Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Nordin N et al. | Platelet-activating factor (PAF) receptor binding activity of the roots of Enicosanthellum pulchrum. | 2012 | Pharm Biol | pmid:22103812 |
Tanaka Y et al. | Stimulation of Ly-6G on neutrophils in LPS-primed mice induces platelet-activating factor (PAF)-mediated anaphylaxis-like shock. | 2012 | J. Leukoc. Biol. | pmid:22131343 |
Shi W et al. | The nondepolarizing, normokalemic cardioplegia formulation adenosine-lidocaine (adenocaine) exerts anti-neutrophil effects by synergistic actions of its components. | 2012 | J. Thorac. Cardiovasc. Surg. | pmid:22079877 |
Detopoulou P et al. | PAF and its metabolic enzymes in healthy volunteers: interrelations and correlations with basic characteristics. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22079887 |
Pawlowic MC and Zhang K | Leishmania parasites possess a platelet-activating factor acetylhydrolase important for virulence. | 2012 | Mol. Biochem. Parasitol. | pmid:22954769 |
Nitoda E et al. | Ocular actions of platelet-activating factor: clinical implications. | 2012 | Expert Opin. Ther. Targets | pmid:22924390 |
Sahu RP et al. | Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis. | 2012 | Carcinogenesis | pmid:22223848 |
Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. | 2012 | Vet. Immunol. Immunopathol. | pmid:22226550 |
Dumas E et al. | Angiopoietin-1 but not angiopoietin-2 promotes neutrophil viability: Role of interleukin-8 and platelet-activating factor. | 2012 | Biochim. Biophys. Acta | pmid:22198097 |
López-Sagaseta J et al. | sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove. | 2012 | Blood | pmid:22167755 |
Park J et al. | Females with angina pectoris have altered lipoprotein metabolism with elevated cholesteryl ester transfer protein activity and impaired high-density lipoproteins-associated antioxidant enzymes. | 2012 | Int. J. Mol. Med. | pmid:22211242 |
Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE3 on human platelet function. | 2012 | Thromb. Haemost. | pmid:22318645 |
Xu LF et al. | Protective effect of intestinal trefoil factor on injury of intestinal epithelial tight junction induced by platelet activating factor. | 2012 | Inflammation | pmid:21452036 |
Zhang XT et al. | [Study on the pharmacokinetics of ginkgolide B for injection in rats]. | 2012 | Zhong Yao Cai | pmid:22876684 |
Flamm MH et al. | Multiscale prediction of patient-specific platelet function under flow. | 2012 | Blood | pmid:22517902 |
Kim HA et al. | PTEN/MAPK pathways play a key role in platelet-activating factor-induced experimental pulmonary tumor metastasis. | 2012 | FEBS Lett. | pmid:23137704 |
Jiang Z et al. | The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. | 2012 | Respir. Res. | pmid:23140447 |
Tsoupras AB et al. | Platelet-activating factor and its basic metabolic enzymes in blood of naive HIV-infected patients. | 2012 | Angiology | pmid:21948973 |
Juchem G et al. | Regulation of coronary venular barrier function by blood borne inflammatory mediators and pharmacological tools: insights from novel microvascular wall models. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22081707 |
Oh SF et al. | Resolvin E2 formation and impact in inflammation resolution. | 2012 | J. Immunol. | pmid:22450811 |