| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Gram-Negative Bacterial Infections | D016905 | 16 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mazer BD et al. | Dose-dependent agonist and antagonist effects of the platelet-activating factor analogue 1-palmitoyl-2-acetoyl-sn-glycero-3-phosphocholine on B lymphocytes. | 1998 | J. Allergy Clin. Immunol. | pmid:9723666 |
| Beyer AJ et al. | PAF and CD18 mediate neutrophil infiltration in upper gastrointestinal tract during intra-abdominal sepsis. | 1998 | Am. J. Physiol. | pmid:9724257 |
| Rougier F and Denizot Y | Platelet-activating factor and the growth of fibroblasts. | 1998 | Mol. Carcinog. | pmid:9726813 |
| Matsumoto K et al. | Eosinophilic airway inflammation induced by repeated exposure to cigarette smoke. | 1998 | Eur. Respir. J. | pmid:9727790 |
| Ibe BO et al. | Platelet-activating factor modulates pulmonary vasomotor tone in the perinatal lamb. | 1998 | J. Appl. Physiol. | pmid:9729586 |
| Qu XW et al. | Interaction of platelet-activating factor, spleen and atrial natriuretic peptide in plasma volume regulation during endotoxaemia in rats. | 1998 | J. Physiol. (Lond.) | pmid:9729632 |
| Ueno M et al. | Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen. | 1998 | Pharmacology | pmid:9730778 |
| Burke-Gaffney A and Hellewell PG | A CD18/ICAM-1-dependent pathway mediates eosinophil adhesion to human bronchial epithelial cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9730868 |
| M'Rabet L et al. | Activation of the small GTPase rap1 in human neutrophils. | 1998 | Blood | pmid:9731072 |
| Cheryk LA et al. | Alterations in blood platelet morphology during aggregate formation in the Asian elephant (Elephas maximus). | 1998 | J. Zoo Wildl. Med. | pmid:9732033 |
| Liu L et al. | Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator. | 1998 | J. Immunol. | pmid:9743372 |
| Kruse-Elliott KT et al. | Low molecular weight heparin alters porcine neutrophil responses to platelet-activating factor. | 1998 | Shock | pmid:9744648 |
| Huang Q et al. | Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. | 1998 | Am. J. Physiol. | pmid:9746460 |
| Rocha MF et al. | Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta. | 1998 | Infect. Immun. | pmid:9746596 |
| Endo S et al. | Administration of methylprednisolone acetate into the subdural cavity in an infant with subdural fluid collection. PAF is a good indicator of the efficacy of the treatment. | 1998 | Childs Nerv Syst | pmid:9753399 |
| Heath MF et al. | Dextran-70 inhibits equine platelet aggregation induced by PAF but not by other agonists. | 1998 | Equine Vet. J. | pmid:9758098 |
| El-Shazly A et al. | Modulation of normal human eosinophil chemotaxis in vitro by herbimycin A, erbstatin and pervanadate. | 1998 | Int. Arch. Allergy Immunol. | pmid:9758889 |
| Matsumoto K et al. | Altered expression of CD11b and CD62L after cross-linking of CD45 isoforms on human eosinophils. | 1998 | Int. Arch. Allergy Immunol. | pmid:9758894 |
| El-Shazly A et al. | Human eotaxin induces eosinophil-derived neurotoxin release from normal human eosinophils. | 1998 | Int. Arch. Allergy Immunol. | pmid:9758899 |
| Kinn JW and Bache RJ | Effect of platelet activation on coronary collateral blood flow. | 1998 | Circulation | pmid:9760298 |
| Tamm M et al. | Hypoxia-induced interleukin-6 and interleukin-8 production is mediated by platelet-activating factor and platelet-derived growth factor in primary human lung cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9761763 |
| Spoelstra FM et al. | Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro. | 1998 | Eur. Respir. J. | pmid:9762784 |
| Kabasakal C et al. | The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis. | 1998 Jul-Sep | Turk. J. Pediatr. | pmid:9763906 |
| Marriott I et al. | Differential kinetics for induction of interleukin-6 mRNA expression in murine peritoneal macrophages: evidence for calcium-dependent and independent-signalling pathways. | 1998 | J. Cell. Physiol. | pmid:9766520 |
| Bozza PT et al. | Pathways for eosinophil lipid body induction: differing signal transduction in cells from normal and hypereosinophilic subjects. | 1998 | J. Leukoc. Biol. | pmid:9766638 |
