Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Coronary Thrombosis D003328 7 associated lipids
Ear Diseases D004427 7 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Klebsiella Infections D007710 7 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Conjunctivitis D003231 7 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Behcet Syndrome D001528 7 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Mucositis D052016 7 associated lipids
Bronchiectasis D001987 7 associated lipids
Agranulocytosis D000380 7 associated lipids
Sneezing D012912 6 associated lipids
Thrombophilia D019851 6 associated lipids
Gliosis D005911 6 associated lipids
Heart Injuries D006335 6 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Coronary Stenosis D023921 6 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Leishmaniasis, Cutaneous D016773 6 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Purpura, Thrombotic Thrombocytopenic D011697 6 associated lipids
Strongylida Infections D017206 5 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
Liver Failure D017093 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Spasm D013035 5 associated lipids
Osteonecrosis D010020 5 associated lipids
Colonic Diseases D003108 5 associated lipids
Shock, Cardiogenic D012770 5 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Brain Injuries D001930 4 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Thrombocytosis D013922 4 associated lipids
Cluster Headache D003027 4 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Thrombasthenia D013915 4 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Viremia D014766 4 associated lipids
Hyperuricemia D033461 4 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Burns, Inhalation D002059 4 associated lipids
Shock, Traumatic D012774 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
pmid:
pmid:3360596
Kelesidis T et al. The Role of Platelet-Activating Factor in Chronic Inflammation, Immune Activation, and Comorbidities Associated with HIV Infection. AIDS Rev pmid:26616844
pmid:9870780
Colwell JA et al. Platelet adhesion and aggregation in diabetes mellitus. 1979 Metab. Clin. Exp. pmid:122293
Benveniste J et al. [Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine]. 1979 C. R. Acad. Sci., D, Sci. Nat. pmid:121258
Namm DH and High JA Thrombin-induced formation of a polar lipid material within platelets that possesses platelet-activating activity. 1980 Thromb. Res. pmid:7209881
Tencé V et al. Release, purification, and characterization of platelet-activating factor (PAF). 1980 Biochimie pmid:17941181
Bussolino F and Benveniste J Pharmacological modulation of platelet-activating factor (PAF) release from rabbit leucocytes. I. Role of cAMP. 1980 Immunology pmid:6159308
Bussolino F and Camussi G Effect of prostacyclin on platelet-activating factor induced rabbit and platelet aggregation. 1980 Prostaglandins pmid:6258196
Vargaftig BB et al. Platelet-tissue interaction: role of platelet-activating factor (PAF-acether). 1980 Agents Actions pmid:7270336
Godfroid JJ et al. Platelet activating factor (PAF-acether): total synthesis of 1-O-octadecyl 2-O-acetyl sn-glycero-3-phosphoryl choline. 1980 FEBS Lett. pmid:7409144
Clark PO et al. Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils. 1980 Biochim. Biophys. Acta pmid:7357030
[Do you know PAF?]. 1980 Nouv Presse Med pmid:7367260
Farr RS et al. Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF). 1980 Clin. Immunol. Immunopathol. pmid:7371225
McManus LM et al. Pathobiology of the intravenous infusion of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), in the rabbit. 1980 J. Immunol. pmid:7373056
Cusack NJ Platelet-activating factor. 1980 Nature pmid:7374771
Hanahan DJ et al. Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine. 1980 J. Biol. Chem. pmid:7380824
Pirotzky E et al. [Release of platelet activating factor (P.A.F.-acether) by isolated perfused rat kidney]. 1980 C. R. Acad. Sci., D, Sci. Nat. pmid:6772322
Chignard M et al. Platelet-activating factor (PAF-acether) secretion from platelets: effect of aggregating agents. 1980 Br. J. Haematol. pmid:6778498
Vargaftig BB et al. One, two, three or more pathways for platelet aggregation. 1980 Acta Med. Scand. Suppl. pmid:6779505
