Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Milk Hypersensitivity D016269 4 associated lipids
Cluster Headache D003027 4 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Thrombasthenia D013915 4 associated lipids
Thrombocytosis D013922 4 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Hyperuricemia D033461 4 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Viremia D014766 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Agwu DE et al. Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by Coomassie blue staining and densitometry. 1989 Biochem. Biophys. Res. Commun. pmid:2466463
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Elzi DJ et al. Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils. 1997 Biochem. Biophys. Res. Commun. pmid:9398641
Chiang CF and Hauser G Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells. 1989 Biochem. Biophys. Res. Commun. pmid:2686644
Levy JV Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. 1987 Biochem. Biophys. Res. Commun. pmid:3619905
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Ieyasu H et al. A role of calcium-activated, phospholipid-dependent protein kinase in platelet-activating factor-induced serotonin release from rabbit platelets. 1982 Biochem. Biophys. Res. Commun. pmid:7181916
Mendlovic F et al. Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. 1984 Biochem. Biophys. Res. Commun. pmid:6435614
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Tokuoka SM et al. Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. 2013 Biochem. Biophys. Res. Commun. pmid:23743196
Resink TJ et al. The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. 1986 Biochem. Biophys. Res. Commun. pmid:2943273
Hayashi M et al. Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor. 1992 Biochem. Biophys. Res. Commun. pmid:1445360
Sha'afi RI and Molski TF Signalling for increased cytoskeletal actin in neutrophils. 1987 Biochem. Biophys. Res. Commun. pmid:3036146
Müller S and Nigam S Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites. 1992 Biochem. Biophys. Res. Commun. pmid:1335246
Satouchi K et al. Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:4004866
Sugimoto T et al. Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. 1992 Biochem. Biophys. Res. Commun. pmid:1281995
Francescangeli E and Goracci G The de novo biosynthesis of platelet-activating factor in rat brain. 1989 Biochem. Biophys. Res. Commun. pmid:2543404
Hussaini IM and Shen TY A specific, photolabile and irreversible antagonist (L662,025) of the PAF-receptor. 1989 Biochem. Biophys. Res. Commun. pmid:2543410
Carveth HJ et al. Neutrophil activating factor (NAF) induces polymorphonuclear leukocyte adherence to endothelial cells and to subendothelial matrix proteins. 1989 Biochem. Biophys. Res. Commun. pmid:2665743
Shukla SD and Hanahan DJ AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6288030
Doebber TW et al. Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6517949
Chesney CM et al. Desensitization of human platelets by platelet activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:3977920
Nogami M et al. The effect of platelet-activating factor on [14C]aminopyrine uptake by isolated guinea pig parietal cells. 1990 Biochem. Biophys. Res. Commun. pmid:2346478
Nakayama R et al. Generation of acetyl glyceryl ether phosphorylcholine from the rat skin and muscle tissues stimulated by moxibustion. 1985 Biochem. Biophys. Res. Commun. pmid:3977939
Swendsen CL et al. 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187. 1983 Biochem. Biophys. Res. Commun. pmid:6407484
Silva-Neto MA et al. Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. 2002 Biochem. Biophys. Res. Commun. pmid:12054663
Caramelo C et al. Presence of platelet-activating factor in blood from humans and experimental animals. Its absence in anephric individuals. 1984 Biochem. Biophys. Res. Commun. pmid:6732788
Lenihan DJ and Lee TC Regulation of platelet activating factor synthesis: modulation of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase by phosphorylation and dephosphorylation in rat spleen microsomes. 1984 Biochem. Biophys. Res. Commun. pmid:6732789
Shindou H et al. Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. 2000 Biochem. Biophys. Res. Commun. pmid:10814544
Palmantier R et al. Biosynthesis of paf-acether. XIV. Paf-acether output in murine peritoneal macrophages is regulated by the level of acetylhydrolase. 1989 Biochem. Biophys. Res. Commun. pmid:2751666
Filep J et al. Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog. 1989 Biochem. Biophys. Res. Commun. pmid:2916986
Barr R et al. The effect of platelet activating factor on electron transport of spinach chloroplasts. 1988 Biochem. Biophys. Res. Commun. pmid:3048258
Catalán RE et al. PAF-induced activation of polyphosphoinositide-hydrolyzing phospholipase C in cerebral cortex. 1992 Biochem. Biophys. Res. Commun. pmid:1311925
Kato T et al. Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). 1988 Biochem. Biophys. Res. Commun. pmid:3202869
