| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Gram-Negative Bacterial Infections | D016905 | 16 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chávez-Cartaya RE et al. | Rat liver blood flow after ischemia and reperfusion. The effects of the platelet-activating factor antagonist WEB-2170 and of removing circulating leukocytes. | 1994 | Transplantation | pmid:8197604 |
| Foegh ML et al. | Prolongation of cardiac allograft survival with BN 52021, a specific antagonist of platelet-activating factor. | 1986 | Transplantation | pmid:3523888 |
| Asako H et al. | Reduction of leukocyte adherence and emigration by cyclosporine and L683,590 (FK506) in postcapillary venules. | 1992 | Transplantation | pmid:1384191 |
| Herrero-Fresneda I et al. | Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor. | 2000 | Transplantation | pmid:11190497 |
| Gilli UO et al. | Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor. | 2005 | Transplantation | pmid:15912099 |
| Freiche JC et al. | Prolonged survival of renal transplants in nonimmunized and hyperimmunized rats receiving a platelet-activating factor antagonist. | 1990 | Transplantation | pmid:2368154 |
| Biancone L et al. | Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. | 2000 | Transplantation | pmid:11063341 |
| Camussi G et al. | Release of platelet-activating factor from rabbit heart perfused in vitro by sera with transplantation alloantibodies. | 1987 | Transplantation | pmid:3299910 |
| Nishiyama R et al. | Platelet-activating factor in hepatic ischemia/reperfusion injury. The effects of a PAF antagonist combined with a prostaglandin I2 analogue. | 1993 | Transplantation | pmid:8516812 |
| Kawahara K et al. | The effect of the platelet-activating factor inhibitor TCV-309 on reperfusion injury in a canine model of ischemic lung. | 1993 | Transplantation | pmid:8516834 |
| Takada Y et al. | Effects of platelet-activating factor antagonist on preservation/reperfusion injury of the graft in porcine orthotopic liver transplantation. | 1995 | Transplantation | pmid:7839408 |
| Marathe GK et al. | Oxidized LDL contains inflammatory PAF-like phospholipids. | 2001 Apr-May | Trends Cardiovasc. Med. | pmid:11686003 |
| Zimmerman GA and McIntyre TM | PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions. | 2004 | Trends Mol Med | pmid:15177186 |
| Braquet P et al. | Is there a case for PAF antagonists in the treatment of ischemic states? | 1989 | Trends Pharmacol. Sci. | pmid:2688213 |
| Izzo AA et al. | Recent findings on the mode of action of laxatives: the role of platelet activating factor and nitric oxide. | 1998 | Trends Pharmacol. Sci. | pmid:9803830 |
| Page C and Abbott A | PAF: new antagonists, new roles in disease and a major role in reproductive biology. | 1989 | Trends Pharmacol. Sci. | pmid:2672467 |
| GarcÃa-Sáinz JA | Intercellular communication within the liver has clinical implications. | 1989 | Trends Pharmacol. Sci. | pmid:2595791 |
| O'Neill C | A physiological role for PAF in the stimulation of mammalian embryonic development. | 1991 | Trends Pharmacol. Sci. | pmid:2053190 |
| GamaleÄ IA et al. | [Post-receptor formation of active forms of oxygen in nonphagocytic cells]. | 1999 | Tsitologiia | pmid:10496012 |
| Harputluoglu MM et al. | The effects of Gingko biloba extract on acetic acid-induced colitis in rats. | 2006 | Turk J Gastroenterol | pmid:16941250 |
| Kabasakal C et al. | The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis. | 1998 Jul-Sep | Turk. J. Pediatr. | pmid:9763906 |
| Hansen JF and Hansen BF | [Unstable angina pectoris, acute myocardial infarct, sudden heart death. Patho-anatomy and pathophysiology]. | 1987 | Ugeskr. Laeg. | pmid:3324429 |
| Vavilova GL et al. | [The role of the thrombocyte-activating factor in inhibiting Na+,K(+)-ATPase in different tissues after ischemia and reperfusion of the small intestine]. | 1996 Mar-Apr | Ukr. Biokhim. Zh. | pmid:9005660 |
