Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Glomerulonephritis D005921 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Psoriasis D011565 47 associated lipids
Brain Edema D001929 20 associated lipids
Leukopenia D007970 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Burns, Inhalation D002059 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Colonic Diseases D003108 5 associated lipids
Per page 10 20 50 100 | Total 288

PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Sibelius U et al. Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation. 2000 Jan 4-11 Circulation pmid:10618308
Thurston G et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. 1999 Science pmid:10617467
Sawai H et al. Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. 1999 J. Biol. Chem. pmid:10608884
Hashimoto S et al. p38 MAP kinase regulates TNF alpha-, IL-1 alpha- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells. 2000 Clin. Exp. Allergy pmid:10606930
Bosch RJ et al. Effects of parathyroid hormone-related protein on human mesangial cells in culture. 1999 Am. J. Physiol. pmid:10600786
Wechsung E and Houvenaghel A Influence of platelet activating factor on gastrointestinal electrical activity and some haematological and clinical parameters in the conscious miniature pig. 1999 J. Vet. Pharmacol. Ther. pmid:10597537
Arbabi S et al. Priming interleukin 8 production: role of platelet-activating factor and p38. 1999 Arch Surg pmid:10593333
Burns AR et al. Analysis of tight junctions during neutrophil transendothelial migration. 2000 J. Cell. Sci. pmid:10591624
Kitsiouli EI et al. Differential determination of phospholipase A(2) and PAF-acetylhydrolase in biological fluids using fluorescent substrates. 1999 J. Lipid Res. pmid:10588961
Kafoury RM et al. Induction of inflammatory mediators in human airway epithelial cells by lipid ozonation products. 1999 Am. J. Respir. Crit. Care Med. pmid:10588609
Byrum RS et al. Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. 1999 J. Immunol. pmid:10586081
Hendrickson HS et al. Intramolecularly quenched BODIPY-labeled phospholipid analogs in phospholipase A(2) and platelet-activating factor acetylhydrolase assays and in vivo fluorescence imaging. 1999 Anal. Biochem. pmid:10585741
Wu R et al. Antibodies to platelet-activating factor are associated with borderline hypertension, early atherosclerosis and the metabolic syndrome. 1999 J. Intern. Med. pmid:10583710
Rodrigues CO et al. Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi. 1999 Biochem. Biophys. Res. Commun. pmid:10581161
Shin BA et al. Lyso-PAF analogues and lysophosphatidylcholines from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis. 1999 J. Nat. Prod. pmid:10579872
Mizuki M et al. Inhibition of eosinophil activation in bronchoalveolar lavage fluid from atopic asthmatics by Y-24180, an antagonist to platelet-activating factor. 1999 Life Sci. pmid:10579457
Goldfarb R Investigations into the polydeterminant nature of sepsis. 1999 Crit. Care Med. pmid:10579296
Quinn JV and Slotman GJ Platelet-activating factor and arachidonic acid metabolites mediate tumor necrosis factor and eicosanoid kinetics and cardiopulmonary dysfunction during bacteremic shock. 1999 Crit. Care Med. pmid:10579269
Grassi S et al. Platelet-activating factor and group I metabotropic glutamate receptors interact for full development and maintenance of long-term potentiation in the rat medial vestibular nuclei. 1999 Neuroscience pmid:10579215
Kuśnierz B and Naskalski JW [Mediators of the inflammatory response in the course of acute pancreatitis]. 1999 Prz. Lek. pmid:10575924
Olszanecki R and Chłopicki S Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia. 1999 J. Physiol. Pharmacol. pmid:10574473
Tekgül H et al. Lymphocyte subsets and inflammatory mediators in patients with subacute sclerosing panencephalitis. 1999 J. Child Neurol. pmid:10573462
