Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Epilepsy D004827 35 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Extravasation of Diagnostic and Therapeutic Materials D005119 3 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Fever D005334 35 associated lipids
Fibrosis D005355 23 associated lipids
Gastritis D005756 27 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Glioma D005910 112 associated lipids
Gliosis D005911 6 associated lipids
Glomerulonephritis D005921 35 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Heart Arrest D006323 13 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Cardiomegaly D006332 31 associated lipids
Heart Injuries D006335 6 associated lipids
Hematoma, Subdural D006408 3 associated lipids
Hemolysis D006461 131 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Agwu DE et al. Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by Coomassie blue staining and densitometry. 1989 Biochem. Biophys. Res. Commun. pmid:2466463
Ichinose M et al. Activation of K+ current in macrophages by platelet activating factor. 1992 Biochem. Biophys. Res. Commun. pmid:1370616
Rezaul K et al. Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. 1997 Biochem. Biophys. Res. Commun. pmid:9345263
Iwamoto S et al. The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. 1997 Biochem. Biophys. Res. Commun. pmid:9345277
Catalán RE et al. Nitric oxide mediates the PAF-stimulated cyclic GMP production in hippocampal slices. 1996 Biochem. Biophys. Res. Commun. pmid:8806587
Lee TC et al. Renal necrosis and the involvement of a single enzyme of the de novo pathway for the biosynthesis of platelet-activating factor in the rat kidney inner medulla. 1989 Biochem. Biophys. Res. Commun. pmid:2551264
Catalán RE et al. Platelet-activating factor stimulates protein kinase C translocation in cerebral microvessels. 1993 Biochem. Biophys. Res. Commun. pmid:8484756
Wang F et al. A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF. 1993 Biochem. Biophys. Res. Commun. pmid:8447826
O'Flaherty JT et al. 5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor. 1983 Biochem. Biophys. Res. Commun. pmid:6403011
Smith RJ et al. Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. 1984 Biochem. Biophys. Res. Commun. pmid:6329191
Dillon AM and Heath MF The effects of tyrphostins B42 and B46 on equine platelet function and protein tyrosine phosphorylation. 1995 Biochem. Biophys. Res. Commun. pmid:7542881
Liu B et al. Implication of protein kinase C alpha in PAF-stimulated phospholipase D activation in Chinese hamster ovary (CHO) cells expressing PAF receptor. 1995 Biochem. Biophys. Res. Commun. pmid:7677747
Yasuda K et al. Platelet-activating factor in normal rat uterus. 1986 Biochem. Biophys. Res. Commun. pmid:3753495
Doebber TW et al. Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. 1985 Biochem. Biophys. Res. Commun. pmid:2985058
Pfeilschifter J et al. Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. 1985 Biochem. Biophys. Res. Commun. pmid:2985064
Lerner R et al. Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils. 1988 Biochem. Biophys. Res. Commun. pmid:2838025
Hwang SB et al. Specific binding sites for platelet activating factor in human lung tissues. 1985 Biochem. Biophys. Res. Commun. pmid:2986633
García-Sáinz JA and Hernández-Sotomayor SM Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. 1985 Biochem. Biophys. Res. Commun. pmid:3933497
Clay KL et al. Structure elucidation of platelet activating factor derived from human neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6430285
Kuiper J et al. The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. 1988 Biochem. Biophys. Res. Commun. pmid:3144970
O'Flaherty JT et al. Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function. 1984 Biochem. Biophys. Res. Commun. pmid:6433920
O'Flaherty JT et al. Evidence for 5, 12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation. 1981 Biochem. Biophys. Res. Commun. pmid:6277309
