Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Glomerulonephritis D005921 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Psoriasis D011565 47 associated lipids
Brain Edema D001929 20 associated lipids
Leukopenia D007970 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Burns, Inhalation D002059 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Colonic Diseases D003108 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Denizot Y et al. PAF and hematopoiesis. VIII. Biosynthesis and metabolism of PAF by human bone marrow stromal cells. 1996 Exp. Hematol. pmid:8862444
Wang X et al. Potentiation of acetylcholine-induced responses in freshly isolated rabbit aortic endothelial cells. 1996 Sep-Oct J. Vasc. Res. pmid:8862147
Saito H et al. Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells. 1996 Int. Arch. Allergy Immunol. pmid:8859220
Jouët P and Sarna SK Platelet-activating factor (PAF) stimulates giant migrating contractions during ileal inflammation. 1996 J. Pharmacol. Exp. Ther. pmid:8858995
Shi LC et al. Guanine nucleotide regulatory proteins, Gq and Gi1/2, mediate platelet-activating factor-stimulated phosphoinositide metabolism in immortalized hippocampal cells. 1996 J. Neurochem. pmid:8858930
Lopes-Martins R et al. Pharmacological evidence of a role for platelet activating factor as a modulator of vasomotor tone and blood pressure. 1996 Eur. J. Pharmacol. pmid:8858301
Abu-Zidan FM et al. Role of platelet-activating factor antagonism in posthemorrhage septic shock in pigs. 1996 J Trauma pmid:8858021
Mastroroberto P et al. Elevated circulating levels of von Willebrand factor and D-dimer in patients with heart failure and mechanical prosthesis. 1996 Scand J Thorac Cardiovasc Surg pmid:8857679
Albert DH et al. ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats. 1996 Shock pmid:8856845
Chen CC et al. Tumor necrosis factor-alpha, platelet-activating factor, and hydrogen peroxide activate protein kinase C subtypes alpha and epsilon in human saphenous vein endothelial cells. 1996 J. Cardiovasc. Pharmacol. pmid:8856479
Ebara T et al. Role of platelet-activating factor and prostanoids in hemodynamic changes in rat experimental endotoxic shock. 1996 Jpn. J. Pharmacol. pmid:8854207
Gaylord MS et al. Altered platelet-activating factor levels and acetylhydrolase activities are associated with increasing severity of bronchopulmonary dysplasia. 1996 Am. J. Med. Sci. pmid:8853062
Hoffman BF et al. Arrhythmias caused by platelet activating factor. 1996 J. Cardiovasc. Electrophysiol. pmid:8853022
Renesto P et al. Protective effect of platelet activating factor antagonists on cultured endothelial cell lysis induced by elastase or activated neutrophils. 1996 Br. J. Pharmacol. pmid:8851508
Hahn M et al. Blockade of receptor-operated calcium channels by mibefradil (Ro 40-5967): effects on intracellular calcium and platelet aggregation. 1995 Cardiovasc Drugs Ther pmid:8850387
Yokota K et al. Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro. 1996 Jpn. J. Pharmacol. pmid:8847836
Libert C et al. Platelet-activating factor is a mediator in tumor necrosis factor/galactosamine-induced lethality. 1995-1996 J. Inflamm. pmid:8844494
Kemény L et al. Effect of locally applied WEB 2086, a platelet-activating factor antagonist, on inflammatory skin conditions in mice. 1996 Arch. Dermatol. Res. pmid:8844132
Paulino N et al. Mechanisms involved in the contractile responses induced by the hydroalcoholic extract of Phyllanthus urinaria on the guinea pig isolated trachea: evidence for participation of tachykinins and influx of extracellular Ca2+ sensitive to ruthenium red. 1996 Gen. Pharmacol. pmid:8842681
Tenor H et al. Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. 1996 Br. J. Pharmacol. pmid:8842438
Isogai E et al. [Platelet activating factor (PAF) and Lyme disease]. 1996 Nippon Saikingaku Zasshi pmid:8840817
Imagawa M et al. Modulation of platelet-activating factor synthesis by recombinant interferon-alpha in human renal cell carcinoma. 1996 Urol. Int. pmid:8840484
Kurata M et al. A comparative study of whole-blood platelet aggregation in laboratory animals: its species differences and comparison with turbidimetric method. 1995 Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. pmid:8838690
