| MeSH term | MeSH ID | Detail |
|---|---|---|
| AIDS Dementia Complex | D015526 | 4 associated lipids |
| Neoplasms, Germ Cell and Embryonal | D009373 | 4 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Shock, Traumatic | D012774 | 4 associated lipids |
| Hypertrophy, Right Ventricular | D017380 | 4 associated lipids |
| Hepatitis B, Chronic | D019694 | 4 associated lipids |
| Lymphoma, T-Cell, Cutaneous | D016410 | 4 associated lipids |
| Milk Hypersensitivity | D016269 | 4 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Thrombocytosis | D013922 | 4 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lukashova V et al. | G-protein-independent activation of Tyk2 by the platelet-activating factor receptor. | 2001 | J. Biol. Chem. | pmid:11309383 |
| Grassi S and Pettorossi VE | Synaptic plasticity in the medial vestibular nuclei: role of glutamate receptors and retrograde messengers in rat brainstem slices. | 2001 | Prog. Neurobiol. | pmid:11311461 |
| Marcano H et al. | Effect of dopamine on platelet activating factor induced-pulmonary edema in isolated and perfused rabbit lungs. | 2001 | Respir Physiol | pmid:11348642 |
| Wild MD and Roudebush WE | Platelet-activating factor improves intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11349157 |
| Wu C et al. | Evidence for the autocrine induction of capacitation of mammalian spermatozoa. | 2001 | J. Biol. Chem. | pmid:11350972 |
| Taylor R et al. | Platelet-activating factor antagonism and streptokinase-induced hypotension in clinical acute myocardial infarction. | 2001 | Clin. Sci. | pmid:11352774 |
| Hayashi J et al. | Platelet-activating factor antagonist, SM-12502, attenuates experimental glomerular thrombosis in rats. | 2001 | Nephron | pmid:11287764 |
| Choi JH et al. | Platelet-activating factor-induced early activation of NF-kappa B plays a crucial role for organ clearance of Candida albicans. | 2001 | J. Immunol. | pmid:11290796 |
| Marathe GK et al. | Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver. | 2001 | J. Lipid Res. | pmid:11290831 |
| Kato M et al. | Platelet activating factor degradation in tear fluid from guinea pigs with allergic conjunctivitis. | 2001 | J Ocul Pharmacol Ther | pmid:11327052 |
| Caplan MS et al. | Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model. | 2001 | Pediatr. Res. | pmid:11328947 |
| Sugano T et al. | Effects of platelet-activating factor on cytokine production by human uterine cervical fibroblasts. | 2001 | Mol. Hum. Reprod. | pmid:11331671 |
| Taylor KE et al. | Could platelet activating factor play a role in developmental dyslexia? | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334553 |
| Gu M et al. | Role of platelet-activating factor in hepatectomy with Pringle's maneuver. | 2001 | J. Surg. Res. | pmid:11266278 |
| Gujrati VR and Sastry BV | Metabolic fate of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by human spermatozoa: biosynthesis and biodegradation. | 2001 | Life Sci. | pmid:11270625 |
| Tong N et al. | Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons. | 2001 | Eur. J. Neurosci. | pmid:11403684 |
| Roudebush WE | Role of platelet-activating factor in reproduction: sperm function. | 2001 | Asian J. Androl. | pmid:11404790 |
| Briton-Jones C et al. | The effects of follicular fluid and platelet-activating factor on motion characteristics of poor-quality cryopreserved human sperm. | 2001 | J. Assist. Reprod. Genet. | pmid:11411433 |
| Mizuno S et al. | Role of PAF in acute liver injury after extended hepatectomy: overexpression of PAF receptor mRNA in Kupffer cells. | 2001 | Dig. Dis. Sci. | pmid:11414308 |
| Tsoukatos DC et al. | Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein. | 2001 | Biochem. J. | pmid:11439095 |
| Roudebush WE and Diehl JR | Platelet-activating factor content in boar spermatozoa correlates with fertility. | 2001 | Theriogenology | pmid:11396471 |
