| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Gram-Negative Bacterial Infections | D016905 | 16 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Renkonen R et al. | Signal transduction during platelet-activating factor-induced lymphocyte binding to endothelial cells. | 1990 | Scand. J. Immunol. | pmid:2159182 |
| Morita E et al. | Production of 15-hydroxyeicosatetraenoic acid by purified human eosinophils and neutrophils. | 1990 | Scand. J. Immunol. | pmid:2125361 |
| O'Donnell MC and Fiedel BA | Histamine secretion from human leucocytes stimulated by basophil-derived platelet-activating factor. | 1981 | Scand. J. Immunol. | pmid:6171870 |
| Morita E et al. | Differential sensitivities of purified human eosinophils and neutrophils to defined chemotaxins. | 1989 | Scand. J. Immunol. | pmid:2544988 |
| Lindström P et al. | Rapid adhesive responses of endothelial cells and of neutrophils induced by leukotriene B4 are mediated by leucocytic adhesion protein CD18. | 1990 | Scand. J. Immunol. | pmid:1972589 |
| Hilliquin P et al. | Correlations between PAF-acether and tumor necrosis factor in rheumatoid arthritis. Influence of parenteral corticosteroids. | 1995 | Scand. J. Rheumatol. | pmid:7777830 |
| Dulioust A et al. | Paf-acether acetylhydrolase activity is increased in patients with rheumatic diseases. | 1992 | Scand. J. Rheumatol. | pmid:1529281 |
| Leistad L et al. | Multiple phospholipase A2 enzymes participate in the inflammatory process in osteoarthritic cartilage. | 2011 | Scand. J. Rheumatol. | pmid:21417548 |
| Schaller MD | [Sepsis syndrome: progress and therapeutic perspectives]. | 1992 | Schweiz Med Wochenschr | pmid:1604283 |
| Ding Z et al. | Inhibitory effects of isoproterenol on PAF-induced endothelial cell permeability and morphological changes. | 1996 | Sci. China, C, Life Sci. | pmid:8760474 |
| Ruan CG et al. | Studies on monoclonal antibodies against human platelets--a monoclonal antibody to human platelet glycoprotein I--SZ-2. | 1987 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:3659897 |
| Voelkel NF et al. | Nonimmunological production of leukotrienes induced by platelet-activating factor. | 1982 | Science | pmid:7123233 |
| Thurston G et al. | Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. | 1999 | Science | pmid:10617467 |
| Kornecki E and Ehrlich YH | Neuroregulatory and neuropathological actions of the ether-phospholipid platelet-activating factor. | 1988 | Science | pmid:3381103 |
| Abisogun AO et al. | The involvement of platelet activating factor in ovulation. | 1989 | Science | pmid:2911750 |
| Darius H et al. | Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis. | 1986 | Science | pmid:3082008 |
| Kornecki E et al. | Platelet-activating factor-induced aggregation of human platelets specifically inhibited by triazolobenzodiazepines. | 1984 | Science | pmid:6150550 |
| Teruel MN and Meyer T | Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module. | 2002 | Science | pmid:11884760 |
| Wang R et al. | [High performance thin layer chromatographic (HPTLC) determination of PAF in cerebrospinal fluid of patients with subarachnoid hemorrhage(SAH)]. | 1999 | Se Pu | pmid:12552702 |
| Igarashi Y | [Physiology of sphingosine 1-phosphate: regulation of cell motility and platelet function]. | 1997 | Seikagaku | pmid:9431007 |
| Sato A and Ebina K | [Interaction between Asp-hemolysin-related synthetic peptides and oxidized LDL/lysophospholipids]. | 2013 | Seikagaku | pmid:23819394 |
| Tokumura A and Tsukatani H | [Antagonists of platelet activating factor]. | 1985 | Seikagaku | pmid:3009656 |
| Shindou H | [Lysophospholipid acyltransferase and platelet-activating factor (PAF) biosynthetic enzyme]. | 2008 | Seikagaku | pmid:18341030 |