Pai JK et al. Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. 1988 Biochem. Biophys. Res. Commun. pmid:3422154
Takayasu M et al. Endothelin-induced mobilization of Ca2+ and the possible involvement of platelet activating factor and thromboxane A2. 1989 Biochem. Biophys. Res. Commun. pmid:2655596
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Lüthje J and Ogilvie A Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. 1984 Biochem. Biophys. Res. Commun. pmid:6704102
Lee TC et al. Activities of enzymes that metabolize platelet-activating factor (1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of a calcium ionophore. 1982 Biochem. Biophys. Res. Commun. pmid:6808993
Schulam PG et al. Evidence for a platelet-activating factor receptor on human lymphoblastoid B cells: activation of the phosphatidylinositol cycle and induction of calcium mobilization. 1990 Biochem. Biophys. Res. Commun. pmid:2154211
Rodrigues CO et al. Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi. 1996 Biochem. Biophys. Res. Commun. pmid:8687466
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Bazan HE et al. The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products. 1987 Biochem. Biophys. Res. Commun. pmid:2827658
Ponpipom MM et al. (+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist. 1988 Biochem. Biophys. Res. Commun. pmid:2829894
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Yang JP and Tashjian AH Platelet-activating factor affects cytosolic free calcium concentration and prolactin secretion in GH4C1 rat pituitary cells. 1991 Biochem. Biophys. Res. Commun. pmid:1847044
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Hauser CJ et al. Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils. 2005 Biochem. Biophys. Res. Commun. pmid:16168959
Mueller HW et al. Synthesis of 1-acyl-2-[3H]acetyl-SN-glycero-3-phosphocholine, a structural analog of platelet activating factor, by vascular endothelial cells. 1991 Biochem. Biophys. Res. Commun. pmid:2039529
Mészáros K Magnetic field elicits hypotension mediated by platelet activating factor in rats injected with iron beads. 1991 Biochem. Biophys. Res. Commun. pmid:1930228
Parent JL et al. Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production. 1996 Biochem. Biophys. Res. Commun. pmid:8645288
Naoki K et al. PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. 2004 Biochem. Biophys. Res. Commun. pmid:15047169
Randell E et al. Interaction between rat serum phosphorylcholine binding protein and platelet activating factor. 1990 Biochem. Biophys. Res. Commun. pmid:2322233
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Chau LY et al. Photoaffinity labeling of platelet activating factor binding sites in rabbit platelet membranes. 1989 Biochem. Biophys. Res. Commun. pmid:2545193
Dutra PM et al. A novel ecto-phosphatase activity of Herpetomonas muscarum muscarum inhibited by platelet-activating factor. 1998 Biochem. Biophys. Res. Commun. pmid:9875238
Smith RJ and Bowman BJ Stimulation of human neutrophil degranulation with 1-O-octadecyl-2-O-acetyl-SN-glyceryl-3-phosphorylcholine: modulation by inhibitors of arachidonic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6803804
Musch MW et al. Antigen-and ionophore-stimulated synthesis of platelet-activating factor by the cloned mast cell line, MC9. 1987 Biochem. Biophys. Res. Commun. pmid:3107564
Lumb RH et al. PAF-acether transfer activity in HL-60 cells is induced during differentiation. 1990 Biochem. Biophys. Res. Commun. pmid:2169726
Müller E et al. Human PAF receptor gene expression: induction during HL-60 cell differentiation. 1991 Biochem. Biophys. Res. Commun. pmid:1722407
Rubin RM and Rosenbaum JT A platelet-activating factor antagonist inhibits interleukin 1-induced inflammation. 1988 Biochem. Biophys. Res. Commun. pmid:3260779
Pannocchia A and Hardisty RM Cyclic AMP inhibits platelet activation independently of its effect on cytosolic free calcium. 1985 Biochem. Biophys. Res. Commun. pmid:2983714
Ye RD et al. Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. 1991 Biochem. Biophys. Res. Commun. pmid:1656963
Nishinaka Y et al. A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells. 1993 Biochem. Biophys. Res. Commun. pmid:8390246
Combadière C et al. Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor. 1990 Biochem. Biophys. Res. Commun. pmid:2158320
Holtzman MJ et al. Synthesis of the 1-O-hexadecyl molecular species of platelet-activating factor by airway epithelial and vascular endothelial cells. 1991 Biochem. Biophys. Res. Commun. pmid:2043121
Shiono S et al. Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors. 1993 Biochem. Biophys. Res. Commun. pmid:8390248
Billah MM and Siegel MI Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6422930
Tokumura A et al. Identification of sn-2-omega-hydroxycarboxylate-containing phospholipids in a lipid extract from bovine brain. 1991 Biochem. Biophys. Res. Commun. pmid:2043133
Prevost MC et al. Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. 1984 Biochem. Biophys. Res. Commun. pmid:6422938