| Bassi F et al. | Detection of platelet-activating factor in gingival tissue surrounding failed dental implants. | 2001 | J. Periodontol. | pmid:11210074 |
| Ferland C et al. | Eotaxin promotes eosinophil transmigration via the activation of the plasminogen-plasmin system. | 2001 | J. Leukoc. Biol. | pmid:11358986 |
| de Meis L | Role of the sarcoplasmic reticulum Ca2+-ATPase on heat production and thermogenesis. | 2001 | Biosci. Rep. | pmid:11725862 |
| Tavakoli S et al. | Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133502 |
| Varon D and Brill A | Platelets cross-talk with tumor cells. | 2001 | Haemostasis | pmid:11990484 |
| Del Sorbo L et al. | Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat. | 2001 | Eur. J. Immunol. | pmid:11180101 |
| Karasawa K | [Physiological role of novel metabolic pathway of platelet-activating factor(PAF): PAF-dependent transacetylation]. | 2001 | Tanpakushitsu Kakusan Koso | pmid:11193332 |
| Urasaki T et al. | Pivotal role of 5-lipoxygenase in the activation of human eosinophils: platelet-activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway. | 2001 | J. Leukoc. Biol. | pmid:11200053 |
| Petty HR and Kindzelskii AL | Dissipative metabolic patterns respond during neutrophil transmembrane signaling. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248046 |
| Hauser CJ et al. | PAF-mediated Ca2+ influx in human neutrophils occurs via store-operated mechanisms. | 2001 | J. Leukoc. Biol. | pmid:11200069 |
| Jeon SY et al. | Nitric oxide mediates platelet activating factor-induced microvascular leakage in rat airways. | 2001 | Ann. Otol. Rhinol. Laryngol. | pmid:11201815 |
| Wittwer T et al. | Impact of PAF antagonist BN 52021 (Ginkolide B) on post-ischemic graft function in clinical lung transplantation. | 2001 | J. Heart Lung Transplant. | pmid:11257563 |
| Clavijo LC et al. | PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat. | 2001 | J. Appl. Physiol. | pmid:11133918 |
| Ko TC et al. | Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11212091 |
| Taggart DP | Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. | 2001 | Ann. Thorac. Surg. | pmid:11216754 |
| Lash GE and Legge M | Localization and distribution of platelet activating factor receptors in the mouse ovary and oviduct during the estrous cycle and early pregnancy. | 2001 | Am. J. Reprod. Immunol. | pmid:11216875 |
| Sun Z et al. | Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion. | 2001 | Scand. J. Gastroenterol. | pmid:11218240 |
| Kwan ML et al. | Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159008 |
| Komori M et al. | PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159026 |
| McManus LM et al. | Agonist-dependent failure of neutrophil function in diabetes correlates with extent of hyperglycemia. | 2001 | J. Leukoc. Biol. | pmid:11527989 |
| Stojanov T and O'Neill C | In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. | 2001 | Biol. Reprod. | pmid:11159375 |
| Qian C et al. | Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor. | 2001 | Pharmacol. Res. | pmid:11529688 |
| Persidsky Y et al. | Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis. | 2001 | J. Neuroimmunol. | pmid:11240016 |
| Jerkić M et al. | The mechanism of increased renal susceptibility to toxic substances in the elderly. Part I. The role of increased vasoconstriction. | 2001 | Int Urol Nephrol | pmid:11989542 |
| Kawaguchi A et al. | Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity. | 2001 | Life Sci. | pmid:11228102 |
| Pettorossi VE and Grassi S | Different contributions of platelet-activating factor and nitric oxide in long-term potentiation of the rat medial vestibular nuclei. | 2001 | Acta Otolaryngol Suppl | pmid:11677732 |
| Wielockx B et al. | Involvement of a serine protease, but not of neutrophil elastase, in tumor necrosis factor-induced lethal hepatitis and induction of platelet-activating factor. | 2001 | J. Hepatol. | pmid:11682033 |