| Kern H et al. | Stimulation of monocytes and platelets by short-chain phosphatidylcholines with and without terminal carboxyl group. | 1998 | Biochim. Biophys. Acta | pmid:9767093 |
| Le Blanc K et al. | Impaired platelet binding of fibrinogen due to a lower number of GPIIB/IIIA receptors in polycythemia vera. | 1998 | Thromb. Res. | pmid:9772010 |
| Abu-Zidan FM | Hope or hype for lexipafant? | 1998 | Nature | pmid:9774090 |
| Perez S et al. | Inhibition by the anti-mitotic drug doxorubicin of platelet-activating-factor-induced late eosinophil accumulation in rats. | 1998 | Eur. J. Pharmacol. | pmid:9774255 |
| Teather LA et al. | Effects of posttraining intrahippocampal injections of platelet-activating factor and PAF antagonists on memory. | 1998 | Neurobiol Learn Mem | pmid:9774526 |
| Suzuki T et al. | 2-(3-Pyridyl)thiazolidine-4-carboxamide derivatives. II. Structure-activity relationships and active configuration of 2-(3-pyridyl)thiazolidine-4-carboxamides as platelet-activating factor receptor antagonists. | 1998 | Chem. Pharm. Bull. | pmid:9775441 |
| Shah BH et al. | The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx. | 1998 | Biochem. Pharmacol. | pmid:9776305 |
| Serebruany VL et al. | Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction. | 1998 | Cardiology | pmid:9778550 |
| Akisü M et al. | The effect of L-carnitine on platelet activating factor concentration in the immature rat model of hypoxic-ischemic brain injury. | 1998 | Acta Med. Okayama | pmid:9781268 |
| SariahmetoÄŸlu M et al. | Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats. | 1998 | Pharmacol. Res. | pmid:9782066 |
| Carlson SA and Jones BD | Inhibition of Salmonella typhimurium invasion by host cell expression of secreted bacterial invasion proteins. | 1998 | Infect. Immun. | pmid:9784535 |
| Akisü M et al. | Platelet-activating factor is an important mediator in hypoxic ischemic brain injury in the newborn rat. Flunarizine and Ginkgo biloba extract reduce PAF concentration in the brain. | 1998 | Biol. Neonate | pmid:9784635 |
| Momose T et al. | Effects of intracellular cyclic AMP modulators on human eosinophil survival, degranulation and CD11b expression. | 1998 | Int. Arch. Allergy Immunol. | pmid:9784658 |
| O'Neill C | Role of autocrine mediators in the regulation of embryo viability: lessons from animal models. | 1998 | J. Assist. Reprod. Genet. | pmid:9785192 |
| Kaneshiro ES et al. | Characterizations of Pneumocystis carinii and rat lung lipids: glyceryl ethers and fatty alcohols. | 1998 | J. Lipid Res. | pmid:9788237 |
| Ohno Y et al. | Effects of platelet activating factor on the tubotympanic mucosa and inner ear in the guinea pig. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9794619 |
| Pestonjamasp VK and Burstein SH | Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system. | 1998 | Biochim. Biophys. Acta | pmid:9795237 |
| Hofbauer B et al. | Effect of recombinant platelet-activating factor acetylhydrolase on two models of experimental acute pancreatitis. | 1998 | Gastroenterology | pmid:9797380 |
| Templeton AG et al. | Effects of S-salbutamol on human isolated bronchus. | 1998 | Pulm Pharmacol Ther | pmid:9802957 |
| Choi IH et al. | Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice. | 1998 | J. Exp. Med. | pmid:9802970 |
| Izzo AA et al. | Recent findings on the mode of action of laxatives: the role of platelet activating factor and nitric oxide. | 1998 | Trends Pharmacol. Sci. | pmid:9803830 |
| Aida Y et al. | Effects of chroman derivatives on platelet aggregation induced by some aggregating agents in rabbits. | 1998 | Clin. Exp. Pharmacol. Physiol. | pmid:9807668 |
| Montrucchio G et al. | Potential angiogenic role of platelet-activating factor in human breast cancer. | 1998 | Am. J. Pathol. | pmid:9811351 |
| Denizot Y et al. | Effects of lipid mediators on the synthesis of leukaemia inhibitory factor and interleukin 6 by human bone marrow stromal cells. | 1998 | Cytokine | pmid:9811531 |
| Song SQ and Hu YM | Effects of tetrandrine, Fura 2-AM, and Bay k 8644 on platelet-activating factor release from rat peritoneal macrophages stimulated by lipopolysaccharides. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9812743 |
| Nakos G et al. | Bronchoalveolar lavage alterations in pulmonary embolism. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9817700 |
