Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Hsueh W et al. | Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. | 1998 Jan-Feb | Pediatr. Dev. Pathol. | pmid:10463267 |
Kaminski JJ et al. | Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. | 1999 | Bioorg. Med. Chem. | pmid:10465415 |
Conroy DM and Sirois P | Early bronchial hyperresponsiveness following injection of sephadex beads in the guinea pig: involvement of platelet activating factor and thromboxane A2. | 1999 | Inflammation | pmid:10466580 |
Ho YS et al. | Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase. | 1999 | Protein Eng. | pmid:10469831 |
Denham W and Norman J | The potential role of therapeutic cytokine manipulation in acute pancreatitis. | 1999 | Surg. Clin. North Am. | pmid:10470326 |
Baker KE and Curtis MJ | Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism. | 1999 | J. Cardiovasc. Pharmacol. | pmid:10470998 |
Oku H and Ishiguro K | Screening method for PAF antagonist substances: on the phenolic compounds from Impatients balsamina L. | 1999 | Phytother Res | pmid:10479766 |
Casale TB et al. | Eosinophils isolated by magnetic cell sorting respond poorly to lipid chemoattractants. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10480585 |
Foitzik T et al. | Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of platelet-activating factor receptor blockade vs. endothelin receptor blockade. | 1999 May-Jun | J. Gastrointest. Surg. | pmid:10481117 |
Calcerrada MC et al. | Modulation of protein kinase C isoforms by PAF in cerebral cortex. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482284 |
Nakasaki T et al. | Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10482285 |
Kapui Z et al. | Experimental studies on guanosine 3',5'-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs. | 1999 | Arzneimittelforschung | pmid:10483515 |
Shah BH et al. | Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. | 1999 | Biochem. Pharmacol. | pmid:10484074 |
Kültürsay N et al. | Platelet-activating factor concentrations in healthy and septic neonates. | 1999 | Eur. J. Pediatr. | pmid:10485307 |
Koyama N and Ogawa Y | Elevated platelet activating factor in the tracheal aspirate at birth and signs of intra-uterine inflammation in infants with neonatal pulmonary emphysema. | 1999 | Eur. J. Pediatr. | pmid:10486094 |
Piccolo MT et al. | Chemotactic mediator requirements in lung injury following skin burns in rats. | 1999 | Exp. Mol. Pathol. | pmid:10486240 |
Triggiani M et al. | Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine. | 1999 | Biochem. Pharmacol. | pmid:10487538 |
Blackstone MO | ICAM-1 in cerulein-induced pancreatitis. | 1999 | Gastroenterology | pmid:10490367 |
Comellas A et al. | Effect of platelet activating factor (PAF) on pulmonary circulation in isolated rabbit lung. | 1999 | J. Physiol. Biochem. | pmid:10494654 |
GamaleÄ IA et al. | [Post-receptor formation of active forms of oxygen in nonphagocytic cells]. | 1999 | Tsitologiia | pmid:10496012 |