Arnoux B et al. Release of platelet-activating factor (PAF-acether) from alveolar macrophages by the calcium ionophore A23187 and phagocytosis. 1980 Eur. J. Clin. Invest. pmid:6788561
Halonen M et al. Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. 1980 Am. Rev. Respir. Dis. pmid:7458063
Kirchmaier CM et al. A platelet stimulating fraction in human and animal tissues. 1980 Artery pmid:6971084
Shaw JO and Henson PM The binding of rabbit basophil-derived platelet-activating factor to rabbit platelets. 1980 Am. J. Pathol. pmid:6987890
Vargaftig BB et al. Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives. 1980 Eur. J. Pharmacol. pmid:6995139
Pinckard RN et al. Molecular pathobiology of acetyl glyceryl ether phosphorylcholine: evidence for the structural and functional identity with platelet-activating factor. 1980 J Reticuloendothel Soc pmid:7003140
Polonsky J et al. Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl platelet-activating factor, from leukocytes: chemical ionization mass spectrometry of phospholipids. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6938950
Check WA A new age in asthma research: study of chemical mediators. 1980 Aug 22-29 JAMA pmid:6104737
Suzuki K et al. The influence of 2-mercaptoethanol on von Willebrand factor and bovine platelet aggregating factor. 1980 Feb 1-15 Thromb. Res. pmid:6966083
Chignard M et al. [Platelet aggregation and platelet activating factor (author's transl)]. 1980 Oct-Dec J Pharmacol pmid:7206730
Camussi G et al. Platelet-activating factor (PAF), a mediator of platelet aggregation. Effect of corticosteroids on PAF-induced platelet aggregation. 1980 Oct-Dec Minerva Nefrol pmid:7254682
Shaw JO et al. Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). 1981 Biochim. Biophys. Acta pmid:7213765
Renooij W and Snyder F Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues. 1981 Biochim. Biophys. Acta pmid:6260215
Mencia-Huerta JM and Benveniste J Platelet-activating factor (PAF-acether) and macrophages. II. Phagocytosis-associated release of PAF-acether from rat peritoneal macrophages. 1981 Cell. Immunol. pmid:6260384
Shaw JO et al. Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor). 1981 J. Immunol. pmid:6267133
Slauson DO and Sanchez-Vizcaino JM Leukocyte-dependent platelet vasoactive amine release and immune complex deposition in African swine fever. 1981 Vet. Pathol. pmid:6170156
O'Donnell MC and Fiedel BA Histamine secretion from human leucocytes stimulated by basophil-derived platelet-activating factor. 1981 Scand. J. Immunol. pmid:6171870
O'Flaherty JT et al. Evidence for 5, 12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation. 1981 Biochem. Biophys. Res. Commun. pmid:6277309
Wykle RL et al. Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils. 1981 Biochem. Biophys. Res. Commun. pmid:7295320
O'Flaherty JT et al. Neutrophil responses to platelet-activating factor. 1981 Inflammation pmid:7298160
Blank ML et al. In vivo metabolism of a new class of biologically active phospholipids: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a platelet activating-hypotensive phospholipid. 1981 Life Sci. pmid:7300575
Satouchi K et al. Influence of alkyl ether chain length of acetyl glyceryl ether phosphorylcholine and its ethanolamine analog on biological activity toward rabbit platelets. 1981 Arch. Biochem. Biophys. pmid:7305392
Gil MG et al. Inhibition of phospholipid methyltransferase during zymosan induced secretion of platelet-activating factor in human polymorphonuclear leukocytes. 1981 Biochem. Biophys. Res. Commun. pmid:7306113
Mencia-Huerta JM et al. Release of a slow-reacting substance from rabbit platelets. 1981 J. Clin. Invest. pmid:6119324
Vargaftig BB et al. Present concepts on the mechanisms of platelet aggregation. 1981 Biochem. Pharmacol. pmid:7011325
Colwell JA Studies on the pathogenesis of diabetic vascular disease. 1981 J S C Med Assoc pmid:7022022
Wintroub BU and Soter NA Biology of the mast cell and its role in cutaneous inflammation. 1981 Springer Semin. Immunopathol. pmid:7022722
Vargaftig BB et al. Background and present status of research on platelet-activating factor (PAF-acether). 1981 Ann. N. Y. Acad. Sci. pmid:7023317
Heymans F et al. New total synthesis and high resolution 1H NMR spectrum of platelet-activating factor, its enantiomer and racemic mixtures. 1981 Biochim. Biophys. Acta pmid:7306563