Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Glomerulonephritis D005921 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Psoriasis D011565 47 associated lipids
Brain Edema D001929 20 associated lipids
Leukopenia D007970 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Burns, Inhalation D002059 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Colonic Diseases D003108 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Moore TL and Weiss TD Mediators of inflammation. 1985 Semin. Arthritis Rheum. pmid:3936177
Juhan-Vague I et al. Possible participation of adenosine 5'-diphosphate, arachidonic acid and paf-acether in the platelet pro-aggregating effect of uncontrolled insulin-dependent diabetic erythrocytes in vitro. 1985 Thromb. Res. pmid:3923649
Steiner M et al. Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). 1985 Biochem. Biophys. Res. Commun. pmid:3936503
MacIntyre DE et al. Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C. 1985 FEBS Lett. pmid:2993027
Hayashi H et al. Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists. 1985 J. Biochem. pmid:2993272
Avdonin PV et al. Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). 1985 Biochem. Biophys. Res. Commun. pmid:2994653
Maridonneau-Parini I et al. Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. 1985 Biochem. Biophys. Res. Commun. pmid:2994661
Zukowska-Grojec Z et al. The adrenergic system and the cardiovascular effects of platelet activating factor (1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) in SHR and WKY rats. 1985 Clin Exp Hypertens A pmid:2994912
Shen TY et al. The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. 1985 Int J Tissue React pmid:2997065
Sánchez Crespo M et al. Synthesis of platelet-activating factor from human polymorphonuclear leukocytes: regulation and pharmacological approaches. 1985 Int J Tissue React pmid:2997066
Davis JW et al. Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. 1985 Clin. Pharmacol. Ther. pmid:3987176
O'Neill C Examination of the causes of early pregnancy-associated thrombocytopenia in mice. 1985 J. Reprod. Fertil. pmid:3989801
Kertscher HP and Ostermann G [Synthesis and biological activity of isomeric structural analogs of platelet activating factor]. 1985 Pharmazie pmid:3991788
Wal F et al. PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. 1985 Thromb. Haemost. pmid:3992525
Khan SN et al. Response to platelet-activating factor of platelets from patients with multiple sclerosis. 1985 Acta Neurol. Scand. pmid:3993327
Tamargo J et al. Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles. 1985 Eur. J. Pharmacol. pmid:3996472
Terashita Z et al. Is platelet activating factor (PAF) a mediator of endotoxin shock? 1985 Eur. J. Pharmacol. pmid:3996473
Otsuka A et al. Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. Effects on hemodynamics and humoral factors. 1985 Prostaglandins Leukot Med pmid:3862138
Archer CB et al. Inflammatory cell accumulation in response to intracutaneous Paf-acether: a mediator of acute and persistent inflammation? 1985 Br. J. Dermatol. pmid:4015978
Morley J et al. The role of circulating cells in skin reactions. 1985 Br. J. Dermatol. pmid:4015983
Pirotzky E et al. A role for Paf-acether (platelet-activating factor) in acute skin inflammation? 1985 Br. J. Dermatol. pmid:4015984
Ohno M et al. An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids. 1985 Chem. Pharm. Bull. pmid:4017109
O'Neill C et al. Maternal blood platelet physiology and luteal-phase endocrinology as a means of monitoring pre- and postimplantation embryo viability following in vitro fertilization. 1985 J In Vitro Fert Embryo Transf pmid:4020241
Heymans F et al. Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . 1985 J. Med. Chem. pmid:4020830
Touqui L et al. 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. 1985 Biochim. Biophys. Acta pmid:3967037
Suemune H et al. Synthetic studies on platelet-activating factor (PAF). 1985 Chem. Pharm. Bull. pmid:4028291
Parente L et al. The release of lyso-PAF from guinea-pig lungs. 1985 Eur. J. Pharmacol. pmid:4029263
Lee TC Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes. 1985 J. Biol. Chem. pmid:4030776
Wissner A et al. Analogues of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone. 1985 J. Med. Chem. pmid:4032422
Scherer GF 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. 1985 Biochem. Biophys. Res. Commun. pmid:4084306
Handley DA et al. Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig. 1985 Thromb. Haemost. pmid:4089809
Hemker HC and Béguin S The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. 1985 Verh. K. Acad. Geneeskd. Belg. pmid:4090648
Hallam TJ et al. Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. 1985 Biochem. J. pmid:4091795
Fouque F and Vargaftig BB Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine. 1985 J Pharmacol pmid:4094442
