Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Handa RK et al. | Selective inhibition of vasoconstrictor responses by platelet-activating factor in rat kidney. | 1991 | Am. J. Physiol. | pmid:1907104 |
Macconi D et al. | PAF mediates neutrophil adhesion to thrombin or TNF-stimulated endothelial cells under shear stress. | 1995 | Am. J. Physiol. | pmid:7631759 |
Kubes P et al. | Excess nitric oxide does not cause cellular, vascular, or mucosal dysfunction in the cat small intestine. | 1995 | Am. J. Physiol. | pmid:7631799 |
Nakao A et al. | cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells. | 1997 | Am. J. Physiol. | pmid:9321918 |
Garland A et al. | Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. | 1997 | Am. J. Physiol. | pmid:9374740 |
Rizzo A et al. | Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A2. | 1995 | Am. J. Physiol. | pmid:7771545 |
Olson NC et al. | Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs. | 1993 | Am. J. Physiol. | pmid:8460710 |
Haller H et al. | Endothelin increases [Ca2+]i, protein phosphorylation, and O2-. production in human alveolar macrophages. | 1991 | Am. J. Physiol. | pmid:1662920 |
Schlondorff D and Neuwirth R | Platelet-activating factor and the kidney. | 1986 | Am. J. Physiol. | pmid:3089026 |
Sasaki T et al. | Platelet-activating factor increases platelet-dependent glycoconjugate secretion from tracheal submucosal gland. | 1989 | Am. J. Physiol. | pmid:2692465 |
Tamaoki J et al. | Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways. | 1999 | Am. J. Physiol. | pmid:9950898 |
Brock TA and Gimbrone MA | Platelet activating factors alters calcium homeostasis in cultured vascular endothelial cells. | 1986 | Am. J. Physiol. | pmid:3717361 |
Kinnula VL et al. | Release of reactive oxygen species by guinea pig tracheal epithelial cells in vitro. | 1992 | Am. J. Physiol. | pmid:1616055 |
Mori N et al. | Ischemia-reperfusion induced microvascular responses in LDL-receptor -/- mice. | 1999 | Am. J. Physiol. | pmid:10330250 |
Kurtel H et al. | Mechanisms of oxidized chylomicron-induced leukocyte-endothelial cell adhesion. | 1995 | Am. J. Physiol. | pmid:7541957 |
Wallace JL et al. | Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach. | 1989 | Am. J. Physiol. | pmid:2650567 |
Koyama S et al. | Human lung fibroblasts release chemokinetic activity for monocytes constitutively. | 1998 | Am. J. Physiol. | pmid:9700081 |
Feuerstein G et al. | Effect of platelet-activating factor on coronary circulation of the domestic pig. | 1984 | Am. J. Physiol. | pmid:6703081 |
Perico N et al. | Platelet-activating factor alters glomerular barrier size selectivity for macromolecules in rats. | 1991 | Am. J. Physiol. | pmid:1713421 |
Wang J and Dunn MJ | Platelet-activating factor mediates endotoxin-induced acute renal insufficiency in rats. | 1987 | Am. J. Physiol. | pmid:2827506 |
Kornecki E and Ehrlich YH | Diminished responsiveness of human platelets to platelet-activating factor during pregnancy. | 1990 | Am. J. Physiol. | pmid:2396687 |
Merendino N et al. | Human intestinal epithelial cells express receptors for platelet-activating factor. | 1999 | Am. J. Physiol. | pmid:10516147 |
Stahl GL et al. | Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. | 1997 | Am. J. Physiol. | pmid:9227410 |
Kubes P et al. | Platelet-activating factor-induced microvascular dysfunction: role of adherent leukocytes. | 1990 | Am. J. Physiol. | pmid:2301577 |
Chang SW et al. | Beneficial effect of a platelet-activating factor antagonist, WEB 2086, on endotoxin-induced lung injury. | 1990 | Am. J. Physiol. | pmid:2301603 |
Rainger GE et al. | Adhesion of flowing neutrophils to cultured endothelial cells after hypoxia and reoxygenation in vitro. | 1995 | Am. J. Physiol. | pmid:7485573 |
Pique JM et al. | Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF. | 1990 | Am. J. Physiol. | pmid:2316650 |
Kubes P et al. | Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence. | 1990 | Am. J. Physiol. | pmid:2166441 |
Harris AG et al. | Mechanisms of cell injury in rat mesentery and cremaster muscle. | 1998 | Am. J. Physiol. | pmid:9530215 |
Chami O et al. | Components of a platelet-activating factor-signaling loop are assembled in the ovine endometrium late in the estrous cycle. | 2004 | Am. J. Physiol. Endocrinol. Metab. | pmid:15271646 |
Cheng L et al. | A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19773578 |
Parkman HP et al. | The contractile action of platelet-activating factor on gallbladder smooth muscle. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10898747 |
Ma J et al. | ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21960521 |
Guarino MP et al. | PAF-like lipids- and PAF-induced gallbladder muscle contraction is mediated by different pathways in guinea pigs. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12936911 |
Si J et al. | STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17947454 |
Cheng L et al. | Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15890711 |
Wang GD et al. | Platelet-activating factor in the enteric nervous system of the guinea pig small intestine. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17030900 |
Claud EC et al. | Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18339705 |
Liu SX et al. | Platelet-activating factor induces the processing of nuclear factor-kappaB p105 into p50, which mediates acute bowel injury in mice. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19460845 |
Lu J et al. | Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14512286 |
Rozenfeld RA et al. | Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11557516 |
Cheng L et al. | HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19389802 |
Lautenschläger I et al. | A model of the isolated perfused rat small intestine. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19910525 |
Lu J et al. | Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18356536 |
Ma J et al. | Signaling in TRPV1-induced platelet activating factor (PAF) in human esophageal epithelial cells. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19959817 |
Han XB et al. | Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15319184 |
Rieder F et al. | Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20299604 |
Oktar BK et al. | Endothelin-1-induced PMN infiltration and mucosal dysfunction in the rat small intestine. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10960346 |
