Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Watschinger K and Werner ER | Orphan enzymes in ether lipid metabolism. | 2013 | Biochimie | pmid:22771767 |
Yamazaki Y et al. | A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice. | 2013 | Biochem. Pharmacol. | pmid:23817078 |
Xia SH et al. | Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. | 2013 | World J. Gastroenterol. | pmid:23840141 |
Mazereeuw G et al. | Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. | 2013 | Neurosci Biobehav Rev | pmid:23800745 |
Wang C et al. | Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain. | 2013 | Lipids Health Dis | pmid:23805935 |
Nettis E et al. | Rupatadine for the treatment of urticaria. | 2013 | Expert Opin Pharmacother | pmid:23806068 |
Sato A and Ebina K | [Interaction between Asp-hemolysin-related synthetic peptides and oxidized LDL/lysophospholipids]. | 2013 | Seikagaku | pmid:23819394 |
Compalati E and Canonica GW | Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. | 2013 | Curr Med Res Opin | pmid:23826741 |
Xu H et al. | Targeted lipidomics - advances in profiling lysophosphocholine and platelet-activating factor second messengers. | 2013 | FEBS J. | pmid:23826908 |
Liu G et al. | Characterization of streptococcal platelet-activating factor acetylhydrolase variants that are involved in innate immune evasion. | 2013 | Infect. Immun. | pmid:23774595 |
Costa M et al. | Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. | 2013 | Stem Cell Res | pmid:23164599 |
Sirangelo I et al. | Amyloid toxicity and platelet-activating factor signaling. | 2013 | J. Cell. Physiol. | pmid:23169529 |
Murakami M and Lambeau G | Emerging roles of secreted phospholipase A(2) enzymes: an update. | 2013 | Biochimie | pmid:23022039 |
Vadas P et al. | Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. | 2013 | J. Allergy Clin. Immunol. | pmid:23040367 |
Kawano DF and Carvalho I | Targeting Trypanosoma cruzi platelet-activating factor receptors: scope for the development of novel drugs to treat Chagas Disease. | 2013 | Mini Rev Med Chem | pmid:23544467 |
Wei JF et al. | Induction of mast-cell accumulation by promutoxin, an Arg-49 phospholipase A2. | 2013 | Biomed Res Int | pmid:23509689 |
Renteria LS et al. | RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation. | 2013 | Cell Prolif. | pmid:24033386 |
Verouti SN et al. | Paricalcitol effects on activities and metabolism of platelet activating factor and on inflammatory cytokines in hemodialysis patients. | 2013 | Int J Artif Organs | pmid:23335378 |
Zhao C et al. | Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. | 2013 | PLoS ONE | pmid:24367540 |
Barbier M et al. | Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia. | 2013 | MBio | pmid:23653444 |