Blank ML et al. Generation of the precursor (lyso-PAF) of platelet-activating factor via a CoA-dependent transacylase. 1995 Biochem. Biophys. Res. Commun. pmid:7763233
Mendlovic F et al. Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. 1984 Biochem. Biophys. Res. Commun. pmid:6435614
Tokumura A et al. Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain. 1987 Biochem. Biophys. Res. Commun. pmid:3593346
Kojima S et al. Cooperativity between platelet-activating factor and collagen in platelet aggregation. 1987 Biochem. Biophys. Res. Commun. pmid:3593379
Tokuoka SM et al. Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. 2013 Biochem. Biophys. Res. Commun. pmid:23743196
Lad PM et al. Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. 1985 Biochem. Biophys. Res. Commun. pmid:2990462
Comminges C et al. Differential labelings suggest two specific phospholipid subclass hydrolysis promoted by PDGF-BB in vascular smooth muscle cells. 1996 Biochem. Biophys. Res. Commun. pmid:8607782
Weber C et al. Platelet activating factor enhances receptor-operated Ca(++)-influx and subsequent prostacyclin synthesis in human endothelial cells. 1993 Biochem. Biophys. Res. Commun. pmid:8373423
Resink TJ et al. The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. 1986 Biochem. Biophys. Res. Commun. pmid:2943273
Hayashi M et al. Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor. 1992 Biochem. Biophys. Res. Commun. pmid:1445360
Svetlov S and Nigam S Evidence for the presence of specific high affinity cytosolic binding sites for platelet-activating factor in human neutrophils. 1993 Biochem. Biophys. Res. Commun. pmid:8380690
Gil MG et al. Inhibition of phospholipid methyltransferase during zymosan induced secretion of platelet-activating factor in human polymorphonuclear leukocytes. 1981 Biochem. Biophys. Res. Commun. pmid:7306113
White GC Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. 1984 Biochem. Biophys. Res. Commun. pmid:6428395
Schlondorff D et al. Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. 1986 Biochem. Biophys. Res. Commun. pmid:3099783
Satouchi K et al. Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:4004866
Sugimoto T et al. Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. 1992 Biochem. Biophys. Res. Commun. pmid:1281995
Francescangeli E and Goracci G The de novo biosynthesis of platelet-activating factor in rat brain. 1989 Biochem. Biophys. Res. Commun. pmid:2543404
Hussaini IM and Shen TY A specific, photolabile and irreversible antagonist (L662,025) of the PAF-receptor. 1989 Biochem. Biophys. Res. Commun. pmid:2543410
Carveth HJ et al. Neutrophil activating factor (NAF) induces polymorphonuclear leukocyte adherence to endothelial cells and to subendothelial matrix proteins. 1989 Biochem. Biophys. Res. Commun. pmid:2665743
Shukla SD and Hanahan DJ AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6288030
Fernández B and Balsinde J Receptor-mediated activation of arachidonic acid release in mouse peritoneal macrophages is linked to extracellular calcium influx. 1991 Biochem. Biophys. Res. Commun. pmid:1659393
Kok PT et al. Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. 1988 Biochem. Biophys. Res. Commun. pmid:3132917
Nogami M et al. The effect of platelet-activating factor on [14C]aminopyrine uptake by isolated guinea pig parietal cells. 1990 Biochem. Biophys. Res. Commun. pmid:2346478
Kojima S et al. Cooperativity between platelet-activating factor and collagen in aggregation of bovine platelets, II. 1990 Biochem. Biophys. Res. Commun. pmid:2346486
Silva-Neto MA et al. Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. 2002 Biochem. Biophys. Res. Commun. pmid:12054663
Caramelo C et al. Presence of platelet-activating factor in blood from humans and experimental animals. Its absence in anephric individuals. 1984 Biochem. Biophys. Res. Commun. pmid:6732788