| Yildirim G et al. | Effects of platelet-activating factor and hyperbaric oxygenation on antioxidant defense and duodenal contractility. | 2000 | Undersea Hyperb Med | pmid:11191161 |
| Mehta A and Sigman M | Identification and preparation of sperm for ART. | 2014 | Urol. Clin. North Am. | pmid:24286775 |
| Imagawa M et al. | Modulation of platelet-activating factor synthesis by recombinant interferon-alpha in human renal cell carcinoma. | 1996 | Urol. Int. | pmid:8840484 |
| Rastogi P et al. | Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ. | 2011 | Urology | pmid:21094990 |
| Baka S et al. | Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. | 2009 | Urology | pmid:19716589 |
| Kim YH et al. | SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells. | 2015 | Vascul. Pharmacol. | pmid:25967595 |
| Marathe GK et al. | Activation of vascular cells by PAF-like lipids in oxidized LDL. | 2002 | Vascul. Pharmacol. | pmid:12449015 |
| Hemker HC and Béguin S | The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. | 1985 | Verh. K. Acad. Geneeskd. Belg. | pmid:4090648 |
| Kulikov VI and Muzia GI | [Phospholipid thrombocyte activating factor, its analogs and antagonists: prospects of their use in medicine]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1801455 |
| Fedorov NA | [Physiological variants of functional and biochemical indicators of thrombocytes]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1801458 |
| Kaminskaia GO and Aladysheva ZhI | [Platelet activating factor and pulmonary tuberculosis]. | 1995 | Vestn. Akad. Med. Nauk SSSR | pmid:7670343 |
| Strukova SM et al. | [Regulation of thrombocyte stimulating and other activities of thrombin by modulators of the recognition site]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1724858 |
| Shabanov VV | [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. | 2003 | Vestn. Akad. Med. Nauk SSSR | pmid:14598737 |
| Moore RM et al. | Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. | 1998 Jan-Feb | Vet Surg | pmid:9449176 |
| Leid RW and Potter KA | Inflammation and mediators of lung injury. | 1985 | Vet. Clin. North Am. Food Anim. Pract. | pmid:3907779 |
| Alarcón P et al. | D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils. | 2011 | Vet. Immunol. Immunopathol. | pmid:21816488 |
| Carretta MD et al. | Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. | 2016 | Vet. Immunol. Immunopathol. | pmid:27288853 |
| Waller KP | Modulation of endotoxin-induced inflammation in the bovine teat using antagonists/inhibitors to leukotrienes, platelet activating factor and interleukin 1 beta. | 1997 | Vet. Immunol. Immunopathol. | pmid:9261962 |
| Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. | 2012 | Vet. Immunol. Immunopathol. | pmid:22226550 |
| Cook VL et al. | The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19136156 |
| Aktan I et al. | PKC isoenzymes in equine platelets and stimulus induced activation. | 2011 | Vet. Immunol. Immunopathol. | pmid:21513989 |
| Topper EK et al. | Induction of tissue eosinophilia by platelet-activating factor in Merino sheep. | 1992 | Vet. Immunol. Immunopathol. | pmid:1604802 |
| Foster AP et al. | Platelet activating factor mimics antigen-induced cutaneous inflammatory responses in sweet itch horses. | 1995 | Vet. Immunol. Immunopathol. | pmid:7747395 |
| Brooks AC et al. | CXCL8 attenuates chemoattractant-induced equine neutrophil migration. | 2011 | Vet. Immunol. Immunopathol. | pmid:21040981 |
| Corl CM et al. | Lipoxygenase metabolites modulate vascular-derived platelet activating factor production following endotoxin challenge. | 2010 | Vet. Immunol. Immunopathol. | pmid:20359754 |
| Strøm H and Thomsen MK | Effects of proinflammatory mediators on canine neutrophil chemotaxis and aggregation. | 1990 | Vet. Immunol. Immunopathol. | pmid:2396362 |
| Larrazabal CS et al. | Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na/H exchanger 1. | 2017 | Vet. Immunol. Immunopathol. | pmid:28895869 |
