| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Gram-Negative Bacterial Infections | D016905 | 16 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sirén AL et al. | Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats. | 1993 | Stroke | pmid:8506560 |
| Lindsberg PJ et al. | Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits. | 1990 | Stroke | pmid:2219210 |
| Sirén AL et al. | Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats. | 1992 | Stroke | pmid:1440713 |
| Joseph R et al. | Effect of therapy on platelet activating factor-induced aggregation in acute stroke. | 1989 | Stroke | pmid:2718200 |
| Joseph R and Welch KM | Granulocytes, platelet activating factor, and stroke. | 1989 | Stroke | pmid:2756548 |
| Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 1. Systemic application. | 1999 | Stroke | pmid:10187894 |
| Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 2. Local application. | 1999 | Stroke | pmid:10187895 |
| Bielenberg GW et al. | Infarct reduction by the platelet activating factor antagonist apafant in rats. | 1992 | Stroke | pmid:1731428 |
| Joseph R et al. | Effect of ticlopidine and aspirin on platelet ionized calcium in ischemic stroke. | 1991 | Stroke | pmid:2024285 |
| Kochanek PM et al. | Endogenous platelet activating factor does not modulate blood flow and metabolism in normal rat brain. | 1990 | Stroke | pmid:2309270 |
| Feuerstein G et al. | Platelet-activating factor. A putative mediator in central nervous system injury? | 1990 | Stroke | pmid:2237991 |
| Yoshida H et al. | Platelet-activating factor acetylhydrolase in red cell membranes. Does decreased activity impair erythrocyte deformability in ischemic stroke patients? | 1993 | Stroke | pmid:8418541 |
| Nishida K and Markey SP | Platelet-activating factor in brain regions after transient ischemia in gerbils. | 1996 | Stroke | pmid:8610322 |
| Wei Y et al. | Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution. | 1998 | Structure | pmid:9562561 |
| Anderson BO et al. | The role of platelet activating factor and its antagonists in shock, sepsis and multiple organ failure. | 1991 | Surg Gynecol Obstet | pmid:1851337 |
| Biffl WL et al. | Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C. | 2001 | Surg Infect (Larchmt) | pmid:12593704 |
| Denham W and Norman J | The potential role of therapeutic cytokine manipulation in acute pancreatitis. | 1999 | Surg. Clin. North Am. | pmid:10470326 |
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| Ono S et al. | Clinical and experimental studies on the role of platelet-activating factor (PAF) in the pathogenesis of septic DIC. | 1993 | Surg. Today | pmid:8467174 |
| Abu-Zidan FM | Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. | 1998 | Surgery | pmid:9481416 |
| Yaffe MB et al. | Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. | 1999 | Surgery | pmid:10455891 |
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| Werner J et al. | Multidrug strategies are effective in the treatment of severe experimental pancreatitis. | 2012 | Surgery | pmid:21982067 |
| Biffl WL et al. | Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation. | 2003 | Surgery | pmid:12874587 |
| Unno N et al. | Single nucleotide polymorphism (G994-->T) in the plasma platelet-activating factor-acetylhydrolase gene is associated with graft patency of femoropopliteal bypass. | 2002 | Surgery | pmid:12110797 |
| Partrick DA et al. | Nitric oxide attenuates platelet-activating factor priming for elastase release in human neutrophils via a cyclic guanosine monophosphate-dependent pathway. | 1997 | Surgery | pmid:9288123 |
| Kim FJ et al. | Disparate signal transduction in neutrophil CD18 adhesion receptor expression versus superoxide generation. | 1994 | Surgery | pmid:8047994 |
| Schurr MJ et al. | Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. | 1997 | Surgery | pmid:9142146 |
| Takada Y et al. | Prolonged hepatic warm ischemia in non-heart-beating donors: protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation. | 1998 | Surgery | pmid:9626320 |
| Porras-Reyes BH and Mustoe TA | Platelet-activating factor: improvement in wound healing by a chemotactic factor. | 1992 | Surgery | pmid:1557687 |
| Cuschieri J et al. | Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. | 2002 | Surgery | pmid:12219006 |
| Read RA et al. | Platelet-activating factor-induced polymorphonuclear neutrophil priming independent of CD11b adhesion. | 1993 | Surgery | pmid:8342134 |
| Liu T et al. | Improved preservation of the rat liver for orthotopic liver transplantation: use of University of Wisconsin-lactobionate solution and retrograde reflushing. | 1990 | Surgery | pmid:2237771 |
| Wang KS et al. | Protective effect of platelet-activating factor antagonist on ischemia-induced liver injury in rats. | 1993 | Surgery | pmid:8417492 |
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| O' Meara CM et al. | Relationship between in vitro sperm functional tests and in vivo fertility of rams following cervical artificial insemination of ewes with frozen-thawed semen. | 2008 | Theriogenology | pmid:18248736 |
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| Kumar S and Sharma A | Platelet activating factor improves the in vitro penetration of zona free hamster eggs by buffalo (Bubalus bubalis) spermatozoa. | 2005 | Theriogenology | pmid:15763101 |
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| McFadden RG et al. | Effect of platelet activating factor (PAF) on the migration of human lymphocytes. | 1995 | Thorax | pmid:7660340 |
| Spring J et al. | Failure of salmeterol to inhibit circulating white cell responses and bronchoconstriction induced by platelet activating factor. | 1992 | Thorax | pmid:1361250 |
| Chung KF et al. | Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by platelet activating factor in man. | 1989 | Thorax | pmid:2648645 |
| Chung KF and Barnes PJ | Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects. | 1989 | Thorax | pmid:2648646 |
| Summers C et al. | Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. | 2014 | Thorax | pmid:24706039 |
| Spencer DA et al. | Participation of the cysteinyl leukotrienes in the acute bronchoconstrictor response to inhaled platelet activating factor in man. | 1991 | Thorax | pmid:1858084 |
| Freitag A et al. | Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses. | 1993 | Thorax | pmid:8346486 |
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