| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lymphoma, T-Cell, Cutaneous | D016410 | 4 associated lipids |
| Hepatitis B, Chronic | D019694 | 4 associated lipids |
| Milk Hypersensitivity | D016269 | 4 associated lipids |
| Thrombasthenia | D013915 | 4 associated lipids |
| Thrombocytosis | D013922 | 4 associated lipids |
| Cluster Headache | D003027 | 4 associated lipids |
| Cholestasis, Intrahepatic | D002780 | 4 associated lipids |
| Optic Nerve Injuries | D020221 | 4 associated lipids |
| Bronchopulmonary Dysplasia | D001997 | 4 associated lipids |
| Viremia | D014766 | 4 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Borin ML et al. | [Relation between the changes in Na+/H+-exchange and cytoplasmic Ca levels in platelet activation]. | 1988 | Biull Eksp Biol Med | pmid:2844320 |
| Joseph R et al. | Cytosolic ionized calcium homeostasis in platelets: an abnormal sensitivity to PAF-activation in migraine. | 1988 | Headache | pmid:2844693 |
| Criscuoli M and Subissi A | Catecholamines released from the adrenal medulla exert a compensatory, protective effect at beta 2-adrenoceptors against Paf-induced death in mice. | 1988 | Br. J. Pharmacol. | pmid:2894872 |
| Bekker AY et al. | Dose-response relationships between platelet activating factor and permeability--surface area product of FITC-dextran 150 in the hamster cheek pouch. | 1988 | Microcirc Endothelium Lymphatics | pmid:2475751 |
| Vivier E et al. | Immunoregulatory functions of paf-acether. II. Decrease of CD2 and CD3 antigen expression. | 1988 | Eur. J. Immunol. | pmid:2895712 |
| Hoffman DR et al. | Synthesis of platelet activating factor by cholinephosphotransferase in developing fetal rabbit lung. | 1988 | Lipids | pmid:2897059 |
| Hanss M and Dechavanne M | 48740 RP, an antagonist of PAF, does not affect human plasma fibrinolysis before and after venous occlusion. | 1988 | Thromb. Res. | pmid:3126559 |
| Acker G et al. | Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021. | 1988 | Prostaglandins | pmid:3129758 |
| Bochner BS et al. | Adherence of human basophils to cultured umbilical vein endothelial cells. | 1988 | J. Clin. Invest. | pmid:3130394 |
| Lerner R et al. | Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2838025 |
| Trovati M et al. | Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo. | 1988 | Diabetes | pmid:2838353 |
| Crouch MF and Lapetina EG | No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132162 |
| Russell JA et al. | Changes in the levels of bioactive components of cotton bracts accompanying senescence. | 1988 | Lung | pmid:3132575 |
| Martins MA et al. | Intravenous injections of PAF-acether induce platelet aggregation in rats. | 1988 | Eur. J. Pharmacol. | pmid:3135199 |
| Peers SH | Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats. | 1988 | Eur. J. Pharmacol. | pmid:3136026 |
| Lefort J et al. | Pharmacological profile of 48740 R.P., a PAF-acether antagonist. | 1988 | Eur. J. Pharmacol. | pmid:2843382 |
| Valone FH and Epstein LB | Biphasic platelet-activating factor synthesis by human monocytes stimulated with IL-1-beta, tumor necrosis factor, or IFN-gamma. | 1988 | J. Immunol. | pmid:3141509 |
| Berti F et al. | New pharmacological data on the bronchospasmolytic activity of bamifylline. | 1988 | Arzneimittelforschung | pmid:3365275 |
| O'Flaherty JT et al. | Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate. | 1988 | J. Immunol. | pmid:2836511 |
| Smith RJ et al. | Diacylglycerols modulate human polymorphonuclear neutrophil responsiveness: effects on intracellular calcium mobilization, granule exocytosis, and superoxide anion production. | 1988 | J. Leukoc. Biol. | pmid:2836539 |
| Rydzewska G and Gabryelewicz A | [Platelet activating factor (PAF) and its inhibitors]. | 1988 | Pol. Arch. Med. Wewn. | pmid:2482481 |
| Jouquey S et al. | Comparison of the effects of the ace inhibitors trandolapril and enalapril on phlogogen induced foot pad oedema in the rat. | 1988 | Agents Actions | pmid:2459935 |
| Lichterfeld A et al. | [Platelet activating factor and its possible role in bronchial asthma]. | 1988 | Prax Klin Pneumol | pmid:3041401 |
