Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Göggel R et al. | PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. | 2004 | Nat. Med. | pmid:14704790 |
Suenaga A and Ueki H | Effect of orthovanadate on platelet aggregation induced by platelet-activating factor. | 2004 | Biol. Pharm. Bull. | pmid:15516737 |
Tsutsumi T et al. | Phorbol myristate acetate stimulates degradation of a structural analogue of platelet-activating factor to a neutral lipid in human leukemic K562 cells: relevance to the release of lipids. | 2004 | Biol. Pharm. Bull. | pmid:14709893 |
Nakagawa K et al. | Sperm-immobilizing antibodies suppress an increase in the plasma membrane fluidity of human spermatozoa. | 2004 | Fertil. Steril. | pmid:15474073 |
Nie ZG et al. | [Effects of ginkgolide B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes]. | 2004 | Yao Xue Xue Bao | pmid:15491096 |
Barnes PJ | Ceramide lances the lungs. | 2004 | Nat. Med. | pmid:14760419 |
Goldring WP and Pattenden G | Total synthesis of (+/-)-phomactin G, a platelet activating factor antagonist from the marine fungus Phoma sp. | 2004 | Org. Biomol. Chem. | pmid:14770224 |
Chami O et al. | Components of a platelet-activating factor-signaling loop are assembled in the ovine endometrium late in the estrous cycle. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:15271646 |
Zhelev DV et al. | Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants. | 2004 | Biophys. J. | pmid:15240502 |
Seyffarth G et al. | Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture. | 2004 | Reprod. Biol. Endocrinol. | pmid:15191613 |
Lekka ME et al. | The impact of intravenous fat emulsion administration in acute lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:14656749 |
Lu J et al. | Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14512286 |
Buduneli E et al. | Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats. | 2004 | J. Periodontol. | pmid:15633329 |
Vardar S et al. | Therapeutic versus prophylactic plus therapeutic administration of omega-3 fatty acid on endotoxin-induced periodontitis in rats. | 2004 | J. Periodontol. | pmid:15732866 |
Morita K et al. | Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice. | 2004 | Pain | pmid:15363879 |
Nemcsik J et al. | Synergistic interaction of endogenous platelet-activating factor and vasopressin in generating angina in rats. | 2004 | Eur. J. Pharmacol. | pmid:15363995 |
Zinchuk O et al. | Dynamics of PAF-induced conjunctivitis reveals differential expression of PAF receptor by macrophages and eosinophils in the rat. | 2004 | Cell Tissue Res. | pmid:15290234 |
Tarricone C et al. | Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. | 2004 | Neuron | pmid:15572112 |
Xu Y et al. | Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neurons. | 2004 | Exp. Neurol. | pmid:15296832 |
Wanten G et al. | Lipid effects on neutrophil calcium signaling induced by opsonized particles: platelet activating factor is only part of the story. | 2004 | Clin Nutr | pmid:15297099 |
Han XB et al. | Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15319184 |
Bossi F et al. | Platelet-activating factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex. | 2004 | J. Immunol. | pmid:15557188 |
Sumita C et al. | Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage. | 2004 | Biochim. Biophys. Acta | pmid:15279882 |
Zimmerman GA and McIntyre TM | PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions. | 2004 | Trends Mol Med | pmid:15177186 |
Lee SH et al. | Role of messenger RNA expression of platelet activating factor and its receptor in porcine in vitro-fertilized and cloned embryo development. | 2004 | Biol. Reprod. | pmid:15151927 |
Ishii S et al. | Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. | 2004 | J. Immunol. | pmid:15153532 |
Zhang C et al. | The effect of Ginkgo biloba extract (EGb 761) on hepatic sinusoidal endothelial cells and hepatic microcirculation in CCl4 rats. | 2004 | Am. J. Chin. Med. | pmid:15154282 |
Saint-Martin F et al. | A randomized, double-blind, parallel-group study, comparing the efficacy and safety of rupatadine (20 and 10 mg), a new PAF and H1 receptor-specific histamine antagonist, to loratadine 10 mg in the treatment of seasonal allergic rhinitis. | 2004 | J Investig Allergol Clin Immunol | pmid:15160440 |
Xu Y and Tao YX | Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. | 2004 | Neuroreport | pmid:15076749 |
Slomiany BL and Slomiany A | Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent constitutive nitric-oxide synthase activation. | 2004 | J. Physiol. Pharmacol. | pmid:15082869 |
Ramos G et al. | Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. | 2004 | Toxicol. Appl. Pharmacol. | pmid:15020195 |
