Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kolko M et al. | Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. | 2003 | Neurosci. Lett. | pmid:12566178 |
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| Farmer PJ et al. | Inhibition of prostaglandin G/H synthase unveils a potent effect of platelet activating factor on the permeability of bovine aortic endothelial cells to albumin. | 2002 | Inflammation | pmid:12546134 |
| Hirayama K et al. | Platelet-activating factor, a critical mediator in the pathogenesis of dextran sulfate sodium-induced colitis in rats. | 2003 | Dis. Colon Rectum | pmid:12544529 |
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| Bussolati B et al. | The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. | 2003 | J. Immunol. | pmid:12538709 |
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| Wang WJ et al. | [Effects of musk glucoprotein on PAF production and cytosolic Ca2+ level in rat polymorphonuclear leukocytes in vitro]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12525061 |
| Zhang Y et al. | Antioxidant superoxide dismutase attenuates increased endothelial permeability induced by platelet-activating factor. | 2003 | J. Soc. Gynecol. Investig. | pmid:12517587 |
| Francescangeli E et al. | Activation of PAF-synthesizing enzymes in rat brain stem slices after LTP induction in the medial vestibular nuclei. | 2002 | Neurochem. Res. | pmid:12512951 |
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| Pan YH et al. | Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive. | 2002 | Biochemistry | pmid:12475227 |
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| Abe Y et al. | Effect of a platelet-activating factor antagonist, E5880, on cerebrovasospasm following subarachnoid hemorrhage in a canine double-hemorrhage model. | 2002 | Eur. J. Pharmacol. | pmid:12445578 |
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| Gélinas DS et al. | Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways. | 2002 | Br. J. Pharmacol. | pmid:12429574 |
| Fallani A et al. | Synthesis of platelet-activating factor (PAF) in transformed cell lines of a different origin. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428690 |
| Dun Y et al. | Activated polymorphonuclear leukocytes induce cardiomyocyte apoptosis and the protective effects of carvedilol. | 2002 | Methods Find Exp Clin Pharmacol | pmid:12428428 |
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| Maniscalco M et al. | Nitric oxide attenuates platelet-activating factor induced nasal airway plasma extravasation in healthy subjects. | 2002 | Eur. J. Clin. Invest. | pmid:12423328 |
| Tanaka S and Koike T | Selective inflammatory stimulations enhance release of microglial response factor (MRF)-1 from cultured microglia. | 2002 | Glia | pmid:12420315 |
| Eikelboom JW et al. | Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes. | 2002 | Eur. Heart J. | pmid:12419297 |
| Farbiszewski R et al. | [The role of platelet activating factor (PAF) in physiology and pathology of the central nervous system]. | 2002 Jul-Aug | Neurol. Neurochir. Pol. | pmid:12418143 |
| Childs EW et al. | In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. | 2002 | Shock | pmid:12412620 |
| Ibe BO et al. | Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. | 2002 | Mol. Genet. Metab. | pmid:12409272 |
| Sakamoto H et al. | Overexpression of phospholipid hydroperoxide glutathione peroxidase modulates acetyl-CoA, 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity. | 2002 | J. Biol. Chem. | pmid:12397078 |
| Sibelius U et al. | Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10. | 2002 | Crit. Care Med. | pmid:12394960 |
| Ueno H et al. | Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure. | 2002 | Crit. Care Med. | pmid:12394951 |
| Kato M et al. | Platelet-activating factor activates two distinct effector pathways in human eosinophils. | 2002 | J. Immunol. | pmid:12391244 |
| Murohisa G et al. | Involvement of platelet-activating factor in hepatic apoptosis and necrosis in chronic ethanol-fed rats given endotoxin. | 2002 | Liver | pmid:12390475 |
| Maul H et al. | Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats. | 2002 | Am. J. Obstet. Gynecol. | pmid:12388958 |
| Shigematsu S et al. | Bradykinin-induced proinflammatory signaling mechanisms. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388246 |
| Michibayashi T | Platelet aggregating response to platelet activating factor participates in activation of the 12-lipoxygenase pathway in platelets from rabbits. | 2002 | Int Angiol | pmid:12384648 |
| Baker PR et al. | Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. | 2002 | Biochim. Biophys. Acta | pmid:12379481 |
| Teather LA et al. | Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. | 2002 | Psychopharmacology (Berl.) | pmid:12373444 |
| Downing SJ et al. | Effect of platelet-activating factor on the electrophysiology of the human Fallopian tube: early mediation of embryo-maternal dialogue? | 2002 | Reproduction | pmid:12361471 |
| Beauchamp MH et al. | Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12356842 |
| Marin V et al. | Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type. | 2002 | Eur. J. Immunol. | pmid:12355450 |
| Brewer C et al. | Platelet activating factor-induced apoptosis is inhibited by ectopic expression of the platelet activating factor G-protein coupled receptor. | 2002 | J. Neurochem. | pmid:12354298 |
