Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Angina Pectoris D000787 27 associated lipids
Gastritis D005756 27 associated lipids
Brain Diseases D001927 27 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Neuralgia D009437 28 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Proteinuria D011507 30 associated lipids
Cardiomegaly D006332 31 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Stroke D020521 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Memory Disorders D008569 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Uremia D014511 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Burns D002056 34 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Fever D005334 35 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Nervous System Diseases D009422 37 associated lipids
Lung Diseases D008171 37 associated lipids
Peritonitis D010538 38 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Arthritis D001168 41 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypotension D007022 41 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hyperalgesia D006930 42 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Psoriasis D011565 47 associated lipids
Thrombosis D013927 49 associated lipids
Osteosarcoma D012516 50 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Kingston JK et al. Measurement of the activation of equine platelets by use of fluorescent-labeled annexin V, anti-human fibrinogen antibody, and anti-human thrombospondin antibody. 2002 Am. J. Vet. Res. pmid:11939312
Kingston JK et al. Effects of formaldehyde fixation on equine platelets using flow cytometric methods to evaluate markers of platelet activation. 2002 Am. J. Vet. Res. pmid:12061530
Dodam JR et al. Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages. 1996 Am. J. Vet. Res. pmid:8712527
Tsuchiya R et al. Role of platelet activating factor in development of thrombocytopenia and neutropenia in dogs with endotoxemia. 1999 Am. J. Vet. Res. pmid:10048555
Watanabe M et al. Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. 2016 Am. J. Vet. Res. pmid:27580108
Burgos RA et al. Determination of specific receptor sites for platelet activating factor in bovine neutrophils. 2004 Am. J. Vet. Res. pmid:15141884
Walz PH et al. Platelet function and association of bovine viral diarrhea virus with platelets of persistently infected cattle. 2005 Am. J. Vet. Res. pmid:16273905
LeBlanc CJ et al. Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs. 2008 Am. J. Vet. Res. pmid:18380580
Lohman IC and Halonen M The effects of combined histamine and platelet-activating factor antagonism on systemic anaphylaxis induced by immunoglobulin E in the rabbit. 1993 Am. Rev. Respir. Dis. pmid:8484635
Thivierge M and Rola-Pleszczynski M Enhancement of pulmonary natural killer cell activity by platelet activating factor. Mechanisms of activation involving Ca2+, protein kinase C, and lipooxygenase products. 1991 Am. Rev. Respir. Dis. pmid:1650153
Hamasaki Y et al. Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. 1984 Am. Rev. Respir. Dis. pmid:6547031
Daniel EE and O'Byrne P Effect of inflammatory mediators on airway nerves and muscle. 1991 Am. Rev. Respir. Dis. pmid:2003686
Meade CJ and Heuer H PAF antagonism as an approach to the treatment of airway hyperreactivity. 1991 Am. Rev. Respir. Dis. pmid:2003696
Rylander R and Beijer L Inhalation of endotoxin stimulates alveolar macrophage production of platelet-activating factor. 1987 Am. Rev. Respir. Dis. pmid:3541718
Smith LJ The role of platelet-activating factor in asthma. 1991 Am. Rev. Respir. Dis. pmid:2018248
Kazimierczak W et al. Deuterium-oxide-induced histamine release from basophils of allergic subjects. I. Responsiveness to deuterium oxide requires an activation step. 1984 Am. Rev. Respir. Dis. pmid:6201094
McMurtry IF and Morris KG Platelet-activating factor causes pulmonary vasodilation in the rat. 1986 Am. Rev. Respir. Dis. pmid:3094417
Christman BW et al. Effect of platelet-activating factor on aerosol histamine responsiveness in awake sheep. 1987 Am. Rev. Respir. Dis. pmid:3592402
Benveniste J A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity? 1987 Am. Rev. Respir. Dis. pmid:3592414
Halonen M et al. Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. 1981 Am. Rev. Respir. Dis. pmid:7294504
