Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Endotoxemia D019446 27 associated lipids
Angina Pectoris D000787 27 associated lipids
Hyperinsulinism D006946 27 associated lipids
Brain Diseases D001927 27 associated lipids
Gastritis D005756 27 associated lipids
Neuralgia D009437 28 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Proteinuria D011507 30 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Cardiomegaly D006332 31 associated lipids
Stroke D020521 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Acute Lung Injury D055371 33 associated lipids
Uremia D014511 33 associated lipids
Memory Disorders D008569 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Burns D002056 34 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Fever D005334 35 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Nervous System Diseases D009422 37 associated lipids
Lung Diseases D008171 37 associated lipids
Peritonitis D010538 38 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Hyperalgesia D006930 42 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Psoriasis D011565 47 associated lipids
Thrombosis D013927 49 associated lipids
Osteosarcoma D012516 50 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Kaplan R et al. Combined defect in membrane expression and activation of platelet GPIIb--IIIa complex without primary sequence abnormalities in myeloproliferative disease. 2000 Br. J. Haematol. pmid:11122160
Bussolati B et al. IL-10 stimulates production of platelet-activating factor by monocytes of patients with active systemic lupus erythematosus (SLE). 2000 Clin. Exp. Immunol. pmid:11122257
Kelly RF Current strategies in lung preservation. 2000 J. Lab. Clin. Med. pmid:11128744
Adams JM et al. G-protein receptor responses in trauma neutrophils. 2000 J Trauma pmid:11130495
Asimakopoulos G et al. Inhibition of neutrophil L-selectin shedding: a potential anti-inflammatory effect of aprotinin. 2000 Perfusion pmid:11131212
Tavakoli S et al. Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11133502
Clavijo LC et al. PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat. 2001 J. Appl. Physiol. pmid:11133918
Galimi F et al. Hepatocyte growth factor is a regulator of monocyte-macrophage function. 2001 J. Immunol. pmid:11145707
Arese M et al. HIV-1 Tat protein stimulates in vivo vascular permeability and lymphomononuclear cell recruitment. 2001 J. Immunol. pmid:11145723
Rabinowitz SS et al. Platelet-activating factor in infants at risk for necrotizing enterocolitis. 2001 J. Pediatr. pmid:11148517
Kwan ML et al. Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11159008
Komori M et al. PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways. 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11159026
Stojanov T and O'Neill C In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. 2001 Biol. Reprod. pmid:11159375
Roudebush WE et al. Impact of blood serum insulin-like growth factor I on platelet-activating factor in bull spermatozoa. 2001 Domest. Anim. Endocrinol. pmid:11164329
Giménez R and Aguilar J Cytidine (5') diphosphocholine-induced decrease in cerebral platelet activating factor is due to inactivation of its synthesizing enzyme cholinephosphotransferase in aged rats. 2001 Neurosci. Lett. pmid:11165772
Goudevenos J et al. Platelet-associated and secreted PAF-acetylhydrolase activity in patients with stable angina: sequential changes of the enzyme activity after angioplasty. 2001 Eur. J. Clin. Invest. pmid:11168434
Rodrigo L et al. Hydrolysis of platelet-activating factor by human serum paraoxonase. 2001 Biochem. J. pmid:11171072
Magai RM and Shukla SD Metabolic fate of [14C]-ethanol into endothelial cell phospholipids including platelet-activating factor, sphingomyelin and phosphatidylethanol. 2001 Jan-Feb J. Biomed. Sci. pmid:11173988
Zaitseva L et al. Role of eicosanoids in regulation of macrophage phagocytic functions by platelet-activating factor during endotoxic shock. 2000 Bull. Exp. Biol. Med. pmid:11177271
Del Sorbo L et al. Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1 Tat. 2001 Eur. J. Immunol. pmid:11180101
Herrero-Fresneda I et al. Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor. 2000 Transplantation pmid:11190497