McDonagh PF et al. | Chronic expression of platelet adhesion proteins is associated with severe ischemic heart disease in type 2 diabetic patients: Chronic platelet activation in diabetic heart patients. | 2003 Sep-Oct | J. Diabetes Complicat. | pmid:12954156 |
Kerek M et al. | Effects of recombinant platelet activating factor acetylhydrolase in obstructive jaundice. | 2003 Jul-Aug | Hepatogastroenterology | pmid:12845989 |
Baltás E et al. | Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. | 2003 Jul-Aug | Skin Pharmacol. Appl. Skin Physiol. | pmid:12784066 |
Hsueh W et al. | Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. | 2003 Jan-Feb | Pediatr. Dev. Pathol. | pmid:12424605 |
Diez-Fraile A et al. | Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. | 2003 Jan-Feb | Vet. Res. | pmid:12588684 |
Saeed SA and Rasheed H | Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation. | 2003 | Acta Pharmacol. Sin. | pmid:12511226 |
Koyama N | Platelet activating factor in surfactant-TA is inhibited by coexisting inhibitors. | 2003 | Lung | pmid:14692561 |
Russo S et al. | Platelet-activating factor mediates CD40-dependent angiogenesis and endothelial-smooth muscle cell interaction. | 2003 | J. Immunol. | pmid:14607955 |
Slomiany BL and Slomiany A | Biphasic role of platelet-activating factor in oral mucosal ulcer healing. | 2003 | IUBMB Life | pmid:14609204 |
Shigematsu S et al. | Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants. | 2003 | Free Radic. Biol. Med. | pmid:12654468 |
Collado MP et al. | Endothelin-1 decreases ethanolamine plasmalogen levels and evokes PAF production in brain microvessels. | 2003 | Microvasc. Res. | pmid:14609525 |
Odeh AI et al. | Effect of platelet-activating factor (PAF) on stallion sperm motility, capacitation and the acrosome reaction. | 2003 | Reproduction | pmid:14611633 |
Sugimoto Y et al. | Inhibitory effects of glucocorticoids on rat eosinophil superoxide generation and chemotaxis. | 2003 | Int. Immunopharmacol. | pmid:12781701 |
Zhu X et al. | Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. | 2003 | Life Sci. | pmid:14519449 |
Gabrijelcic J et al. | Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression. | 2003 | Eur. Respir. J. | pmid:12952263 |
Tokuoka SM et al. | Involvement of platelet-activating factor and LIS1 in neuronal migration. | 2003 | Eur. J. Neurosci. | pmid:12911752 |
Lupia E et al. | Intra-plaque production of platelet-activating factor correlates with neoangiogenesis in human carotid atherosclerotic lesions. | 2003 | Int. J. Mol. Med. | pmid:12883648 |
Handa RK et al. | Role of Nitric oxide in the renal and systemic vasodilatory responses to platelet-activating factor in the rat, in vivo. | 2003 | Kidney Blood Press. Res. | pmid:12886044 |
Taggart DP et al. | Neuroprotection during cardiac surgery: a randomised trial of a platelet activating factor antagonist. | 2003 | Heart | pmid:12860868 |
Takafuji S et al. | Matrix metalloproteinase-9 release from human leukocytes. | 2003 | J Investig Allergol Clin Immunol | pmid:12861851 |
Bar-Or D et al. | Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. | 2003 | Shock | pmid:12865660 |
Kujiraoka T et al. | Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus. | 2003 | J. Lipid Res. | pmid:12867534 |
D'Andrea D et al. | Induction of tissue factor in the arterial wall during recurrent thrombus formation. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12869352 |
Lupia E et al. | The membrane attack complex of complement contributes to plasmin-induced synthesis of platelet-activating factor by endothelial cells and neutrophils. | 2003 | Immunology | pmid:12871223 |
Fernandes ES et al. | Mechanisms underlying the modulatory action of platelet activating factor (PAF) on the upregulation of kinin B1 receptors in the rat paw. | 2003 | Br. J. Pharmacol. | pmid:12839871 |
Saruc M et al. | An experimental model of hemolysis-induced acute pancreatitis. | 2003 | Braz. J. Med. Biol. Res. | pmid:12845374 |
Nomikos TN et al. | Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue. | 2003 | Eur. J. Biochem. | pmid:12846832 |
Liu J et al. | Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. | 2003 | J. Biol. Chem. | pmid:12949078 |
Mano T et al. | Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase. | 2003 | Bioorg. Med. Chem. | pmid:12927848 |
Talvani A et al. | Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice. | 2003 | Microbes Infect. | pmid:12850205 |
Triggiani M et al. | Secretory phospholipases A2 activate selective functions in human eosinophils. | 2003 | J. Immunol. | pmid:12626587 |
Strait RT et al. | IL-4 exacerbates anaphylaxis. | 2003 | J. Immunol. | pmid:12646651 |