| Marr KA et al. | Agonist-induced adherence of equine neutrophils to fibronectin- and serum-coated plastic is CD18 dependent. | 1999 | Vet. Immunol. Immunopathol. | pmid:10532398 |
| Van de Weerdt ML et al. | Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves. | 1999 | Vet. J. | pmid:10030127 |
| Michelotto PV et al. | Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training. | 2011 | Vet. J. | pmid:22108190 |
| da Silva MB et al. | Effect of ketoprofen on PAF-induced bovine platelet aggregation. | 1998 | Vet. J. | pmid:9564275 |
| Slauson DO and Sanchez-Vizcaino JM | Leukocyte-dependent platelet vasoactive amine release and immune complex deposition in African swine fever. | 1981 | Vet. Pathol. | pmid:6170156 |
| Wimberly HC et al. | Functional and biochemical characterization of immunologically derived equine platelet-activating factor. | 1985 | Vet. Pathol. | pmid:4035942 |
| Van de Weerdt ML et al. | Effect of platelet-activating factor on bovine pulmonary function. | 1997 | Vet. Rec. | pmid:9290195 |
| Bastos da Silva M et al. | Morphological alterations of blood platelets induced by platelet activating factor (PAF) and partial inhibition by ketoprofen in calves. | 1997 Sep-Oct | Vet. Res. | pmid:9342825 |
| Lallès JP et al. | Small intestinal motility disorders in preruminant calves chronically fed a diet based on antigenic soya: characterization and possible mediators. | 1998 Jan-Feb | Vet. Res. | pmid:9559521 |
| Bastos da Silva M et al. | In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. | 2000 Mar-Apr | Vet. Res. | pmid:10779205 |
| Diez-Fraile A et al. | Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. | 2003 Jan-Feb | Vet. Res. | pmid:12588684 |
| Bastos da Silva MB et al. | The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. | 1997 | Vet. Res. Commun. | pmid:9345719 |
| da Silva MB et al. | Protective effects of WEB 2086 (PAF antagonist) and ketoprofen (NSAID) on PAF-induced changes in the morphological ultrastructure of blood platelets in calves. | 1998 | Vet. Res. Commun. | pmid:9686442 |
| Dawson J et al. | Platelet activating factor as a mediator of equine cell locomotion. | 1988 | Vet. Res. Commun. | pmid:3188378 |
| Venugopalan CS et al. | Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. | 1998 | Vet. Res. Commun. | pmid:9868763 |
| DaÄkhin EI et al. | [Clinical significance of studies of platelet activating factor (review of the literature)]. | 1989 Mar-Apr | Vopr. Med. Khim. | pmid:2662595 |
| Shebzukhov IuV and Mysiakin EB | [Platelet activating factor--role in regulating the functional activity of the mononuclear phagocyte system]. | 1996 Oct-Dec | Vopr. Med. Khim. | pmid:9254510 |
| Muzia GI et al. | [Inhibition of formation of superoxide radicals in leukocytes of hypercholesteremic patients under the effect of a lipid platelet activation factor antagonist]. | 1995 Jul-Aug | Vopr. Med. Khim. | pmid:8571587 |
| Denizot Y and Nathan N | Platelet-activating factor in operative salvaged blood. | 1994 | Vox Sang. | pmid:7801619 |
| Silliman CC et al. | Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor. | 1992 | Vox Sang. | pmid:1332255 |
| Sieunarine K et al. | Plasma levels of the lipid mediators, leukotriene B4 and lyso platelet-activating factor, in intraoperative salvaged blood. | 1992 | Vox Sang. | pmid:1333134 |
| Robeva R et al. | [Changes in blood coagulation in glomerulonephritis]. | 1982 | Vutr Boles | pmid:6219496 |
| Guan Z et al. | [Role of interleukin-6 and platelet-activating factor in delaying neutrophil apoptosis]. | 2000 | Wei Sheng Yan Jiu | pmid:12725051 |
| Chmiel B | [The influence of select pathophysiologic factors of acute pancreatitis on erythrocytes' deformability examined in vitro]. | 2002 | Wiad. Lek. | pmid:12715347 |
| Keck M et al. | Pathophysiology of burns. | 2009 | Wien Med Wochenschr | pmid:19652939 |
| Czarnetzki BM | [Mediators and the bronchial system. Pathophysiologic and biochemical aspects of mediators of the bronchial system]. | 1987 | Wien Med Wochenschr Suppl | pmid:3078398 |