| Barnes PJ | Inflammatory mechanisms and nocturnal asthma. | 1988 | Am. J. Med. | pmid:3041827 |
| Greenberg S et al. | Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms. | 1988 | J. Biol. Chem. | pmid:3392016 |
| Camussi G and Salvidio G | Platelet-activating factor in graft rejection. | 1988 | Prog Biochem Pharmacol | pmid:3043426 |
| Wallace JL and MacNaughton WK | Gastrointestinal damage induced by platelet-activating factor: role of leukotrienes. | 1988 | Eur. J. Pharmacol. | pmid:2843390 |
| Hénocq E | PAF-acether and eosinophils. | 1988 | Prog Biochem Pharmacol | pmid:3043428 |
| Serio R and Daniel EE | Thromboxane effects on canine trachealis neuromuscular function. | 1988 | J. Appl. Physiol. | pmid:2839451 |
| Etienne A et al. | Possible involvement of platelet-activating factor in endotoxin-induced abortion. | 1988 | Prog. Clin. Biol. Res. | pmid:3393560 |
| Lagente V and Fortes ZB | Role of PAF-acether in the vascular events of inflammation. | 1988 | Prog Biochem Pharmacol | pmid:3043429 |
| Kok PT et al. | Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132917 |
| Lazanas M et al. | PAF of biological fluids in disease: IV. Levels in blood in allergic reactions induced by drugs. | 1988 | Arch. Dermatol. Res. | pmid:3395143 |
| Satoh K et al. | Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from patients with ischemic cerebrovascular disease. | 1988 | Prostaglandins | pmid:3399678 |
| There is a case for PAF-acether antagonists. Abstracts of the conference. Paris, France, May 25-27, 1988. | 1988 | Prostaglandins | pmid:3399682 | |
| Valone FH | Platelet-activating factor binding and metabolism during human platelet aggregation. | 1988 | Thromb. Res. | pmid:3400077 |
| Bratton DL et al. | Effects of platelet activating factor on calcium-lipid interactions and lateral phase separations in phospholipid vesicles. | 1988 | Biochim. Biophys. Acta | pmid:3401478 |
| Evans TW et al. | Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea-pig and platelet aggregation in man. | 1988 | Br. J. Pharmacol. | pmid:3401633 |
| Lagente V et al. | Interference of the Paf antagonist Ro 19-3704 with Paf and antigen-induced bronchoconstriction in the guinea-pig. | 1988 | Br. J. Pharmacol. | pmid:3401641 |
| Coyle AJ et al. | The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation. | 1988 | Eur. J. Pharmacol. | pmid:3383997 |
| Tokumura A et al. | Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis. | 1988 | Eur. J. Pharmacol. | pmid:3384001 |
| Pirotzky E and Braquet P | [The role of the platelet-activating factor (PAF-acether) in renal pathology]. | 1988 | Presse Med | pmid:2966954 |
| Willuweit B and Aktories K | Heparin and heparinoids impair adrenaline and platelet-activating factor but not thrombin-induced inhibition of adenylate cyclase and stimulation of GTP hydrolysis in human platelet membranes. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2969081 |
| Freitas JC et al. | Inhibition of platelet aggregation by manoalide: preliminary results. | 1988 | Braz. J. Med. Biol. Res. | pmid:3203166 |
| Pai JK et al. | Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes. | 1988 | J. Biol. Chem. | pmid:3165977 |
| Collier M et al. | Biochemical and pharmacological characterization of human embryo-derived platelet activating factor. | 1988 | Hum. Reprod. | pmid:3204154 |
| Rosario-Jansen T et al. | Phospholipids chiral at phosphorus. Synthesis and stereospecificity of phosphorothioate analogues of platelet-activating factor. | 1988 | Biochemistry | pmid:3167004 |
| Prévost MC et al. | Possible origins of PAF-acether and lyso-PAF-acether in rat lung alveoli secondary to hypoxia. | 1988 | Biochim. Biophys. Acta | pmid:3167085 |
| Nagpurkar A et al. | Effect of rat phosphorylcholine-binding protein on platelet aggregation. | 1988 | Biochim. Biophys. Acta | pmid:3167098 |
| Wallace JL | Release of platelet-activating factor (PAF) and accelerated healing induced by a PAF antagonist in an animal model of chronic colitis. | 1988 | Can. J. Physiol. Pharmacol. | pmid:3167675 |
