| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Song SQ and Hu YM | Effects of tetrandrine, Fura 2-AM, and Bay k 8644 on platelet-activating factor release from rat peritoneal macrophages stimulated by lipopolysaccharides. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9812743 |
| Chen SF et al. | Three drugs inhibit phospholipase A2-induced high permeability of endothelial monolayers. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7801767 |
| Shen ZQ et al. | Effect of protopine on cytosolic Ca2+ in rabbit platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10452120 |
| Li SH et al. | Effects of platelet-activating factor on rat mesenteric microcirculation. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2104488 |
| Zeng GQ and Rui YC | [Inhibitory effect of dauricine on platelet activating factor released from calcimycin-induced mouse peritoneal macrophages]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2104489 |
| Fu Y and Hu YM | Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10678147 |
| Wang XD and Bian RL | [Effects of ketotifen on rabbit platelet aggregation and platelet activating factor formation from rat neutrophils]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2130617 |
| Yi FX and Guo ZG | Platelet-released ADP stabilizes PAF-induced rabbit platelet aggregation by stabilizing intracellular calcium. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10375790 |
| Sun DX et al. | Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1333718 |
| Li SH et al. | Pentoxifylline attenuates platelet activating factor-induced permeable edema in isolated perfused guinea pig lungs. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7976374 |
| Zhang M et al. | Effects of tetrandrine on rabbit platelet aggregation and platelet activating factor generation. | 1995 | Zhongguo Yao Li Xue Bao | pmid:7660812 |
| Ju DW et al. | Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro. | 1994 | Zhongguo Yao Li Xue Bao | pmid:8010089 |
| Qian R et al. | Platelet activation by platelet aggregation factor from Eisenia foelide. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7717070 |
| Hong JL et al. | [Effects of tetrandrine on cytoplasmic free calcium in rat neutrophils]. | 1989 | Zhongguo Yao Li Xue Bao | pmid:2561935 |
| Zeng S and Guo ZG | Mepyramine inhibits platelet activating factor-induced rabbit platelet aggregation: role of intracellular histamine. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072970 |
| Zeng GQ et al. | Dauricine and anisodamine inhibited leukotrienes- and platelet activating factor-induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249627 |
| Zhang B and Long K | Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249632 |
| Sun DX et al. | Platelet activating factor production in bovine cerebral microvascular endothelial cells and its drug inhibition. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8503282 |
| Zeng S et al. | Regulatory role of protein tyrosine phosphorylation in platelet activating factor-induced signal transduction in platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10437164 |
| Zhao W et al. | [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21038678 |
| Di Y et al. | [Effect of ginkgolide B on plasma levels of interleukin-12 and PAF in severe acute pancreatitis in rats]. | 2008 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21141514 |
| Zhao W et al. | [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180114 |
| Dong J et al. | [Effect of platelet-activating factor on long-term potentiation in rat hippocampal slices]. | 2005 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21171322 |
| Liu SH et al. | [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21189571 |
| Dong JC et al. | [Experimental study on antagonism of ginkgolides against effect of platelet-activating factor on lung strip of guinea pigs]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:10322836 |
| Yang AP and Chen Q | [Correlation between blood-stasis tongue figure and platelet activating factor (PAF) and acetyl hydrolase of PAF (PAF-AH) in patients with primary dysmenorrhea]. | 2011 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:21485072 |
| Dong JC et al. | [Ginkgolides antagonizing some effects of platelet-activating factor in vitro]. | 1995 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8704427 |
| Zhang J et al. | [Experimental study on effect of Buyang Huanwu decoction on arterial blood platelet activating factor content pre- and post-arterial thrombosis of rats]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11475720 |
| Shao P et al. | [Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17186728 |
| Wang J et al. | [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. | 2004 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:15143716 |
| Chen WM et al. | [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. | 2002 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12584792 |
| Zang BX et al. | [Inhibitory effect of kaempferol against binding of platelet activating factor to its receptor]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15506296 |
| Wang WJ et al. | [Effects of musk glucoprotein on PAF production and cytosolic Ca2+ level in rat polymorphonuclear leukocytes in vitro]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12525061 |
| Cheng NN and Ma YM | [A hypotensive analog of platelet-activating factor (PAF) in pheretima]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8011088 |
| Shi W et al. | [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309677 |
| Li SH et al. | [Effect of an extract from the cauline of Piper kadsura ohwi on endotoxin-induced hypotension and lung injury in rats]. | 1989 | Zhongguo Zhong Yao Za Zhi | pmid:2619897 |
| Li XG and Luo HM | [Progress in studies of chemical constituents and pharmacological activities of Kadsura]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15617488 |
| Chen ZN et al. | [Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8216803 |
| Chen ZN | [Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8274205 |
| Li XJ et al. | [Expression of platelet-activating factor in necrotizing enterocolitis and its clinical significance]. | 2011 | Zhonghua Bing Li Xue Za Zhi | pmid:21426810 |
| Zhang GQ et al. | [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion]. | 2003 | Zhonghua Er Ke Za Zhi | pmid:14751060 |
| Wu B et al. | [Effects of bificobacterium longum on neonatal rat model of necrotizing enterocolitis and roles of platelet-activating factor and tumor necrosis factor-alpha]. | 2007 | Zhonghua Er Ke Za Zhi | pmid:17953818 |
| Huang LG et al. | [Effects of glycomacropeptide on damage to intestinal tissue and apoptosis of intestinal epithelial cells in neonatal rats with necrotizing enterocolitis]. | 2012 | Zhonghua Er Ke Za Zhi | pmid:22932017 |
| Lu H and Xue XD | [Platelet-activating factor and neonatal necrotizing enterocolitis]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:15189692 |
| Zhang S et al. | [Determination of platelet activating factor and platelet associated IgG in pregnancy-induced hypertension]. | 1996 | Zhonghua Fu Chan Ke Za Zhi | pmid:9206185 |
| Jiang W et al. | [Effects and mechanisms of platelet-activating factor on the invasiveness of ovarian cancer cells in vitro]. | 2011 | Zhonghua Fu Chan Ke Za Zhi | pmid:22333285 |
| Wang F et al. | [The effect of platelet activating factor on the biosynthesis of thromboxane A2 and prostaglandin I2 in human placental villi and umbilical artery]. | 1997 | Zhonghua Fu Chan Ke Za Zhi | pmid:9596897 |
| Cheng DY and Chen WB | [The current status of the research on platelet activating factor and pulmonary hypertension]. | 1993 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:8403064 |
| Tu W et al. | [Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis]. | 2000 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11372382 |
| Zhou X et al. | [Monocellular quantitative study on the adhesive ability of eosinophils in the course of eosinophils activation]. | 1996 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:9387483 |