| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Gram-Negative Bacterial Infections | D016905 | 16 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Manabe H et al. | Anti-inflammatory and bronchodilator properties of KF19514, a phosphodiesterase 4 and 1 inhibitor. | 1997 | Eur. J. Pharmacol. | pmid:9298930 |
| Stewart A et al. | The regulation by phosphorylation of 'priming' of phospholipase A2 activity in the neutrophil model system, differentiated HL60 cells. | 1997 | Br. J. Pharmacol. | pmid:9298523 |
| O'Brien JG et al. | Effects of tranexamic acid and aprotinin on PAF-induced vascular permeability in normal, thrombocytopenic or neutropenic rats. | 1997 | Inflamm. Res. | pmid:9297553 |
| Albert DH et al. | ABT-491, a highly potent and selective PAF antagonist, inhibits nasal vascular permeability associated with experimental allergic rhinitis in brown Norway rats. | 1997 | Inflamm. Res. | pmid:9297547 |
| Perico N et al. | Platelet-activating factor mediates angiotensin II-induced proteinuria in isolated perfused rat kidney. | 1997 | J. Am. Soc. Nephrol. | pmid:9294830 |
| Bozza PT et al. | Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation. | 1997 | J. Exp. Med. | pmid:9294145 |
| Partrick DA et al. | Lipid mediators up-regulate CD11b and prime for concordant superoxide and elastase release in human neutrophils. | 1997 | J Trauma | pmid:9291376 |
| Van de Weerdt ML et al. | Effect of platelet-activating factor on bovine pulmonary function. | 1997 | Vet. Rec. | pmid:9290195 |
| Partrick DA et al. | Nitric oxide attenuates platelet-activating factor priming for elastase release in human neutrophils via a cyclic guanosine monophosphate-dependent pathway. | 1997 | Surgery | pmid:9288123 |
| Karzai W and Reinhart K | Immune modulation and sepsis. | 1997 | Int. J. Clin. Pract. | pmid:9287265 |
| Edwards CM et al. | Effects of the co-polymer surfactant, Pluronic F-68, on platelet aggregation in human whole blood. | 1997 | Artif Cells Blood Substit Immobil Biotechnol | pmid:9285052 |
| Bastos da Silva M et al. | Combined effect of Web 2086 (Paf antagonist) and ketoprofen (Nsaid) on Paf-induced ex vivo platelet aggregation in bovine. | 1997 | Zentralbl Veterinarmed A | pmid:9284631 |
| Xie XQ et al. | Differential scanning calorimetry and small angle x-ray diffraction study of the interaction of (R)-PAF, (R)-ET-18-OME and (R)-Lyso-PAF with model membranes. | 1997 | Life Sci. | pmid:9284084 |
| Roudebush WE et al. | Evidence for the presence of the platelet-activating factor receptor in the CFW mouse preimplantation two-cell-stage embryo. | 1997 | Biol. Reprod. | pmid:9282993 |
| Kintner DB et al. | Hyperglycemic damage to mitochondrial membranes during cerebral ischemia: amelioration by platelet-activating factor antagonist BN 50739. | 1997 | J. Neurochem. | pmid:9282946 |
| RodrÃguez Roisin R | [Platelet activating factor and bronchial asthma. Is it relevant?]. | 1997 | Arch. Bronconeumol. | pmid:9280556 |
| Oh SO et al. | Platelet-activating factor in plasma of patients with sickle cell disease in steady state. | 1997 | J. Lab. Clin. Med. | pmid:9280146 |
| Kume K and Shimizu T | Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. | 1997 | J. Biol. Chem. | pmid:9278453 |
| Bkaily G et al. | The use of confocal microscopy in the investigation of cell structure and function in the heart, vascular endothelium and smooth muscle cells. | 1997 | Mol. Cell. Biochem. | pmid:9278244 |
| Yamashita A et al. | Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells. | 1997 | J. Biochem. | pmid:9276665 |
| Ren G and Ye R | [Changes in urinary excretion of platelet activating factor and its significance in patients with primary nephrotic syndrome]. | 1996 | Zhonghua Nei Ke Za Zhi | pmid:9275622 |
| Cheng D and Chen W | Effects of ginkgolide B on isobaric hypoxic pulmonary hypertension in rats. | 1996 | Chin. Med. J. | pmid:9275375 |
| Chen D and Chen W | Changes of distribution of platelet activating factor in the lung of rats with hypoxic pulmonary hypertension. | 1996 | Chin. Med. J. | pmid:9275354 |
| Klouche M et al. | Endocytosis, storage, and release of IgE by human platelets: differences in patients with type I allergy and nonatopic subjects. | 1997 | J. Allergy Clin. Immunol. | pmid:9275146 |
