| MeSH term | MeSH ID | Detail |
|---|---|---|
| Toxemia | D014115 | 3 associated lipids |
| Thyroiditis, Autoimmune | D013967 | 9 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Thrombocytosis | D013922 | 4 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Thrombasthenia | D013915 | 4 associated lipids |
| Thalassemia | D013789 | 8 associated lipids |
| Tangier Disease | D013631 | 8 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Subacute Sclerosing Panencephalitis | D013344 | 3 associated lipids |
| Stomatitis | D013280 | 14 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Spasm | D013035 | 5 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Shock, Traumatic | D012774 | 4 associated lipids |
| Shock, Septic | D012772 | 11 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tselepis AD et al. | Electrocardiographic alterations induced by AGEPC in Wistar rats in relation to its hypotensive and hematologic effects. | 1987 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:2885139 |
| Nomura H | Biological action and structural specificity of diacylglycerol in platelet activation. | 1987 | Kobe J Med Sci | pmid:3695296 |
| Hayashi M et al. | Characterization of the activity of a platelet activating factor antagonist, CV-3988. | 1987 | Jpn. J. Pharmacol. | pmid:2888915 |
| Grignani G and Jamieson GA | Tissue factor-dependent activation of platelets by cells and microvesicles of SK-OS-10 human osteogenic sarcoma cell line. | 1987 | Invasion Metastasis | pmid:3036740 |
| Snyder F et al. | Measurement of key enzyme activities involved in the metabolism of platelet activating factor. | 1987 | Meth. Enzymol. | pmid:3037250 |
| Ingraham LM et al. | In vitro and in vivo effects of treatment by platelet-activating factor on N-formyl-met-leu-phe-mediated responses of polymorphonuclear leucocytes. | 1987 | Br. J. Haematol. | pmid:3038160 |
| Criscuoli M and Subissi A | Paf-acether-induced death in mice: involvement of arachidonate metabolites and beta-adrenoceptors. | 1987 | Br. J. Pharmacol. | pmid:2880624 |
| Englberger W et al. | Influence of lysophospholipids and PAF on the oxidative burst of PMNL. | 1987 | Int. J. Immunopharmacol. | pmid:3038761 |
| Handley DA et al. | Inhibition by SRI 63-072 and SRI 63-119 of PAF-acether and immune complex effects in the guinea pig. | 1987 | Eur. J. Pharmacol. | pmid:2959489 |
| Doly M et al. | Effects of platelet-activating factor on electrophysiology of isolated retinas and their inhibition by BN 52021, a specific PAF-acether receptor antagonist. | 1987 | Immunopharmacology | pmid:3038784 |
| Montrucchio G et al. | In vitro oxytocic activity of platelet-activating factor on human myometrium. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960158 |
| Homma H et al. | Binding and internalization of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in washed rabbit platelets. | 1987 | J. Biol. Chem. | pmid:3038889 |
| Mallet AI et al. | Platelet activating factor in chronic plaque psoriasis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960170 |
| Bourgain RH et al. | Effect of ginkgolide PAF-acether antagonists on arterial thrombosis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960196 |
| Braquet P et al. | Platelet-activating factor: a potential mediator of shock. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960197 |
| Myers A et al. | Pharmacological manipulation of platelet-activating factor toxicity in rodents. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960198 |
| Ninio E et al. | Biosynthesis of paf-acether. IX. Role for a phosphorylation-dependent activation of acetyltransferase in antigen-stimulated mouse mast cells. | 1987 | J. Immunol. | pmid:3584983 |
| Casals-Stenzel J | Triazolodiazepines are potent antagonists of platelet activating factor (PAF) in vitro and in vivo. | 1987 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3587377 |
| Brambilla A et al. | WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage. | 1987 | Pharmacol Res Commun | pmid:3588650 |
| Jancar S et al. | Comparative effects of platelet activating factor, leukotriene D4 and histamine on guinea pig trachea, bronchus and lung parenchyma. | 1987 | Prostaglandins | pmid:3588970 |
| Malo PE et al. | Enhancement of leukotriene D4-induced contraction of guinea-pig isolated trachea by platelet activating factor. | 1987 | Prostaglandins | pmid:3588971 |