Lenihan DJ and Lee TC Regulation of platelet activating factor synthesis: modulation of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase by phosphorylation and dephosphorylation in rat spleen microsomes. 1984 Biochem. Biophys. Res. Commun. pmid:6732789
Palmantier R et al. Biosynthesis of paf-acether. XIV. Paf-acether output in murine peritoneal macrophages is regulated by the level of acetylhydrolase. 1989 Biochem. Biophys. Res. Commun. pmid:2751666
Filep J et al. Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog. 1989 Biochem. Biophys. Res. Commun. pmid:2916986
Pinckard RN et al. Molecular heterogeneity of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. 1984 Biochem. Biophys. Res. Commun. pmid:6743335
Barr R et al. The effect of platelet activating factor on electron transport of spinach chloroplasts. 1988 Biochem. Biophys. Res. Commun. pmid:3048258
Rigat B et al. GM2 activator protein inhibits platelet activating factor signaling in rats. 2009 Biochem. Biophys. Res. Commun. pmid:19486886
Catalán RE et al. PAF-induced activation of polyphosphoinositide-hydrolyzing phospholipase C in cerebral cortex. 1992 Biochem. Biophys. Res. Commun. pmid:1311925
Kato T et al. Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). 1988 Biochem. Biophys. Res. Commun. pmid:3202869
Pai JK et al. Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. 1988 Biochem. Biophys. Res. Commun. pmid:3422154
Takayasu M et al. Endothelin-induced mobilization of Ca2+ and the possible involvement of platelet activating factor and thromboxane A2. 1989 Biochem. Biophys. Res. Commun. pmid:2655596
Blank ML et al. A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn-glycerols, a precursor of platelet activating factor. 1984 Biochem. Biophys. Res. Commun. pmid:6696762
Sakakibara M et al. Induction of photoresponse by the hydrolysis of polyphosphoinositides in the Hermissenda type B photoreceptor. 1994 Biochem. Biophys. Res. Commun. pmid:7518677
Schulam PG et al. Evidence for a platelet-activating factor receptor on human lymphoblastoid B cells: activation of the phosphatidylinositol cycle and induction of calcium mobilization. 1990 Biochem. Biophys. Res. Commun. pmid:2154211
Rodrigues CO et al. Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi. 1996 Biochem. Biophys. Res. Commun. pmid:8687466
Panetta T et al. Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemia-reperfusion induced cerebral injury. 1987 Biochem. Biophys. Res. Commun. pmid:2827647
Bazan HE et al. The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products. 1987 Biochem. Biophys. Res. Commun. pmid:2827658
Ponpipom MM et al. (+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist. 1988 Biochem. Biophys. Res. Commun. pmid:2829894
Sugiura T et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. 1996 Biochem. Biophys. Res. Commun. pmid:8954083
Domingo MT et al. Presence of specific binding sites for platelet-activating factor (PAF) in brain. 1988 Biochem. Biophys. Res. Commun. pmid:2831903
Nakayama R et al. 1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity. 1988 Biochem. Biophys. Res. Commun. pmid:3355555
Beaubien BB et al. Platelet-activating factor stimulation of peptidoleukotriene release: inhibition by vasoactive polypeptide. 1984 Biochem. Biophys. Res. Commun. pmid:6594998
Levine L Regulation of arachidonic acid metabolism by phenylarsine oxide. 1991 Biochem. Biophys. Res. Commun. pmid:1859423
Slomiany BL and Slomiany A Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. 2003 Biochem. Biophys. Res. Commun. pmid:12788098
Waga I et al. Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin. 1993 Biochem. Biophys. Res. Commun. pmid:8267581
Diserbo M et al. Activation of large conductance Ca(2+)-activated K+ channels in N1E-115 neuroblastoma cells by platelet-activating factor. 1996 Biochem. Biophys. Res. Commun. pmid:8579584
Iwamoto S et al. Platelet microparticles: a carrier of platelet-activating factor? 1996 Biochem. Biophys. Res. Commun. pmid:8579618