| Gaumond F et al. | Differential signaling pathways in platelet-activating factor-induced proliferation and interleukin-6 production by rat vascular smooth muscle cells. | 1997 | J. Cardiovasc. Pharmacol. | pmid:9269943 |
| Grigoriadis G and Stewart AG | Human monocytes maintained in culture acquire functional responsiveness to platelet-activating factor that is independent of increases in protein tyrosine phosphorylation. | 1997 | Clin. Exp. Pharmacol. Physiol. | pmid:9269528 |
| Shindo K et al. | PAF-induced eosinophil chemotaxis increases during an asthmatic attack and is inhibited by prednisolone in vivo and in vitro. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9266847 |
| Albert DH et al. | Ex vivo inhibition of beta-thromboglobulin release following administration to man of ABT-299, a novel prodrug of a potent platelet activating factor antagonist. | 1997 | Inflamm. Res. | pmid:9266276 |
| Waller KP | Modulation of endotoxin-induced inflammation in the bovine teat using antagonists/inhibitors to leukotrienes, platelet activating factor and interleukin 1 beta. | 1997 | Vet. Immunol. Immunopathol. | pmid:9261962 |
| Tung DK et al. | Leukocyte contribution to parenchymal cell death in an experimental model of inflammation. | 1997 | J. Leukoc. Biol. | pmid:9261330 |
| Le Gouill C et al. | Structural and functional requirements for agonist-induced internalization of the human platelet-activating factor receptor. | 1997 | J. Biol. Chem. | pmid:9261140 |
| Ruiz-Ortega M et al. | Platelet-activating factor stimulates gene expression and synthesis of matrix proteins in cultured rat and human mesangial cells: role of TGF-beta. | 1997 | J. Am. Soc. Nephrol. | pmid:9259353 |
| Palmer JS et al. | A platelet activating factor antagonist attenuates the effects of testicular ischemia. | 1997 | J. Urol. | pmid:9258168 |
| Alonso MT et al. | Dissociation of the effects of the antitumour ether lipid ET-18-OCH3 on cytosolic calcium and on apoptosis. | 1997 | Br. J. Pharmacol. | pmid:9257915 |
| Grimminger F et al. | Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin. | 1997 | J. Immunol. | pmid:9257856 |
| Weiss DJ and Evanson OA | Detection of activated platelets and platelet-leukocyte aggregates in horses. | 1997 | Am. J. Vet. Res. | pmid:9256963 |
| Takahashi S et al. | Role of platelet-activating factor in two-kidney, one-clip hypertension. | 1997 | Int. J. Urol. | pmid:9256329 |
| Teng CM et al. | Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. | 1997 | J. Pharm. Pharmacol. | pmid:9255715 |
| Shebzukhov IuV and Mysiakin EB | [Platelet activating factor--role in regulating the functional activity of the mononuclear phagocyte system]. | 1996 Oct-Dec | Vopr. Med. Khim. | pmid:9254510 |
| Saito M et al. | Association of granular exocytosis with Ca(2+)-activated K+ channels in human eosinophils. | 1997 | Am. J. Physiol. | pmid:9252535 |
| Sun X et al. | P-selectin-deficient mice are protected from PAF-induced shock, intestinal injury, and lethality. | 1997 | Am. J. Physiol. | pmid:9252509 |
| Balsinde J et al. | Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis. | 1997 | J. Biol. Chem. | pmid:9252342 |
| Avramopoulou V et al. | Synthesis of a new phosphoglycolipid with biological activity towards platelets. | 1997 | Int. J. Biochem. Cell Biol. | pmid:9251244 |
| Korth RM | Specific binding sites for 1-O-alkyl-sn-glyceryl-3-phosphorylcholine on intact human blood neutrophils. | 1997 | Int. Arch. Allergy Immunol. | pmid:9250592 |
| Montrucchio G et al. | Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha. | 1997 | Am. J. Pathol. | pmid:9250168 |
| MartÃnez-Salgado C et al. | Involvement of phospholipase A2 in gentamicin-induced rat mesangial cell activation. | 1997 | Am. J. Physiol. | pmid:9249592 |
| Xie J et al. | Dissociation of TNF-alpha from endotoxin-induced nitric oxide and acute-phase hypotension. | 1997 | Am. J. Physiol. | pmid:9249487 |
| Ereth MH et al. | Does the platelet-activated clotting test (HemoSTATUS) predict blood loss and platelet dysfunction associated with cardiopulmonary bypass? | 1997 | Anesth. Analg. | pmid:9249097 |
| Binisti C et al. | A new phospholipase A2 inhibitor, unrelated to substrate analogues: kinetic characterization of the inhibition of secretory phospholipases A2 by PMS 832. | 1997 | J Lipid Mediat Cell Signal | pmid:9246606 |