Al-Darmaki S et al. | Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells. | 2003 | J. Immunol. | pmid:12496397 |
Lie WJ et al. | Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12911788 |
Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
Gödecke A | PAF, PIP(3) and NO: emerging role in reperfusion injury. | 2003 | Cardiovasc. Res. | pmid:14613846 |
Alloatti G et al. | Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. | 2003 | Cardiovasc. Res. | pmid:14613853 |
Akisu M et al. | Supplementation with Saccharomyces boulardii ameliorates hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice. | 2003 | Eur J Pediatr Surg | pmid:14618522 |
Zhang X et al. | Age-related increase of plasma platelet-activating factor concentrations in Chinese. | 2003 | Clin. Chim. Acta | pmid:14568193 |
De Vriese AS and Bourgeois M | Pharmacologic treatment of acute renal failure in sepsis. | 2003 | Curr Opin Crit Care | pmid:14639066 |
Alviano DS et al. | Differentiation of Fonsecaea pedrosoi mycelial forms into sclerotic cells is induced by platelet-activating factor. | 2003 | Res. Microbiol. | pmid:14643407 |
Chlopicki S et al. | Obligatory role of lipid mediators in platelet-neutrophil adhesion. | 2003 | Thromb. Res. | pmid:14592550 |
Montrucchio G et al. | Mechanisms of the priming effect of low doses of lipopoly-saccharides on leukocyte-dependent platelet aggregation in whole blood. | 2003 | Thromb. Haemost. | pmid:14597983 |
Shabanov VV | [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. | 2003 | Vestn. Akad. Med. Nauk SSSR | pmid:14598737 |
Estellés R et al. | Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo. | 2003 | Br. J. Pharmacol. | pmid:14559857 |
Fang HY et al. | Cyclooxygenase-2 in human non-small cell lung cancer. | 2003 | Eur J Surg Oncol | pmid:12633561 |
Witko-Sarsat V et al. | AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteine treatment in dialysis patients. | 2003 | Kidney Int. | pmid:12787398 |
Slomiany BL and Slomiany A | Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788098 |
Schuster DP et al. | Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. | 2003 | Crit. Care Med. | pmid:12794395 |
Rabinovici R | Platelet activating factor inhibition in sepsis: the end? | 2003 | Crit. Care Med. | pmid:12794432 |
Saraf MK et al. | Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. | 2003 | Behav. Brain Res. | pmid:12798263 |
Denizot Y et al. | Platelet-activating factor and normal or leukaemic haematopoiesis. | 2003 | Leuk. Lymphoma | pmid:12802913 |
Olanders K et al. | Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. | 2003 | Scand. J. Gastroenterol. | pmid:12825870 |
Adamson RH et al. | PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12649070 |
Haraldsen P et al. | Multimodal management - of value in fulminant acute pancreatitis? | 2003 | Pancreatology | pmid:12649560 |
Denizot Y et al. | No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis. | 2003 | Mediators Inflamm. | pmid:12775360 |
Yan W et al. | Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12775763 |
Nie ZG and Wang WJ | [Effect of ginkgolide B on platelet-activating factor induced activation of rat polymorphonuclear leukocytes]. | 2003 | Yao Xue Xue Bao | pmid:12778742 |
Fragopoulou E et al. | Structure elucidation of phenolic compounds from red/white wine with antiatherogenic properties. | 2003 | Biochim. Biophys. Acta | pmid:12782155 |
Zang BX et al. | [Antagonistic effect of myricetin on platelet activing factor]. | 2003 | Yao Xue Xue Bao | pmid:14991995 |
Simon HU et al. | Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. | 2003 | Eur. J. Immunol. | pmid:12672048 |
Teather LA and Wurtman RJ | Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes. | 2003 | Neurosci. Lett. | pmid:12672535 |
Kordan W et al. | Functions of platelet activating factor (PAF) in mammalian reproductive processes: a review. | 2003 | Pol J Vet Sci | pmid:12675470 |
Loucks EB et al. | Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. | 2003 | Can J Cardiol | pmid:12677282 |
Ginesta MM et al. | Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. | 2003 | APMIS | pmid:12752216 |
Wu B et al. | Platelet-activating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion. | 2003 | FASEB J. | pmid:12709415 |
Bussolati B et al. | The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. | 2003 | J. Immunol. | pmid:12538709 |
Hirayama K et al. | Platelet-activating factor, a critical mediator in the pathogenesis of dextran sulfate sodium-induced colitis in rats. | 2003 | Dis. Colon Rectum | pmid:12544529 |
Balestrieri ML et al. | Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress. | 2003 | J. Lipid Res. | pmid:12576520 |