| Dutra PM et al. | Platelet-activating factor modulates a secreted phosphatase activity of the trypanosomatid parasite Herpetomonas muscarum muscarum. | 2001 | Curr. Microbiol. | pmid:11683365 |
| Mathison R et al. | Regulation of leukocyte adhesion to heart by the tripeptides feG and feG(NH2). | 2001 | Can. J. Physiol. Pharmacol. | pmid:11599779 |
| Havt A et al. | The renal effects of Bothrops jararacussu venom and the role of PLA(2) and PAF blockers. | 2001 | Toxicon | pmid:11600146 |
| Claman P | Platelet activating factor does not improve intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11717679 |
| Caplan MS and Jilling T | The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis. | 2001 | Lipids | pmid:11724457 |
| Kaul DK et al. | Ameliorating effects of fluorocarbon emulsion on sickle red blood cell-induced obstruction in an ex vivo vasculature. | 2001 | Blood | pmid:11698300 |
| Casao MA et al. | Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies. | 2001 | J. Med. Microbiol. | pmid:11699593 |
| Lendvai B et al. | Platelet-activating factor evokes Ca2+ transients after the blockade of ryanodine receptor by dantrolene in RAW 264.7 macrophages. | 2001 | Neurochem. Res. | pmid:11699928 |
| Houghton TJ et al. | Efficient assembly of the phomactin core via two different macrocyclization protocols. | 2001 | Org. Lett. | pmid:11700095 |
| Adams JM et al. | Entry of gut lymph into the circulation primes rat neutrophil respiratory burst in hemorrhagic shock. | 2001 | Crit. Care Med. | pmid:11700422 |
| Masuhara K et al. | Involvement of platelet activation in experimental osteonecrosis in rabbits. | 2001 | Int J Exp Pathol | pmid:11703540 |
| Bernatchez PN et al. | Regulation of VEGF-induced endothelial cell PAF synthesis: role of p42/44 MAPK, p38 MAPK and PI3K pathways. | 2001 | Br. J. Pharmacol. | pmid:11704645 |
| Ibe BO et al. | Maturational changes in ovine pulmonary metabolism of platelet-activating factor: implications for postnatal adaptation. | 2001 | Mol. Genet. Metab. | pmid:11708870 |
| Suwaki T et al. | Modification of eosinophil function by suplatast tosilate (IPD), a novel anti-allergic drug. | 2001 | Int. Immunopharmacol. | pmid:11710545 |
| Macphee CH | Lipoprotein-associated phospholipase A2: a potential new risk factor for coronary artery disease and a therapeutic target. | 2001 | Curr Opin Pharmacol | pmid:11714085 |
| Khoo C et al. | Inhibition of store-operated Ca(2+) influx by acidic extracellular pH in cultured human microglia. | 2001 | Glia | pmid:11571781 |
| Stafforini DM | PAF acetylhydrolase gene polymorphisms and asthma severity. | 2001 | Pharmacogenomics | pmid:11535107 |
| Steer ML | Relationship between pancreatitis and lung diseases. | 2001 | Respir Physiol | pmid:11535257 |
| Tokutomi T et al. | Production of platelet-activating factor by neuronal cells in the rat brain with cold injury. | 2001 | Neurol. Res. | pmid:11547929 |
| Chemler SR et al. | Enantioselective synthesis of the oxadecalin core of phomactin A via a highly stereoselective Diels-Alder reaction. | 2001 | Org. Lett. | pmid:11554815 |
| Kavakli K et al. | Intraleucocyte platelet-activating factor levels in desmopressin-treated patients with haemophilia A and von Willebrand disease. | 2001 | Haemophilia | pmid:11554936 |
| Rozenfeld RA et al. | Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557516 |
| Stoddart NR et al. | Exogenous platelet-activating factor stimulates cell proliferation in mouse pre-implantation embryos prior to the fourth cell cycle and shows isoform-specific stimulatory effects. | 2001 | Zygote | pmid:11510473 |
| Feldman C et al. | Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro. | 2001 | Eur. Respir. J. | pmid:11510782 |
| Mooren FC et al. | Decoupling of intracellular calcium signaling in granulocytes after exhaustive exercise. | 2001 | Int J Sports Med | pmid:11510867 |
| Hermoso M et al. | Platelet activating factor increases ciliary activity in the hamster oviduct through epithelial production of prostaglandin E2. | 2001 | Pflugers Arch. | pmid:11484763 |