| Connolly AB and Vernon DR | Manipulations of the metabolic response for management of patients with severe surgical illness: review. | 2000 | World J Surg | pmid:10773122 |
| Bang UC et al. | Pharmacological approach to acute pancreatitis. | 2008 | World J. Gastroenterol. | pmid:18494044 |
| Xia SH et al. | Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021. | 2007 | World J. Gastroenterol. | pmid:17589953 |
| Xia SH et al. | Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. | 2013 | World J. Gastroenterol. | pmid:23840141 |
| Chen Y et al. | Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. | 2008 | World J. Gastroenterol. | pmid:18186558 |
| Lu YY et al. | Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis. | 2008 | World J. Gastroenterol. | pmid:18205269 |
| Cao HC et al. | Determination of platelet-activating factor by reverse phase high-performance liquid chromatography and its application in viral hepatitis. | 2005 | World J. Gastroenterol. | pmid:16437644 |
| Bock J et al. | Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function. | 2007 | World J. Gastroenterol. | pmid:17876892 |
| Liu LR and Xia SH | Role of platelet-activating factor in the pathogenesis of acute pancreatitis. | 2006 | World J. Gastroenterol. | pmid:16489665 |
| Zhou ZG and Chen YD | Influencing factors of pancreatic microcirculatory impairment in acute panceatitis. | 2002 | World J. Gastroenterol. | pmid:12046059 |
| Torres MI and Rios A | Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy. | 2008 | World J. Gastroenterol. | pmid:18395894 |
| Yang YP et al. | Effect of increased hepatic platelet activating factor and its receptor portal hypertension in CCl4-induced liver cirrhosis. | 2006 | World J. Gastroenterol. | pmid:16521183 |
| Mathonnet M et al. | Platelet-activating factor in cirrhotic liver and hepatocellular carcinoma. | 2006 | World J. Gastroenterol. | pmid:16718768 |
| Karidis NP et al. | Platelet-activating factor in liver injury: a relational scope. | 2006 | World J. Gastroenterol. | pmid:16773686 |
| Zhao H et al. | Influence of platelet activating factor on expression of adhesion molecules in experimental pancreatitis. | 2003 | World J. Gastroenterol. | pmid:12532462 |
| Sperling RI | Effects of dietary fish oil on leukocyte leukotriene and PAF generation and on neutrophil chemotaxis. | 1991 | World Rev Nutr Diet | pmid:2053354 |
| Tanaka E et al. | Dual effects of a novel thienodiazepine platelet-activating factor antagonist, on drug-oxidizing enzymes in beagle dog. | 1994 | Xenobiotica | pmid:8059533 |
| Nunoya K et al. | S-oxidation of (+)-cis-3,5-dimethyl-2-(3-pyridyl)-thiazolidin-4-one hydrochloride by rat hepatic flavin-containing monooxygenase 1 expressed in yeast. | 1995 | Xenobiotica | pmid:8719904 |
| Thomson KL et al. | Metabolism of the platelet-activating factor antagonist (+/-)-trans-2-(3'-methoxy-5'-methylsulphonyl-4'-propoxyphenyl)-5-(3",4" ,5"- trimethoxyphenyl)tetrahydrofuran (L-659,989) in rhesus monkeys. | 1991 | Xenobiotica | pmid:1949894 |
| Kobayashi T et al. | Metabolism and disposition of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate (MOTP) in rats and dogs. | 1988 | Xenobiotica | pmid:3354232 |
| Kusano K et al. | Pharmacokinetics of a new thienodiazepine platelet activating factor receptor antagonist (E6123) in laboratory animals. Is there a metabolic polymorphism in the rhesus monkey? | 1993 | Xenobiotica | pmid:8212733 |
| Kusano K et al. | Metabolic polymorphism of E6123 in rhesus monkey. | 1993 | Xenobiotica | pmid:8212734 |
| Matsubara C et al. | [Densitometric quantitation of platelet activating factor and other phospholipids in human saliva using enzyme reaction on a silica plate]. | 1994 | Yakugaku Zasshi | pmid:7965653 |
| Ohishi S | [Evaluation of time course and inter-relationship of inflammatory mediators in experimental inflammatory reaction]. | 2000 | Yakugaku Zasshi | pmid:10825809 |