Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Glomerulonephritis D005921 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Psoriasis D011565 47 associated lipids
Brain Edema D001929 20 associated lipids
Leukopenia D007970 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Burns, Inhalation D002059 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Colonic Diseases D003108 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Rezaul K et al. Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. 1997 Biochem. Biophys. Res. Commun. pmid:9345263
Iwamoto S et al. The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. 1997 Biochem. Biophys. Res. Commun. pmid:9345277
Kuruvilla A et al. High-level expression of functional platelet-activating factor receptors on a human B lymphoblastoid cell line. 1991 Biochem. Biophys. Res. Commun. pmid:1659411
Catalán RE et al. Nitric oxide mediates the PAF-stimulated cyclic GMP production in hippocampal slices. 1996 Biochem. Biophys. Res. Commun. pmid:8806587
Catalán RE et al. Platelet-activating factor stimulates protein kinase C translocation in cerebral microvessels. 1993 Biochem. Biophys. Res. Commun. pmid:8484756
Wang F et al. A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF. 1993 Biochem. Biophys. Res. Commun. pmid:8447826
O'Flaherty JT et al. 5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor. 1983 Biochem. Biophys. Res. Commun. pmid:6403011
Smith RJ et al. Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. 1984 Biochem. Biophys. Res. Commun. pmid:6329191
Dillon AM and Heath MF The effects of tyrphostins B42 and B46 on equine platelet function and protein tyrosine phosphorylation. 1995 Biochem. Biophys. Res. Commun. pmid:7542881
Doebber TW et al. Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. 1985 Biochem. Biophys. Res. Commun. pmid:2985058
Pfeilschifter J et al. Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. 1985 Biochem. Biophys. Res. Commun. pmid:2985064
Lerner R et al. Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils. 1988 Biochem. Biophys. Res. Commun. pmid:2838025
Crouch MF and Lapetina EG No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation. 1988 Biochem. Biophys. Res. Commun. pmid:3132162
Hwang SB et al. Specific binding sites for platelet activating factor in human lung tissues. 1985 Biochem. Biophys. Res. Commun. pmid:2986633
Naccache PH et al. Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester. 1985 Biochem. Biophys. Res. Commun. pmid:2992480
Avdonin PV et al. Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). 1985 Biochem. Biophys. Res. Commun. pmid:2994653
Wirthmueller U et al. Studies on the mechanism of platelet-activating factor production in GM-CSF primed neutrophils: involvement of protein synthesis and phospholipase A2 activation. 1990 Biochem. Biophys. Res. Commun. pmid:2166499
Maridonneau-Parini I et al. Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. 1985 Biochem. Biophys. Res. Commun. pmid:2994661
García-Sáinz JA and Hernández-Sotomayor SM Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. 1985 Biochem. Biophys. Res. Commun. pmid:3933497
Levy JV Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. 1987 Biochem. Biophys. Res. Commun. pmid:3619905
Lachachi H et al. Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. 1985 Biochem. Biophys. Res. Commun. pmid:2998370
Clay KL et al. Structure elucidation of platelet activating factor derived from human neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6430285
Tokumura A et al. Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain. 1987 Biochem. Biophys. Res. Commun. pmid:3593346
Touvay C et al. Effect of cyclosporin A and the platelet-activating factor (PAF) antagonist, BN 52021, on PAF- and antigen- induced bronchoconstriction in the guinea-pig. 1989 Biochem. Biophys. Res. Commun. pmid:2775253
Tokuoka SM et al. Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. 2013 Biochem. Biophys. Res. Commun. pmid:23743196
Lad PM et al. Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. 1985 Biochem. Biophys. Res. Commun. pmid:2990462
Comminges C et al. Differential labelings suggest two specific phospholipid subclass hydrolysis promoted by PDGF-BB in vascular smooth muscle cells. 1996 Biochem. Biophys. Res. Commun. pmid:8607782
Weber C et al. Platelet activating factor enhances receptor-operated Ca(++)-influx and subsequent prostacyclin synthesis in human endothelial cells. 1993 Biochem. Biophys. Res. Commun. pmid:8373423
Wykle RL et al. Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils. 1981 Biochem. Biophys. Res. Commun. pmid:7295320
Hayashi M et al. Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor. 1992 Biochem. Biophys. Res. Commun. pmid:1445360
Gil MG et al. Inhibition of phospholipid methyltransferase during zymosan induced secretion of platelet-activating factor in human polymorphonuclear leukocytes. 1981 Biochem. Biophys. Res. Commun. pmid:7306113
Sha'afi RI and Molski TF Signalling for increased cytoskeletal actin in neutrophils. 1987 Biochem. Biophys. Res. Commun. pmid:3036146
Müller S and Nigam S Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites. 1992 Biochem. Biophys. Res. Commun. pmid:1335246
