Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Matsumoto M and Miwa M | Platelet-activating factor-binding protein in human serum. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004155 |
Leid RW and Potter KA | Inflammation and mediators of lung injury. | 1985 | Vet. Clin. North Am. Food Anim. Pract. | pmid:3907779 |
Roubin R and Benveniste J | Formation of prostaglandins, leukotrienes and paf-acether by macrophages. | 1985 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:3910339 |
Billah MM et al. | Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor. | 1985 | Prostaglandins | pmid:3936121 |
Sybertz EJ et al. | Cardiac, coronary and peripheral vascular effects of acetyl glyceryl ether phosphoryl choline in the anesthetized dog. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3917504 |
Harlan JM | Leukocyte-endothelial interactions. | 1985 | Blood | pmid:3918593 |
Doebber TW et al. | Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985058 |
Pfeilschifter J et al. | Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985064 |
Hwang SB et al. | Specific binding sites for platelet activating factor in human lung tissues. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2986633 |
Sturk A et al. | Synergistic effects of platelet-activating factor and other platelet agonists in human platelet aggregation and release: the role of ADP and products of the cyclooxygenase pathway. | 1985 | Thromb. Res. | pmid:2934863 |
Maes L et al. | In vivo arterial platelet-vessel wall interaction and thrombosis: induction, on-line registration and ultrastructural control. | 1985 | Adv. Exp. Med. Biol. | pmid:3832867 |
Tuffin DP et al. | Specific binding of [3H]-1-O-octadecyl Paf-acether to washed human platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:3834789 |
Parente L and Flower RJ | Hydrocortisone and 'macrocortin' inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes. | 1985 | Life Sci. | pmid:3838566 |
Kumar R et al. | Occurrence of glyceryl ethers in the phosphatidylcholine fraction of surfactant from dog lungs. | 1985 | Biochim. Biophys. Acta | pmid:3839684 |
Hayashi H et al. | Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. | 1985 | J. Biochem. | pmid:3839790 |
Tokumura A and Tsukatani H | [Antagonists of platelet activating factor]. | 1985 | Seikagaku | pmid:3009656 |
MacIntyre DE et al. | Agonist-induced inositol phospholipid metabolism and Ca++ flux in human platelet activation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010662 |
Hallam TJ et al. | Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010663 |
Gerrard JM et al. | Platelet protein phosphorylation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010667 |
Zimmerman GA et al. | Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin. | 1985 | Circulation | pmid:3928193 |
Valone FH | Inhibition of binding of the platelet-activating factor AGEPC to platelets by the AGEPC analog rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate (CV-3988). | 1985 | Biochem. Biophys. Res. Commun. | pmid:3970703 |
Camussi G and Brentjens JR | Inhalation of horseradish peroxidase by rabbits with specific IgE antibodies results in release into the circulation of platelet-activating factor and in lung lesions. | 1985 | Clin. Immunol. Immunopathol. | pmid:3971603 |
Darius H et al. | Beneficial effects of a new potent and specific thromboxane receptor antagonist (SQ-29,548) in vitro and in vivo. | 1985 | J. Pharmacol. Exp. Ther. | pmid:2997428 |
Chesney CM et al. | Desensitization of human platelets by platelet activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977920 |
Nakayama R et al. | Generation of acetyl glyceryl ether phosphorylcholine from the rat skin and muscle tissues stimulated by moxibustion. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977939 |
Archer CB et al. | Accumulation of inflammatory cells in response to intracutaneous platelet activating factor (Paf-acether) in man. | 1985 | Br. J. Dermatol. | pmid:3978036 |
Gerdin B et al. | Permeability-increasing ability of PAF-acether in rat skin. | 1985 | Inflammation | pmid:3980073 |
Surles JR et al. | Facile synthesis of platelet-activating factor and racemic analogues containing unsaturation in the sn-1-alkyl chain. | 1985 | J. Med. Chem. | pmid:4038418 |
Aul C et al. | [Thrombotic thrombocytopenic purpura]. | 1985 | Klin. Wochenschr. | pmid:4038757 |
Hanahan DJ et al. | A novel approach to structure proof of glyceryl ether-containing glycerophospholipids. Base-catalyzed methanolysis of platelet-activating factor (AGEPC) at 60 degrees C. | 1985 | J. Lipid Res. | pmid:4067422 |
Atkins JN | Platelet-aggregating factor in thrombotic thrombocytopenic purpura. | 1985 | Ann. Intern. Med. | pmid:4038861 |
Klöcking HP et al. | Release of tissue-type plasminogen activator by platelet-activating factor. | 1985 | Thromb. Res. | pmid:4040278 |
Pedersen AK and FitzGerald GA | Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing. | 1985 | Clin. Pharmacol. Ther. | pmid:3917387 |
Monnens L et al. | Platelet aggregating factor in the epidemic form of hemolytic-uremic syndrome in childhood. | 1985 | Clin. Nephrol. | pmid:4042442 |
Pirotzky E et al. | Vascular permeability induced by Paf-acether (platelet-activating factor) in the isolated perfused rat kidney. | 1985 | Agents Actions | pmid:4003192 |
Page CP et al. | Platelet activating factor (Paf-acether) may account for late-onset reactions to allergen inhalation. | 1985 | Agents Actions | pmid:4003195 |
Page CP et al. | Suppression of Paf-acether responses: an anti-inflammatory effect of anti-asthma drugs. | 1985 | Agents Actions | pmid:4003196 |
Spicer BA et al. | An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity. | 1985 | Agents Actions | pmid:4003197 |
Sandler RM et al. | Heparin-induced thrombocytopenia and thrombosis: detection and specificity of a platelet-aggregating IgG. | 1985 | Am. J. Clin. Pathol. | pmid:4003343 |
Oda M et al. | Production of platelet-activating factor by washed rabbit platelets. | 1985 | J. Lipid Res. | pmid:3934305 |
Shen TY et al. | Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2983307 |
Pannocchia A and Hardisty RM | Cyclic AMP inhibits platelet activation independently of its effect on cytosolic free calcium. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2983714 |
Avdonin PV et al. | [Mechanism of increase in Ca2+ level in platelet cytoplasm induced by aggregating factors]. | 1985 | Biokhimiia | pmid:3000463 |
Nishihira J et al. | Purification and characterization of the specific binding protein for platelet activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from human platelets. | 1985 | Tohoku J. Exp. Med. | pmid:3001971 |
Snyder F | Chemical and biochemical aspects of platelet activating factor: a novel class of acetylated ether-linked choline-phospholipids. | 1985 Jan-Mar | Med Res Rev | pmid:2984489 |
Kozubski W and Stańczyk L | [Platelet aggregation in patients with migraine during the pain attack and in the pain-free period]. | 1985 Jul-Aug | Neurol. Neurochir. Pol. | pmid:4094642 |
Bette-Bobillo P et al. | Synthesis and characterization of a radioiodinated, photoreactive and physiologically active analogue of platelet activating factor. | 1985 Jun-Jul | Chem. Phys. Lipids | pmid:4042252 |
Leprán I and Lefer AM | Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. | 1985 Mar-Apr | Basic Res. Cardiol. | pmid:4039929 |
Feuerstein G et al. | Thyrotropin-releasing hormone blocks the hypotensive effects of platelet-activating factor in the unanesthetized guinea pig. | 1985 Mar-Apr | J. Cardiovasc. Pharmacol. | pmid:2581089 |
Mencia-Huerta JM | Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. | 1985 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:3878684 |