| Stenson WF | Platelet-activating factor and inflammatory bowel disease. | 1988 | Gastroenterology | pmid:3169505 |
| Valone FH et al. | Enhanced human monocyte cytotoxicity by platelet-activating factor. | 1988 | Immunology | pmid:3169845 |
| Popovich KJ et al. | Role of platelets in contraction of canine tracheal muscle elicited by PAF in vitro. | 1988 | J. Appl. Physiol. | pmid:3170437 |
| Armstead WM et al. | Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs. | 1988 | Circ. Res. | pmid:3335052 |
| Bonventre JV et al. | PAF and PDGF increase cytosolic [Ca2+] and phospholipase activity in mesangial cells. | 1988 | Am. J. Physiol. | pmid:3337246 |
| Wallace JL and Whittle BJ | Gastrointestinal damage induced by platelet-activating factor. Inhibition by the corticoid, dexamethasone. | 1988 | Dig. Dis. Sci. | pmid:3338370 |
| Benveniste J et al. | Preformed PAF-acether and lyso PAF-acether are bound to blood lipoproteins. | 1988 | FEBS Lett. | pmid:3338565 |
| Lagente V et al. | Involvement of PAF-acether in anaphylactic bronchoconstriction induced in guinea pigs by aerosolized antigen. | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3338855 |
| Imai T et al. | Pulmonary hypertension and edema induced by platelet-activating factor in isolated, perfused rat lungs are blocked by BN52021. | 1988 | J. Lab. Clin. Med. | pmid:3339274 |
| Wichrowski B et al. | Structure-activity relationship in PAF-acether. 4. Synthesis and biological activities of carboxylate isosteres. | 1988 | J. Med. Chem. | pmid:3339611 |
| Tilley JW et al. | Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists. | 1988 | J. Med. Chem. | pmid:3339617 |
| Domingo MT et al. | Presence of specific binding sites for platelet-activating factor (PAF) in brain. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2831903 |
| Dillon PK et al. | Vasoconstrictor effects of platelet-activating factor in the hamster cheek pouch microcirculation: dose-related relations and pathways of action. | 1988 | Circ. Res. | pmid:2832096 |
| Ma YH and Dunham EW | Antagonism of the vasodilator effects of a platelet activating factor precursor in anesthetized spontaneously hypertensive rats. | 1988 | Eur. J. Pharmacol. | pmid:2832188 |
| Hellegouarch A et al. | Lack of effect of atrial natriuretic factor on the tone induced in rat portal vein by platelet-activating factor. | 1988 | Eur. J. Pharmacol. | pmid:2832190 |
| Valone FH | Identification of platelet-activating factor receptors in P388D1 murine macrophages. | 1988 | J. Immunol. | pmid:2832476 |
| Homma H and Hanahan DJ | Attenuation of platelet activating factor (PAF)-induced stimulation of rabbit platelet GTPase by phorbol ester, dibutyryl cAMP, and desensitization: concomitant effects on PAF receptor binding characteristics. | 1988 | Arch. Biochem. Biophys. | pmid:2833174 |
| Huang SJ et al. | Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages. | 1988 | Biochem. J. | pmid:2833227 |
| Rees RS et al. | Plasma components are required for platelet activation by the toxin of Loxosceles reclusa. | 1988 | Toxicon | pmid:3245050 |
| Brass LF et al. | Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase. | 1988 | J. Biol. Chem. | pmid:2833506 |
| Mencia-Huerta JM et al. | [Effect of long-term administration of platelet activating factor on pulmonary response and morphology in the guinea pig]. | 1988 | Allerg Immunol (Paris) | pmid:3245884 |
| Takeuchi N et al. | The antagonist effects of compounds derived from khellactone on platelet-activating factor. | 1988 | Chem. Pharm. Bull. | pmid:3245999 |
| Hasegawa T and Nakajima S | [Recent topics on platelet-activating-factor (PAF)]. | 1988 | Nippon Ika Daigaku Zasshi | pmid:3360909 |
| Chau LY and Jii YJ | Characterization of 3H-labelled platelet activating factor receptor complex solubilized from rabbit platelet membranes. | 1988 | Biochim. Biophys. Acta | pmid:2838093 |
| Kimani G et al. | Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activating factor. | 1988 | J. Immunol. | pmid:3361129 |
