| MeSH term | MeSH ID | Detail |
|---|---|---|
| Viremia | D014766 | 4 associated lipids |
| AIDS Dementia Complex | D015526 | 4 associated lipids |
| Neoplasms, Germ Cell and Embryonal | D009373 | 4 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Shock, Traumatic | D012774 | 4 associated lipids |
| Hypertrophy, Right Ventricular | D017380 | 4 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Hepatitis B, Chronic | D019694 | 4 associated lipids |
| Lymphoma, T-Cell, Cutaneous | D016410 | 4 associated lipids |
| Milk Hypersensitivity | D016269 | 4 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dearn S et al. | Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line. | 2000 | Mol. Med. | pmid:10803407 |
| Kosaka T et al. | Spectrophotometric assay for serum platelet-activating factor acetylhydrolase activity. | 2000 | Clin. Chim. Acta | pmid:10807978 |
| Kulikov VI and Muzya GI | Bioactive amide of prostaglandin E1 and ethanolamine plasmalogen analog of platelet-activating factor inhibits several pathways of human platelet aggregation. | 2000 | Biochemistry Mosc. | pmid:10810178 |
| Shindou H et al. | Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10814544 |
| Luu NT et al. | Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. | 2000 | J. Immunol. | pmid:10820279 |
| Sugatani J et al. | Inhibition of rabbit platelet aggregation by nucleoside 5'-alkylphosphates: correlation with inhibition of agonist-induced calcium influx. | 2000 | Biochem. Pharmacol. | pmid:10825464 |
| Ohishi S | [Evaluation of time course and inter-relationship of inflammatory mediators in experimental inflammatory reaction]. | 2000 | Yakugaku Zasshi | pmid:10825809 |
| Asai Y et al. | Characterization of the physicochemical properties of the micelles of platelet-activating factor (C18:0). | 2000 | Drug Dev Ind Pharm | pmid:10826115 |
| Tokumura A et al. | Structural identification of phosphatidylcholines having an oxidatively shortened linoleate residue generated through its oxygenation with soybean or rabbit reticulocyte lipoxygenase. | 2000 | J. Lipid Res. | pmid:10828088 |
| Mizutani Y et al. | Cloning and expression of rat neutral sphingomyelinase: enzymological characterization and identification of essential histidine residues. | 2000 | Biochim. Biophys. Acta | pmid:10832103 |
| Serradji N et al. | Structure-activity relationships in platelet-activating factor (PAF). 10. From PAF antagonism to inhibition of HIV-1 replication. | 2000 | J. Med. Chem. | pmid:10841793 |
| Ma X and Bazan HE | Increased platelet-activating factor receptor gene expression by corneal epithelial wound healing. | 2000 | Invest. Ophthalmol. Vis. Sci. | pmid:10845588 |
| Kobayashi N et al. | Transepithelial migration of activated eosinophils induces a decrease of E-cadherin expression in cultured human nasal epithelial cells. | 2000 | Clin. Exp. Allergy | pmid:10848899 |
| Poveshchenko AF and Kozlov VA | [The effect of platelet-activating factor and its antagonist--BN 52021--on immune reactions in vivo in mice and in vitro]. | 1999 Jul-Aug | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:10852052 |
| Fukuyama S et al. | Effect of eotaxin and platelet-activating factor on airway inflammation and hyperresponsiveness in guinea pigs in vivo. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10852755 |
| Zhu X et al. | A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1. | 2000 | J. Immunol. Methods | pmid:10854610 |
| Caslake MJ et al. | Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease. | 2000 | Atherosclerosis | pmid:10856534 |
| Nakajima T et al. | Phospholipase A2-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulation. | 2000 | Int. J. Biochem. Cell Biol. | pmid:10856708 |
| Denizot Y et al. | Effect of cytokines and lipid mediators on the synthesis of interleukin 1 beta by human bone marrow stromal cells. | 2000 | Cytokine | pmid:10857767 |
| Huo LJ and Yang ZM | Effects of platelet activating factor on capacitation and acrosome reaction in mouse spermatozoa. | 2000 | Mol. Reprod. Dev. | pmid:10862011 |