Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hyperinsulinism D006946 27 associated lipids
Brain Diseases D001927 27 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Gastritis D005756 27 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Neuralgia D009437 28 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Proteinuria D011507 30 associated lipids
Cardiomegaly D006332 31 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Stroke D020521 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Uremia D014511 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Memory Disorders D008569 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Burns D002056 34 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Fever D005334 35 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Nervous System Diseases D009422 37 associated lipids
Lung Diseases D008171 37 associated lipids
Peritonitis D010538 38 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hyperalgesia D006930 42 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Psoriasis D011565 47 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Thrombosis D013927 49 associated lipids
Osteosarcoma D012516 50 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Cheng DY and Chen WB [The current status of the research on platelet activating factor and pulmonary hypertension]. 1993 Zhonghua Jie He He Hu Xi Za Zhi pmid:8403064
Li Q [Effects of inhaled aerosol of platelet activating factor on pulmonary function and airway responsiveness in normal subjects]. 1992 Zhonghua Jie He He Hu Xi Za Zhi pmid:1307517
Wang C et al. [Inhalation of platelet-activating factor induced guinea pig airway hyperresponsiveness: role of eosinophils activation]. 1995 Zhonghua Jie He He Hu Xi Za Zhi pmid:8565083
Chou CT et al. Neutrophil chemiluminescence and superoxide production in patients with rheumatoid arthritis: the effect of zymosan, phorbol myristate acetate and platelet-activating factor. 1991 Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi pmid:1667989
Huang QY and Li MJ [Effect of platelet-activating factor on sperm function]. 2007 Zhonghua Nan Ke Xue pmid:17615981
Yu HP et al. [Experimental and clinical study of activated platelet in allergic asthma]. 1991 Zhonghua Nei Ke Za Zhi pmid:1806336
Wang ZY [Advances in the physiopathology of platelets]. 1984 Zhonghua Nei Ke Za Zhi pmid:6099795
Shi H et al. [Effects of a platelet-activating factor antagonist ONO-6240 on antigen induced eosinophil infiltration into the airways]. 1995 Zhonghua Nei Ke Za Zhi pmid:8731847
Ren G and Ye R [Changes in urinary excretion of platelet activating factor and its significance in patients with primary nephrotic syndrome]. 1996 Zhonghua Nei Ke Za Zhi pmid:9275622
Han E et al. [Effect of chronic antiplatelet treatment on platelet activating factor-induced platelet activity in stroke]. 1991 Zhonghua Shen Jing Jing Shen Ke Za Zhi pmid:1868762
Qin X et al. [The effect of platelet-activating factor antagonists on early bacteria translocation of rat after burn injury]. 1995 Zhonghua Wai Ke Za Zhi pmid:7587673
Ji Z et al. [The role of platelet activating factor in pathogenesis of acute pancreatitis in dogs]. 1997 Zhonghua Wai Ke Za Zhi pmid:10374489
Xiao J et al. [Effects of platelet activating factor and platelet activating factor receptor antagonist on spinal cord blood flow after spinal cord injury]. 1995 Zhonghua Wai Ke Za Zhi pmid:8762548
Yu P et al. [The roles of platelet activating factor in intestinal mucosal barrier injury after burn]. 1995 Zhonghua Wai Ke Za Zhi pmid:8565724
Ma X et al. [Corneal epithelial wound healing is delayed by platelet activating factor treatment]. 2004 Zhonghua Yan Ke Za Zhi pmid:15307983
Zhang F [Protective effect of a platelet activating factor antagonist in experimental liver injury]. 1990 Zhonghua Yi Xue Za Zhi pmid:2171727
Ji Z et al. [The role of platelet activating factor in mesenterioangial microcirculatory disturbance complicated with acute pancreatitis in rats]. 1995 Zhonghua Yi Xue Za Zhi pmid:7780816
Xiao J et al. [Effect of platelet activating factor receptor at spinal cord neurocyte membrane on secondary damage after spinal cord injury]. 1996 Zhonghua Yi Xue Za Zhi pmid:8758444
Liu BJ et al. [Effect of BN52021 on platelet activating factor induced aggregation of psoriatic polymorphonuclear neutrophils]. 1994 Zhonghua Yi Xue Za Zhi pmid:7994650
Zeng N [Determination of plasma level of platelet activating factor in cirrhotic patients and its relation to endotoxemia]. 1992 Zhonghua Yi Xue Za Zhi pmid:1319804
Chen SH [Purification and some properties of platelet aggregating protein (PAP) from the plasma of a patient with thrombotic thrombocytopenic purpura]. 1989 Zhonghua Yi Xue Za Zhi pmid:2598093
Wang CP et al. [Influence of platelet activating factor and its antagonist on portal hypertension associated with liver cirrhosis: an experiment with rats]. 2005 Zhonghua Yi Xue Za Zhi pmid:16409839
Yu P et al. [Pathogenetic effect of platelet activating factor on enterogenic endotoxemia after burn]. 1999 Zhonghua Yi Xue Za Zhi pmid:11601022
Yu P et al. [A study on changes and its mechanisms of intestinal mucosal permeability after severe burn]. 1996 Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi pmid:9387456
Liu Y et al. [The role and significance of PAF in the early pulmonary injury following burns combined with endotoxemia in rats]. 1999 Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi pmid:11501075
Stoddart NR et al. Exogenous platelet-activating factor stimulates cell proliferation in mouse pre-implantation embryos prior to the fourth cell cycle and shows isoform-specific stimulatory effects. 2001 Zygote pmid:11510473