| MeSH term | MeSH ID | Detail |
|---|---|---|
| Toxemia | D014115 | 3 associated lipids |
| Thyroiditis, Autoimmune | D013967 | 9 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Thrombocytosis | D013922 | 4 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Thrombasthenia | D013915 | 4 associated lipids |
| Thalassemia | D013789 | 8 associated lipids |
| Tangier Disease | D013631 | 8 associated lipids |
| Subarachnoid Hemorrhage | D013345 | 17 associated lipids |
| Subacute Sclerosing Panencephalitis | D013344 | 3 associated lipids |
| Stomatitis | D013280 | 14 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Staphylococcal Infections | D013203 | 15 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Spasm | D013035 | 5 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Shock, Traumatic | D012774 | 4 associated lipids |
| Shock, Septic | D012772 | 11 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Freitag A et al. | Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses. | 1993 | Thorax | pmid:8346486 |
| Villa L et al. | Chiral PAF agonists: synthesis, theoretical analysis of their stereoelectronic properties and structure activity relationships. | 1993 | Farmaco | pmid:8343209 |
| Hofer RE et al. | The effect of a platelet activating factor antagonist (BN 52021) on neurologic outcome and histopathology in a canine model of complete cerebral ischemia. | 1993 | Anesthesiology | pmid:8342844 |
| Gulbins E et al. | Effects of rC5a on the circulation of normal and split hydronephrotic rat kidneys. | 1993 | Am. J. Physiol. | pmid:8342619 |
| Read RA et al. | Platelet-activating factor-induced polymorphonuclear neutrophil priming independent of CD11b adhesion. | 1993 | Surgery | pmid:8342134 |
| Bozza PT et al. | Pharmacological modulation of lipopolysaccharide-induced pleural eosinophilia in the rat; a role for a newly generated protein. | 1993 | Eur. J. Pharmacol. | pmid:8339753 |
| Kawamura M et al. | Inhibitory effect of TCV-309, a novel platelet activating factor (PAF) antagonist, on endotoxin-induced disseminated intravascular coagulation in rats: possible role of PAF in tissue factor generation. | 1993 | Thromb. Res. | pmid:8332959 |
| Onuki Y et al. | [Experimental studies on the relation of platelet activating factor (PAF) to high mortality in sublethal endotoxemia after massive hepatectomy and effects of its antagonist]. | 1993 | Nihon Geka Gakkai Zasshi | pmid:8332121 |
| Kohler C et al. | Effect of a series of 1-alkyl ether lipids on inhibition of phospholipase A2 activity and PAF responses. | 1993 | Inflammation | pmid:8330926 |
| Barr RM et al. | Platelet activating factor, lyso-platelet activating factor and arachidonic acid release in normal human skin and the influence of topical steroid treatment. | 1993 | Br J Clin Pharmacol | pmid:8329291 |
| Tanaka T et al. | Effect of a novel xanthine derivative on experimental ulcers in rats. | 1993 | Arzneimittelforschung | pmid:8329000 |
| Patterson WR et al. | Aggregation of killer whale platelets. | 1993 | Thromb. Res. | pmid:8327987 |
| Ohashi M et al. | Effect of ibudilast, a novel antiasthmatic agent, on anaphylactic bronchoconstriction: predominant involvement of endogenous slow reacting substance of anaphylaxis. | 1993 | Int. Arch. Allergy Immunol. | pmid:8324390 |
| Amorim CZ et al. | Interference of PCA 4248, a novel PAF receptor antagonist, with antigen-induced paw edema in mice. | 1993 | Eur. J. Pharmacol. | pmid:8319756 |
| Chiche D et al. | Pulmonary edema and shock after high-dose aracytine-C for lymphoma; possible role of TNF-alpha and PAF. | 1993 Mar-Apr | Eur. Cytokine Netw. | pmid:8318674 |