| Joseph R et al. | Sensitivity to PAF is increased in migraine patients. | 1987 | Thromb. Haemost. | pmid:3590077 |
| Valone FH | Inhibition of platelet-activating factor binding to human platelets by calcium channel blockers. | 1987 | Thromb. Res. | pmid:3590086 |
| Tokumura A et al. | Platelet aggregation induced by ether-linked phospholipids. 2. Mechanism of desensitization of rabbit platelets by platelet activating factor and reversibility of inhibitory actions of its antagonists. | 1987 | Thromb. Res. | pmid:3590110 |
| Bamford CH et al. | Polymeric inhibitors of platelet aggregation. II. Copolymers of dipyridamole and related drugs with N-vinylpyrrolidone. | 1987 | Biochim. Biophys. Acta | pmid:3828396 |
| Shigenobu K et al. | Potentiation by bovine serum albumin (BSA) of endothelium-dependent vasodilator response to acetyl glyceryl ether phosphorylcholine (AGEPC). | 1987 | J. Pharmacobio-dyn. | pmid:3625454 |
| Jensen NJ et al. | FAB MS/MS for phosphatidylinositol, -glycerol, -ethanolamine and other complex phospholipids. | 1987 | Lipids | pmid:3626775 |
| Cox CP and Wood KL | Selective antagonism of platelet-activating factor (PAF)-induced aggregation and secretion in washed rabbit platelets by CV-3988, L-652731, triazolam and alprazolam. | 1987 | Thromb. Res. | pmid:3629553 |
| Ostermann G et al. | Plasma from atherosclerotic patients exerts an increased degradation of platelet-activating factor. | 1987 | Thromb. Res. | pmid:3629555 |
| Pettipher ER et al. | PAF-acether in chronic arthritis. | 1987 | Agents Actions | pmid:3630862 |
| Neuwirth R et al. | Effect of platelet activating factor antagonists on cultured rat mesangial cells. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3119816 |
| Fennessy MR et al. | Lipid mediators of anaphylaxis and increased airways reactivity. | 1987 | Clin. Exp. Pharmacol. Physiol. | pmid:2824102 |
| Hansen JF and Hansen BF | [Unstable angina pectoris, acute myocardial infarct, sudden heart death. Patho-anatomy and pathophysiology]. | 1987 | Ugeskr. Laeg. | pmid:3324429 |
| Levin M et al. | Platelet immune complex interaction in the pathogenesis of Kawasaki disease. | 1987 | Prog. Clin. Biol. Res. | pmid:3423040 |
| Violi F et al. | Human platelet aggregation by PAF and thromboxane production. | 1987 | Thromb. Res. | pmid:3424290 |
| Muirhead EE | Vasodepressor lipid of the renomedullary interstitial cells of the renal papilla is a prohormone activated by the liver. | 1987 | Agents Actions Suppl. | pmid:3324720 |
| Mest HJ et al. | Relevance of eicosanoids for biochemical regulation of cardiac rhythm disturbances. | 1987 | Biomed. Biochim. Acta | pmid:3325045 |
| Bloom JW et al. | Intravenous platelet activating factor does not affect lung epithelial permeability. | 1987 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3326081 |
| de Almeida PJ et al. | [Biochemical bases of platelet activity in homeostasis and thrombogenesis. III]. | 1987 | Arq. Bras. Cardiol. | pmid:3328601 |
| Kester M et al. | Elevation of cytosolic free calcium by platelet-activating factor in cultured rat mesangial cells. | 1987 | FASEB J. | pmid:2442057 |
| Chabot MC et al. | Reacylation of platelet activating factor with eicosapentaenoic acid in fish-oil-enriched monkey neutrophils. | 1987 | Biochim. Biophys. Acta | pmid:2823907 |
| Wang J and Dunn MJ | Platelet-activating factor mediates endotoxin-induced acute renal insufficiency in rats. | 1987 | Am. J. Physiol. | pmid:2827506 |
| Panetta T et al. | Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemia-reperfusion induced cerebral injury. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827647 |
| HÃ¥kansson L et al. | New method for the measurement of eosinophil migration. | 1987 | J. Leukoc. Biol. | pmid:2445885 |
| Bazan HE et al. | The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827658 |
| Sciberras DG et al. | Inflammatory responses to intradermal injection of platelet activating factor, histamine and prostaglandin E2 in healthy volunteers: a double blind investigation. | 1987 | Br J Clin Pharmacol | pmid:2449904 |
| Czarnetzki BM | [Mediators and the bronchial system. Pathophysiologic and biochemical aspects of mediators of the bronchial system]. | 1987 | Wien Med Wochenschr Suppl | pmid:3078398 |