Yildirim G et al. Effects of platelet-activating factor and hyperbaric oxygenation on antioxidant defense and duodenal contractility. 2000 Undersea Hyperb Med pmid:11191161
Kecskeméti V and Balogh I The role of platelet-activating factor (PAF) antagonists and nitric oxide in cardiac actions of PAF. Electrophysiological and morphological study. 2000 J. Physiol. Pharmacol. pmid:11192945
Karasawa K [Physiological role of novel metabolic pathway of platelet-activating factor(PAF): PAF-dependent transacetylation]. 2001 Tanpakushitsu Kakusan Koso pmid:11193332
Urasaki T et al. Pivotal role of 5-lipoxygenase in the activation of human eosinophils: platelet-activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway. 2001 J. Leukoc. Biol. pmid:11200053
Hauser CJ et al. PAF-mediated Ca2+ influx in human neutrophils occurs via store-operated mechanisms. 2001 J. Leukoc. Biol. pmid:11200069
Jeon SY et al. Nitric oxide mediates platelet activating factor-induced microvascular leakage in rat airways. 2001 Ann. Otol. Rhinol. Laryngol. pmid:11201815
Baker RR and Chang HY The regulation of CoA-independent transacylation reactions in neuronal nuclei by lysophospholipid, free fatty acid, and lysophospholipase: the control of nuclear lyso platelet-activating factor metabolism. 2000 Mol. Cell. Biochem. pmid:11204449
Mannori G et al. Interaction of tumor cells with vascular endothelia: role of platelet-activating factor. 2000 Clin. Exp. Metastasis pmid:11206844
Bassi F et al. Detection of platelet-activating factor in gingival tissue surrounding failed dental implants. 2001 J. Periodontol. pmid:11210074
Ko TC et al. Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents. 2001 Bioorg. Med. Chem. Lett. pmid:11212091
Taggart DP Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. 2001 Ann. Thorac. Surg. pmid:11216754
Lash GE and Legge M Localization and distribution of platelet activating factor receptors in the mouse ovary and oviduct during the estrous cycle and early pregnancy. 2001 Am. J. Reprod. Immunol. pmid:11216875
Sun Z et al. Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion. 2001 Scand. J. Gastroenterol. pmid:11218240
Tohda Y et al. Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. 2001 Respiration pmid:11223734
Kawaguchi A et al. Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity. 2001 Life Sci. pmid:11228102
Tokumura A et al. Platelet-activating factor (PAF)-like oxidized phospholipids: relevance to atherosclerosis. 2000 Biofactors pmid:11237195
Persidsky Y et al. Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis. 2001 J. Neuroimmunol. pmid:11240016
Bachert C Decongestant efficacy of desloratadine in patients with seasonal allergic rhinitis. 2001 Allergy pmid:11243500
Gandhi CR et al. A23187 causes release of inositol phosphates from cultured rat Kupffer cells. 2001 Eur. J. Pharmacol. pmid:11245846
Petty HR and Kindzelskii AL Dissipative metabolic patterns respond during neutrophil transmembrane signaling. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11248046
Denis MA et al. Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease. 2001 Scand. J. Gastroenterol. pmid:11252412
Wittwer T et al. Impact of PAF antagonist BN 52021 (Ginkolide B) on post-ischemic graft function in clinical lung transplantation. 2001 J. Heart Lung Transplant. pmid:11257563
Chen YG et al. Lignans from Kadsura angustifolia. 1998 J Asian Nat Prod Res pmid:11261213
Gu M et al. Role of platelet-activating factor in hepatectomy with Pringle's maneuver. 2001 J. Surg. Res. pmid:11266278
Iwazaki S et al. FR128998 ameliorates liver injury in extended liver resection with ischemia in dogs. 2001 Jan-Feb Hepatogastroenterology pmid:11268964
Gujrati VR and Sastry BV Metabolic fate of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by human spermatozoa: biosynthesis and biodegradation. 2001 Life Sci. pmid:11270625
Zeng S et al. Platelet activating factor-induced P-selectin expression in platelets and its related signal transduction. 1999 Zhongguo Yao Li Xue Bao pmid:11270998
Ulrich CD Lexipafant in severe acute pancreatitis: the final word? 2001 Curr Gastroenterol Rep pmid:11276374
Beales IL Effect of platelet-activating factor on gastrin release from cultured rabbit G-cells. 2001 Dig. Dis. Sci. pmid:11284466