White GC Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. 1984 Biochem. Biophys. Res. Commun. pmid:6428395
Fukao M et al. Structural differences in the ability of lysophospholipids to inhibit endothelium-dependent hyperpolarization by acetylcholine in rat mesenteric arteries. 1996 Biochem. Biophys. Res. Commun. pmid:8878540
Schlondorff D et al. Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. 1986 Biochem. Biophys. Res. Commun. pmid:3099783
Satouchi K et al. Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:4004866
Sugimoto T et al. Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. 1992 Biochem. Biophys. Res. Commun. pmid:1281995
Xu N et al. Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells. 2002 Biochem. Biophys. Res. Commun. pmid:11944906
Shukla SD and Hanahan DJ AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6288030
Kok PT et al. Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. 1988 Biochem. Biophys. Res. Commun. pmid:3132917
Nogami M et al. The effect of platelet-activating factor on [14C]aminopyrine uptake by isolated guinea pig parietal cells. 1990 Biochem. Biophys. Res. Commun. pmid:2346478
Nakayama R et al. Generation of acetyl glyceryl ether phosphorylcholine from the rat skin and muscle tissues stimulated by moxibustion. 1985 Biochem. Biophys. Res. Commun. pmid:3977939
Kojima S et al. Cooperativity between platelet-activating factor and collagen in aggregation of bovine platelets, II. 1990 Biochem. Biophys. Res. Commun. pmid:2346486
Watson F and Edwards SW Stimulation of primed neutrophils by soluble immune complexes: priming leads to enhanced intracellular Ca2+ elevations, activation of phospholipase D, and activation of the NADPH oxidase. 1998 Biochem. Biophys. Res. Commun. pmid:9647777
Caramelo C et al. Presence of platelet-activating factor in blood from humans and experimental animals. Its absence in anephric individuals. 1984 Biochem. Biophys. Res. Commun. pmid:6732788
Lenihan DJ and Lee TC Regulation of platelet activating factor synthesis: modulation of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase by phosphorylation and dephosphorylation in rat spleen microsomes. 1984 Biochem. Biophys. Res. Commun. pmid:6732789
Lagente V et al. Pharmacological modulation of the bronchopulmonary action of the vasoactive peptide, endothelin, administered by aerosol in the guinea-pig. 1989 Biochem. Biophys. Res. Commun. pmid:2645865
Mollinedo F et al. Intracellular localization of platelet-activating factor synthesis in human neutrophils. 1988 Biochem. Biophys. Res. Commun. pmid:3408495
Joseph R and Han E Amyloid beta-protein fragment 25-35 causes activation of cytoplasmic calcium in neurons. 1992 Biochem. Biophys. Res. Commun. pmid:1590803
Hirafuji M et al. Transient increase of cytosolic free calcium in cultured human vascular endothelial cells by platelet-activating factor. 1988 Biochem. Biophys. Res. Commun. pmid:3408504
Filep J et al. Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog. 1989 Biochem. Biophys. Res. Commun. pmid:2916986
Catalán RE et al. PAF-induced activation of polyphosphoinositide-hydrolyzing phospholipase C in cerebral cortex. 1992 Biochem. Biophys. Res. Commun. pmid:1311925
Kato T et al. Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). 1988 Biochem. Biophys. Res. Commun. pmid:3202869
Blank ML et al. A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn-glycerols, a precursor of platelet activating factor. 1984 Biochem. Biophys. Res. Commun. pmid:6696762
Denizot Y et al. Paf-acether production by Escherichia coli. 1989 Biochem. Biophys. Res. Commun. pmid:2660796
Patrignani P et al. Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. 1987 Biochem. Biophys. Res. Commun. pmid:2825672
Földes-Filep E et al. Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. 1987 Biochem. Biophys. Res. Commun. pmid:2825685
Sakakibara M et al. Induction of photoresponse by the hydrolysis of polyphosphoinositides in the Hermissenda type B photoreceptor. 1994 Biochem. Biophys. Res. Commun. pmid:7518677
Schulam PG et al. Evidence for a platelet-activating factor receptor on human lymphoblastoid B cells: activation of the phosphatidylinositol cycle and induction of calcium mobilization. 1990 Biochem. Biophys. Res. Commun. pmid:2154211
Crouch MF and Lapetina EG Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. 1988 Biochem. Biophys. Res. Commun. pmid:3178827
Rodrigues CO et al. Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi. 1996 Biochem. Biophys. Res. Commun. pmid:8687466
Domingo MT et al. Presence of specific binding sites for platelet-activating factor (PAF) in brain. 1988 Biochem. Biophys. Res. Commun. pmid:2831903
Nakayama R et al. 1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity. 1988 Biochem. Biophys. Res. Commun. pmid:3355555
Beaubien BB et al. Platelet-activating factor stimulation of peptidoleukotriene release: inhibition by vasoactive polypeptide. 1984 Biochem. Biophys. Res. Commun. pmid:6594998
Levine L Regulation of arachidonic acid metabolism by phenylarsine oxide. 1991 Biochem. Biophys. Res. Commun. pmid:1859423