| Ohar JA et al. | Platelet-activating factor induces selective pulmonary arterial hyperreactivity in isolated perfused rabbit lungs. | 1993 | Am. Rev. Respir. Dis. | pmid:8317792 |
| Boonen GJ et al. | Activation of neutrophil migration by dioctanoyl-sn-glycerol and fMet-Leu-Phe is controlled by different pathways. | 1993 | Agents Actions | pmid:8317308 |
| Kantar A et al. | Effect of PAF on human lymphocyte membranes: a fluorescence study. | 1993 | Agents Actions | pmid:8317302 |
| Silliman CC et al. | Compounds biologically similar to platelet activating factor are present in stored blood components. | 1993 | Lipids | pmid:8316049 |
| Matsumoto K et al. | [Platelet activating factor and tumor necrosis factor-alpha in bronchoalveolar lavage fluid of patients with ARDS]. | 1993 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8315901 |
| Senoh M et al. | Early release of neutrophil chemotactic factor from isolated rat heart subjected to regional ischaemia followed by reperfusion. | 1993 | Cardiovasc. Res. | pmid:8313428 |
| Ripps BA et al. | Platelet-activating factor production from in vitro and in vivo fertilized murine embryos is similar. | 1993 Sep-Oct | Am. J. Reprod. Immunol. | pmid:8311917 |
| Katoh N et al. | [Evaluation of the mechanism of endothelin-induced rat gastric mucosal lesion formation]. | 1994 | Nihon Shokakibyo Gakkai Zasshi | pmid:8309086 |
| Okawa T et al. | [Endothelin-1-induced contraction of pregnant rat myometrium: role of platelet-activating factor]. | 1994 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:8308402 |
| Stoll LL et al. | Platelet-activating factor may stimulate both receptor-dependent and receptor-independent increases in [Ca2+] in human airway epithelial cells. | 1994 | J. Biol. Chem. | pmid:8307989 |
| Stroman PW et al. | Evaluation of effects of PAF on alveolar fluid clearance with use of NMR imaging. | 1993 | J. Appl. Physiol. | pmid:8307842 |
| Denizot Y and Chaussade S | Tumor necrosis factor and platelet activating factor in stool during salmonellosis. | 1994 | Gut | pmid:8307492 |
| Sun X et al. | Tumour necrosis factor and endotoxin synergistically activate intestinal phospholipase A2 in mice. Role of endogenous platelet activating factor and effect of exogenous platelet activating factor. | 1994 | Gut | pmid:8307472 |
| Denizot Y and Chaussade S | Platelet activating factor and Crohn's disease. | 1994 | Gut | pmid:8307440 |
| Graham RM et al. | Plasma degradation of platelet-activating factor in severely ill patients with clinical sepsis. | 1994 | Crit. Care Med. | pmid:8306677 |
| Yamanaka S et al. | Effect of the platelet-activating factor antagonist, TCV-309, and the cyclo-oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock. | 1993 | Br. J. Pharmacol. | pmid:8306093 |
| Filep JG and Földes-Filep E | Modulation by nitric oxide of platelet-activating factor-induced albumin extravasation in the conscious rat. | 1993 | Br. J. Pharmacol. | pmid:8306074 |
| Thorne JR and Broadley KJ | Adenosine-induced bronchoconstriction in conscious hyperresponsive and sensitized guinea pigs. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8306036 |
| Nishihira J et al. | A role for oxygen radicals in rat monocytic leukemia cell differentiation under stimulation with platelet-activating factor. | 1994 | Biochim. Biophys. Acta | pmid:8305501 |
| Jambou D et al. | [Mediators of the vascular endothelium as markers of myocardial ischemia and reperfusion]. | 1993 | Arch Mal Coeur Vaiss | pmid:8304814 |