Matsumoto T et al. G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe. 1987 Biochem. Biophys. Res. Commun. pmid:3032170
Errasfa M et al. Inhibition of phospholipase A2 activity of guinea-pig alveolar macrophages by lipocortin-like proteins purified from mice lung. 1988 Biochem. Biophys. Res. Commun. pmid:2968795
Saxena SP et al. Histamine formed in stimulated human platelets is cytoplasmic. 1989 Biochem. Biophys. Res. Commun. pmid:2803292
Hauser CJ et al. Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils. 2005 Biochem. Biophys. Res. Commun. pmid:16168959
Mueller HW et al. Synthesis of 1-acyl-2-[3H]acetyl-SN-glycero-3-phosphocholine, a structural analog of platelet activating factor, by vascular endothelial cells. 1991 Biochem. Biophys. Res. Commun. pmid:2039529
O'Flaherty JT and Jacobson D Protein kinase C blockers and neutrophil receptors for leukotriene B4. 1989 Biochem. Biophys. Res. Commun. pmid:2551291
Mészáros K Magnetic field elicits hypotension mediated by platelet activating factor in rats injected with iron beads. 1991 Biochem. Biophys. Res. Commun. pmid:1930228
Naoki K et al. PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. 2004 Biochem. Biophys. Res. Commun. pmid:15047169
Randell E et al. Interaction between rat serum phosphorylcholine binding protein and platelet activating factor. 1990 Biochem. Biophys. Res. Commun. pmid:2322233
Rigat B et al. The GM2 activator protein, a novel inhibitor of platelet-activating factor. 1999 Biochem. Biophys. Res. Commun. pmid:10329374
Inui H et al. Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells. 1994 Biochem. Biophys. Res. Commun. pmid:7802667
Hartiala KT et al. Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes. 1987 Biochem. Biophys. Res. Commun. pmid:3034265
Chau LY et al. Photoaffinity labeling of platelet activating factor binding sites in rabbit platelet membranes. 1989 Biochem. Biophys. Res. Commun. pmid:2545193
Smith RJ and Bowman BJ Stimulation of human neutrophil degranulation with 1-O-octadecyl-2-O-acetyl-SN-glyceryl-3-phosphorylcholine: modulation by inhibitors of arachidonic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6803804
Musch MW et al. Antigen-and ionophore-stimulated synthesis of platelet-activating factor by the cloned mast cell line, MC9. 1987 Biochem. Biophys. Res. Commun. pmid:3107564
Wirthmueller U et al. Receptor-operated activation of polymorphonuclear leukocytes: different effects of NAP-1/IL-8 and fMet-Leu-Phe or C5a. 1991 Biochem. Biophys. Res. Commun. pmid:1645549
Müller E et al. Human PAF receptor gene expression: induction during HL-60 cell differentiation. 1991 Biochem. Biophys. Res. Commun. pmid:1722407
Rubin RM and Rosenbaum JT A platelet-activating factor antagonist inhibits interleukin 1-induced inflammation. 1988 Biochem. Biophys. Res. Commun. pmid:3260779
Ye RD et al. Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. 1991 Biochem. Biophys. Res. Commun. pmid:1656963
Nishinaka Y et al. A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells. 1993 Biochem. Biophys. Res. Commun. pmid:8390246
Combadière C et al. Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor. 1990 Biochem. Biophys. Res. Commun. pmid:2158320
Holtzman MJ et al. Synthesis of the 1-O-hexadecyl molecular species of platelet-activating factor by airway epithelial and vascular endothelial cells. 1991 Biochem. Biophys. Res. Commun. pmid:2043121
Shiono S et al. Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors. 1993 Biochem. Biophys. Res. Commun. pmid:8390248
Billah MM and Siegel MI Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6422930
Tokumura A et al. Identification of sn-2-omega-hydroxycarboxylate-containing phospholipids in a lipid extract from bovine brain. 1991 Biochem. Biophys. Res. Commun. pmid:2043133
Prevost MC et al. Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. 1984 Biochem. Biophys. Res. Commun. pmid:6422938