| MeSH term | MeSH ID | Detail |
|---|---|---|
| Disseminated Intravascular Coagulation | D004211 | 7 associated lipids |
| Glomerulonephritis, IGA | D005922 | 7 associated lipids |
| Behcet Syndrome | D001528 | 7 associated lipids |
| Infant, Premature, Diseases | D007235 | 7 associated lipids |
| Mucositis | D052016 | 7 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Pneumococcal Infections | D011008 | 7 associated lipids |
| Rheumatic Diseases | D012216 | 7 associated lipids |
| Pelvic Pain | D017699 | 7 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Coronary Thrombosis | D003328 | 7 associated lipids |
| Arthus Reaction | D001183 | 8 associated lipids |
| Peripheral Vascular Diseases | D016491 | 8 associated lipids |
| Corneal Neovascularization | D016510 | 8 associated lipids |
| Lupus Nephritis | D008181 | 8 associated lipids |
| Aggressive Periodontitis | D010520 | 8 associated lipids |
| Tangier Disease | D013631 | 8 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Thalassemia | D013789 | 8 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tomeo AC and Durán WN | Resistance and exchange microvessels are modulated by different PAF receptors. | 1991 | Am. J. Physiol. | pmid:1659229 |
| Hines KL and Fisher RA | Regulation of hepatic glycogenolysis and vasoconstriction during antigen-induced anaphylaxis. | 1992 | Am. J. Physiol. | pmid:1375439 |
| Livio M et al. | Role of platelet-activating factor in primary hemostasis. | 1988 | Am. J. Physiol. | pmid:2837916 |
| Huber W et al. | Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. | 1993 | Am. J. Physiol. | pmid:8279553 |
| Del Maschio A et al. | Platelet activation by polymorphonuclear leukocytes exposed to chemotactic agents. | 1990 | Am. J. Physiol. | pmid:2156456 |
| DeFily DV et al. | PAF attenuates endothelium-dependent coronary arteriolar vasodilation. | 1996 | Am. J. Physiol. | pmid:8764261 |
| Munoz NM et al. | Effects of PAF on isolated rat airways perfused with blood-free solution. | 1991 | Am. J. Physiol. | pmid:2018147 |
| Schlondorff D et al. | Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells. | 1986 | Am. J. Physiol. | pmid:3087218 |
| Wallace JL et al. | Platelet-activating factor mediates gastric damage induced by hemorrhagic shock. | 1990 | Am. J. Physiol. | pmid:2372058 |
| Montrucchio G et al. | Release of platelet-activating factor from ischemic-reperfused rabbit heart. | 1989 | Am. J. Physiol. | pmid:2539755 |
| Kurose I et al. | Microvascular dysfunction induced by nonsteroidal anti-inflammatory drugs: role of leukocytes. | 1996 | Am. J. Physiol. | pmid:8779980 |
| Gozal D et al. | Platelet-activating factor modulates cardiorespiratory responses in the conscious rat. | 1998 | Am. J. Physiol. | pmid:9688699 |
| Suzuki M et al. | Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets. | 1998 | Am. J. Physiol. | pmid:9458712 |
| Conyers G et al. | A factor in serum lowers resistance and opens tight junctions of MDCK cells. | 1990 | Am. J. Physiol. | pmid:2221039 |
| Kvietys PR et al. | Ethanol enhances leukocyte-endothelial cell interactions in mesenteric venules. | 1990 | Am. J. Physiol. | pmid:2221068 |
| Harris NR et al. | Capillary filtration during acute inflammation: role of adherent neutrophils. | 1993 | Am. J. Physiol. | pmid:7902014 |
| Bussolino F et al. | Platelet activating factor induces dopamine release in PC-12 cell line. | 1988 | Am. J. Physiol. | pmid:3177629 |
| Sun X et al. | P-selectin-deficient mice are protected from PAF-induced shock, intestinal injury, and lethality. | 1997 | Am. J. Physiol. | pmid:9252509 |
| Saito M et al. | Association of granular exocytosis with Ca(2+)-activated K+ channels in human eosinophils. | 1997 | Am. J. Physiol. | pmid:9252535 |
| Gulbins E et al. | Effects of rC5a on the circulation of normal and split hydronephrotic rat kidneys. | 1993 | Am. J. Physiol. | pmid:8342619 |
| Kobayashi I et al. | Platelet-activating factor modulates microvascular transport by stimulation of protein kinase C. | 1994 | Am. J. Physiol. | pmid:8160825 |
