| MeSH term | MeSH ID | Detail |
|---|---|---|
| Epilepsy | D004827 | 35 associated lipids |
| Leukemia, Erythroblastic, Acute | D004915 | 41 associated lipids |
| Escherichia coli Infections | D004927 | 17 associated lipids |
| Extravasation of Diagnostic and Therapeutic Materials | D005119 | 3 associated lipids |
| Fetal Growth Retardation | D005317 | 9 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Gastroesophageal Reflux | D005764 | 10 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Gliosis | D005911 | 6 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Glomerulonephritis, IGA | D005922 | 7 associated lipids |
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Heart Arrest | D006323 | 13 associated lipids |
| Heart Defects, Congenital | D006330 | 20 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Hematoma, Subdural | D006408 | 3 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jarvis GE et al. | The role of ADP in endotoxin-induced equine platelet activation. | 1996 | Eur. J. Pharmacol. | pmid:8960885 |
| Stoddart NR et al. | Stimulation of development in vitro by platelet-activating factor receptor ligands released by mouse preimplantation embryos. | 1996 | J. Reprod. Fertil. | pmid:8958827 |
| Tiemann U et al. | Effect of ATP and platelet-activating factor on intracellular calcium concentrations of cultured oviductal cells from cows. | 1996 | J. Reprod. Fertil. | pmid:8958821 |
| Wiebe SH et al. | Osteoclast activation in inflammatory periodontal diseases. | 1996 | Oral Dis | pmid:8957930 |
| Iwahisa Y et al. | Effect of Y-24180, a platelet-activating factor-receptor antagonist, on the antigen-induced airway microvascular leakage in guinea pigs. | 1996 | Jpn. J. Pharmacol. | pmid:8957681 |
| Noel AA et al. | Platelet-activating factor and nitric oxide mediate microvascular permeability in ischemia-reperfusion injury. | 1996 | Microvasc. Res. | pmid:8954863 |
| Howard AD and Erickson KL | Alteration of macrophage responsiveness to platelet-activating factor by interferon-gamma and lipopolysaccharide. | 1996 | Cell. Immunol. | pmid:8954615 |
| Sugiura T et al. | 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954083 |
| Mavromoustakos T et al. | The conformational properties of the antineoplastic ether lipid 1-thiohexadecyl-2-O-methyl-S-glycero-3-phosphocholine. | 1996 | Chem. Phys. Lipids | pmid:8952050 |
| Shindo K and Fukumura M | Azelastine hydrochloride inhibits platelet activating factor-like activity in human eosinophils. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951989 |
| Lin CC et al. | Determination of plasma concentrations of SCH 44643 by a GC method and correlation of plasma concentration and anti-PAF activity in cynomolgus monkeys. | 1996 | J Pharm Biomed Anal | pmid:8951694 |
| Bhatia AM et al. | Developmental susceptibility to intestinal injury by platelet-activating factor in the newborn rat. | 1996 Sep-Oct | J Invest Surg | pmid:8951658 |
| Yanoshita R et al. | Inhibition of lysoPAF acetyltransferase activity by flavonoids. | 1996 | Inflamm. Res. | pmid:8951505 |
| Sagara H et al. | [PAF receptor antagonist in asthma therapy]. | 1996 | Nippon Rinsho | pmid:8950954 |
| Fouda SI et al. | Effect of lipopolysaccharide on mitogen-activated protein kinases and cytosolic phospholipase A2. | 1995 | Biochem. J. | pmid:8948437 |
| Liu XH et al. | The platelet-activating factor antagonist BN 52021 attenuates hypoxic-ischemic brain injury in the immature rat. | 1996 | Pediatr. Res. | pmid:8947953 |
