| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cholestasis | D002779 | 23 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Brain Edema | D001929 | 20 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Gram-Negative Bacterial Infections | D016905 | 16 associated lipids |
| Fetal Weight | D020567 | 12 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chomyszyn-Gajewska M | [Evaluation of chosen salivary periodontal disease markers]. | 2010 | Prz. Lek. | pmid:20687387 |
| Thiele T et al. | [Heparin-induced thrombocytopenia]. | 2010 | Internist (Berl) | pmid:20694716 |
| Jiang P et al. | PMS-1077, a PAF antagonist, induced differentiation of HL-60 cells with its novel activity. | 2010 | Cell Biol. Int. | pmid:20812915 |
| Renteria LS et al. | Prolonged hypoxia modulates platelet activating factor receptor-mediated responses by fetal ovine pulmonary vascular smooth muscle cells. | 2010 | Mol. Genet. Metab. | pmid:20813571 |
| Church MK | Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males. | 2010 | Br. J. Dermatol. | pmid:20819087 |
| Hasan AM et al. | Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. | 2010 | Int. Immunopharmacol. | pmid:20685403 |
| Zhao W et al. | [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21038678 |
| Asaka N et al. | Effects of the new benzimidazole derivative TAS-203, an orally active phosphodiesterase 4 inhibitor, on airway inflammation in rats and emetic responses in ferrets. | 2010 | Arzneimittelforschung | pmid:21117500 |
| Lin S et al. | Abietane and C20-norabietane diterpenes from the stem bark of Fraxinus sieboldiana and their biological activities. | 2010 | J. Nat. Prod. | pmid:20961093 |
| He J et al. | The induction of an angiogenic response in corneal myofibroblasts by platelet-activating factor (PAF). | 2010 | Curr. Eye Res. | pmid:20961214 |
| Rechka A et al. | Identification of VEGF receptor-2 tyrosine phosphorylation sites involved in VEGF-mediated endothelial platelet-activating factor synthesis. | 2010 | Can. J. Physiol. Pharmacol. | pmid:20962896 |
| Soliman A et al. | Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. | 2010 | PLoS ONE | pmid:20976181 |
| Gao F et al. | [The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude]. | 2010 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:20979844 |
| Xu CL et al. | [Inhibitory effect of TBN on platelet aggregation in rabbit]. | 2010 | Zhong Yao Cai | pmid:21243778 |
| de Souza Carmo EV et al. | Neutrophils reduce the parasite burden in Leishmania (Leishmania) amazonensis-infected macrophages. | 2010 | PLoS ONE | pmid:21082032 |
| Zhu X et al. | Effects of ropivacaine on adhesion molecule CD11b expression and function in human neutrophils. | 2010 | Int. Immunopharmacol. | pmid:20348036 |
| Zhao D et al. | PAF exerts a direct apoptotic effect on the rat H9c2 cardiomyocytes in Ca2+-dependent manner. | 2010 | Int. J. Cardiol. | pmid:19237210 |
| Karantonis HC et al. | Platelet-activating factor involvement in thioacetamide-induced experimental liver fibrosis and cirrhosis. | 2010 | Dig. Dis. Sci. | pmid:19242794 |
| Lefebvre JS et al. | Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor. | 2010 | FASEB J. | pmid:19843712 |
| Borthakur A et al. | Platelet-activating factor-induced NF-kappaB activation and IL-8 production in intestinal epithelial cells are Bcl10-dependent. | 2010 | Inflamm. Bowel Dis. | pmid:19714753 |
| Fité R and Borja J | Rupatadine and heart rhythm disturbances. | 2010 | Clin. Pharmacol. Ther. | pmid:19727070 |
| Kida T et al. | Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. | 2010 | Exp. Eye Res. | pmid:20412793 |
| Lorrain DS et al. | Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. | 2010 | Eur. J. Pharmacol. | pmid:20519143 |
| Salmon MD and Ahluwalia J | Discrimination between receptor- and store-operated Ca(2+) influx in human neutrophils. | 2010 | Cell. Immunol. | pmid:20716450 |