Louis RE and Radermecker MF Acute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine. 1996 Eur. Respir. J. pmid:8836652
Barkai U and Kraicer PF Intrauterine signaling and embryonic implantation. 1996 Mar-Apr Biol. Signals pmid:8836494
Taylor ML et al. Differential expression of platelet activation markers in aspirin-sensitive asthmatics and normal subjects. 1996 Clin. Exp. Allergy pmid:8835129
Gabryelewicz A Etiology and pathogenesis of acute pancreatitis--current view. 1995 Rocz. Akad. Med. Bialymst. pmid:8834603
Matsuo Y et al. Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain. 1996 Brain Res. pmid:8833766
Tsukioka K et al. Increased plasma level of platelet-activating factor (PAF) and decreased serum PAF acetylhydrolase (PAFAH) activity in adults with bronchial asthma. 1996 Jan-Feb J Investig Allergol Clin Immunol pmid:8833165
Savu SR et al. Determination of 1-O-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, platelet-activating factor and related phospholipids in biological samples by high-performance liquid chromatography--tandem mass spectrometry. 1996 J. Chromatogr. B, Biomed. Appl. pmid:8832423
Ribaldi E et al. Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation. 1996 Br. J. Pharmacol. pmid:8832056
Sandoval D et al. The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. 1996 Gastroenterology pmid:8831604
Galloway SW and Kingsnorth AN Lung injury in the microembolic model of acute pancreatitis and amelioration by lexipafant (BB-882), a platelet-activating factor antagonist. 1996 Pancreas pmid:8829181
Spangelo BL and Jarvis WD Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. 1996 Endocrinology pmid:8828503
López-Novoa JM et al. The role of platelet-activating factor and the effect of PAF blocking receptors on the outcome of ARF. 1996 Ren Fail pmid:8827995
Grinyó JM et al. The role of platelet-activating factor antagonists in the prophylaxis of posttransplant acute tubular necrosis. 1996 Ren Fail pmid:8827990
Burt RP et al. The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens. 1996 Br. J. Pharmacol. pmid:8825367
Predescu D et al. The vascular distribution of the platelet-activating factor receptor. 1996 Eur. J. Cell Biol. pmid:8825027
Yang HO et al. Biological and pharmacological effects of pinusolide, a novel platelet activating factor antagonist. 1995 Planta Med. pmid:8824945
Murakami K et al. A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats. 1996 Thromb. Haemost. pmid:8822594
Miguélez R et al. Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antiproteinase activity in an experimental model of acute urate crystal arthritis. 1996 J Lipid Mediat Cell Signal pmid:8821809
Kuitert L and Barnes NC PAF and asthma--time for an appraisal? 1995 Clin. Exp. Allergy pmid:8821294
Lin J et al. Effects of platelet-activating factor (PAF) receptor blockage on mucous glycoprotein secretion in cultured chinchilla middle ear epithelium. 1996 Acta Otolaryngol. pmid:8820353
Abu-Zidan FM and Walther S Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs. 1996 Eur J Surg pmid:8817228
Le Solleu H et al. A pharmacophore for high affinity PAF antagonists. I. Electronic model using molecular electrostatic potential. 1996 J Lipid Mediat Cell Signal pmid:8816988
Le Texier L et al. Structure-activity relationships in platelet-activating factor (PAF). 8. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors: anti-acetylcholinesterase activity and comparative SAR. 1996 J Lipid Mediat Cell Signal pmid:8816985
Le Texier L et al. Structure-activity relationships in platelet-activating factor (PAF). 7. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors. Synthesis and PAF-antagonistic activity. 1996 J Lipid Mediat Cell Signal pmid:8816984
Bauldry SA and Wooten RE Leukotriene B4 and platelet activating factor production in permeabilized human neutrophils: role of cytosolic PLA2 in LTB4 and PAF generation. 1996 Biochim. Biophys. Acta pmid:8816854
Sato E et al. Bradykinin stimulates alveolar macrophages to release neutrophil, monocyte, and eosinophil chemotactic activity. 1996 J. Immunol. pmid:8816423
