| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Gram-Negative Bacterial Infections | D016905 | 16 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Han GQ et al. | [The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim]. | 1989 | Yao Xue Xue Bao | pmid:2609983 |
| Zeng GQ et al. | Effects of dauricine and tetrandrine on [3H] WEB 2086 specific binding to bovine anterior cerebral arterial smooth muscle cells in vitro. | 1993 | Yao Xue Xue Bao | pmid:8285049 |
| Zang BX et al. | [Antagonistic effect of myricetin on platelet activing factor]. | 2003 | Yao Xue Xue Bao | pmid:14991995 |
| Ma Y et al. | [Studies on PAF antagonistic bicyclo(3,2,1) octanoid neolignans from Piper kadsura]. | 1993 | Yao Xue Xue Bao | pmid:8368081 |
| Peng SY et al. | [Effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes]. | 2010 | Yao Xue Xue Bao | pmid:21351565 |
| Kase N et al. | [Pharmacological profile of F-0401, a novel dihydropyridine derivative. III. The anti-aggregatory action of F-0401 on rabbit platelets]. | 1995 | Yakugaku Zasshi | pmid:7699581 |
| Matsubara C et al. | [Densitometric quantitation of platelet activating factor and other phospholipids in human saliva using enzyme reaction on a silica plate]. | 1994 | Yakugaku Zasshi | pmid:7965653 |
| Ohishi S | [Evaluation of time course and inter-relationship of inflammatory mediators in experimental inflammatory reaction]. | 2000 | Yakugaku Zasshi | pmid:10825809 |
| Tanaka E et al. | Dual effects of a novel thienodiazepine platelet-activating factor antagonist, on drug-oxidizing enzymes in beagle dog. | 1994 | Xenobiotica | pmid:8059533 |
| Nunoya K et al. | S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast. | 1995 | Xenobiotica | pmid:8719904 |
| Thomson KL et al. | Metabolism of the platelet-activating factor antagonist (+/-)-trans-2-(3'-methoxy-5'-methylsulphonyl-4'-propoxyphenyl)-5-(3",4" ,5"- trimethoxyphenyl)tetrahydrofuran (L-659,989) in rhesus monkeys. | 1991 | Xenobiotica | pmid:1949894 |
| Kobayashi T et al. | Metabolism and disposition of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate (MOTP) in rats and dogs. | 1988 | Xenobiotica | pmid:3354232 |
| Kusano K et al. | Pharmacokinetics of a new thienodiazepine platelet activating factor receptor antagonist (E6123) in laboratory animals. Is there a metabolic polymorphism in the rhesus monkey? | 1993 | Xenobiotica | pmid:8212733 |
| Kusano K et al. | Metabolic polymorphism of E6123 in rhesus monkey. | 1993 | Xenobiotica | pmid:8212734 |
| Sperling RI | Effects of dietary fish oil on leukocyte leukotriene and PAF generation and on neutrophil chemotaxis. | 1991 | World Rev Nutr Diet | pmid:2053354 |
| Xia SH et al. | Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. | 2013 | World J. Gastroenterol. | pmid:23840141 |
| Lu YY et al. | Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis. | 2008 | World J. Gastroenterol. | pmid:18205269 |
| Zhou ZG and Chen YD | Influencing factors of pancreatic microcirculatory impairment in acute panceatitis. | 2002 | World J. Gastroenterol. | pmid:12046059 |
| Yang YP et al. | Effect of increased hepatic platelet activating factor and its receptor portal hypertension in CCl4-induced liver cirrhosis. | 2006 | World J. Gastroenterol. | pmid:16521183 |
| Zhao H et al. | Influence of platelet activating factor on expression of adhesion molecules in experimental pancreatitis. | 2003 | World J. Gastroenterol. | pmid:12532462 |