| Dupuis F et al. | PAF and haematopoiesis XII: macrophage colony-stimulating factor (M-CSF) decreases platelet-activating factor (PAF) acetylhydrolase production in macrophagic J774 cells. | 1996 | Cancer Lett. | pmid:8947513 |
| Packard MG et al. | Effects of intrastriatal injections of platelet-activating factor and the PAF antagonist BN 52021 on memory. | 1996 | Neurobiol Learn Mem | pmid:8946410 |
| Kelly KJ et al. | An oral platelet-activating factor antagonist, Ro-24-4736, protects the rat kidney from ischemic injury. | 1996 | Am. J. Physiol. | pmid:8946001 |
| Kalra VK et al. | Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes. | 1996 | Am. J. Physiol. | pmid:8945922 |
| Botha AJ et al. | Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure. | 1996 | Br J Surg | pmid:8944457 |
| Frenkel RA et al. | The biochemical role of platelet-activating factor in reproduction. | 1996 | Prog. Lipid Res. | pmid:8944225 |
| Kitchen E et al. | Demonstration of reversible priming of human neutrophils using platelet-activating factor. | 1996 | Blood | pmid:8943870 |
| Rosenthal J et al. | Neutrophils from patients after burn injury express a deficiency of the oxidase components p47-phox and p67-phox. | 1996 | Blood | pmid:8943869 |
| Libert C et al. | alpha1-Antitrypsin inhibits the lethal response to TNF in mice. | 1996 | J. Immunol. | pmid:8943423 |
| Kurashima K et al. | The role of vacuolar H(+)-ATPase in the control of intragranular pH and exocytosis in eosinophils. | 1996 | Lab. Invest. | pmid:8941214 |
| Darbha S and Marchase RB | Regulation of intracellular calcium is closely linked to glucose metabolism in J774 macrophages. | 1996 | Cell Calcium | pmid:8939356 |
| Tocher DR et al. | Production of eicosanoids derived from 20:4n-6 and 20:5n-3 in primary cultures of turbot (Scophthalmus maximus) brain astrocytes in response to platelet activating factor, substance P and interleukin-1 beta. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8939002 |
| Uhlig S et al. | Effect of urodilatin on platelet-activating factor-induced bronchoconstriction, vasoconstriction and edema formation in isolated rat lung. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8938670 |
| Klosterhalfen B et al. | Influence of heat shock protein 70 and metallothionein induction by zinc-bis-(DL-hydrogenaspartate) on the release of inflammatory mediators in a porcine model of recurrent endotoxemia. | 1996 | Biochem. Pharmacol. | pmid:8937427 |
| Muraki T et al. | Effect of S-ethylisothiourea, a putative inhibitor of inducible nitric oxide synthase, on mouse skin vascular permeability. | 1996 | Jpn. J. Pharmacol. | pmid:8935721 |
| Qu X et al. | Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method. | 1996 | Prostaglandins | pmid:8935185 |
| el-Shazly AE et al. | Inhibition of human eosinophil chemotaxis in vitro by the anti-allergic agent emedastine difumarate. | 1996 | Immunopharmacol Immunotoxicol | pmid:8933171 |
| Cardile V et al. | The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro. | 1996 | Cytokine | pmid:8932980 |
| Brus F et al. | Activation of circulating polymorphonuclear leukocytes in preterm infants with severe idiopathic respiratory distress syndrome. | 1996 | Pediatr. Res. | pmid:8929866 |
| Staffolani N et al. | [The measurement of PAF (platelet activating factor) in human saliva: standardization of the method]. | 1996 | Minerva Stomatol | pmid:8926976 |
| Walker BA | Effects of adenosine on guinea pig pulmonary eosinophils. | 1996 | Inflammation | pmid:8926045 |
| Montrucchio G et al. | Plasmin promotes an endothelium-dependent adhesion of neutrophils. Involvement of platelet activating factor and P-selectin. | 1996 | Circulation | pmid:8925584 |