Grutters JC et al. Asthma therapy modulates priming-associated blood eosinophil responsiveness in allergic asthmatics. 1999 Eur. Respir. J. pmid:10573242
Bratt T et al. Interactions between neutrophil gelatinase-associated lipocalin and natural lipophilic ligands. 1999 Biochim. Biophys. Acta pmid:10572948
Torras J et al. Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats. 1999 Kidney Int. pmid:10571788
Ozaki N et al. Mechanosensitive properties of gastric vagal afferent fibers in the rat. 1999 J. Neurophysiol. pmid:10561400
Fuentes E et al. Lysophospholipids trigger calcium signals but not DNA synthesis in cortical astrocytes. 1999 Glia pmid:10559786
Lauener RW et al. A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin. 1999 Biochim. Biophys. Acta pmid:10559473
Falk S et al. Quinolines attenuate PAF-induced pulmonary pressor responses and edema formation. 1999 Am. J. Respir. Crit. Care Med. pmid:10556149
Adunsky A et al. Infarct volume, neurological severity and PAF binding to platelets of patients with acute cerebral ischemic stroke. 1999 Neurol. Res. pmid:10555184
Wang MM et al. Stereoselective actions of hepoxilins A3 and B3 and their cyclopropane analogs (HxdeltaA3 and HxdeltaB3) on bradykinin and PAF-evoked potentiation of vascular leakage in rat skin. 1999 Gen. Pharmacol. pmid:10553878
Biancone L et al. Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis. 1999 Am. J. Pathol. pmid:10550329
Li S et al. Experimental therapy of a platelet-activating factor antagonist (ginkgolide B) on photochemically induced thrombotic cerebral ischaemia in tree shrews. 1999 Clin. Exp. Pharmacol. Physiol. pmid:10549411
Uluoglu C and Timlioglu O Endothelium-dependent vasodilation in the isolated rabbit kidney following in vivo and in vitro ischaemia and reperfusion: effects of antagonizing platelet activating factor (PAF). 1999 Naunyn Schmiedebergs Arch. Pharmacol. pmid:10543435
Gómez FP et al. Gas exchange response to a PAF receptor antagonist, SR 27417A, in acute asthma: a pilot study. 1999 Eur. Respir. J. pmid:10543285
Echazarreta AL et al. Effects of inhaled furosemide on platelet-activating factor challenge in mild asthma. 1999 Eur. Respir. J. pmid:10543284
Koyama S et al. The potential of various lipopolysaccharides to release monocyte chemotactic activity from lung epithelial cells and fibroblasts. 1999 Eur. Respir. J. pmid:10543273
Manya H et al. Biochemical characterization of various catalytic complexes of the brain platelet-activating factor acetylhydrolase. 1999 J. Biol. Chem. pmid:10542206
Ernest S and Bello-Reuss E Secretion of platelet-activating factor is mediated by MDR1 P-glycoprotein in cultured human mesangial cells. 1999 J. Am. Soc. Nephrol. pmid:10541289
Tselepis AD et al. Platelet aggregatory response to platelet activating factor (PAF), ex vivo, and PAF-acetylhydrolase activity in patients with unstable angina: effect of c7E3 Fab (abciximab) therapy. 1999 Cardiovasc. Res. pmid:10536703
McKenna CJ et al. Familial dilated cardiomyopathy. 1999 Circulation pmid:10534480
Nicholson SC et al. Echocardiographic and survival studies in mice undergoing endotoxic shock: effects of genetic ablation of inducible nitric oxide synthase and pharmacologic antagonism of platelet-activating factor. 1999 J. Surg. Res. pmid:10534424
Mustafa SB et al. Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells. 1999 Hepatology pmid:10534342
Serou MJ et al. Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression. 1999 J. Neurosci. Res. pmid:10533051
Marr KA et al. Agonist-induced adherence of equine neutrophils to fibronectin- and serum-coated plastic is CD18 dependent. 1999 Vet. Immunol. Immunopathol. pmid:10532398
Stammberger U et al. Combined treatment with endothelin- and PAF-antagonists reduces posttransplant lung ischemia/reperfusion injury. 1999 J. Heart Lung Transplant. pmid:10528748
Vergnolle N Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo. 1999 J. Immunol. pmid:10528212