| Kwiterovich PO | The antiatherogenic role of high-density lipoprotein cholesterol. | 1998 | Am. J. Cardiol. | pmid:9819099 |
| Siafaka-Kapadai A et al. | Effects of suramin on human platelet aggregation and Ca2+ mobilization induced by thrombin and other agonists. | 1998 | Life Sci. | pmid:9820121 |
| Malpuech-Brugère C et al. | Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis. | 1998 | Life Sci. | pmid:9820125 |
| Takafuji S et al. | Release of granule proteins from human eosinophils stimulated with mast-cell mediators. | 1998 | Allergy | pmid:9821474 |
| Akisü M et al. | Plasma platelet-activating factor levels in newborn infants with and without perinatal asphyxia: is it an additional marker of perinatal asphyxia? | 1998 | Acta Paediatr Jpn | pmid:9821700 |
| Pulliam L et al. | Differential modulation of cell death proteins in human brain cells by tumor necrosis factor alpha and platelet activating factor. | 1998 | J. Neurosci. Res. | pmid:9822163 |
| Kilgore KS et al. | Neutrophil adhesion to human endothelial cells is induced by the membrane attack complex: the roles of P-selectin and platelet activating factor. | 1998 | Inflammation | pmid:9824773 |
| Smalley DM et al. | Platelet activating factor (PAF) increases leukocyte adhesion but does not alter vessel diameter in the rat mesenteric microcirculation. | 1998 | Microvasc. Res. | pmid:9828165 |
| Itabe H | Oxidized phospholipids as a new landmark in atherosclerosis. | 1998 Jul-Aug | Prog. Lipid Res. | pmid:9829125 |
| Ohashi H et al. | Sulochrin inhibits eosinophil activation and chemotaxis. | 1998 | Inflamm. Res. | pmid:9831326 |
| Auchampach JA et al. | Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. | 1998 | Basic Res. Cardiol. | pmid:9833148 |
| Stack WA et al. | Lack of effectiveness of the platelet-activating factor antagonist SR27417A in patients with active ulcerative colitis: a randomized controlled trial. The Platelet Activating Factor Antagonist Study Group in Ulcerative Colitis. | 1998 | Gastroenterology | pmid:9834260 |
| Dupuis F et al. | Effect of platelet-activating factor on the growth of human erythroid and myeloid CD34+ progenitors. | 1998 | Mediators Inflamm. | pmid:9836496 |
| Travers J et al. | Antiinflammatory activity of the platelet-activating factor receptor antagonist A-85783. | 1998 | Arch. Dermatol. Res. | pmid:9836508 |
| Ottlakán A | Role of platelet-activating factor in glucose uptake and utilization of different tissues. | 1998 | Eur Surg Res | pmid:9838231 |
| Takada Y et al. | Energy metabolism of hepatic allografts subjected to prolonged warm ischemia and pharmacologic modulation with FK506 and platelet activating factor antagonist. | 1998 | Transplant. Proc. | pmid:9838621 |
| Fukunaga K et al. | Successful liver transplantation from non-heart-beating donors by blockade of endothelin and PAE. | 1998 | Transplant. Proc. | pmid:9838664 |
| Witko-Sarsat V et al. | Priming of blood neutrophils in children with cystic fibrosis: correlation between functional and phenotypic expression of opsonin receptors before and after platelet-activating factor priming. | 1999 | J. Infect. Dis. | pmid:9841834 |
| Kimura S et al. | Suppressive effects of antihistaminic and/or anti-PAF agents on passive anaphylactic shock in mice sensitized with allogeneic monoclonal IgE and IgG1 antibodies and hyperimmune serum. | 1998 | Immunol. Invest. | pmid:9845423 |
| Koyama S et al. | Bradykinin stimulates type II alveolar cells to release neutrophil and monocyte chemotactic activity and inflammatory cytokines. | 1998 | Am. J. Pathol. | pmid:9846978 |
| Masubuchi T et al. | Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity. | 1998 | Am. J. Pathol. | pmid:9846980 |
| Jean WC et al. | Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon. | 1998 | Neurosurgery | pmid:9848853 |
| Swain SD et al. | Platelet-activating factor induces a concentration-dependent spectrum of functional responses in bovine neutrophils. | 1998 | J. Leukoc. Biol. | pmid:9850166 |
| Steil AA et al. | Modulation by lipid mediators of immune complex-induced lung inflammation in mice. | 1998 | Eur. J. Pharmacol. | pmid:9851546 |
