| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Thiele T et al. | [Heparin-induced thrombocytopenia]. | 2010 | Internist (Berl) | pmid:20694716 |
| Jiang P et al. | PMS-1077, a PAF antagonist, induced differentiation of HL-60 cells with its novel activity. | 2010 | Cell Biol. Int. | pmid:20812915 |
| Renteria LS et al. | Prolonged hypoxia modulates platelet activating factor receptor-mediated responses by fetal ovine pulmonary vascular smooth muscle cells. | 2010 | Mol. Genet. Metab. | pmid:20813571 |
| Church MK | Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males. | 2010 | Br. J. Dermatol. | pmid:20819087 |
| Hasan AM et al. | Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. | 2010 | Int. Immunopharmacol. | pmid:20685403 |
| Zhao W et al. | [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21038678 |
| Asaka N et al. | Effects of the new benzimidazole derivative TAS-203, an orally active phosphodiesterase 4 inhibitor, on airway inflammation in rats and emetic responses in ferrets. | 2010 | Arzneimittelforschung | pmid:21117500 |
| Kordan W et al. | Effect of platelet activating factor (PAF) supplementation in semen extender on viability and ATP content of cryopreserved canine spermatozoa. | 2010 | Pol J Vet Sci | pmid:21370733 |
| Soliman A et al. | Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. | 2010 | PLoS ONE | pmid:20976181 |
| Gao F et al. | [The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude]. | 2010 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:20979844 |
| Xu CL et al. | [Inhibitory effect of TBN on platelet aggregation in rabbit]. | 2010 | Zhong Yao Cai | pmid:21243778 |
| Zhu X et al. | Effects of ropivacaine on adhesion molecule CD11b expression and function in human neutrophils. | 2010 | Int. Immunopharmacol. | pmid:20348036 |
| Zhao D et al. | PAF exerts a direct apoptotic effect on the rat H9c2 cardiomyocytes in Ca2+-dependent manner. | 2010 | Int. J. Cardiol. | pmid:19237210 |
| Karantonis HC et al. | Platelet-activating factor involvement in thioacetamide-induced experimental liver fibrosis and cirrhosis. | 2010 | Dig. Dis. Sci. | pmid:19242794 |
| Lefebvre JS et al. | Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor. | 2010 | FASEB J. | pmid:19843712 |
| Kida T et al. | Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. | 2010 | Exp. Eye Res. | pmid:20412793 |
| Lorrain DS et al. | Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. | 2010 | Eur. J. Pharmacol. | pmid:20519143 |
| Chen S et al. | [Induction effect of platelet-activating factor on Src-suppressed C kinase substrate gene expression in rat pulmonary microvascular endothelial cells]. | 2010 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:20367900 |
| Leoni G et al. | The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature. | 2010 | Br. J. Pharmacol. | pmid:20331604 |
| Danker K et al. | Glycosidated phospholipids: uncoupling of signalling pathways at the plasma membrane. | 2010 | Br. J. Pharmacol. | pmid:20331609 |
| Kajiwara N et al. | Activation of human mast cells through the platelet-activating factor receptor. | 2010 | J. Allergy Clin. Immunol. | pmid:20392487 |
| Corl CM et al. | Lipoxygenase metabolites modulate vascular-derived platelet activating factor production following endotoxin challenge. | 2010 | Vet. Immunol. Immunopathol. | pmid:20359754 |
| Shi C et al. | H2O2 and PAF mediate Abeta1-42-induced Ca2+ dyshomeostasis that is blocked by EGb761. | 2010 | Neurochem. Int. | pmid:20362023 |
| Coy B ED et al. | The first diastereoselective synthesis of cinerins A-C, PAF-antagonistic macrophyllin-type bicyclo[3.2.1]octane neolignans, using a novel Pd-catalysed oxyarylation. | 2010 | Org. Biomol. Chem. | pmid:20401372 |
| Ritter JM | Novel targets and regulatory ordeal by QT interval. | 2010 | Br J Clin Pharmacol | pmid:20406216 |