| Schlondorff D et al. | Relationship of GTP-binding proteins, phospholipase C, and PGE2 synthesis in rat glomerular mesangial cells. | 1989 | Am. J. Physiol. | pmid:2492160 |
| Bellan JA et al. | Analysis of pulmonary and systemic vascular responses to platelet-activating factor in the cat. | 1992 | Am. J. Physiol. | pmid:1379004 |
| Arnould T et al. | Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1. | 1993 | Am. J. Physiol. | pmid:8098907 |
| Shibamoto T et al. | PAF increases capillary pressure but not vascular permeability in isolated blood-perfused canine lungs. | 1993 | Am. J. Physiol. | pmid:8498559 |
| Wallace JL | Lipid mediators of inflammation in gastric ulcer. | 1990 | Am. J. Physiol. | pmid:2405704 |
| Miura S et al. | Attenuation of endotoxin-induced intestinal microcirculatory damage by eicosapentanoic acid. | 1993 | Am. J. Physiol. | pmid:8498509 |
| Huang Q et al. | Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. | 1998 | Am. J. Physiol. | pmid:9746460 |
| Milhoan KA et al. | Hypoxia induces endothelial cells to increase their adherence for neutrophils: role of PAF. | 1992 | Am. J. Physiol. | pmid:1415623 |
| Dorn GW and Davis MG | Differential megakaryocytic desensitization to platelet agonists. | 1992 | Am. J. Physiol. | pmid:1415671 |
| Faden AI and Tzendzalian PA | Platelet-activating factor antagonists limit glycine changes and behavioral deficits after brain trauma. | 1992 | Am. J. Physiol. | pmid:1415805 |
| Montrucchio G et al. | Potential angiogenic role of platelet-activating factor in human breast cancer. | 1998 | Am. J. Pathol. | pmid:9811351 |
| O'Flaherty JT et al. | Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents. | 1981 | Am. J. Pathol. | pmid:6274199 |
| Reznichenko A and Korstanje R | The role of platelet-activating factor in mesangial pathophysiology. | 2015 | Am. J. Pathol. | pmid:25655028 |
| Rampart M and Williams TJ | Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration. | 1986 | Am. J. Pathol. | pmid:3524253 |
| Lehr HA et al. | In vitro effects of oxidized low density lipoprotein on CD11b/CD18 and L-selectin presentation on neutrophils and monocytes with relevance for the in vivo situation. | 1995 | Am. J. Pathol. | pmid:7531948 |
| Byrne SN et al. | The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation. | 2011 | Am. J. Pathol. | pmid:21703403 |
| Montrucchio G et al. | Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha. | 1997 | Am. J. Pathol. | pmid:9250168 |
| Zhou WG et al. | Evidence for platelet-activating factor as a late-phase mediator of chronic pancreatitis in the rat. | 1990 | Am. J. Pathol. | pmid:1701964 |
| O'Flaherty JT et al. | 1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants. | 1981 | Am. J. Pathol. | pmid:7223864 |
| Boccellino M et al. | Platelet-activating factor regulates cadherin-catenin adhesion system expression and beta-catenin phosphorylation during Kaposi's sarcoma cell motility. | 2005 | Am. J. Pathol. | pmid:15855650 |
| Montrucchio G et al. | Role of platelet-activating factor in the reperfusion injury of rabbit ischemic heart. | 1990 | Am. J. Pathol. | pmid:2372044 |
| Singh TP et al. | Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice. | 2011 | Am. J. Pathol. | pmid:21281802 |
| Koyama S et al. | Bradykinin stimulates type II alveolar cells to release neutrophil and monocyte chemotactic activity and inflammatory cytokines. | 1998 | Am. J. Pathol. | pmid:9846978 |
| Masubuchi T et al. | Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity. | 1998 | Am. J. Pathol. | pmid:9846980 |
| Stimler NP and O'Flaherty JT | Spasmogenic properties of platelet-activating factor: evidence for a direct mechanism in the contractile response of pulmonary tissues. | 1983 | Am. J. Pathol. | pmid:6624879 |
| Wolf P et al. | Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. | 2006 | Am. J. Pathol. | pmid:16936256 |
