Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Bronchiectasis D001987 7 associated lipids
Agranulocytosis D000380 7 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Rheumatic Diseases D012216 7 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Ear Diseases D004427 7 associated lipids
Pelvic Pain D017699 7 associated lipids
Postoperative Hemorrhage D019106 7 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Klebsiella Infections D007710 7 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Conjunctivitis D003231 7 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Purpura, Thrombotic Thrombocytopenic D011697 6 associated lipids
Sneezing D012912 6 associated lipids
Thrombophilia D019851 6 associated lipids
Gliosis D005911 6 associated lipids
Heart Injuries D006335 6 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Coronary Stenosis D023921 6 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Blood Loss, Surgical D016063 6 associated lipids
Leishmaniasis, Cutaneous D016773 6 associated lipids
Shock, Cardiogenic D012770 5 associated lipids
Strongylida Infections D017206 5 associated lipids
Liver Failure D017093 5 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Spasm D013035 5 associated lipids
Osteonecrosis D010020 5 associated lipids
Colonic Diseases D003108 5 associated lipids
Shock, Traumatic D012774 4 associated lipids
Hypertrophy, Right Ventricular D017380 4 associated lipids
Hepatitis B, Chronic D019694 4 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Milk Hypersensitivity D016269 4 associated lipids
Brain Injuries D001930 4 associated lipids
Cluster Headache D003027 4 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Thrombasthenia D013915 4 associated lipids
Thrombocytosis D013922 4 associated lipids
Optic Nerve Injuries D020221 4 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Hyperuricemia D033461 4 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Viremia D014766 4 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Straube W [Early embryonal signals]. 1989 Zentralbl Gynakol pmid:2665388
Straube W [Which signals of early pregnancy are known currently, what cer- tainty have they and exactly how far are they applicable in practice?]. 1989 Zentralbl Gynakol pmid:2655355
Marzi I et al. [Involvement of platelet activating factors in pathologic leukocyte-endothelium interactions in the liver after hemorrhagic shock]. 1994 Zentralbl Chir pmid:7846961
Uhlmann D et al. Importance of microcirculatory disturbances in the pathogenesis of pancreatitis. 2001 Zentralbl Chir pmid:11753796
Becker BF et al. [Interaction of adenosine with leukocytes and thrombocytes]. 1996 Z Kardiol pmid:9064961
Krämer K et al. Studies on the metabolism of metallothionein and alkaline phosphatase of adult rat primary hepatocyte cultures: role of fetal calf serum and agonists of the phosphoinositide cascade. 1993 Z Ernahrungswiss pmid:8237077
Li SH et al. Effects of platelet-activating factor antagonist SRI 63-441 on endotoxin-induced changes in rat mesenteric microcirculation. 1991 Yao Xue Xue Bao pmid:1887797
Han GQ et al. [The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim]. 1989 Yao Xue Xue Bao pmid:2609983
Han GQ et al. [Neolignans from Piper hancei Maxim]. 1986 Yao Xue Xue Bao pmid:3776545
Cheng NN et al. [The composition of phospholipid and biosynthesis of platelet-activating factor in earthworm (Eisenia foetida)]. 1992 Yao Xue Xue Bao pmid:1299136
Ju DW et al. [Leflunomide inhibits PAF induced DNA synthesis in rabbit synovial cells and PAF production from rat peritoneal macrophages]. 1994 Yao Xue Xue Bao pmid:8042517
Hu JH et al. [Effects of calcimycin on platelet adhesion to cultured bovine cerebral microvascular endothelial cells and its antagonism by drugs]. 1994 Yao Xue Xue Bao pmid:7976350
Zeng GQ et al. Effects of dauricine and tetrandrine on [3H] WEB 2086 specific binding to bovine anterior cerebral arterial smooth muscle cells in vitro. 1993 Yao Xue Xue Bao pmid:8285049
Ma Y et al. [Studies on PAF antagonistic bicyclo(3,2,1) octanoid neolignans from Piper kadsura]. 1993 Yao Xue Xue Bao pmid:8368081
Peng SY et al. [Effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes]. 2010 Yao Xue Xue Bao pmid:21351565
Zhang LL et al. [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. 2007 Yao Xue Xue Bao pmid:17520822
Zang BX et al. [Antagonistic effect of myricetin on platelet activing factor]. 2003 Yao Xue Xue Bao pmid:14991995
Nie ZG et al. [Effects of ginkgolide B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes]. 2004 Yao Xue Xue Bao pmid:15491096
Ou-Yang XY et al. [Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation]. 2005 Yao Xue Xue Bao pmid:16011257
Peng SY et al. Effect of ginkgolide B on the platelet-activating factor induced changes of chemotaxis and cytoskeleton of macrophages. 2006 Yao Xue Xue Bao pmid:16671547