Sun Z et al. Roles of platelet-activating factor, interleukin-1beta and interleukin-6 in intestinal barrier dysfunction induced by mesenteric arterial ischemia and reperfusion. 1999 J. Surg. Res. pmid:10527709
Kinlough-Rathbone RL et al. Effects of cathepsin G pretreatment of platelets on their subsequent responses to aggregating agents. 1999 Thromb. Res. pmid:10527409
Wang X et al. Platelet-activating factor induced Ca(2+) signaling in human microglia. 1999 Brain Res. pmid:10526106
Nagase T et al. Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice. 1999 J. Clin. Invest. pmid:10525045
Prescott SM et al. Two of the usual suspects, platelet-activating factor and its receptor, implicated in acute lung injury. 1999 J. Clin. Invest. pmid:10525039
Monteiro HS et al. Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor. 1999 Pharmacol. Toxicol. pmid:10522748
Hocke M et al. Platelet activating factor in stool from patients with ulcerative colitis and Crohn's disease. 1999 Jul-Aug Hepatogastroenterology pmid:10521992
Sugiura T et al. Occurrence of lysophosphatidic acid and its alkyl ether-linked analog in rat brain and comparison of their biological activities toward cultured neural cells. 1999 Biochim. Biophys. Acta pmid:10521703
Bernatchez PN et al. Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent. 1999 J. Biol. Chem. pmid:10521504
Greenberg SG and Clark KE Hemodynamic effects of platelet-activating factor in nonpregnant and pregnant sheep. 1999 Am. J. Physiol. pmid:10516237
Merendino N et al. Human intestinal epithelial cells express receptors for platelet-activating factor. 1999 Am. J. Physiol. pmid:10516147
Peplow PV Regulation of platelet-activating factor (PAF) activity in human diseases by phospholipase A2 inhibitors, PAF acetylhydrolases, PAF receptor antagonists and free radical scavengers. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10509861
Tiemann U et al. Influence of inhibitors on increase in intracellular free calcium and proliferation induced by platelet-activating factor in bovine oviductal cells. 1999 J. Reprod. Fertil. pmid:10505057
Min JH et al. Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase. 1999 Biochemistry pmid:10504265
Imrie CW and McKay CJ The scientific basis of medical therapy of acute pancreatitis. Could it work, and is there a role for lexipafant? 1999 Gastroenterol. Clin. North Am. pmid:10503138
Sakaguchi T et al. Participation of platelet-activating factor in the lipopolysaccharide-induced liver injury in partially hepatectomized rats. 1999 Hepatology pmid:10498648
Marathe GK et al. Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. 1999 J. Biol. Chem. pmid:10497200
Mitidieri F and de Meis L Ca(2+) release and heat production by the endoplasmic reticulum Ca(2+)-ATPase of blood platelets. Effect of the platelet activating factor. 1999 J. Biol. Chem. pmid:10497193
Dekkers PE et al. Divergent roles of tumor necrosis factor and platelet-activating factor in endotoxin-induced release of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta in chimpanzees. 1999 Infect. Immun. pmid:10496934
GamaleÄ­ IA et al. [Post-receptor formation of active forms of oxygen in nonphagocytic cells]. 1999 Tsitologiia pmid:10496012
Comellas A et al. Effect of platelet activating factor (PAF) on pulmonary circulation in isolated rabbit lung. 1999 J. Physiol. Biochem. pmid:10494654
Blackstone MO ICAM-1 in cerulein-induced pancreatitis. 1999 Gastroenterology pmid:10490367
Triggiani M et al. Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine. 1999 Biochem. Pharmacol. pmid:10487538
Piccolo MT et al. Chemotactic mediator requirements in lung injury following skin burns in rats. 1999 Exp. Mol. Pathol. pmid:10486240
Koyama N and Ogawa Y Elevated platelet activating factor in the tracheal aspirate at birth and signs of intra-uterine inflammation in infants with neonatal pulmonary emphysema. 1999 Eur. J. Pediatr. pmid:10486094