| Nowak D et al. | Comparison of PAF- and fMLP-induced [Ca2+]i transients in human polymorphonuclear leukocytes. | 1996 | J Lipid Mediat Cell Signal | pmid:8925197 |
| Kurosawa M et al. | CV6209 inhibits airway wall thickening and airway hyperresponsiveness to histamine induced by intravenous administration of platelet-activating factor in guinea pigs. | 1996 | J Lipid Mediat Cell Signal | pmid:8925195 |
| da Silva MB et al. | Inhibition of PAF-induced platelet aggregation by WEB 2086 'in-vitro', an antagonist to the receptor for platelet-activating factor, in bovine. | 1996 | Zentralbl Veterinarmed A | pmid:8921726 |
| Wang KS and Monden M | Ex vivo evidence of platelet activating factor on ischemic liver injury. | 1996 | Changgeng Yi Xue Za Zhi | pmid:8921640 |
| Liu CY and Kuo HP | The different effect of salbutamol and aminophylline on platelet activating factor-induced plasma exudation into guinea pig tracheal wall and lumen. | 1996 | Changgeng Yi Xue Za Zhi | pmid:8921637 |
| Lin J et al. | Effect of lipoxygenase inhibition on mucous glycoprotein secretion from chinchilla middle ear epithelial cells in vitro. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8916869 |
| Kimura S et al. | Heterogeneity of drug susceptibility of mouse active anaphylactic shock. | 1996 Sep-Nov | Immunol. Invest. | pmid:8915680 |
| Elizarova EP | Effects of taurine on calcium in platelets and their aggregation. | 1996 | Adv. Exp. Med. Biol. | pmid:8915398 |
| Walsh GM et al. | Integrin alpha 4 beta 7 mediates human eosinophil interaction with MAdCAM-1, VCAM-1 and fibronectin. | 1996 | Immunology | pmid:8911148 |
| Condliffe AM et al. | Priming differentially regulates neutrophil adhesion molecule expression/function. | 1996 | Immunology | pmid:8911147 |
| MartÃnez-Cuesta MA et al. | Involvement of prostaglandins and 5-hydroxytryptamine in the contractile effect of platelet-activating factor in rat isolated gastric corpus. | 1996 | J. Pharm. Pharmacol. | pmid:8910861 |
| Richardson RM et al. | Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways. | 1996 | J. Biol. Chem. | pmid:8910508 |
| Herbert JM et al. | Hypoxia primes endotoxin-induced tissue factor expression in human monocytes and endothelial cells by a PAF-dependent mechanism. | 1996 | J. Cell. Physiol. | pmid:8908196 |
| Kleuser B et al. | Measurement of phospholipase A2 and 1-alkylglycerophosphocholine acetyltransferase activities in stimulated alveolar macrophages by HPLC analysis of NBD-labeled ether lipids. | 1996 | Chem. Phys. Lipids | pmid:8907240 |
| Thivierge M et al. | Modulation of human platelet-activating factor receptor gene expression by protein kinase C activation. | 1996 | J. Immunol. | pmid:8906849 |
| Kato K and Zorumski CF | Platelet-activating factor as a potential retrograde messenger. | 1996 | J Lipid Mediat Cell Signal | pmid:8906580 |
| Williams JH | Retrograde messengers and long-term potentiation: a progress report. | 1996 | J Lipid Mediat Cell Signal | pmid:8906579 |
| Bazan NG and Allan G | Platelet-activating factor in the modulation of excitatory amino acid neurotransmitter release and of gene expression. | 1996 | J Lipid Mediat Cell Signal | pmid:8906578 |
| Kornecki E et al. | Platelet activating factor (PAF) in memory formation: role as a retrograde messenger in long-term potentiation. | 1996 | J Lipid Mediat Cell Signal | pmid:8906554 |
| Feuerstein GZ | Platelet-activating factor: a case for its role in CNS function and brain injury. | 1996 | J Lipid Mediat Cell Signal | pmid:8906553 |