Erger RA and Casale TB Eosinophil migration in response to three molecular species of platelet activating factor. 1996 Inflamm. Res. pmid:8814455
Tao Y et al. Platelet-activating factor enhances urokinase-type plasminogen activator gene expression in corneal epithelium. 1996 Invest. Ophthalmol. Vis. Sci. pmid:8814143
Durán WN et al. Platelet-activating factor modulates leukocyte adhesion to endothelium in ischemia-reperfusion. 1996 Microvasc. Res. pmid:8812764
Yasugahira H et al. [The changes of blood gas analysis values and platelet aggregability on acute phase in the experimental model of pulmonary embolism prepared by sephadex G-75 (SG-75) injection]. 1996 Nihon Kyobu Shikkan Gakkai Zasshi pmid:8810754
Tachibana F et al. Platelet-activating factor and leukotrienes in acute otitis media, secretory otitis media, and chronic otitis media on the acute excerbation. 1996 Auris Nasus Larynx pmid:8809319
Arima S et al. Platelet-activating factor dilates efferent arterioles through glomerulus-derived nitric oxide. 1996 J. Am. Soc. Nephrol. pmid:8808114
Dunlop ME et al. Production of hyaluronan by glomerular mesangial cells in response to fibronectin and platelet-derived growth factor. 1996 Kidney Int. pmid:8807570
Baskin SI et al. The effects of EDRF/NO releasers or calcium ionophore A23187 on cyanide toxicity in mice. 1996 Toxicol. Appl. Pharmacol. pmid:8806852
Catalán RE et al. Nitric oxide mediates the PAF-stimulated cyclic GMP production in hippocampal slices. 1996 Biochem. Biophys. Res. Commun. pmid:8806587
Marrakchi N et al. [Biochemical and pharmacologic properties of platelet aggregants and platelet antiaggregants of viper venoms in Tunisia]. 1994 Jul-Oct Arch Inst Pasteur Tunis pmid:8801850
Noguchi K et al. Involvement of nitric oxide and eicosanoids in platelet-activating factor-induced haemodynamic and haematological effects in dogs. 1996 Br. J. Pharmacol. pmid:8799566
Civelli M et al. The involvement of the release of nitric oxide in the pharmacological activity of the new furoxan derivative CHF 2363. 1996 Br. J. Pharmacol. pmid:8799563
Westmoreland SV et al. Toxicity of TNF alpha and platelet activating factor for human NT2N neurons: a tissue culture model for human immunodeficiency virus dementia. 1996 J. Neurovirol. pmid:8799203
van Rossem K et al. The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits. 1996 Adv. Exp. Med. Biol. pmid:8798843
Marcheselli VL and Bazan NG Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. 1996 J. Biol. Chem. pmid:8798751
Parent JL et al. Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis. 1996 J. Biol. Chem. pmid:8798529
Abebe W et al. Platelet-activating factor-induced inositol 1,4,5-trisphosphate generation in undifferentiated and differentiated U937 cells: role of tyrosine kinase. 1996 Int. J. Immunopharmacol. pmid:8796445
Takeda H et al. Release of fructose and hexose phosphates from perivascular cells induced by low density lipoprotein and acceleration of protein glycation in vitro. 1996 Diabetes Res. Clin. Pract. pmid:8792096
Weikert LF and Bernard GR Pharmacotherapy of sepsis. 1996 Clin. Chest Med. pmid:8792067
Aïssa J et al. Biochemical and cellular effects of heparin-protamine injection in rabbits are partially inhibited by a PAF-acether receptor antagonist. 1996 Eur. J. Pharmacol. pmid:8791000
Naraba H et al. Inhibitory effect of arachidonic acid on platelet-activating factor production in rat neutrophils. 1996 Eur. J. Pharmacol. pmid:8790999
Bazan NG and Allan G Platelet-activating factor is both a modulator of synaptic function and a mediator of cerebral injury and inflammation. 1996 Adv Neurol pmid:8790822
Hirafuji M et al. Involvement of platelet cyclic GMP but not cyclic AMP suppression in leukocyte-dependent platelet adhesion to endothelial cells induced by platelet-activating factor in vitro. 1996 Br. J. Pharmacol. pmid:8789382
Battye KM et al. Ovine endometrium synthesizes and releases platelet-activating factor, which can cause the release of prostaglandin F2 alpha by the uterus in situ. 1996 Biol. Reprod. pmid:8788186
Yoshii H et al. Neurotropin inhibits accumulation of eosinophils induced by allergen through the suppression of sensitized T-cells. 1995 Int. J. Immunopharmacol. pmid:8788117