| Schwertschlag U et al. | L-platelet activating factor induces changes on renal vascular resistance, vascular reactivity, and renin release in the isolated perfused rat kidney. | 1987 | Circ. Res. | pmid:3297384 |
| Page CP | A role for platelet activating factor and platelets in the induction of bronchial hyperreactivity. | 1987 | Int J Tissue React | pmid:3298115 |
| Lian EC | Pathogenesis of thrombotic thrombocytopenic purpura. | 1987 | Semin. Hematol. | pmid:3299722 |
| Touvay C et al. | Gossypol: a potent inhibitor of PAF-acether- and leukotriene-induced contractions of guinea-pig lung parenchyma strips. | 1987 | J. Pharm. Pharmacol. | pmid:2886603 |
| Sudan BJ | Ketoconazole, leukotrienes, Paf-acether and nicotine as a hapten: the possible aetiology of seborrhoeic dermatitis. | 1987 | Med. Hypotheses | pmid:2886895 |
| Ostermann G et al. | Modification of the polar head group of platelet-activating factor: influence on the biological activity. | 1987 | Chem. Phys. Lipids | pmid:3607969 |
| Chung KF et al. | Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. | 1987 | Lancet | pmid:2880069 |
| Casals-Stenzel J and Weber KH | Triazolodiazepines: dissociation of their Paf (platelet activating factor) antagonistic and CNS activity. | 1987 | Br. J. Pharmacol. | pmid:2880622 |
| Lagente V et al. | Platelet-activating factor (PAF-acether) and microcirculation: effect of Lyso-PAF and PAF-antagonists. | 1987 | Braz. J. Med. Biol. Res. | pmid:3452452 |
| Gentry PA et al. | Inhibitory effect of trichothecene mycotoxins on bovine platelets stimulated by platelet activating factor. | 1987 | Can. J. Vet. Res. | pmid:3453270 |
| Sugatani J et al. | Potential involvement of vicinal sulfhydryls in stimulus-induced rabbit platelet activation. | 1987 | J. Biol. Chem. | pmid:2824509 |
| Spinks NR and O'Neill C | Embryo-deprived platelet-activating factor is essential for establishment of pregnancy in the mouse. | 1987 | Lancet | pmid:2432367 |
| Evans TW et al. | Effect of platelet-activating factor on airway vascular permeability: possible mechanisms. | 1987 | J. Appl. Physiol. | pmid:3115939 |
| McIntyre TM et al. | Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils. | 1987 | J. Biol. Chem. | pmid:2824456 |
| Knudsen BS et al. | Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells. | 1987 | J. Clin. Invest. | pmid:3116043 |
| Bussolino F et al. | Human endothelial cells are target for platelet-activating factor. I. Platelet-activating factor induces changes in cytoskeleton structures. | 1987 | J. Immunol. | pmid:3116081 |
| Hartiala KT et al. | Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034265 |
| Bitterman H et al. | Beneficial actions of RO 15-1788, a benzodiazepine receptor antagonist, in hemorrhagic shock. | 1987 | Methods Find Exp Clin Pharmacol | pmid:3116357 |
| Gateau O | [Role of PAF-acether (platelet activating factor) in cardio-vascular pathology]. | 1987 | Arch Mal Coeur Vaiss | pmid:3117010 |
| Altin JG et al. | Evidence that Ca2+ fluxes and respiratory, glycogenolytic and vasoconstrictive effects induced by the action of platelet-activating factor and L-alpha-lysophosphatidylcholine in the perfused rat liver are mediated by products of the cyclo-oxygenase pathway. | 1987 | Biochem. J. | pmid:3117040 |
| Terashita Z et al. | A lethal role of platelet activating factor in anaphylactic shock in mice. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3118009 |
| Musch MW et al. | Antigen-and ionophore-stimulated synthesis of platelet-activating factor by the cloned mast cell line, MC9. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3107564 |
| Sisson JH et al. | Production of platelet-activating factor by stimulated human polymorphonuclear leukocytes. Correlation of synthesis with release, functional events, and leukotriene B4 metabolism. | 1987 | J. Immunol. | pmid:3035016 |
| Sweatt JD et al. | Evidence for a role for Na+-H+ exchange in activation of human platelets by PAF. | 1987 | Circ. Res. | pmid:2822286 |
| Liu BN | [Neoplastic membrane-toxic activity as one of the pathogenetic factors in blood cell and tumor growth changes]. | 1987 Jan-Feb | Patol Fiziol Eksp Ter | pmid:3550649 |
| Lurie A et al. | Exercise- and allergen-induced asthma do not change the production of Paf-acether by neutrophils and platelets. | 1987 Jul-Aug | Bull Eur Physiopathol Respir | pmid:3690021 |