| Shimizu T et al. | Platelet-activating factor and somatostatin activate mitogen-activated protein kinase (MAP kinase) and arachidonate release. | 1996 | J Lipid Mediat Cell Signal | pmid:8906552 |
| Hattori M et al. | PAF and PAF acetylhydrolase in the nervous system. | 1996 | J Lipid Mediat Cell Signal | pmid:8906551 |
| Francescangeli E et al. | Relative contribution of the de novo and remodelling pathways to the synthesis of platelet-activating factor in brain areas and during ischemia. | 1996 | J Lipid Mediat Cell Signal | pmid:8906550 |
| Neville LF et al. | Application of differential display to isolate novel genes in interleukin-2-induced adult respiratory distress syndrome. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8906233 |
| Kishimoto S et al. | Enhanced expression of platelet-activating factor receptor on human eosinophils by interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. | 1996 | Int. Arch. Allergy Immunol. | pmid:8906117 |
| Greenberg SS et al. | Ethanol suppresses endotoxin but not platelet activating factor-induced hypotension and nitric oxide. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8904980 |
| Koyama M et al. | Surface coverage of vascular grafts with cultured human endothelial cells from subcutaneous fat tissue obtained with a biopsy needle. | 1996 | Thromb. Haemost. | pmid:8903004 |
| Fujimura M et al. | Involvement of PAF in postallergic propranolol-induced bronchoconstriction in guinea-pigs. | 1996 | Eur. Respir. J. | pmid:8902468 |
| Cortijo J et al. | Antiasthma activity of the novel antihistamine E-4716 in guinea pigs in vivo. | 1996 | Methods Find Exp Clin Pharmacol | pmid:8900220 |
| Kishi K et al. | Gq-coupled receptors transmit the signal for GLUT4 translocation via an insulin-independent pathway. | 1996 | J. Biol. Chem. | pmid:8900127 |
| Catalán RE et al. | Endothelin stimulates phosphoinositide hydrolysis and PAF synthesis in brain microvessels. | 1996 | J. Cereb. Blood Flow Metab. | pmid:8898708 |
| Cominacini L et al. | Increased levels of plasma ELAM-1, ICAM-1 and VCAM-1 in NIDDM: possible role of oxidized LDL. | 1996 | Diabetologia | pmid:8897020 |
| Lithner F | Diabetes mellitus and Alzheimer's disease. | 1996 | Diabetologia | pmid:8897018 |
| Winlove CP et al. | Interactions of elastin and aorta with sugars in vitro and their effects on biochemical and physical properties. | 1996 | Diabetologia | pmid:8896999 |
| Ishizuka T et al. | Thromboxane A2 receptor blockade suppresses intercellular adhesion molecule-1 expression by stimulated vascular endothelial cells. | 1996 | Eur. J. Pharmacol. | pmid:8894620 |
| Mancuso F et al. | Inhibition of zymosan-induced air-pouch inflammation by rat seminal vesicle protein and by its spermidine derivative. | 1996 | Eur. J. Pharmacol. | pmid:8894615 |
| Krüll M et al. | Escherichia coli hemolysin and Staphylococcus aureas alpha-toxin potently induce neutrophil adhesion to cultured human endothelial cells. | 1996 | J. Immunol. | pmid:8892649 |
| Alves AC et al. | Selective inhibition of phosphodiesterase type IV suppresses the chemotactic responsiveness of rat eosinophils in vitro. | 1996 | Eur. J. Pharmacol. | pmid:8891583 |
| Nishida K and Markey SP | Nicardipine and MK-801 attenuate platelet-activating factor increases following cerebral ischemia-reperfusion in gerbils. | 1996 | Brain Res. | pmid:8891303 |
| Niu XF et al. | A balance between nitric oxide and oxidants regulates mast cell-dependent neutrophil-endothelial cell interactions. | 1996 | Circ. Res. | pmid:8888691 |