| Sachais BS | Platelet-endothelial interactions in atherosclerosis. | 2001 | Curr Atheroscler Rep | pmid:11487452 |
| Jantan I et al. | Inhibition of platelet-activating factor receptor binding by aporphine and phenanthrenoid alkaloids from Aromadendron elegans. | 2001 | Planta Med. | pmid:11488464 |
| Hu LH et al. | Synthesis and biological activity of amide derivatives of ginkgolide A. | 2001 | J Asian Nat Prod Res | pmid:11491398 |
| Alvarez A and Sanz MJ | Reactive oxygen species mediate angiotensin II-induced leukocyte-endothelial cell interactions in vivo. | 2001 | J. Leukoc. Biol. | pmid:11493611 |
| Raggers RJ et al. | Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor. | 2001 | Biochem. J. | pmid:11463358 |
| Hollmann MW et al. | Local anesthetic effects on priming and activation of human neutrophils. | 2001 | Anesthesiology | pmid:11465548 |
| Lane JS et al. | Platelet activating factor antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis. | 2001 | J. Surg. Res. | pmid:11469912 |
| Thomet OA et al. | Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. | 2001 | Biochem. Pharmacol. | pmid:11286996 |
| Velasquez LA et al. | PAF receptor and PAF acetylhydrolase expression in the endosalpinx of the human Fallopian tube: possible role of embryo-derived PAF in the control of embryo transport to the uterus. | 2001 | Hum. Reprod. | pmid:11473946 |
| Akisu M et al. | The role of recombinant human erythropoietin in lipid peroxidation and platelet-activating factor generation in a rat model of necrotizing enterocolitis. | 2001 | Eur J Pediatr Surg | pmid:11475112 |
| Chang PY et al. | Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids. | 2001 | Circulation | pmid:11479258 |
| Küçükhüseyin C et al. | Renovascular actions of adenosine in the isolated perfused rat kidney: possible underlying mechanisms. | 2001 | J Basic Clin Physiol Pharmacol | pmid:11868905 |
| Tibiriçá E | Cardiovascular properties of yangambin, a lignan isolated from Brazilian plants. | 2001 | Cardiovasc Drug Rev | pmid:11830750 |
| Burke JR et al. | BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11408565 |
| Murakami M et al. | Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. | 2001 | J. Biol. Chem. | pmid:11106649 |
| Ottino P and Bazan HE | Corneal stimulation of MMP-1, -9 and uPA by platelet-activating factor is mediated by cyclooxygenase-2 metabolites. | 2001 | Curr. Eye Res. | pmid:11840344 |
| Ribeiro JM and Francischetti IM | Platelet-activating-factor-hydrolyzing phospholipase C in the salivary glands and saliva of the mosquito Culex quinquefasciatus. | 2001 | J. Exp. Biol. | pmid:11807106 |
| Shah BH et al. | Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine. | 2001 | Exp. Mol. Med. | pmid:11795484 |
| Cao YZ et al. | Selenium modulates 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) biosynthesis in bovine aortic endothelial cells. | 2001 | Antioxid. Redox Signal. | pmid:11813988 |
| den Dekker E et al. | Biogenesis of G-protein mediated calcium signaling in human megakaryocytes. | 2001 | Thromb. Haemost. | pmid:11686331 |
| Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
| Tsai MH et al. | Effect of platelet activating factor and butyrate on the expression of interleukin-2 receptor alpha in nasopharyngeal carcinoma cells. | 2001 | Int. J. Oncol. | pmid:11605008 |
| Fabi F et al. | Nitric oxide (NO) modulation of PAF-induced cardiopulmonary action: interaction between NO synthase and cyclo-oxygenase-2 pathways. | 2001 | Br. J. Pharmacol. | pmid:11606318 |
| Añel RL and Kumar A | Experimental and emerging therapies for sepsis and septic shock. | 2001 | Expert Opin Investig Drugs | pmid:11772263 |
| Min JH et al. | Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme. | 2001 | Biochemistry | pmid:11294621 |
| Berdyshev EV et al. | Activation of PAF receptors results in enhanced synthesis of 2-arachidonoylglycerol (2-AG) in immune cells. | 2001 | FASEB J. | pmid:11641243 |