| Rougier F et al. | Platelet-activating factor and antagonists modulate DNA synthesis in human bone marrow stromal cell cultures. | 1997 | J Lipid Mediat Cell Signal | pmid:9246604 |
| Travers JB et al. | Identification of sn-2 acetyl glycerophosphocholines in human keratinocytes. | 1997 | J Lipid Mediat Cell Signal | pmid:9246603 |
| Dupuis F et al. | Effects of lipidic mediators on the growth of human myeloid and erythroid marrow progenitors. | 1997 | J Lipid Mediat Cell Signal | pmid:9246601 |
| Barnett CC et al. | Beta-adrenergic stimulation down-regulates neutrophil priming for superoxide generation, but not elastase release. | 1997 | J. Surg. Res. | pmid:9245567 |
| Nakajima K et al. | Activated mast cells release extracellular type platelet-activating factor acetylhydrolase that contributes to autocrine inactivation of platelet-activating factor. | 1997 | J. Biol. Chem. | pmid:9242626 |
| Henninger DD et al. | Low-density lipoprotein receptor knockout mice exhibit exaggerated microvascular responses to inflammatory stimuli. | 1997 | Circ. Res. | pmid:9242189 |
| Davies MG and Hagen PO | Systemic inflammatory response syndrome. | 1997 | Br J Surg | pmid:9240130 |
| Bunting M et al. | Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells. | 1997 | J. Clin. Invest. | pmid:9239403 |
| Sengoku K et al. | Involvement of protein kinases in platelet activating factor-induced acrosome reaction of human spermatozoa. | 1996 | Mol. Hum. Reprod. | pmid:9238710 |
| Roussev RG et al. | Embryonic origin of preimplantation factor (PIF): biological activity and partial characterization. | 1996 | Mol. Hum. Reprod. | pmid:9237230 |
| Filep JG et al. | Glucocorticoid receptor regulates expression of L-selectin and CD11/CD18 on human neutrophils. | 1997 | Circulation | pmid:9236448 |
| Wang X and Evans RD | Effect of endotoxin and platelet-activating factor on lipid oxidation in the rat heart. | 1997 | J. Mol. Cell. Cardiol. | pmid:9236145 |
| Pearson JM et al. | Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration. | 1997 | Toxicology | pmid:9231696 |
| Triggiani M et al. | Characterization of platelet-activating factor acetylhydrolase in human bronchoalveolar lavage. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9230731 |
| DÃaz O et al. | Inhibition of PAF-induced gas exchange defects by beta-adrenergic agonists in mild asthma is not due to bronchodilation. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9230720 |
| Evans DJ et al. | Effects of a potent platelet-activating factor antagonist, SR27417A, on allergen-induced asthmatic responses. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9230719 |
| Rhee CK et al. | Effects of platelet activating factor on vascular permeability of the middle ear mucosa. | 1997 | Ann. Otol. Rhinol. Laryngol. | pmid:9228864 |
| Ammit AJ and O'Neill C | Studies of the nature of the binding by albumin of platelet-activating factor released from cells. | 1997 | J. Biol. Chem. | pmid:9228051 |
| Sirois MG and Edelman ER | VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. | 1997 | Am. J. Physiol. | pmid:9227554 |
| Stahl GL et al. | Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. | 1997 | Am. J. Physiol. | pmid:9227410 |
| Denault S et al. | Transcriptional activation of the interleukin-8 gene by platelet-activating factor in human peripheral blood monocytes. | 1997 | Immunology | pmid:9227331 |
| Dupuis F et al. | Production and metabolism of platelet-activating factor by human bone marrow cells. | 1997 | Res. Immunol. | pmid:9226766 |
| Serra MF et al. | Anti-allergic properties of the natural PAF antagonist yangambin. | 1997 | Planta Med. | pmid:9225600 |
| Lopes AH et al. | Effect of platelet-activating factor on the process of cellular differentiation of Herpetomonas muscarum muscarum. | 1997 Jul-Aug | J. Eukaryot. Microbiol. | pmid:9225446 |
| Korotaeva AA et al. | Effect of lysophosphatidylcholine on the structure and function of low density lipoproteins. | 1997 | Membr Cell Biol | pmid:9225256 |
| Schwartz JD et al. | Lexipafant inhibits platelet activating factor enhanced neutrophil functions. | 1997 | J. Surg. Res. | pmid:9224389 |
| Winkler JD et al. | Evidence that 85 kDa phospholipase A2 is not linked to CoA-independent transacylase-mediated production of platelet-activating factor in human monocytes. | 1997 | Biochim. Biophys. Acta | pmid:9219900 |