| Enzan K et al. | Thromboxane rather than platelet activating factor mediates pulmonary vasoconstriction after antigen challenge in rabbits. | 1996 | Shock | pmid:8885083 |
| Ferreira HH et al. | Inhibition of eosinophil chemotaxis by chronic blockade of nitric oxide biosynthesis. | 1996 | Eur. J. Pharmacol. | pmid:8884218 |
| Siegel A and Baker RR | Activities of enzymes in platelet activating factor biosynthetic pathways in the gerbil model of cerebral ischemia. | 1996 | Biochem. Cell Biol. | pmid:8883840 |
| Perretti M et al. | Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1. | 1996 | Br. J. Pharmacol. | pmid:8882609 |
| Fairbairn SM et al. | Effects of platelet activating factor on the distribution of radiolabelled leucocytes and platelets in normal horses and asymptomatic horses with chronic obstructive pulmonary disease. | 1996 | Res. Vet. Sci. | pmid:8880978 |
| Fukao M et al. | Structural differences in the ability of lysophospholipids to inhibit endothelium-dependent hyperpolarization by acetylcholine in rat mesenteric arteries. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8878540 |
| Zimmerman GA et al. | Adhesion and signaling in vascular cell--cell interactions. | 1996 | J. Clin. Invest. | pmid:8878418 |
| Verhoef J et al. | Issues in the adjunct therapy of severe sepsis. | 1996 | J. Antimicrob. Chemother. | pmid:8877531 |
| Takafuji S et al. | Effects of interleukin (IL)-3 and IL-5 on human eosinophil degranulation induced by complement components C3a and C5a. | 1996 | Allergy | pmid:8874660 |
| Tenscher K et al. | Recombinant human eotaxin induces oxygen radical production, Ca(2+)-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein. | 1996 | Blood | pmid:8874220 |
| Balsa D et al. | Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: a comparison of a microplate filtration system and a standard method. | 1996 | J Pharmacol Toxicol Methods | pmid:8872920 |
| Poch B et al. | Release of histamine in whole blood by oxygen radicals: division between specific and unspecific processes. | 1996 | Inflamm. Res. | pmid:8872518 |
| Baluk P et al. | NK1 receptor antagonist CP-99,994 inhibits cigarette smoke-induced neutrophil and eosinophil adhesion in rat tracheal venules. | 1996 Jul-Aug | Exp. Lung Res. | pmid:8872085 |
| Kecskeméti V and Balogh I | Cardiac ultrastructural effects of the platelet-activating factor and its antagonist BN 52021. | 1995 | Exp. Toxicol. Pathol. | pmid:8871085 |
| Weller PF et al. | Role of the eosinophil in allergic reactions. | 1996 | Eur Respir J Suppl | pmid:8871054 |
| Huang YH et al. | Induction of IL-4 by platelet-activating factor. | 1996 | Clin. Exp. Immunol. | pmid:8870712 |
| Elferink JG and de Koster BM | Modulation of human neutrophil chemotaxis by the endothelin-B receptor agonist sarafotoxin S6c. | 1996 | Chem. Biol. Interact. | pmid:8870686 |
| Guastoni C et al. | Mechanisms and kinetics of the synthesis and release of platelet-activating factor (PAF) by polyacrylonitrile membranes. | 1996 | Clin. Nephrol. | pmid:8869791 |
| Ackerman Z et al. | Gastric and colonic inflammatory and vasoactive mediators in experimental portal hypertension. | 1996 | Liver | pmid:8868072 |
| Kamata K et al. | Characteristics of vasodilatation induced by acetylcholine and platelet-activating factor in the rat mesenteric arterial bed. | 1996 | Eur. J. Pharmacol. | pmid:8867099 |
| Medina JH and Izquierdo I | Retrograde messengers, long-term potentiation and memory. | 1995 | Brain Res. Brain Res. Rev. | pmid:8866674 |
| Kingsnorth AN | Platelet-activating factor. | 1996 | Scand. J. Gastroenterol. Suppl. | pmid:8865468 |