| Donado E et al. | No cardiac effects of therapeutic and supratherapeutic doses of rupatadine: results from a 'thorough QT/QTc study' performed according to ICH guidelines. | 2010 | Br J Clin Pharmacol | pmid:20406224 |
| Saad MM et al. | Persistency and pathway of isoflurane-induced inhibition of superoxide production by neutrophils. | 2010 | Can J Anaesth | pmid:19882198 |
| Chen H et al. | Platelet-activating factor levels of serum and gingival crevicular fluid in nonsmoking patients with periodontitis and/or coronary heart disease. | 2010 | Clin Oral Investig | pmid:19826843 |
| Esquenazi S and Bazan HE | Role of platelet-activating factor in cell death signaling in the cornea: A review. | 2010 | Mol. Neurobiol. | pmid:20431963 |
| Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. | 2010 | Platelets | pmid:20433310 |
| Denizot Y | Platelet-activating factor and acute myelogenous leukemia. | 2010 | Exp. Hematol. | pmid:20303379 |
| Rieder F et al. | Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20299604 |
| Prokosch V et al. | Alpha2-adrenergic receptors and their core involvement in the process of axonal growth in retinal explants. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20592227 |
| Morimoto R et al. | Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages. | 2010 | J. Biol. Chem. | pmid:20663880 |
| Balestrieri ML et al. | Endothelial progenitor cells express PAF receptor and respond to PAF via Ca(2+)-dependent signaling. | 2010 | Biochim. Biophys. Acta | pmid:20637897 |
| Karasuyama H et al. | Role for basophils in systemic anaphylaxis. | 2010 | Chem Immunol Allergy | pmid:20519883 |
| Sanz ML et al. | In vitro diagnosis of anaphylaxis. | 2010 | Chem Immunol Allergy | pmid:20519886 |
| Sharma J et al. | Endothelial cell prostaglandin I(2) and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A(2)beta knockout mouse. | 2010 | Biochemistry | pmid:20521843 |
| Cerkiene Z et al. | Immune factors in human embryo culture and their significance. | 2010 | Medicina (Kaunas) | pmid:20571290 |
| Adamson RH et al. | Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels. | 2010 | Cardiovasc. Res. | pmid:20542878 |
| Liu SH et al. | Protection of carbon monoxide intraperitoneal administration from rat intestine injury induced by lipopolysaccharide. | 2010 | Chin. Med. J. | pmid:20497711 |
| Kuebler WM et al. | Vascular barrier regulation by PAF, ceramide, caveolae, and NO - an intricate signaling network with discrepant effects in the pulmonary and systemic vasculature. | 2010 | Cell. Physiol. Biochem. | pmid:20502002 |
| Wang L et al. | Three new compounds from Morus nigra L. | 2010 | J Asian Nat Prod Res | pmid:20552479 |
| Lu J et al. | Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. | 2010 | Pediatr. Res. | pmid:20531249 |
| Dyer KD et al. | Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. | 2010 | J. Immunol. | pmid:20421642 |
| Bate C et al. | Glycosylphosphatidylinositol anchor analogues sequester cholesterol and reduce prion formation. | 2010 | J. Biol. Chem. | pmid:20427265 |
| Shin SH et al. | Platelet-activating factor receptor mediates oxidized low density lipoprotein-induced migration of bone marrow-derived mesenchymal stem cells. | 2010 | Cell. Physiol. Biochem. | pmid:21063106 |
| Grassi G et al. | Exogenous platelet-activating factor improves the motility of human spermatozoa evaluated with C.A.S.A.: optimal concentration and incubation time. | 2010 | J. Endocrinol. Invest. | pmid:20220291 |
| Binder U et al. | The antifungal protein PAF interferes with PKC/MPK and cAMP/PKA signalling of Aspergillus nidulans. | 2010 | Mol. Microbiol. | pmid:19889092 |
| Shindou H | [Discovery and characterization of novel lysophospholipid acyltransferases]. | 2010 | Seikagaku | pmid:21348263 |