| Warren JS | Relationship between interleukin-1 beta and platelet-activating factor in the pathogenesis of acute immune complex alveolitis in the rat. | 1992 | Am. J. Pathol. | pmid:1519663 |
| Flickinger BD and Olson MS | Localization of the platelet-activating factor receptor to rat pancreatic microvascular endothelial cells. | 1999 | Am. J. Pathol. | pmid:10329588 |
| O'Flaherty JT et al. | Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. | 1981 | Am. J. Pathol. | pmid:6271016 |
| Souza-Fiho MV et al. | Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis. | 1997 | Am. J. Pathol. | pmid:9006340 |
| Valone FH and Goetzl EJ | Enhancement of human polymorphonuclear leukocyte adherence by the phospholipid mediator 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC). | 1983 | Am. J. Pathol. | pmid:6624880 |
| Bussolati B et al. | PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis. | 2000 | Am. J. Pathol. | pmid:11073830 |
| Sun XM et al. | Effects of in vivo 'priming' on endotoxin-induced hypotension and tissue injury. The role of PAF and tumor necrosis factor. | 1990 | Am. J. Pathol. | pmid:2327475 |
| Doi K et al. | Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. | 2006 | Am. J. Pathol. | pmid:16651609 |
| McManus LM and Pinckard RN | Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit. | 1985 | Am. J. Pathol. | pmid:4050977 |
| Montrucchio G et al. | Role of platelet-activating factor in polymorphonuclear neutrophil recruitment in reperfused ischemic rabbit heart. | 1993 | Am. J. Pathol. | pmid:8434642 |
| Hsueh W et al. | Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis. | 1986 | Am. J. Pathol. | pmid:3080895 |
| Bussolati B et al. | Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change. | 1999 | Am. J. Pathol. | pmid:10027419 |
| Elovitz MA et al. | A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. | 2003 | Am. J. Pathol. | pmid:14578208 |
| Gonzalez-Crussi F and Hsueh W | Experimental model of ischemic bowel necrosis. The role of platelet-activating factor and endotoxin. | 1983 | Am. J. Pathol. | pmid:6859226 |
| Camussi G et al. | Acute lung inflammation induced in the rabbit by local instillation of 1-0-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine or of native platelet-activating factor. | 1983 | Am. J. Pathol. | pmid:6859232 |
| Kispert S et al. | Cigarette Smoke Regulates Calcium-Independent Phospholipase A Metabolic Pathways in Breast Cancer. | 2017 | Am. J. Pathol. | pmid:28618256 |
| Stimler NP et al. | Anaphylactic actions of platelet-activating factor. | 1981 | Am. J. Pathol. | pmid:6975043 |
| Shaw JO and Henson PM | The binding of rabbit basophil-derived platelet-activating factor to rabbit platelets. | 1980 | Am. J. Pathol. | pmid:6987890 |
| Zhou W et al. | Role of platelet-activating factor in pancreatitis-associated acute lung injury in the rat. | 1992 | Am. J. Pathol. | pmid:1562055 |
| Zhou W et al. | Platelet-activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation. | 1993 | Am. J. Pathol. | pmid:8494049 |
| Humphrey DM | Inflammatory exudates in skin windows induced by 1-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine. | 1990 | Am. J. Pathol. | pmid:2407127 |
| Biancone L et al. | Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis. | 1999 | Am. J. Pathol. | pmid:10550329 |
| Emanuelli G et al. | Experimental acute pancreatitis induced by platelet activating factor in rabbits. | 1989 | Am. J. Pathol. | pmid:2464939 |
| Wild MD and Roudebush WE | Platelet-activating factor improves intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11349157 |
| Hoffman DR et al. | The role of platelet-activating factor in human fetal lung maturation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3728606 |
| Tabor BL et al. | Platelet-activating factor antagonists decrease lung protein leak in preterm ventilated rabbits. | 1992 | Am. J. Obstet. Gynecol. | pmid:1530043 |
| Narahara H and Johnston JM | Effects of endotoxins and cytokines on the secretion of platelet-activating factor-acetylhydrolase by human decidual macrophages. | 1993 | Am. J. Obstet. Gynecol. | pmid:8372856 |