Slomiany BL and Slomiany A Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. 2003 Biochem. Biophys. Res. Commun. pmid:12788098
Levi R et al. Alkyl chain homologs of platelet-activating factor and their effects on the mammalian heart. 1989 Biochem. Biophys. Res. Commun. pmid:2742592
Touvay C et al. Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin. 1988 Biochem. Biophys. Res. Commun. pmid:2835036
Yamada T et al. Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat. 1991 Biochem. Biophys. Res. Commun. pmid:2025290
Diserbo M et al. Activation of large conductance Ca(2+)-activated K+ channels in N1E-115 neuroblastoma cells by platelet-activating factor. 1996 Biochem. Biophys. Res. Commun. pmid:8579584
Iwamoto S et al. Platelet microparticles: a carrier of platelet-activating factor? 1996 Biochem. Biophys. Res. Commun. pmid:8579618
Chignard M et al. Paf-acether formation and arachidonic acid freeing from platelet ether-linked glyceryl-phosphorylcholine. 1984 Biochem. Biophys. Res. Commun. pmid:6437404
Errasfa M et al. Inhibition of phospholipase A2 activity of guinea-pig alveolar macrophages by lipocortin-like proteins purified from mice lung. 1988 Biochem. Biophys. Res. Commun. pmid:2968795
Hauser CJ et al. Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils. 2005 Biochem. Biophys. Res. Commun. pmid:16168959
Ng DS and Wong K Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. 1988 Biochem. Biophys. Res. Commun. pmid:2843182
Parent JL et al. Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production. 1996 Biochem. Biophys. Res. Commun. pmid:8645288
Naoki K et al. PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. 2004 Biochem. Biophys. Res. Commun. pmid:15047169
Rigat B et al. The GM2 activator protein, a novel inhibitor of platelet-activating factor. 1999 Biochem. Biophys. Res. Commun. pmid:10329374
Inui H et al. Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells. 1994 Biochem. Biophys. Res. Commun. pmid:7802667
Hartiala KT et al. Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes. 1987 Biochem. Biophys. Res. Commun. pmid:3034265
Chau LY et al. Photoaffinity labeling of platelet activating factor binding sites in rabbit platelet membranes. 1989 Biochem. Biophys. Res. Commun. pmid:2545193
Rouis M et al. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. 1988 Biochem. Biophys. Res. Commun. pmid:2847729
Doni MG et al. Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses. 1988 Biochem. Biophys. Res. Commun. pmid:2847730
Yoshizumi M et al. Interleukin 1 increases the production of endothelin-1 by cultured endothelial cells. 1990 Biochem. Biophys. Res. Commun. pmid:2405848
Smith RJ and Bowman BJ Stimulation of human neutrophil degranulation with 1-O-octadecyl-2-O-acetyl-SN-glyceryl-3-phosphorylcholine: modulation by inhibitors of arachidonic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6803804
Musch MW et al. Antigen-and ionophore-stimulated synthesis of platelet-activating factor by the cloned mast cell line, MC9. 1987 Biochem. Biophys. Res. Commun. pmid:3107564
Lumb RH et al. PAF-acether transfer activity in HL-60 cells is induced during differentiation. 1990 Biochem. Biophys. Res. Commun. pmid:2169726
Alonso MT et al. Monitoring of the activation of receptor-operated calcium channels in human platelets. 1989 Biochem. Biophys. Res. Commun. pmid:2546547
Kroegel C et al. Evidence for two platelet activating factor receptors on eosinophils: dissociation between PAF-induced intracellular calcium mobilization degranulation and superoxides anion generation in eosinophils. 1989 Biochem. Biophys. Res. Commun. pmid:2546554
Rubin RM and Rosenbaum JT A platelet-activating factor antagonist inhibits interleukin 1-induced inflammation. 1988 Biochem. Biophys. Res. Commun. pmid:3260779
Pannocchia A and Hardisty RM Cyclic AMP inhibits platelet activation independently of its effect on cytosolic free calcium. 1985 Biochem. Biophys. Res. Commun. pmid:2983714
Nishinaka Y et al. A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells. 1993 Biochem. Biophys. Res. Commun. pmid:8390246
Holtzman MJ et al. Synthesis of the 1-O-hexadecyl molecular species of platelet-activating factor by airway epithelial and vascular endothelial cells. 1991 Biochem. Biophys. Res. Commun. pmid:2043121
Shiono S et al. Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors. 1993 Biochem. Biophys. Res. Commun. pmid:8390248
Billah MM and Siegel MI Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6422930
Ng DS and Wong K GTP regulation of platelet-activating factor binding to human neutrophil membranes. 1986 Biochem. Biophys. Res. Commun. pmid:3026378
Tokumura A et al. Identification of sn-2-omega-hydroxycarboxylate-containing phospholipids in a lipid extract from bovine brain. 1991 Biochem. Biophys. Res. Commun. pmid:2043133
Prevost MC et al. Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. 1984 Biochem. Biophys. Res. Commun. pmid:6422938
Corl CM et al. Oxidant stress enhances Lyso-PAF-AcT activity by modifying phospholipase D and phosphatidic acid in aortic endothelial cells. 2003 Biochem. Biophys. Res. Commun. pmid:12615078