| Buerke M et al. | Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil-released mediators. | 1994 | Am. J. Physiol. | pmid:8304493 |
| Northover AM and Northover BJ | Involvement of protein kinase C in the control of microvascular permeability to colloidal carbon. | 1993 | Agents Actions | pmid:8304240 |
| Kosar-Hashemi B et al. | Glyceryl ether monooxygenase [EC 1.14.16.5]: stoichiometry and inhibition. | 1993 | Adv. Exp. Med. Biol. | pmid:8304231 |
| Saeed SA et al. | Rhazimine from Rhazya stricta: a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation. | 1993 | Planta Med. | pmid:8302958 |
| David S et al. | Adherence of human monocytes to haemodialysis membranes. | 1993 | Nephrol. Dial. Transplant. | pmid:8302460 |
| Caplan MS et al. | The role of endogenous nitric oxide and platelet-activating factor in hypoxia-induced intestinal injury in rats. | 1994 | Gastroenterology | pmid:8299901 |
| Sjogren R et al. | Role of Shiga-like toxin I in bacterial enteritis: comparison between isogenic Escherichia coli strains induced in rabbits. | 1994 | Gastroenterology | pmid:8299898 |
| Shinozaki K et al. | A new method of purification and sensitive bioassay of platelet-activating factor (PAF) in human whole blood. | 1994 | Life Sci. | pmid:8295490 |
| Hodgkin EE et al. | A Monte Carlo pharmacophore generation procedure: application to the human PAF receptor. | 1993 | J. Comput. Aided Mol. Des. | pmid:8294944 |
| Honda Z et al. | Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells. | 1994 | J. Biol. Chem. | pmid:8294489 |
| Bell M et al. | Effect of cryoprotective additives and cryopreservation protocol on sperm membrane lipid peroxidation and recovery of motile human sperm. | 1993 Nov-Dec | J. Androl. | pmid:8294232 |
| Pi F et al. | Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation. | 1994 | Transplantation | pmid:8291097 |
| Chang SW | Endotoxin-induced pulmonary leukostasis in the rat: role of platelet-activating factor and tumor necrosis factor. | 1994 | J. Lab. Clin. Med. | pmid:8288963 |
| Sugatani J et al. | Quantitative analysis of platelet-activating factor in human plasma. Application to patients with liver cirrhosis and disseminated intravascular coagulation. | 1993 | J. Immunol. Methods | pmid:8288878 |
| Parks JE and Hough SR | Platelet-activating factor acetylhydrolase activity in bovine seminal plasma. | 1993 Sep-Oct | J. Androl. | pmid:8288488 |
| Leoncini G et al. | S-D-lactoylglutathione accumulation in activated human platelets. | 1993 | Int. J. Biochem. | pmid:8288025 |
| Chen BN et al. | Effect of ischaemia and role of eicosanoids in release of atrial natriuretic factor from rat heart. | 1993 | Cardiovasc. Res. | pmid:8287433 |
| Chupin VV et al. | [Formation of a structural isomer of platelet activating factor during acetylation of 1-alkyl-sn-glycero-3-phosphocholine]. | 1993 | Bioorg. Khim. | pmid:8285924 |
| Gupta JB et al. | Platelet-activating-factor-induced changes in cardiovascular function and oxyradical status of myocardium in presence of the PAF antagonist CV-6209. | 1994 | Angiology | pmid:8285381 |
| Zeng GQ et al. | Effects of dauricine and tetrandrine on [3H] WEB 2086 specific binding to bovine anterior cerebral arterial smooth muscle cells in vitro. | 1993 | Yao Xue Xue Bao | pmid:8285049 |
| Gerard NP and Gerard C | Receptor-dependent internalization of platelet-activating factor. | 1994 | J. Immunol. | pmid:8283052 |
| Tordai A et al. | Autocrine stimulation of B lymphocytes by a platelet-activating factor receptor agonist, 1-palmitoyl-2-acetyl-sn-glycero-3-phosphocholine. | 1994 | J. Immunol. | pmid:8283038 |