| Auriault C et al. | The effector function of platelets is induced and regulated by T lymphocytes. | 1987 Jul-Aug | Ann. Inst. Pasteur Immunol. | pmid:3118905 |
| Fiedler VB et al. | Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. | 1987 Mar-Apr | Basic Res. Cardiol. | pmid:3606544 |
| Arnoux B et al. | Antigenic release of paf-acether and beta-glucuronidase from alveolar macrophages of asthmatics. | 1987 Mar-Apr | Bull Eur Physiopathol Respir | pmid:3607326 |
| Berdel WE et al. | Lack of correlation between cytotoxicity of agonists and antagonists of platelet activating factor [paf-acether] in neoplastic cells and modulation of [3H]-paf-acether binding to platelets from humans in vitro. | 1987 Nov-Dec | Anticancer Res. | pmid:3442414 |
| Lakin KM et al. | [Action of calcium antagonists on thrombocyte aggregation]. | 1987 Sep-Oct | Farmakol Toksikol | pmid:2826225 |
| Hanss M and Dechavanne M | 48740 RP, an antagonist of PAF, does not affect human plasma fibrinolysis before and after venous occlusion. | 1988 | Thromb. Res. | pmid:3126559 |
| Acker G et al. | Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021. | 1988 | Prostaglandins | pmid:3129758 |
| Lefort J et al. | Pharmacological profile of 48740 R.P., a PAF-acether antagonist. | 1988 | Eur. J. Pharmacol. | pmid:2843382 |
| O'Flaherty JT et al. | Mechanism involved in the mobilization of neutrophil calcium by 5-hydroxyeicosatetraenoate. | 1988 | J. Immunol. | pmid:2836511 |
| Greenberg S et al. | Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms. | 1988 | J. Biol. Chem. | pmid:3392016 |
| Etienne A et al. | Possible involvement of platelet-activating factor in endotoxin-induced abortion. | 1988 | Prog. Clin. Biol. Res. | pmid:3393560 |
| Coyle AJ et al. | The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation. | 1988 | Eur. J. Pharmacol. | pmid:3383997 |
| Tokumura A et al. | Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis. | 1988 | Eur. J. Pharmacol. | pmid:3384001 |
| Lagarde M | Metabolism of fatty acids by platelets and the functions of various metabolites in mediating platelet function. | 1988 | Prog. Lipid Res. | pmid:3060881 |
| Freitas JC et al. | Inhibition of platelet aggregation by manoalide: preliminary results. | 1988 | Braz. J. Med. Biol. Res. | pmid:3203166 |
| Pai JK et al. | Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes. | 1988 | J. Biol. Chem. | pmid:3165977 |
| Collier M et al. | Biochemical and pharmacological characterization of human embryo-derived platelet activating factor. | 1988 | Hum. Reprod. | pmid:3204154 |
| Armstead WM et al. | Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs. | 1988 | Circ. Res. | pmid:3335052 |
| Domingo MT et al. | Presence of specific binding sites for platelet-activating factor (PAF) in brain. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2831903 |
| Dillon PK et al. | Vasoconstrictor effects of platelet-activating factor in the hamster cheek pouch microcirculation: dose-related relations and pathways of action. | 1988 | Circ. Res. | pmid:2832096 |
| Ma YH and Dunham EW | Antagonism of the vasodilator effects of a platelet activating factor precursor in anesthetized spontaneously hypertensive rats. | 1988 | Eur. J. Pharmacol. | pmid:2832188 |
| Hasegawa T and Nakajima S | [Recent topics on platelet-activating-factor (PAF)]. | 1988 | Nippon Ika Daigaku Zasshi | pmid:3360909 |
| Chau LY and Jii YJ | Characterization of 3H-labelled platelet activating factor receptor complex solubilized from rabbit platelet membranes. | 1988 | Biochim. Biophys. Acta | pmid:2838093 |
| Thelen M et al. | Activation of monocytes by interferon-gamma has no effect on the level or affinity of the nicotinamide adenine dinucleotide-phosphate oxidase and on agonist-dependent superoxide formation. | 1988 | J. Clin. Invest. | pmid:2838524 |
| Eliakim R et al. | Role of platelet-activating factor in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine and prednisolone. | 1988 | Gastroenterology | pmid:2901995 |
| Lellouch-Tubiana A et al. | Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. | 1988 | Am. Rev. Respir. Dis. | pmid:3281530 |
| Chung KF and Barnes PJ | PAF antagonists. Their potential therapeutic role in asthma. | 1988 | Drugs | pmid:3281823 |