| Nakayama R and Saito K | [PAF and its physiological significance in normal tissue]. | 1988 | Seikagaku | pmid:3286791 |
| Satouchi K | [Platelet activating factor (PAF)--a new chemical mediator of inflammation]. | 1983 | Seikagaku | pmid:6350499 |
| Shindou H | [Discovery and characterization of novel lysophospholipid acyltransferases]. | 2010 | Seikagaku | pmid:21348263 |
| Moschos MM et al. | In Vitro Effects of Anti-Glaucomatous Eye Drops on Platelet-Activating Factor and its Metabolism. | 2017 | Semin Ophthalmol | pmid:26270771 |
| Felsen D et al. | Inflammatory mediators and interstitial cystitis. | 1991 | Semin Urol | pmid:1853005 |
| Moore TL and Weiss TD | Mediators of inflammation. | 1985 | Semin. Arthritis Rheum. | pmid:3936177 |
| Lorant DE et al. | Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion. | 1995 | Semin. Cell Biol. | pmid:8562922 |
| Murer EH | The role of platelet calcium. | 1985 | Semin. Hematol. | pmid:3901271 |
| Lian EC | Pathogenesis of thrombotic thrombocytopenic purpura. | 1987 | Semin. Hematol. | pmid:3299722 |
| Barnes JL and Venkatachalam MA | The role of platelets and polycationic mediators in glomerular vascular injury. | 1985 | Semin. Nephrol. | pmid:2957770 |
| Fischereder M et al. | Therapeutic strategies in the prevention of acute renal failure. | 1994 | Semin. Nephrol. | pmid:8140341 |
| Caplan MS et al. | The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. | 2005 | Semin. Pediatr. Surg. | pmid:16084401 |
| Frost BL and Caplan MS | Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. | 2013 | Semin. Pediatr. Surg. | pmid:23611612 |
| Frost BL et al. | The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis. | 2008 | Semin. Perinatol. | pmid:18346533 |
| Roudebush WE | Seminal platelet-activating factor. | 2007 | Semin. Thromb. Hemost. | pmid:17253192 |
| Carveth HJ et al. | Regulation of platelet-activating factor (PAF) synthesis and PAF-mediated neutrophil adhesion to endothelial cells activated by thrombin. | 1992 | Semin. Thromb. Hemost. | pmid:1315452 |
| Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
| Silvestro L et al. | Platelet-activating factor-induced endothelial cell expression of adhesion molecules and modulation of surface glycocalyx, evaluated by electron spectroscopy chemical analysis. | 1994 | Semin. Thromb. Hemost. | pmid:7527938 |
| Braquet P et al. | Effect of platelet-activating factor on platelets and vascular endothelium. | 1989 | Semin. Thromb. Hemost. | pmid:2546255 |
| Fu JM | [Effects of platelet activating factor on blood platelets]. | 1989 | Sheng Li Ke Xue Jin Zhan | pmid:2549618 |
| Yu SQ | [Effects of platelet-activating factor (PAF) and its antagonists on the male reproduction]. | 1995 | Sheng Li Ke Xue Jin Zhan | pmid:7604226 |
| Wang YY and Li CL | [Platelet-activating factor antagonists and asthma]. | 1992 | Sheng Li Ke Xue Jin Zhan | pmid:1329195 |
| Yin M and Fang ZY | [Platelet-activating factor]. | 1989 | Sheng Li Ke Xue Jin Zhan | pmid:2692167 |
| Liu Y and Kang GF | [Lipid mediators and liver injury]. | 1995 | Sheng Li Ke Xue Jin Zhan | pmid:8745570 |
| Wu QX | [Amplification and desensitization in platelet activation]. | 1992 | Sheng Li Ke Xue Jin Zhan | pmid:1299958 |
| Li SQ | [Platelet activating factor and cerebral ischemia]. | 1991 | Sheng Li Ke Xue Jin Zhan | pmid:1796263 |
| Shen YZ and Li CL | [The pathophysiological role of the platelet activating factor]. | 1991 | Sheng Li Ke Xue Jin Zhan | pmid:1796277 |
| Zeng NX | [Platelet activating factor and gastrointestinal mucosa injuries]. | 1991 | Sheng Li Ke Xue Jin Zhan | pmid:1947987 |
| Chen DC | [Phosphoinositide metabolism and platelet activation]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2838899 |