| Rodriguez-Roisin R et al. | Platelet-activating factor causes ventilation-perfusion mismatch in humans. | 1994 | J. Clin. Invest. | pmid:8282786 |
| Maziere C et al. | 1 Acyl-2 acetyl-sn-glycero-3 phosphocholine decreases the susceptibility of low-density lipoprotein to oxidative modification by copper ions, monocytes or endothelial cells. | 1994 | Biochim. Biophys. Acta | pmid:8280775 |
| O'Flaherty JT et al. | Comparison of 1-O-alkyl-, 1-O-alk-1'-enyl-, and 1-O-acyl-2-acetyl-sn-glycero-3-phosphoethanolamines and -3-phosphocholines as agonists of the platelet-activating factor family. | 1994 | Biochim. Biophys. Acta | pmid:8280772 |
| Tanaka T et al. | Platelet-aggregating effects of platelet-activating factor-like phospholipids formed by oxidation of phosphatidylcholines containing an sn-2-polyunsaturated fatty acyl group. | 1994 | Biochim. Biophys. Acta | pmid:8280771 |
| Parent JL and Stankova J | Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8280163 |
| Turner JS et al. | Plasmin modulates the thrombin-evoked calcium response in C6 glioma cells. | 1994 | Biochem. J. | pmid:8280096 |
| Thompson WA et al. | The metabolic effects of platelet-activating factor antagonism in endotoxemic man. | 1994 | Arch Surg | pmid:8279943 |
| Huber W et al. | Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. | 1993 | Am. J. Physiol. | pmid:8279553 |
| Denizot Y et al. | [Fecal platelet-activating factor (PAF). A marker of digestive inflammatory disorders]. | 1993 | Presse Med | pmid:8278326 |
| Zhou W et al. | Lipid mediator production in acute and chronic pancreatitis in the rat. | 1994 | J. Surg. Res. | pmid:8277767 |
| DeJoy SQ et al. | Effect of CL 184,005, a platelet-activating factor antagonist in a murine model of Staphylococcus aureus-induced gram-positive sepsis. | 1994 | J. Infect. Dis. | pmid:8277176 |
| Montero A et al. | A role for platelet-activating factor in endothelin-1-induced rat mesangial cell proliferation. | 1993 | Eur. J. Pharmacol. | pmid:8276075 |
| Chau LY and Hu CY | Platelet-activating factor receptor-mediated calcium influx in NG 108-15 cells. | 1993 | Chin J Physiol | pmid:8275798 |
| Chen ZN | [Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8274205 |
| Glaser KB et al. | Pharmacological characterization of WAY-121,520: a potent anti-inflammatory indomethacin-based inhibitor of 5-lipoxygenase (5-LO)/phospholipase A2 (PLA2). | 1993 | Agents Actions | pmid:8273577 |
| Thomas TK et al. | Differential antagonism of platelet activating factor-induced neutrophilia and gastric hemorrhage in the rat. | 1993 | Agents Actions | pmid:8273566 |
| Meats JE et al. | Identification of phospholipase D (PLD) activity in mouse peritoneal macrophages. | 1993 | Agents Actions | pmid:8273553 |
| Raff GW et al. | Procoagulant property of platelet activating factor (PAF). | 1993 | Agents Actions | pmid:8273543 |
| Jørgensen L et al. | Rabbit lung macrophages stimulate platelets in vitro as observed by density-gradient centrifugation and transmission electron microscopy. | 1993 | Scand. J. Clin. Lab. Invest. | pmid:8272758 |
| Roberts C et al. | Platelet activating factor (PAF) enhances mitosis in preimplantation mouse embryos. | 1993 | Reprod. Fertil. Dev. | pmid:8272531 |
| Hirashima Y et al. | Platelet-activating factor (PAF) concentration and PAF acetylhydrolase activity in cerebrospinal fluid of patients with subarachnoid hemorrhage. | 1994 | J. Neurosurg. | pmid:8271019 |
| Stephens CJ et al. | Variation in plasma platelet-activating factor degradation and serum lipids after acute myocardial infarction. | 1993 | Coron. Artery Dis. | pmid:8269210 |