| Claman P | Platelet activating factor does not improve intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11717679 |
| Benedetto C et al. | Reduced serum inhibition of platelet-activating factor activity in preeclampsia. | 1989 | Am. J. Obstet. Gynecol. | pmid:2912073 |
| Morris C et al. | Effects of platelet-activating factor on prostaglandin E2 production by intact fetal membranes. | 1992 | Am. J. Obstet. Gynecol. | pmid:1566774 |
| Maul H et al. | Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats. | 2002 | Am. J. Obstet. Gynecol. | pmid:12388958 |
| Zhu YP et al. | The presence of platelet-activating factor binding sites in human myometrium and their role in uterine contraction. | 1992 | Am. J. Obstet. Gynecol. | pmid:1314480 |
| Rowland BL et al. | Elevated circulating concentrations of platelet activating factor in preeclampsia. | 2000 | Am. J. Obstet. Gynecol. | pmid:11035340 |
| Matorras R and Pijoan JI | The improvement in pregnancy rates with platelet-activating factor in intrauterine insemination was not demonstrated. | 2002 | Am. J. Obstet. Gynecol. | pmid:11904634 |
| Hoffman DR et al. | Detection of platelet-activating factor in amniotic fluid of complicated pregnancies. | 1990 | Am. J. Obstet. Gynecol. | pmid:2309839 |
| Thaete LG and Neerhof MG | Endothelin and platelet-activating factor: significance in the pathophysiology of ischemia/reperfusion-induced fetal growth restriction in the rat. | 2006 | Am. J. Obstet. Gynecol. | pmid:16579936 |
| Roudebush WE et al. | Platelet activating factor enhances in vitro fertilization of rabbit oocytes. | 1990 | Am. J. Obstet. Gynecol. | pmid:2240122 |
| Minhas BS et al. | Effects of platelet activating factor on mouse oocyte fertilization in vitro. | 1989 | Am. J. Obstet. Gynecol. | pmid:2603931 |
| Frostegård J et al. | Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion. | 2003 | Am. J. Obstet. Gynecol. | pmid:14520236 |
| Silver RK et al. | Anticardiolipin antibody-positive serum enhances endothelial cell platelet-activating factor production. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750472 |
| Minhas BS | Platelet-activating factor treatment of human spermatozoa enhances fertilization potential. | 1993 | Am. J. Obstet. Gynecol. | pmid:8475981 |
| Sueoka K et al. | Platelet activating factor-induced early pregnancy factor activity from the perfused rabbit ovary and oviduct. | 1988 | Am. J. Obstet. Gynecol. | pmid:3207134 |
| Perico N and Remuzzi G | Role of platelet-activating factor in renal immune injury and proteinuria. | 1990 | Am. J. Nephrol. | pmid:2256482 |
| Kees-Folts D and Diamond JR | Relationship between hyperlipidemia, lipid mediators, and progressive glomerulosclerosis in the nephrotic syndrome. | 1993 | Am. J. Nephrol. | pmid:8116689 |
| Camussi G et al. | Platelet-activating factor in renal diseases. | 1989 | Am. J. Nephrol. | pmid:2646923 |
| Ganong BR | Roles of lipid turnover in transmembrane signal transduction. | 1991 | Am. J. Med. Sci. | pmid:1661067 |
| Muirhead EE et al. | Biologic contrasts between medullipin I and vasoactive glyceryl compounds. | 1989 | Am. J. Med. Sci. | pmid:2764021 |
| Gaylord MS et al. | Altered platelet-activating factor levels and acetylhydrolase activities are associated with increasing severity of bronchopulmonary dysplasia. | 1996 | Am. J. Med. Sci. | pmid:8853062 |
| Pitcock JA | Morphometric studies of the renomedullary interstitial cells. | 1988 | Am. J. Med. Sci. | pmid:3284348 |
| Barnes PJ | Inflammatory mechanisms and nocturnal asthma. | 1988 | Am. J. Med. | pmid:3041827 |
| Wasserman SI | The mast cell and theophylline in asthma. | 1985 | Am. J. Med. | pmid:3002176 |
| Wright NR et al. | Purulent Pericarditis and Abscessed Myocardium with Acute Myocardial Infarction. | 2016 | Am. J. Med. | pmid:26524710 |
| Tetta C et al. | Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. | 1997 | Am. J. Kidney Dis. | pmid:9372980 |