| Svetlov SI et al. | Regulation of platelet-activating factor (PAF) biosynthesis via coenzyme A-independent transacylase in the macrophage cell line IC-21 stimulated with lipopolysaccharide. | 1997 | Biochim. Biophys. Acta | pmid:9219895 |
| Balestrieri ML et al. | The role of platelet-activating factor-dependent transacetylase in the biosynthesis of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine by stimulated endothelial cells. | 1997 | J. Biol. Chem. | pmid:9211886 |
| Hoffman BF et al. | Electrophysiologic effects of interactions between activated canine neutrophils and cardiac myocytes. | 1997 | J. Cardiovasc. Electrophysiol. | pmid:9209969 |
| Bellone G et al. | Bone marrow stroma-derived prolactin is involved in basal and platelet-activating factor-stimulated in vitro erythropoiesis. | 1997 | Blood | pmid:9207433 |
| Zhang S et al. | [Determination of platelet activating factor and platelet associated IgG in pregnancy-induced hypertension]. | 1996 | Zhonghua Fu Chan Ke Za Zhi | pmid:9206185 |
| Liu B et al. | Effects of MTX and BN52021 on PAF-induced chemotaxis of PMNs and intraepidermal accumulation of inflammatory cells in guinea pigs. | 1996 | Chin. Med. J. | pmid:9206081 |
| Lin J et al. | Dexamethasone inhibits mucous glycoprotein secretion via a phospholipase A2-dependent mechanism in cultured chinchilla middle ear epithelial cells. | 1997 | Acta Otolaryngol. | pmid:9199527 |
| Rocha MF et al. | Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1beta, tumor necrosis factor alpha, and leukotrienes. | 1997 | Infect. Immun. | pmid:9199444 |
| Rodriguez-Roisin R | Acute severe asthma: pathophysiology and pathobiology of gas exchange abnormalities. | 1997 | Eur. Respir. J. | pmid:9192945 |
| Sharma R et al. | Direct effects of platelet-activating factor on glomerular capillary permeability. | 1997 | Kidney Blood Press. Res. | pmid:9192907 |
| Teixeira MM et al. | Pertussis toxin shows distinct early signalling events in platelet-activating factor-, leukotriene B4-, and C5a-induced eosinophil homotypic aggregation in vitro and recruitment in vivo. | 1997 | Blood | pmid:9192781 |
| Hinterleitner TA et al. | Platelet-activating factor contributes to immune cell and oxidant-mediated intestinal secretion. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9190862 |
| Chen J and Giri SN | Differences in platelet-activating factor receptor mediated Ca++ response between hamster and guinea pig alveolar macrophages. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9190835 |
| van der Weiden RM and Wouters JM | Infertility may sometimes be associated with non-steroidal anti-inflammatory drug consumption. | 1997 | Br. J. Rheumatol. | pmid:9189067 |
| Lacasse C et al. | Platelet-activating factor stimulates interleukin-6 production by human endothelial cells and synergizes with tumor necrosis factor for enhanced production of granulocyte-macrophage colony stimulating factor. | 1997 | Inflammation | pmid:9187959 |
| Okubo Y et al. | Inhibitory effects of theophylline and procaterol on eosinophil function. | 1997 | Intern. Med. | pmid:9187566 |
| Mathiak G et al. | Platelet-activating factor (PAF) in experimental and clinical sepsis. | 1997 | Shock | pmid:9185238 |
| Bazan HE and Tao Y | PAF antagonists as possible inhibitors of corneal epithelial defects and ulceration. | 1997 | J Ocul Pharmacol Ther | pmid:9185044 |
| Ephgrave K et al. | The role of platelet-activating factor in conscious, normotensive endotoxemia. | 1997 | J. Surg. Res. | pmid:9184676 |
| Salcedo R et al. | Endogenous fibronectin of blood polymorphonuclear leukocytes: stimulus-induced secretion and proteolysis by cell surface-bound elastase. | 1997 | Exp. Cell Res. | pmid:9184073 |
| Stotland MA and Kerrigan CL | The role of platelet-activating factor in musculocutaneous flap reperfusion injury. | 1997 | Plast. Reconstr. Surg. | pmid:9180723 |
| Kelefiotis D and Vakirtzi-Lemonias C | Kinetics of PAF transfer, distribution and metabolism in human blood in vitro. | 1997 | Life Sci. | pmid:9180364 |
| Vasänge M et al. | A sulphonoglycolipid from the fern Polypodium decumanum and its effect on the platelet activating-factor receptor in human neutrophils. | 1997 | J. Pharm. Pharmacol. | pmid:9178195 |
| Lin CN et al. | 2',5'-Dihydroxychalcone as a potent chemical mediator and cyclooxygenase inhibitor. | 1997 | J. Pharm. Pharmacol. | pmid:9178190 |