Vigo C Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization. 1985 J. Biol. Chem. pmid:3919022
Armstrong RA et al. Mechanism of the inhibition of platelet aggregation produced by prostaglandin F2 alpha. 1985 Prostaglandins pmid:2988022
Dewald B and Baggiolini M Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. 1985 Biochem. Biophys. Res. Commun. pmid:2985075
Peach MJ et al. Mechanisms of endothelium-dependent vascular smooth muscle relaxation. 1985 Biochem. Pharmacol. pmid:2988558
Orlov SM et al. [Histamine release from human leukocytes after treatment with 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) and its structural analogs]. 1985 Biokhimiia pmid:2408682
Braquet M et al. Leukocytic functions in burn-injured patients. 1985 Prostaglandins pmid:2989978
Hallam TJ and Rink TJ Agonists stimulate divalent cation channels in the plasma membrane of human platelets. 1985 FEBS Lett. pmid:2408921
O'Neill C et al. Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. 1985 Ann. N. Y. Acad. Sci. pmid:2409860
Sage SO and Rink TJ Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets. 1985 FEBS Lett. pmid:2410292
Tou J Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. 1985 Biochem. Biophys. Res. Commun. pmid:3921017
Snyder F Chemical and biochemical aspects of platelet activating factor: a novel class of acetylated ether-linked choline-phospholipids. 1985 Jan-Mar Med Res Rev pmid:2984489
Kozubski W and Stańczyk L [Platelet aggregation in patients with migraine during the pain attack and in the pain-free period]. 1985 Jul-Aug Neurol. Neurochir. Pol. pmid:4094642
Bette-Bobillo P et al. Synthesis and characterization of a radioiodinated, photoreactive and physiologically active analogue of platelet activating factor. 1985 Jun-Jul Chem. Phys. Lipids pmid:4042252
Leprán I and Lefer AM Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. 1985 Mar-Apr Basic Res. Cardiol. pmid:4039929
Feuerstein G et al. Thyrotropin-releasing hormone blocks the hypotensive effects of platelet-activating factor in the unanesthetized guinea pig. 1985 Mar-Apr J. Cardiovasc. Pharmacol. pmid:2581089
Mencia-Huerta JM Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. 1985 Sep-Oct Ann. Inst. Pasteur Immunol. pmid:3878684
Masugi F et al. Role of acetyl glyceryl ether phosphorylcholine in blood pressure regulation in rats. 1985 Sep-Oct Hypertension pmid:4030044
Yamazaki H [Recent medical topics on platelets in hemorrhagic and thrombotic diseases]. 1986 Nippon Naika Gakkai Zasshi pmid:3027214
Rink TJ Stimulus-response coupling mechanisms in human platelets. 1986 Agents Actions Suppl. pmid:3028101
Baroggi N et al. Changes in cytosolic free calcium induced by platelet-activating factor in rabbit platelets: specific inhibition by BN 52021 and structurally related compounds. 1986 Agents Actions Suppl. pmid:3028108
Hwang SB et al. Specific binding of [3H]dihydrokadsurenone to rabbit platelet membranes and its inhibition by the receptor agonists and antagonists of platelet-activating factor. 1986 J. Biol. Chem. pmid:3020044
Biftu T et al. Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists. 1986 J. Med. Chem. pmid:3020247
Zanetti A et al. The effect of AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxy- carbonylmethoxycoumarin) on washed human platelet aggregation induced by platelet activating factor (PAF) and epinephrine. 1986 Eur. J. Pharmacol. pmid:2944757
Bush LR and Smith SG Antagonism of U46619-induced aggregation of human and canine platelets by four TXA2 receptor antagonists. 1986 Thromb. Res. pmid:2948294
Valone FH and Ruis NM Platelet-activating factor binding to human platelet membranes. 1986 Biotechnol. Appl. Biochem. pmid:3021183
Braquet P Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L. 1986 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2949548
Naccache PH et al. Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. 1986 J. Leukoc. Biol. pmid:3021882
Panchenko EP et al. [Free cytoplasmic calcium and thrombocyte aggregation in patients with ischemic heart disease. The effect of ADP, thrombocyte activation factor and serotonin]. 1986 Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR pmid:3801147
Chamone DF et al. Increased levels of eosinophil-derived PAF-acether activity in a patient with idiopathic hypereosinophilic syndrome. 1986 Braz. J. Med. Biol. Res. pmid:3801724
Toth PD and Mikulaschek AW Effects of a platelet-activating factor antagonist, CV-3988, on different shock models in the rat. 1986 Circ. Shock pmid:3802423
Desquand S et al. Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. 1986 Eur. J. Pharmacol. pmid:3019727
Daniel LW et al. A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine. 1986 J. Biol. Chem. pmid:3087989
Simpson AW et al. Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. 1986 FEBS Lett. pmid:3086128