| Chen S et al. | [Induction effect of platelet-activating factor on Src-suppressed C kinase substrate gene expression in rat pulmonary microvascular endothelial cells]. | 2010 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:20367900 |
| Yang Y et al. | Platelet-activating factor reduces endothelial nitric oxide production: role of acid sphingomyelinase. | 2010 | Eur. Respir. J. | pmid:19926744 |
| Cureton EL et al. | Endothelin 1 and prostacyclin attenuate increases in hydraulic permeability caused by platelet-activating factor in rats. | 2010 | Shock | pmid:19940814 |
| Coppo R et al. | Aberrantly glycosylated IgA1 induces mesangial cells to produce platelet-activating factor that mediates nephrin loss in cultured podocytes. | 2010 | Kidney Int. | pmid:20016469 |
| Xu Z et al. | Induction of shock after intravenous injection of adenovirus vectors: a critical role for platelet-activating factor. | 2010 | Mol. Ther. | pmid:19953082 |
| Ma J et al. | Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19959817 |
| Hasegawa S et al. | Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain. | 2010 | PLoS ONE | pmid:20454616 |
| Yang L et al. | Chronic alcohol exposure increases circulating bioactive oxidized phospholipids. | 2010 | J. Biol. Chem. | pmid:20460374 |
| Esquenazi S and Bazan HE | Role of platelet-activating factor in cell death signaling in the cornea: A review. | 2010 | Mol. Neurobiol. | pmid:20431963 |
| Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. | 2010 | Platelets | pmid:20433310 |
| Denizot Y | Platelet-activating factor and acute myelogenous leukemia. | 2010 | Exp. Hematol. | pmid:20303379 |
| Rieder F et al. | Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20299604 |
| Prokosch V et al. | Alpha2-adrenergic receptors and their core involvement in the process of axonal growth in retinal explants. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20592227 |
| Morimoto R et al. | Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages. | 2010 | J. Biol. Chem. | pmid:20663880 |
| Balestrieri ML et al. | Endothelial progenitor cells express PAF receptor and respond to PAF via Ca(2+)-dependent signaling. | 2010 | Biochim. Biophys. Acta | pmid:20637897 |
| Karasuyama H et al. | Role for basophils in systemic anaphylaxis. | 2010 | Chem Immunol Allergy | pmid:20519883 |
| Xiping Z et al. | Effects of dexamethasone and Salvia miltiorrhizae on the small intestine and immune organs of rats with severe acute pancreatitis. | 2010 | Inflammation | pmid:20127399 |
| Incorvaia C et al. | Anaphylaxis: an update on its understanding and management. | 2010 | Recent Pat Inflamm Allergy Drug Discov | pmid:20100165 |
| Moriguchi S et al. | Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region. | 2010 | Neuroscience | pmid:20074623 |
| Zhou X and He P | Endothelial [Ca2+]i and caveolin-1 antagonistically regulate eNOS activity and microvessel permeability in rat venules. | 2010 | Cardiovasc. Res. | pmid:20080986 |
| Kenchegowda S and Bazan HE | Significance of lipid mediators in corneal injury and repair. | 2010 | J. Lipid Res. | pmid:19965607 |
| Jørgensen KM et al. | Platelet activating factor stimulates arachidonic acid release in differentiated keratinocytes via arachidonyl non-selective phospholipase A2. | 2010 | Arch. Dermatol. Res. | pmid:20041255 |
| Coy Barrera ED and Cuca Suárez LE | In vitro inhibitory activities of Lauraceae aporphine alkaloids. | 2010 | Nat Prod Commun | pmid:20420312 |
| Dyer KD et al. | Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. | 2010 | J. Immunol. | pmid:20421642 |
| Bate C et al. | Glycosylphosphatidylinositol anchor analogues sequester cholesterol and reduce prion formation. | 2010 | J. Biol. Chem. | pmid:20427265 |
| Shin SH et al. | Platelet-activating factor receptor mediates oxidized low density lipoprotein-induced migration of bone marrow-derived mesenchymal stem cells. | 2010 | Cell. Physiol. Biochem. | pmid:21063106 |