| Hu GL and Guo HS | [Progress in platelet-activating factor receptor research]. | 1997 | Sheng Li Ke Xue Jin Zhan | pmid:10921090 |
| Hu DH and Ma CT | [Effect of platelet activating factor on TxA2, PGI2 and Ca(2+)-ATPase activity in the intra-pulmonary artery smooth muscle cells]. | 1996 | Sheng Li Xue Bao | pmid:9389196 |
| Zheng HL et al. | [Role of platelet-activating factor in progesterone synthesis and vascular endothelial growth factor expression in rat luteal cells]. | 2008 | Sheng Li Xue Bao | pmid:18425318 |
| Tu Q and Zhang QX | [Stimulation of megakaryocyte maturation and thrombopoiesis in vitro by thrombocytopoiesis-stimulating factor]. | 1990 | Sheng Li Xue Bao | pmid:2263959 |
| Ma CT | [Variation of plasma platelet activating factor during development and reversal of hypoxic pulmonary hypertension in conscious sheep]. | 1994 | Sheng Li Xue Bao | pmid:7973831 |
| Du YM et al. | Effects of platelet activating factor on action potentials and potassium channels in guinea-pig ventricular myocytes. | 2004 | Sheng Li Xue Bao | pmid:15224138 |
| Yan GT et al. | [Effect of calcium overload and platelet activating factor on calcitonin gene related peptide release from lung tissue]. | 1998 | Sheng Li Xue Bao | pmid:11324524 |
| Jin Y et al. | [The effect of autocrine factors on development of early embryos of mouse]. | 2001 | Shi Yan Sheng Wu Xue Bao | pmid:12549014 |
| Mathiak G et al. | Platelet-activating factor (PAF) in experimental and clinical sepsis. | 1997 | Shock | pmid:9185238 |
| Kruse-Elliott KT et al. | Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. | 1998 | Shock | pmid:9466472 |
| Chen LW et al. | Differential regulation of Ca2+ influx by fMLP and PAF in human neutrophils: possible involvement of store-operated Ca2+ channel. | 2000 | Shock | pmid:10718373 |
| Kruse-Elliott KT et al. | Low molecular weight heparin alters porcine neutrophil responses to platelet-activating factor. | 1998 | Shock | pmid:9744648 |
| Kruse-Elliott KT et al. | Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist. | 1996 | Shock | pmid:8721386 |
| Cuschieri J et al. | Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming. | 2005 | Shock | pmid:15665723 |
| Wang HG et al. | The role of endogenous nitric oxide in the sympathetic and hemodynamic response to platelet activating factor-induced hypotension in anesthetized dogs. | 1998 | Shock | pmid:9466475 |
| Bar-Or D et al. | Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. | 2003 | Shock | pmid:12865660 |
| Rios-Santos F et al. | A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis. | 2003 | Shock | pmid:12558146 |
| Ruggiero V et al. | Beneficial effects of a novel platelet-activating factor receptor antagonist, ST 899, on endotoxin-induced shock in mice. | 1994 | Shock | pmid:7757521 |
| Froon AM et al. | Treatment with the platelet-activating factor antagonist TCV-309 in patients with severe systemic inflammatory response syndrome: a prospective, multi-center, double-blind, randomized phase II trial. | 1996 | Shock | pmid:9156785 |
| Buripakdi D and Karlstad MD | The role of platelet-activating factor in alterations of system A amino acid transport in rat soleus and extensor digitorum longus muscles during endotoxic shock. | 1994 | Shock | pmid:7735984 |
| Enzan K et al. | Thromboxane rather than platelet activating factor mediates pulmonary vasoconstriction after antigen challenge in rabbits. | 1996 | Shock | pmid:8885083 |
| Koch T et al. | Effects of stroma-free hemoglobin solutions on pulmonary vascular resistance and mediator release in the isolated perfused rabbit lung. | 1994 | Shock | pmid:7538430 |