Sánchez FA et al. | Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18708444 |
Zhou X and He P | Temporal and spatial correlation of platelet-activating factor-induced increases in endothelial [Ca²âº]i, nitric oxide, and gap formation in intact venules. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21873500 |
Ajiro Y et al. | Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21949111 |
Curry FE et al. | Thrombin increases permeability only in venules exposed to inflammatory conditions. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12893636 |
Zhu L and He P | Platelet-activating factor increases endothelial [Ca2+]i and NO production in individually perfused intact microvessels. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15665052 |
Barbuti A et al. | Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003807 |
Mayer K et al. | Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12124231 |
Finnegan EM et al. | Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17483236 |
Owaki T et al. | Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10644608 |
Zhou W et al. | Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17322418 |
Adamson RH et al. | Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18178724 |
He P et al. | Leukocyte-platelet aggregate adhesion and vascular permeability in intact microvessels: role of activated endothelial cells. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16517944 |
Ibe BO et al. | Platelet-activating factor receptors in lamb lungs are downregulated immediately after birth. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10749711 |
Haynes J and Obiako B | Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11748055 |
Shigematsu S et al. | Bradykinin-induced proinflammatory signaling mechanisms. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388246 |
Leary PJ et al. | A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441203 |
Minnear FL et al. | Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15778280 |
Thom SR et al. | Roles for platelet-activating factor and *NO-derived oxidants causing neutrophil adherence after CO poisoning. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11454599 |
Juchem G et al. | Regulation of coronary venular barrier function by blood borne inflammatory mediators and pharmacological tools: insights from novel microvascular wall models. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22081707 |
Penna C et al. | Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15637120 |
Sánchez FA et al. | Functional significance of differential eNOS translocation. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16679407 |
Adamson RH et al. | PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12649070 |
Zhu L et al. | Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12946927 |
Guequén A et al. | S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26921435 |
Jiang Y et al. | Three-dimensional localization and quantification of PAF-induced gap formation in intact venular microvessels. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18515648 |
Lee YM et al. | Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893205 |
Sharma J et al. | Lung endothelial cell platelet-activating factor production and inflammatory cell adherence are increased in response to cigarette smoke component exposure. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:21984569 |
Bixby CE et al. | Role of platelet-activating factor in pulmonary vascular remodeling associated with chronic high altitude hypoxia in ovine fetal lambs. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17951313 |
Grimminger F et al. | PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666110 |
Tavakoli S et al. | Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133502 |
Kwan ML et al. | Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159008 |
Rastogi P et al. | Tryptase activates calcium-independent phospholipase A2 and releases PGE2 in airway epithelial cells. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18790994 |
Komori M et al. | PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159026 |
Rose F et al. | E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893208 |
Koyama S et al. | The potential of various lipopolysaccharides to release IL-8 and G-CSF. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10749742 |
Blanchet MR et al. | Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16782754 |
Martin C et al. | Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15064228 |
Bouayad A et al. | Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14715488 |
Alloatti G et al. | Role of NO and PAF in the impairment of skeletal muscle contractility induced by TNF-alpha. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11080081 |
Ivanov AI et al. | Albumin is not an irreplaceable carrier for amphipathic mediators of thermoregulatory responses to LPS: compensatory role of alpha1-acid glycoprotein. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15576666 |
Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
Reeves SR and Gozal D | Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15087283 |
Handa RK et al. | Platelet-activating factor and solute transport processes in the kidney. | 2003 | Am. J. Physiol. Renal Physiol. | pmid:12529272 |
Meyer MC et al. | Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:16079184 |
Elzi DJ et al. | Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11401859 |
McHowat J et al. | Platelet-activating factor and metastasis: calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21228317 |
Dinubile MJ | Plasma gelsolin: in search of its raison d'etre. Focus on "Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin". | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17428843 |
Eckels PC et al. | Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19295175 |
Fazal N et al. | PAF receptor antagonist modulates neutrophil responses with thermal injury in vivo. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11546669 |
Osborn TM et al. | Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17135294 |
Meyer MC et al. | Calcium-independent phospholipase A2 is regulated by a novel protein kinase C in human coronary artery endothelial cells. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15643055 |
Kaul DK et al. | Peptides based on alphaV-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation. | 2006 | Am. J. Physiol., Cell Physiol. | pmid:16738001 |