Ohar JA et al. A rabbit model of pulmonary hypertension induced by the synthetic platelet-activating factor acetylglyceryl ether phosphorylcholine. 1990 Am. Rev. Respir. Dis. pmid:2297169
Lohman I and Halonen M Effects of the PAF antagonist WEB 2086 on PAF-induced physiologic alterations and on IgE anaphylaxis in the rabbit. 1990 Am. Rev. Respir. Dis. pmid:2382903
Stenmark KR et al. Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. 1987 Am. Rev. Respir. Dis. pmid:3631747
Barer GR et al. Reactivity and site of vasomotion in pulmonary vessels of chronically hypoxic rats: relation to structural changes. 1989 Am. Rev. Respir. Dis. pmid:2817616
Oda M et al. The presence of platelet-activating factor associated with eosinophil and/or neutrophil accumulations in the pleural fluids. 1990 Am. Rev. Respir. Dis. pmid:2350088
Nakajima H et al. CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. 1992 Am. Rev. Respir. Dis. pmid:1362635
Smith LJ et al. Mechanism of platelet activating factor-induced bronchoconstriction in humans. 1988 Am. Rev. Respir. Dis. pmid:3195800
Bienenstock J et al. Mast cell involvement in various inflammatory processes. 1987 Am. Rev. Respir. Dis. pmid:3109295
Henson PM et al. NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities. 1992 Am. Rev. Respir. Dis. pmid:1312316
Schellenberg RR Airway responses to platelet-activating factor. 1987 Am. Rev. Respir. Dis. pmid:3310779
Miadonna A et al. Evidence of PAF-acether metabolic pathway activation in antigen challenge of upper respiratory airways. 1989 Am. Rev. Respir. Dis. pmid:2546468
Pretolani M et al. Protection by nedocromil sodium of active immunization-induced bronchopulmonary alterations in the guinea pig. 1990 Am. Rev. Respir. Dis. pmid:2160213
Schleimer RP et al. Characterization of inflammatory mediator release from purified human lung mast cells. 1986 Am. Rev. Respir. Dis. pmid:3485946
Morgan WK et al. Byssinosis: some unanswered questions. 1982 Am. Rev. Respir. Dis. pmid:6808880
Lantz RC et al. The role of platelet-activating factor in the pulmonary response to inhaled bacterial endotoxin. 1991 Am. Rev. Respir. Dis. pmid:2064124
Zimmerman GA et al. Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells. 1987 Am. Rev. Respir. Dis. pmid:3300444
Murphy RC and Clay KL Measurement of platelet-activating factor by physicochemical technique s. 1987 Am. Rev. Respir. Dis. pmid:3300445
Page CP Mechanisms of hyperresponsiveness: platelet-activating factor. 1992 Am. Rev. Respir. Dis. pmid:1734810
Halonen M et al. Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. 1980 Am. Rev. Respir. Dis. pmid:7458063
Scappaticci E et al. Platelet-activating factor in bronchoalveolar lavage from patients with sarcoidosis. 1992 Am. Rev. Respir. Dis. pmid:1336939
Tokuyama K et al. Mechanism of airway narrowing caused by inhaled platelet-activating factor. Role of airway microvascular leakage. 1991 Am. Rev. Respir. Dis. pmid:2048823
Boschetto P et al. Effect of antiasthma drugs on microvascular leakage in guinea pig airways. 1989 Am. Rev. Respir. Dis. pmid:2563319
Lansing MW et al. Lipid mediators contribute to oxygen-radical-induced airway responses in sheep. 1991 Am. Rev. Respir. Dis. pmid:1741541
Ohar JA et al. Platelet-activating factor induces selective pulmonary arterial hyperreactivity in isolated perfused rabbit lungs. 1993 Am. Rev. Respir. Dis. pmid:8317792
Smith LJ et al. Effect of leukotriene D4 and platelet-activating factor on human alveolar macrophage eicosanoid and PAF synthesis. 1993 Am. Rev. Respir. Dis. pmid:8368641
Watson JW et al. IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators. 1990 Am. Rev. Respir. Dis. pmid:2240832
Tocker JE et al. Phospholipase A2-induced pulmonary and hemodynamic responses in the guinea pig. Effects of enzyme inhibitors and mediators antagonists. 1990 Am. Rev. Respir. Dis. pmid:2240843
Lellouch-Tubiana A et al. Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. 1988 Am. Rev. Respir. Dis. pmid:3281530
Wardlaw AJ et al. Effects of inhaled PAF in humans on circulating and bronchoalveolar lavage fluid neutrophils. Relationship to bronchoconstriction and changes in airway responsiveness. 1990 Am. Rev. Respir. Dis. pmid:2405759
Robertson DN et al. The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways. 1988 Am. Rev. Respir. Dis. pmid:2849329