| David S et al. | Production of platelet activating factor by human neutrophils after backfiltration of endotoxin contaminated dialysate. | 1993 Jul-Sep | ASAIO J. | pmid:8268642 |
| Okamoto Y et al. | PAF-releasing factor in human serum and inflammatory exudate. | 1993 | J Lipid Mediat | pmid:8268461 |
| Vásquez-Bravo YL et al. | Differential sensitivity of mouse strains to platelet activating factor-induced vasopermeability and mortality: effect of antagonists. | 1993 | J Lipid Mediat | pmid:8268459 |
| Tjebbes GW et al. | Production of lipid mediators in experimental keratitis of rabbit eye. | 1993 | J Lipid Mediat | pmid:8268458 |
| Manzini S et al. | Interactions between sensory neuropeptides and lipid mediators in the airways. | 1993 | J Lipid Mediat | pmid:8268456 |
| Waga I et al. | Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267581 |
| Corcoran PC et al. | Reduction of conjugated dienes in lung transplantation: effect of BN 52021. | 1993 | Ann. Thorac. Surg. | pmid:8267425 |
| Freire-Maia L and de Matos IM | Heparin or a PAF antagonist (BN-52021) prevents the acute pulmonary edema induced by Tityus serrulatus scorpion venom in the rat. | 1993 | Toxicon | pmid:8266352 |
| McManus LM et al. | PAF molecular heterogeneity: pathobiological implications. | 1993 | Lab. Invest. | pmid:8264227 |
| Rabinovici R et al. | Tumor necrosis factor-alpha mediates endotoxin-induced lung injury in platelet activating factor-primed rats. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8263817 |
| Raeburn D and Karlsson JA | Effects of isoenzyme-selective inhibitors of cyclic nucleotide phosphodiesterase on microvascular leak in guinea pig airways in vivo. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8263775 |
| Hartnell A et al. | CD69 is expressed by human eosinophils activated in vivo in asthma and in vitro by cytokines. | 1993 | Immunology | pmid:8262555 |
| Elwood W et al. | Role of cyclooxygenase and 5-lipoxygenase metabolites, platelet-activating factor and 5-hydroxytryptamine in allergen-induced airway responses in the brown Norway rat. | 1994 | Int. Arch. Allergy Immunol. | pmid:8260852 |
| MacKendrick W et al. | Increase in plasma platelet-activating factor levels in enterally fed preterm infants. | 1993 | Biol. Neonate | pmid:8260551 |
| Steen VM et al. | The platelet-stimulating effect of adrenaline through alpha 2-adrenergic receptors requires simultaneous activation by a true stimulatory platelet agonist. Evidence that adrenaline per se does not induce human platelet activation in vitro. | 1993 | Thromb. Haemost. | pmid:8259557 |
| Doly M et al. | Prevention of chloroquine-induced electroretinographic damage by a new platelet-activating factor antagonist, BN 50730. | 1993 | Ophthalmic Res. | pmid:8259265 |
| Noris M et al. | Defective glomerular [3H]lysoPAF metabolism in the autologous phase of rabbit nephrotoxic nephritis. | 1993 | Kidney Int. | pmid:8258952 |
| Squadrito F et al. | Platelet activating factor interaction with tumor necrosis factor in myocardial ischaemia-reperfusion injury. | 1993 | J Lipid Mediat | pmid:8257777 |
| Herbert JM et al. | Biochemical and pharmacological properties of SR 27388, a dual antioxidant and PAF receptor antagonist. | 1993 | J Lipid Mediat | pmid:8257776 |
| Chopra K et al. | Involvement of oxygen free radicals in the action of BN 52021 (PAF antagonist) to limit myocardial infarct size. | 1993 | Methods Find Exp Clin Pharmacol | pmid:8255122 |
| Palmblad J et al. | Signal transduction mechanisms for leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils. | 1994 | J. Immunol. | pmid:8254196 |