| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Gram-Negative Bacterial Infections | D016905 | 16 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Balazy M et al. | A novel method for the analysis of PAF and alkyl-ether phospholipids by mass spectrometry. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825562 |
| Magni F et al. | Determination of platelet-activating factor in biological samples by high resolution mass spectrometry. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825563 |
| Coceani F et al. | Leukotrienes in cerebrospinal fluid of the conscious cat: effect of platelet-activating factor and pyrogens. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825586 |
| Shen TY et al. | Recent development of platelet-activating factor antagonists. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546389 |
| Handley DA et al. | Chemistry and pharmacology of PAF antagonists. Evaluation of changes at potential metabolism sites on activity and duration of activity. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546390 |
| Dray F et al. | Recent studies on icosanoids and PAF-acether modulation of some central neurosecretions in the rat. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546391 |
| Desquand S et al. | Interference of the PAF-acether antagonist BN 52021 with anaphylaxis in the guinea pig. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2445183 |
| Benveniste J | PAF-acether (platelet-activating factor). | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526498 |
| Hsueh W and Sun XM | Tumor necrosis factor-induced bowel necrosis: the role of platelet-activating factor. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526499 |
| Pignol B et al. | Effect of chronic administration of platelet-activating factor (PAF) in the guinea-pig and the rat. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526500 |
| Foegh ML et al. | Platelet-activating factor in organ transplant rejection. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526501 |
| Pickett WC and Ramesha C | Modulation of mediator precursors by changes in essential fatty acid composition. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526546 |
| Bussolino F et al. | Chick retina generates platelet-activating factor. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2890284 |
| Livio M et al. | A platelet-activating factor receptor antagonist protects against renal function deterioration in nephrotoxic nephritis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823570 |
| Vargaftig BB et al. | Synergized activation of human platelets by epinephrine and platelet-activating factor-acether is adenosine diphosphate and thromboxane A2-independent. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221558 |
| Voelkel NF et al. | Platelet-activating factor causes pulmonary vasoconstriction and edema via platelet-independent leukotriene formation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221590 |
| Izumi T et al. | Regulation and signal transduction of PAF receptor. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732892 |
| Bennett SA and Birnboim HC | Platelet activating factor induces transformation of human fibroblasts. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732893 |
| Summers JB et al. | ABT-299, a potent antagonist of platelet activating factor. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732895 |
| Ramesha CS et al. | Identification and quantitation of PAF from psoriatic scales. | 1987 | Agents Actions | pmid:3687590 |