | Neurosci. Lett. | pmid:12672535 |
| Reiner B et al. | Platelet-activating factor attenuation of long-term potentiation in rat hippocampal slices via protein tyrosine kinase signaling. | 2016 | Neurosci. Lett. | pmid:26808643 |
| Jiang ZG et al. | Platelet-activating factor inhibits excitatory transmission in rat neostriatum. | 1993 | Neurosci. Lett. | pmid:8104322 |
| Kushikata T et al. | Platelet activating factor and its metabolite promote sleep in rabbits. | 2006 | Neurosci. Lett. | pmid:16263215 |
| Kolko M et al. | Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. | 2003 | Neurosci. Lett. | pmid:12566178 |
| Adachi T et al. | PAF analogues capable of inhibiting PAF acetylhydrolase activity suppress migration of isolated rat cerebellar granule cells. | 1997 | Neurosci. Lett. | pmid:9406887 |
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| Mazereeuw G et al. | Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. | 2013 | Neurosci Biobehav Rev | pmid:23800745 |
| Lo EJ et al. | Bradykinin-induced neurogenic migration of neutrophils into the rat knee joint. | 1999 | Neuroreport | pmid:10716216 |
| Chen C and Bazan NG | Platelet-activating factor inhibits ionotropic GABA receptor activity in cultured hippocampal neurons. | 1999 | Neuroreport | pmid:10716218 |
| Hostettler ME and Carlson SL | PAF antagonist treatment reduces pro-inflammatory cytokine mRNA after spinal cord injury. | 2002 | Neuroreport | pmid:11924887 |
| Clark GD et al. | Lipids as axon guidance molecules? | 1995 | Neuroreport | pmid:8741737 |
| Clark GD et al. | Platelet-activating factor produces neuronal growth cone collapse. | 1995 | Neuroreport | pmid:8741765 |
| Tran KC et al. | Induction of angiogenesis by platelet-activating factor in the rat striatum. | 2005 | Neuroreport | pmid:16148749 |
| Zabøocka B and Domańska-Janik K | PAF antagonist, BN52021, inhibits [3H]D-aspartate release after ischaemia in vitro. | 1994 | Neuroreport | pmid:7703435 |
| Xu Y and Tao YX | Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. | 2004 | Neuroreport | pmid:15076749 |
| Bate C et al. | The role of platelet activating factor in prion and amyloid-beta neurotoxicity. | 2004 | Neuroreport | pmid:15094513 |
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| Bate C et al. | Platelet-activating factor antagonists protect amyloid-beta damaged neurons from microglia-mediated death. | 2006 | Neuropharmacology | pmid:16678220 |
| Gleason MM et al. | Comparison of endothelin binding and calcium mobilization in C6-BU-1 rat glioma and N18TG2 mouse neuroblastoma cells. | 1991 | Neuropeptides | pmid:1654531 |
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| Di Marzo V et al. | Neuropeptides and leukotriene release: effect of peptide histidine isoleucine and secretin in platelet activating factor-stimulated rat lung. | 1987 | Neuropeptides | pmid:3031537 |
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| Clark GD et al. | Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor. | 1992 | Neuron | pmid:1334422 |
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