| Leung SW et al. | Platelet-activating factor enhanced the pressor response of endothelin-1. | 2002 | J. Cardiovasc. Pharmacol. | pmid:12352314 |
| Donnard M et al. | Membrane and intracellular platelet-activating factor receptor expression in leukemic blasts of patients with acute myeloid and lymphoid leukemia. | 2002 | Stem Cells | pmid:12351810 |
| Akai T et al. | Modulation of tissue-type plasminogen activator expression by platelet activating factor in human glioma cells. | 2002 | J. Neurooncol. | pmid:12241114 |
| Han SJ et al. | Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-kappa B (NF-kappa B). | 2002 | J. Biol. Chem. | pmid:12235132 |
| Weyrich AS et al. | Platelets, endothelial cells, inflammatory chemokines, and restenosis: complex signaling in the vascular play book. | 2002 | Circulation | pmid:12234942 |
| Bussolati B et al. | Nitric oxide/platelet activating factor cross-talk in mesangial cells modulates the interaction with leukocytes. | 2002 | Kidney Int. | pmid:12234302 |
| Colwell JA et al. | Platelet adhesion and aggregation in diabetes mellitus. | 1979 | Metab. Clin. Exp. | pmid:122293 |
| Cuschieri J et al. | Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. | 2002 | Surgery | pmid:12219006 |
| Cadwallader KA et al. | Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents. | 2002 | J. Immunol. | pmid:12218155 |
| Bussolati B et al. | Expression of CD154 on renal cell carcinomas and effect on cell proliferation, motility and platelet-activating factor synthesis. | 2002 | Int. J. Cancer | pmid:12209602 |
| Bazan H and Ottino P | The role of platelet-activating factor in the corneal response to injury. | 2002 | Prog Retin Eye Res | pmid:12207945 |
| Göggel R et al. | Platelet-activating factor-induced pulmonary edema is partly mediated by prostaglandin E(2), E-prostanoid 3-receptors, and potassium channels. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12204861 |
| Ewer AK | Role of platelet-activating factor in the pathophysiology of necrotizing enterocolitis. | 2002 | Acta Paediatr Suppl | pmid:12200892 |
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| Takizawa T et al. | Inhibition of protein kinases A and C demonstrates dual modes of response in human eosinophils stimulated with platelet-activating factor. | 2002 | J. Allergy Clin. Immunol. | pmid:12170264 |
| Ryan KL et al. | Platelet-activating factor does not mediate circulatory failure induced by 35-GHz microwave heating. | 2002 | Methods Find Exp Clin Pharmacol | pmid:12168504 |
| Li L et al. | Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica. | 2002 | Eur. J. Pharmacol. | pmid:12163102 |
| Fonteh AN | Differential effects of arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils. Evidence for different arachidonate pools. | 2002 | Eur. J. Biochem. | pmid:12153573 |
| De Plaen IG et al. | Endotoxin, but not platelet-activating factor, activates nuclear factor-kappaB and increases IkappaBalpha and IkappaBbeta turnover in enterocytes. | 2002 | Immunology | pmid:12153521 |
| Claud EC et al. | Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. | 2002 | Pediatr. Res. | pmid:12149490 |
| McLennan SV et al. | Effects of mesangium glycation on matrix metalloproteinase activities: possible role in diabetic nephropathy. | 2002 | Diabetes | pmid:12145178 |
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| Fujiu T et al. | Cellular adhesion is required for effector functions of human eosinophils via G-protein coupled receptors. | 2002 | Ann. Allergy Asthma Immunol. | pmid:12141728 |
| Teather LA et al. | Platelet-activating factor increases prostaglandin E(2) release from astrocyte-enriched cortical cell cultures. | 2002 | Brain Res. | pmid:12133598 |
| Megens AA et al. | Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12130734 |
| Leusch A et al. | Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice. | 2002 | Eur J Pharm Sci | pmid:12128165 |
| Kulikov VI and Muzya GI | Influence of platelet-activating factor, its cell analogs, and antagonist on the production of superoxide radicals by blood leukocytes of healthy and hypercholesterolemic individuals. | 2002 | Biochemistry Mosc. | pmid:12126473 |
| Benveniste J et al. | [Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine]. | 1979 | C. R. Acad. Sci., D, Sci. Nat. | pmid:121258 |
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| Mayer K et al. | Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12124231 |
| Sun Z et al. | Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1. | 2002 | J. Surg. Res. | pmid:12121711 |
| Talvani A et al. | Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. | 2002 | Infect. Immun. | pmid:12117933 |
| Chang HW et al. | Platelet-activating factor acetylhydrolase activity in cerebrospinal fluid of children with acute systemic or neurological illness. | 2002 | Ann. Neurol. | pmid:12112082 |
| Parker MA et al. | Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. | 2002 | J. Neurosci. Res. | pmid:12111814 |
| Unno N et al. | Single nucleotide polymorphism (G994-->T) in the plasma platelet-activating factor-acetylhydrolase gene is associated with graft patency of femoropopliteal bypass. | 2002 | Surgery | pmid:12110797 |
| Yoshida H et al. | Platelet-activating factor enhances the expression of vascular endothelial growth factor in normal human astrocytes. | 2002 | Brain Res. | pmid:12106666 |
| Mohr PJ and Halcomb RL | Convergent enantioselective synthesis of the tricyclic core of phomactin A. | 2002 | Org. Lett. | pmid:12098260 |