Nakaya H and Tohse N Electrophysiological effects of acetyl glyceryl ether phosphorylcholine on cardiac tissues: comparison with lysophosphatidylcholine and long chain acyl carnitine. 1986 Br. J. Pharmacol. pmid:3814909
Schlondorff D et al. Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells. 1986 Am. J. Physiol. pmid:3087218
Coëffier E et al. Effects of PAF-acether and structural analogues on platelet activation and bronchoconstriction in guinea-pigs. 1986 Eur. J. Pharmacol. pmid:3816952
Oda M et al. Polymorphonuclear leukocyte-platelet interactions: acetylglyceryl ether phosphocholine-induced platelet activation under stimulation with chemotactic peptide. 1986 J. Biochem. pmid:3818574
Nishihira J and Ishibashi T A phospholipase C with a high specificity for platelet-activating factor in rabbit liver light mitochondria. 1986 Lipids pmid:3821393
Kloprogge E et al. Stimulus-aggregation coupling in platelets activated with PAF-acether. 1986 Biochim. Biophys. Acta pmid:3089297
Lynch JM and Henson PM The intracellular retention of newly synthesized platelet-activating factor. 1986 J. Immunol. pmid:3093579
McMurtry IF and Morris KG Platelet-activating factor causes pulmonary vasodilation in the rat. 1986 Am. Rev. Respir. Dis. pmid:3094417
Alexandre A et al. Inhibition by antioxidants of agonist evoked cytosolic Ca++ increase, ATP secretion and aggregation of aspirinated human platelets. 1986 Biochem. Biophys. Res. Commun. pmid:3094518
Alam I and Silver MJ Acetyltransferase activity in human platelet microsomes and washed platelets. 1986 Biochim. Biophys. Acta pmid:3094588
Gillespie MN and Bowdy BD Impact of platelet activating factor on vascular responsiveness in isolated rat lungs. 1986 J. Pharmacol. Exp. Ther. pmid:3944767
Viero P et al. Thrombotic thrombocytopenic purpura and high-dose immunoglobulin treatment. 1986 Ann. Intern. Med. pmid:3946966
Siafaka-Kapadai A et al. Biological activity of lipids of pine pollen on platelet aggregation in correlation with the platelet activating factor. 1986 Biochem. Int. pmid:3947373
McNamara PJ et al. Autacoid binding to serum proteins. Interaction of platelet activating factor (PAF) with human serum alpha-1-acid glycoprotein (AAG). 1986 Biochem. Pharmacol. pmid:3947392
Anderson RC et al. Platelet-activating factor analogs. II. Synthesis of the 1-O-(4-decyloxymethylphenyl)- and 1-O-(4-decyloxyphenylmethyl) analogs. 1986 Chem. Phys. Lipids pmid:3948294
Davis RB and Johnson MF Effects of bacterial endotoxin and platelet activating factor (PAF) on human platelet aggregation in native whole blood. 1986 Thromb. Res. pmid:3544327
Patscheke H and Dierichs R Cationized ferritin as a platelet-stimulating surface probe. Binding to platelets and effects on platelet function. 1986 Eur. J. Cell Biol. pmid:3084260
O'Flaherty JT et al. Binding and metabolism of platelet-activating factor by human neutrophils. 1986 J. Clin. Invest. pmid:3016027
Hanahan DJ Platelet activating factor: a biologically active phosphoglyceride. 1986 Annu. Rev. Biochem. pmid:3017194
Bette-Bobillo P et al. Interaction between blood components and a spin-labeled analogue of PAF-acether. 1986 Biochim. Biophys. Acta pmid:3017416
Levesque JP et al. Fibrinogen mitogenic effect on hemopoietic cell lines: control via receptor modulation. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3018735
Raaijmakers JA et al. Phospholipase A2 products induce pulmonary beta-adrenoceptor deviations. 1986 Eur. J. Pharmacol. pmid:3019725
Foegh ML et al. Fatty acids and eicosanoids in organ transplantation. 1986 Prog. Lipid Res. pmid:3321095
Dewald B and Baggiolini M Platelet-activating factor as a stimulus of exocytosis in human neutrophils. 1986 Biochim. Biophys. Acta pmid:3017443
Ostermann G et al. Stimulation and desensitization of human and rabbit platelets by 1-O-hexadecyl-2-O-methyl-rac-glycero-3-phosphocholine and analogues. 1986 Thromb. Res. pmid:3764811
First International Alexis Carrel Conference on Lipid Mediators in Organ Transplantation. April 8-10, 1986, Washington, DC. 1986 Transplant. Proc. pmid:3765055
Satoh K and Takamatsu S [Inactivation by plasma of platelet-activating factor]. 1986 Nippon Ketsueki Gakkai Zasshi pmid:3766067
Gordeev KIu et al. [Synthesis of thioanalogs of platelet activating factor (PAF)]. 1986 Bioorg. Khim. pmid:3768051
Hoffman DR et al. Metabolism and function of platelet-activating factor in fetal rabbit lung development. 1986 Biochim. Biophys. Acta pmid:3768390
Thomas Y et al. [Synthesis of paf-acether by E. coli K12]. 1986 C. R. Acad. Sci. III, Sci. Vie pmid:3101984
Küster LJ and Frölich JC Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man. 1986 Prostaglandins pmid:3097760
Cordeiro RS et al. Salicylates inhibit PAF-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective. 1986 Prostaglandins pmid:3103172
Hwang SB et al. Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes. 1986 J. Biol. Chem. pmid:3001070