Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Archer SL and Roudebush WE | Enhancement of sperm motility using pentoxifylline and platelet-activating factor. | 2013 | Methods Mol. Biol. | pmid:22992918 |
Flasiński M et al. | Interactions between single-chained ether phospholipids and sphingomyelin in mixed monolayers at the air/water interface-Grazing incidence X-ray diffraction and Brewster angle microscopy studies. | 2013 | Colloids Surf B Biointerfaces | pmid:23777791 |
Grotta MB et al. | Obesity increases eosinophil activity in asthmatic children and adolescents. | 2013 | BMC Pulm Med | pmid:23773659 |
Zhou Z et al. | Chemical constituents of Callicarpa nudiflora and their anti-platelet aggregation activity. | 2013 | Fitoterapia | pmid:23669034 |
Wang TM et al. | Alkyl and phenolic glycosides from Saussurea stella. | 2013 | Fitoterapia | pmid:23567860 |
Hirayama F | Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment. | 2013 | Br. J. Haematol. | pmid:23215650 |
Harleton E et al. | Ability to induce atrial fibrillation in the peri-operative period is associated with phosphorylation-dependent inhibition of TWIK protein-related acid-sensitive potassium channel 1 (TASK-1). | 2013 | J. Biol. Chem. | pmid:23229553 |
Xu B et al. | Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers. | 2013 | Br. J. Cancer | pmid:23949154 |
Shi YM et al. | Lancolides, antiplatelet aggregation nortriterpenoids with tricyclo[6.3.0.0(2,11)]undecane-bridged system from Schisandra lancifolia. | 2013 | Org. Lett. | pmid:24059675 |
Kang JW et al. | Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans. | 2013 | Phytother Res | pmid:23296979 |