| Hofmann B et al. | Effect of specific antagonists on PAF-induced platelet aggregation and release of plasminogen activator. | 1988 | Biomed. Biochim. Acta | pmid:3248103 |
| Robertson DA et al. | Negative inotropic effect of platelet-activating factor: association with a decrease in intracellular sodium activity. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3361438 |
| Thelen M et al. | Activation of monocytes by interferon-gamma has no effect on the level or affinity of the nicotinamide adenine dinucleotide-phosphate oxidase and on agonist-dependent superoxide formation. | 1988 | J. Clin. Invest. | pmid:2838524 |
| Terashita Z et al. | Protective action of prostaglandin E1 (PGE1) against constrictor mediators in isolated rat heart and lung. | 1988 | Biochem. Pharmacol. | pmid:2839198 |
| Prpic V et al. | Biochemical and functional responses stimulated by platelet-activating factor in murine peritoneal macrophages. | 1988 | J. Cell Biol. | pmid:2839520 |
| Kroegel C | The potential pathophysiological role of platelet-activating factor in human diseases. | 1988 | Klin. Wochenschr. | pmid:2839728 |
| Errasfa M et al. | Inhibition of phospholipase A2 activity of guinea-pig alveolar macrophages by lipocortin-like proteins purified from mice lung. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2968795 |
| Hammerschmidt DE et al. | Pentoxifylline inhibits granulocyte and platelet function, including granulocyte priming by platelet activating factor. | 1988 | J. Lab. Clin. Med. | pmid:2840477 |
| Hwang SB et al. | Biochemical and pharmacological characterization of L-659,989: an extremely potent, selective and competitive receptor antagonist of platelet-activating factor. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2841449 |
| Parnham MJ | PAF receptors. | 1988 | Prog Biochem Pharmacol | pmid:2841664 |
| Chung KF and Barnes PJ | PAF antagonists. Their potential therapeutic role in asthma. | 1988 | Drugs | pmid:3281823 |
| Plante GE et al. | Platelet activating factor antagonism with BN52021 protects the kidney against acute ischemic injury. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3231663 |
| Stephens LR et al. | Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. | 1988 | Biochem. J. | pmid:2845930 |
| Santos JC et al. | Effect of intrarenal infusion of synthetic PAF-acether in dogs. | 1988 | Rev. Esp. Fisiol. | pmid:3231880 |
| Ukena D and Sybrecht GW | [Function of platelet activating factor in asthma]. | 1988 | Dtsch. Med. Wochenschr. | pmid:2846251 |
| Ostermann G et al. | The degradation of platelet-activating factor in serum and its discriminative value in atherosclerotic patients. | 1988 | Thromb. Res. | pmid:3232123 |
| Ng DS and Wong K | Effect of sulfhydryl reagents on PAF binding to human neutrophils and platelets. | 1988 | Eur. J. Pharmacol. | pmid:2846326 |
| Avdonin PV et al. | Blocking of the receptor-stimulated calcium entry into human platelets by verapamil and nicardipine. | 1988 | Thromb. Res. | pmid:3232128 |
| Storch J et al. | Influence of platelet activating factor and a nonmetabolizable analogue on superoxide production by bone marrow derived macrophages. | 1988 | J. Leukoc. Biol. | pmid:2846728 |
| Kiktev VG et al. | [Calcium metabolism of the thrombocytes in ischemic heart disease]. | 1988 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:3233156 |
| Bussolino F et al. | Acetylcholine and dopamine promote the production of platelet activating factor in immature cells of chick embryonic retina. | 1988 | J. Neurochem. | pmid:2846783 |
| Yamada K et al. | Highly sensitive gas chromatographic--mass spectrometric method for the determination of platelet-activating factor in human blood. | 1988 | J. Chromatogr. | pmid:3235552 |
| Birkle DL et al. | Platelet-activating factor antagonist BN52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock. | 1988 | J. Neurochem. | pmid:2846788 |
| Yoshikawa D and Goto F | [Interactions between platelet activating factor and leukotrienes during endotoxin shock in the rat]. | 1988 | Masui | pmid:3236398 |
| Rouis M et al. | Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847729 |