| Shouji K et al. | Platelet-activating factor is a key mediator of pulmonary vasoconstriction and bronchoconstriction after antigen challenge in the perfused sensitized rabbit lung. | 1998 | Shock | pmid:9645492 |
| Laniyonu AA et al. | Endotoxin-induced microvascular leakage is prevented by a PAF antagonist and NO synthase inhibitor. | 1997 | Shock | pmid:8989836 |
| Albert DH et al. | ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats. | 1996 | Shock | pmid:8856845 |
| Poeze M et al. | Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: a prospective, multicenter, double-blind, randomized phase II trial. TCV-309 Septic Shock Study Group. | 2000 | Shock | pmid:11049104 |
| Karlstad MD et al. | Platelet-activating factor (PAF)-induced decreases in whole-body and skeletal muscle protein synthesis. | 2000 | Shock | pmid:11049115 |
| James JH and Fischer JE | Are the effects of platelet-activating factor on muscle metabolism of carbohydrates, amino acids and proteins attributable mainly to epinephrine? | 2000 | Shock | pmid:11049116 |
| Ciesla DJ et al. | Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling. | 2000 | Shock | pmid:11028541 |
| Childs EW et al. | In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. | 2002 | Shock | pmid:12412620 |
| Gomes RN et al. | Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. | 2006 | Shock | pmid:16783197 |
| Chen LW et al. | Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. | 2006 | Shock | pmid:16783201 |
| Klabunde RE and Calvello C | Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor. | 1995 | Shock | pmid:8595525 |
| Cureton EL et al. | Endothelin 1 and prostacyclin attenuate increases in hydraulic permeability caused by platelet-activating factor in rats. | 2010 | Shock | pmid:19940814 |
| Zallen G et al. | Postinjury suppression of human neutrophil cytokine production results from the stabilization of inhibitory kappaB. | 1999 | Shock | pmid:10030791 |
| Granger J and Remick D | Acute pancreatitis: models, markers, and mediators. | 2005 | Shock | pmid:16374372 |
| Bulger EM et al. | The macrophage response to endotoxin requires platelet activating factor. | 2002 | Shock | pmid:11900334 |
| Mitsuoka H et al. | Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. | 2002 | Shock | pmid:11900339 |
| Mariano F et al. | Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production. | 2003 | Shock | pmid:12688545 |
| Park EJ et al. | Dietary ganglioside inhibits acute inflammatory signals in intestinal mucosa and blood induced by systemic inflammation of Escherichia coli lipopolysaccharide. | 2007 | Shock | pmid:17510604 |
| Aiboshi J et al. | Blood transfusion and the two-insult model of post-injury multiple organ failure. | 2001 | Shock | pmid:11303730 |
| Glaser KB et al. | Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2. | 1995 | Skin Pharmacol. | pmid:8688196 |
| Baltás E et al. | Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. | 2003 Jul-Aug | Skin Pharmacol. Appl. Skin Physiol. | pmid:12784066 |
| Wintroub BU and Soter NA | Biology of the mast cell and its role in cutaneous inflammation. | 1981 | Springer Semin. Immunopathol. | pmid:7022722 |
| Costa M et al. | Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. | 2013 | Stem Cell Res | pmid:23164599 |
| Donnard M et al. | Membrane and intracellular platelet-activating factor receptor expression in leukemic blasts of patients with acute myeloid and lymphoid leukemia. | 2002 | Stem Cells | pmid:12351810 |
| Liu J et al. | New vernocuminosides from the stem barks of Vernonia cumingiana Benth. | 2009 | Steroids | pmid:18840454 |
| Leont'ev VK and Kankanian AP | [The local activation of leukocytes and thrombocytes in periodontal diseases: the role of thrombocyte-activating factor]. | 1996 | Stomatologiia (Mosk) | pmid:8658569 |