Kültürsay N et al. Platelet-activating factor concentrations in healthy and septic neonates. 1999 Eur. J. Pediatr. pmid:10485307
Shah BH et al. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. 1999 Biochem. Pharmacol. pmid:10484074
Kapui Z et al. Experimental studies on guanosine 3',5'-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs. 1999 Arzneimittelforschung pmid:10483515
Nakasaki T et al. Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia. 1999 Prostaglandins Other Lipid Mediat. pmid:10482285
Calcerrada MC et al. Modulation of protein kinase C isoforms by PAF in cerebral cortex. 1999 Prostaglandins Other Lipid Mediat. pmid:10482284
Foitzik T et al. Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of platelet-activating factor receptor blockade vs. endothelin receptor blockade. 1999 May-Jun J. Gastrointest. Surg. pmid:10481117
Casale TB et al. Eosinophils isolated by magnetic cell sorting respond poorly to lipid chemoattractants. 1999 Ann. Allergy Asthma Immunol. pmid:10480585
Oku H and Ishiguro K Screening method for PAF antagonist substances: on the phenolic compounds from Impatients balsamina L. 1999 Phytother Res pmid:10479766
Baker KE and Curtis MJ Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism. 1999 J. Cardiovasc. Pharmacol. pmid:10470998
Denham W and Norman J The potential role of therapeutic cytokine manipulation in acute pancreatitis. 1999 Surg. Clin. North Am. pmid:10470326
Ho YS et al. Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase. 1999 Protein Eng. pmid:10469831
Conroy DM and Sirois P Early bronchial hyperresponsiveness following injection of sephadex beads in the guinea pig: involvement of platelet activating factor and thromboxane A2. 1999 Inflammation pmid:10466580
Kaminski JJ et al. Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. 1999 Bioorg. Med. Chem. pmid:10465415
Hsueh W et al. Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. 1998 Jan-Feb Pediatr. Dev. Pathol. pmid:10463267
Zardini DM et al. Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium. 1999 Cell Calcium pmid:10463102
Rengan R and Omann GM Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. 1999 Biochem. Biophys. Res. Commun. pmid:10462500
Downing SJ et al. Effect of inflammatory mediators on the electrophysiology of the human oviduct. 1999 Biol. Reprod. pmid:10456842
Yaffe MB et al. Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. 1999 Surgery pmid:10455891
Subbanagounder G et al. Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086. 1999 Circ. Res. pmid:10455059
Nikbakht-Sangari M et al. Platelet-activating factor plays a role in the mechanism of major histocompatibility complex in T lymphocytes. 1999 Immunol. Invest. pmid:10454000
Dervenis C et al. Diagnosis, objective assessment of severity, and management of acute pancreatitis. Santorini consensus conference. 1999 Int. J. Pancreatol. pmid:10453421
Sakaguchi T et al. Acute portal hypertension increases ileal vulnerability to platelet-activating factor in rats. 1999 J. Surg. Res. pmid:10452877
Partrick DA et al. Cardiopulmonary bypass renders patients at risk for multiple organ failure via early neutrophil priming and late neutrophil disability. 1999 J. Surg. Res. pmid:10452867
Shen ZQ et al. Effect of protopine on cytosolic Ca2+ in rabbit platelets. 1999 Zhongguo Yao Li Xue Bao pmid:10452120
Birk-Sørensen L et al. Platelet activating factor antagonism in pure skin flaps exposed to ischaemia-reperfusion injury. 1999 Scand J Plast Reconstr Surg Hand Surg pmid:10450571
Wang H et al. Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora. 1999 Immunology pmid:10447766
Alvi SA et al. The production of interleukin-1beta from human fetal membranes is not obligatory for increased prostaglandin output. 1999 Immunology pmid:10447739
Davies D et al. VCAM-1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM-1 in rat skin. 1999 Immunology pmid:10447726