| Xiao YQ et al. | Pharmacological analysis of protein kinases responsible for chemotaxis of rat peritoneal neutrophils. | 1998 | Eur. J. Pharmacol. | pmid:9851586 |
| Reverdiau-Moalic P et al. | Human allogeneic lymphocytes trigger endothelial cell tissue factor expression by a tumor necrosis factor-dependent pathway. | 1998 | J. Lab. Clin. Med. | pmid:9851744 |
| Reiner O and Sapir T | Abnormal cortical development; towards elucidation of the LIS1 gene product function (review). | 1998 | Int. J. Mol. Med. | pmid:9852306 |
| Gardner JP and Zhang L | Glucocorticoid modulation of Ca2+ homeostasis in human B lymphoblasts. | 1999 | J. Physiol. (Lond.) | pmid:9852321 |
| Stamatiou P et al. | 5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rats. | 1998 | J. Clin. Invest. | pmid:9854052 |
| Sharif NA et al. | Human corneal epithelial cell functional responses to inflammatory agents and their antagonists. | 1998 | Invest. Ophthalmol. Vis. Sci. | pmid:9856766 |
| Chihara J et al. | Inhibitory effect of ibudilast (KC-404) on the expression of the beta2 integrin family on an eosinophilic cell line (EoL-1). | 1998 | Ann. Allergy Asthma Immunol. | pmid:9860039 |
| Egesten A and Malm J | Eosinophil leukocyte degranulation in response to serum-opsonized beads: C5a and platelet-activating factor enhance ECP release, with roles for protein kinases A and C. | 1998 | Allergy | pmid:9860239 |
| Nagai H et al. | Effect of overproduction of interleukin 5 on dinitrofluorobenzene-induced allergic cutaneous response in mice. | 1999 | J. Pharmacol. Exp. Ther. | pmid:9862751 |
| Jeanneton O et al. | Correlation of desensitisation of platelet activating factor (PAF) receptors with intensity of inflammation and intestinal PAF content during experimental ileitis in guinea pig. | 1998 | Gut | pmid:9863481 |
| Hammer C et al. | Xenogeneic rejection mechanisms shown by intravital microscopy. | 1998 | Transplant. Proc. | pmid:9865335 |
| Pesce L et al. | Effect of Fenoterol on PAF-induced lung edema in isolated and perfused rabbit lungs. | 1998 | Respir Physiol | pmid:9865589 |
| Kaminskaia GO et al. | [Oxidative metabolic changes, antioxidantion, and platelet activation rat phagocytes during development of experimental specific tuberculous changes]. | 1998 | Probl Tuberk | pmid:9866402 |
| Venugopalan CS et al. | Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. | 1998 | Vet. Res. Commun. | pmid:9868763 |
| pmid:9870780 | ||||
| Powell WS et al. | 5-oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of L-selectin shedding, surface expression of CD11b, actin polymerization, and calcium mobilization in human eosinophils. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:9870930 |
| Chen JZ et al. | A 3D-QSAR study on ginkgolides and their analogues with comparative molecular field analysis. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871752 |
| Dutra PM et al. | A novel ecto-phosphatase activity of Herpetomonas muscarum muscarum inhibited by platelet-activating factor. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9875238 |
| Huh H et al. | PAF antagonistic activity of 2-hydroxy-3-methoxybenzoic acid glucose ester from Gentiana scabra. | 1998 | Arch. Pharm. Res. | pmid:9875472 |
| Zhang J et al. | Strategies of myocardial protection for operation in chronic model of cyanotic heart disease. | 1998 | Ann. Thorac. Surg. | pmid:9875743 |
| Dhainaut JF et al. | Confirmatory platelet-activating factor receptor antagonist trial in patients with severe gram-negative bacterial sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. BN 52021 Sepsis Investigator Group. | 1998 | Crit. Care Med. | pmid:9875905 |
| Kawasaki Y et al. | Specific detections of the early process of the glycation reaction by fructose and glucose in diabetic rat lens. | 1998 | FEBS Lett. | pmid:9877177 |
| Todoroki H et al. | Possible role of platelet-activating factor in the in vivo expression of tissue factor in neutrophils. | 1998 | J. Surg. Res. | pmid:9878306 |
| Nakano T et al. | Roxythromycin reinforces epithelial defence function in rabbit trachea. | 1998 | Acta Otolaryngol Suppl | pmid:9879427 |
| Chang FR et al. | Two new 7-dehydroaporphine alkaloids and antiplatelet action aporphines from the leaves of Annona purpurea. | 1998 | Phytochemistry | pmid:9883592 |