Baker RR Enzymes of platelet activating factor synthesis in brain. 1995 Neurochem. Res. pmid:8786821
Ogundaini A et al. Isolation of two new antiinflammatory biflavanoids from Sarcophyte piriei. 1996 J. Nat. Prod. pmid:8786365
Uhlig S et al. Cyclooxygenase-2-dependent bronchoconstriction in perfused rat lungs exposed to endotoxin. 1996 Mol. Med. pmid:8784790
Sasaki T et al. A distribution study of 11C platelet-activating factor (PAF) analogs in normal and tumor-bearing mice. 1996 Nucl. Med. Biol. pmid:8782242
Almer S et al. Concentrations of platelet activating factor in rectal mucosa in patients with ulcerative colitis. 1996 Eur J Surg pmid:8781921
Yang X et al. Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective phospholipase C activation. 1996 Blood pmid:8781423
Khoury J and Langleben D Platelet-activating factor stimulates lung pericyte growth in vitro. 1996 Am. J. Physiol. pmid:8780000
Kurose I et al. Microvascular dysfunction induced by nonsteroidal anti-inflammatory drugs: role of leukocytes. 1996 Am. J. Physiol. pmid:8779980
Sterner-Kock A et al. Recombinant tumour necrosis factor-alpha and platelet-activating factor synergistically increase intercellular adhesion molecule-1 and E-selectin-dependent neutrophil adherence to endothelium in vitro. 1996 Immunology pmid:8778033
Izumi T et al. Platelet-activating factor receptor. 1995 J Lipid Mediat Cell Signal pmid:8777584
Sobhani I et al. Helicobacter pylori stimulates gastric acid secretion via platelet activating factor. 1996 J. Physiol. Pharmacol. pmid:8777297
Ayala A and Chaudry IH Platelet activating factor and its role in trauma, shock, and sepsis. 1996 New Horiz pmid:8774801
Nabe T et al. Sephadex G-200-induced eosinophil infiltration into airways in non-sensitized and sensitized guinea pigs, and responsiveness of the cells to stimuli in vitro. 1996 Jpn. J. Pharmacol. pmid:8774762
Ueno A et al. The mediators involved in endotoxin-induced vascular permeability increase in the rat skin and their interactions. 1996 Jpn. J. Pharmacol. pmid:8774757
Moriguchi T et al. Diamide primes neutrophils for enhanced release of superoxide anion: relationship to S-thiolation of cellular proteins. 1996 J. Leukoc. Biol. pmid:8773580
Kamata K et al. Mechanisms of desensitization of vasodilatation induced by platelet-activating factor in hypertensive rats. 1996 Eur. J. Pharmacol. pmid:8773455
Sun XM et al. Role of leukocyte beta 2-integrin in PAF-induced shock and intestinal injury. 1996 Am. J. Physiol. pmid:8772517
Reinhardt PH et al. Monosodium urate crystals promote neutrophil adhesion via a CD18-independent and selectin-independent mechanism. 1996 Am. J. Physiol. pmid:8772427
Shebzukhov IuV et al. [The effect of platelet-activating factor and its synthetic analogs on Ia-antigen expression by mouse peritoneal macrophages]. 1996 May-Jun Zh. Mikrobiol. Epidemiol. Immunobiol. pmid:8771751
Walcher F et al. Platelet-activating factor is involved in the regulation of pathological leukocyte adhesion after liver transplantation. 1996 J. Surg. Res. pmid:8769973
Harris NR and Granger DN Mechanisms underlying enhanced capillary filtration induced by platelet-activating factor. 1996 Am. J. Physiol. pmid:8769743
de Paulis A et al. Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. 1996 J. Allergy Clin. Immunol. pmid:8765829
Baker RR and Chang HY Alkylglycerophosphate acetyltransferase and lyso platelet activating factor acetyltransferase, two key enzymes in the synthesis of platelet activating factor, are found in neuronal nuclei isolated from cerebral cortex. 1996 Biochim. Biophys. Acta pmid:8765148
Xie X et al. Interdigitation of bilayers from ether lipid analogs: (R)-PAF, (R)-Lyso-PAF and the antineoplastic (R)-ET-18-OMe. 1996 Biochim. Biophys. Acta pmid:8765102
Lupia E et al. Role of tumor necrosis factor-alpha and platelet-activating factor in neoangiogenesis induced by synovial fluids of patients with rheumatoid arthritis. 1996 Eur. J. Immunol. pmid:8765007
DeFily DV et al. PAF attenuates endothelium-dependent coronary arteriolar vasodilation. 1996 Am. J. Physiol. pmid:8764261