Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li SQ et al. | Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrewa. | 2007 | Chin. Med. J. | pmid:17908463 |
| Wang S et al. | Opposite effects of WEB2086 on angiogenesis in atheromas and ischemic hindlimb of apoE gene deficient mice. | 2007 | Chin. Med. J. | pmid:17543178 |
| Kulkarni S et al. | Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading. | 2007 | Blood | pmid:17548580 |
| Zhang LL et al. | [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. | 2007 | Yao Xue Xue Bao | pmid:17520822 |
| Witzenrath M et al. | Role of platelet-activating factor in pneumolysin-induced acute lung injury. | 2007 | Crit. Care Med. | pmid:17522574 |
| Keles GC et al. | Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery. | 2007 | Clin Oral Investig | pmid:17522901 |
| Simonenko VB et al. | [Comparative evaluation of the influence of sulfhydryl and phosphate ACE inhibitors on thrombocyte aggregation in patients suffering from atrerial hypertension with metabolic syndrome]. | 2007 | Klin Med (Mosk) | pmid:17564032 |
| Li Y et al. | Autocrine activation of ion currents in the two-cell mouse embryo. | 2007 | Exp. Cell Res. | pmid:17583695 |
| Martin J et al. | The dialogue between endothelial cells and monocytes/macrophages in vascular syndromes. | 2007 | Curr. Pharm. Des. | pmid:17584105 |
| Ferreira MA et al. | Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF). | 2007 | Life Sci. | pmid:17588613 |
| Zhao W et al. | [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180114 |
| Huang QY and Li MJ | [Effect of platelet-activating factor on sperm function]. | 2007 | Zhonghua Nan Ke Xue | pmid:17615981 |
| Orr Y et al. | Conformational activation of CD11b without shedding of L-selectin on circulating human neutrophils. | 2007 | J. Leukoc. Biol. | pmid:17675559 |
| Bozlu G et al. | Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. | 2007 | Brain Res. | pmid:17320823 |
| Zhou W et al. | Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17322418 |
| Tsutsumi T et al. | Movement of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcine kidney epithelial cell line LLC-PK1. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259070 |
| Viergutz T and Löhrke B | Role of the platelet-activating factor and its receptor in the proliferative regulation of bovine ovarian granulosa cells. | 2007 | Cell Prolif. | pmid:18021181 |
| Chen Q et al. | The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover. | 2007 | FEBS Lett. | pmid:17996202 |
| Ezoulin MJ et al. | A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine. | 2007 | Int. Immunopharmacol. | pmid:17996678 |
| Li J et al. | Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity. | 2007 | Int. J. Neuropsychopharmacol. | pmid:16426477 |
| Bock J et al. | Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function. | 2007 | World J. Gastroenterol. | pmid:17876892 |
| Ryan SD et al. | Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. | 2007 | J. Neurochem. | pmid:17877634 |
| Madsen NJ et al. | Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents. | 2007 | Am. J. Cardiol. | pmid:17697836 |
| Tsoupras AB et al. | Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells. | 2007 | Mediators Inflamm. | pmid:17710109 |
| Melnikova V and Bar-Eli M | Inflammation and melanoma growth and metastasis: the role of platelet-activating factor (PAF) and its receptor. | 2007 | Cancer Metastasis Rev. | pmid:17721743 |
| Lo GK et al. | What is the potential for overdiagnosis of heparin-induced thrombocytopenia? | 2007 | Am. J. Hematol. | pmid:17722079 |
| Chen J et al. | Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. | 2007 | J. Lipid Res. | pmid:17693621 |
| Kuckleburg CJ et al. | Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation. | 2007 | Infect. Immun. | pmid:17118985 |
| Ibe BO et al. | Platelet-activating factor modulates activity of cyclic nucleotides in fetal ovine pulmonary vascular smooth muscle. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17085546 |
| Ali A et al. | Essential role of platelet-activating factor in male reproduction: a review. | 2007 | Reprod. Biomed. Online | pmid:17298732 |
| Subbotina LA | [Procedure of blood agregation system analysis]. | 2006 Sep-Oct | Aviakosm Ekolog Med | pmid:17357632 |
| Givehchi A et al. | Analysis of activity space by fragment fingerprints, 2D descriptors, and multitarget dependent transformation of 2D descriptors. | 2006 May-Jun | J Chem Inf Model | pmid:16711727 |
| Lang F et al. | Osmotic shock-induced suicidal death of erythrocytes. | 2006 May-Jun | Acta Physiol (Oxf) | pmid:16734755 |
| Zhu T et al. | Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. | 2006 Mar-Apr | Can. J. Physiol. Pharmacol. | pmid:16902584 |
| Gu Y et al. | PAF levels and PAF-AH activities in placentas from normal and preeclamptic pregnancies. | 2006 Jun-Jul | Placenta | pmid:16122793 |
| Lang F et al. | Mechanisms and significance of eryptosis. | 2006 Jul-Aug | Antioxid. Redox Signal. | pmid:16910766 |
| Vasques E et al. | Impairment of endothelium-dependent aorta relaxation by phospholipid components of oxidized low-density lipoprotein. | 2006 Jan-Feb | Endothelium | pmid:16885061 |
| Flamand N et al. | Effects of pyrrophenone, an inhibitor of group IVA phospholipase A2, on eicosanoid and PAF biosynthesis in human neutrophils. | 2006 | Br. J. Pharmacol. | pmid:16967052 |
| Heinrich S et al. | Evidence-based treatment of acute pancreatitis: a look at established paradigms. | 2006 | Ann. Surg. | pmid:16432347 |
| Ezoulin MJ et al. | Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment. | 2006 | Toxicol In Vitro | pmid:16472967 |
| Dianzani C et al. | Evaluation of in-vitro anti-inflammatory activity of some 2-alkyl-4,6-dimethoxy-1,3,5-triazines. | 2006 | J. Pharm. Pharmacol. | pmid:16451750 |
| Slomiany BL and Slomiany A | Leptin modulates the detrimental effect of Porphyromonas gingivalis lipopolysaccharide-induced cytosolic phospholipase A2 activation on salivary mucin synthesis via ERK-signal transduction. | 2006 | Inflammopharmacology | pmid:17093905 |
| Kaneko MK et al. | Conservation of a platelet activating domain of Aggrus/podoplanin as a platelet aggregation-inducing factor. | 2006 | Gene | pmid:16766141 |
| De Plaen IG et al. | Lipopolysaccharide induces CXCL2/macrophage inflammatory protein-2 gene expression in enterocytes via NF-kappaB activation: independence from endogenous TNF-alpha and platelet-activating factor. | 2006 | Immunology | pmid:16771850 |
| Karabina SA and Ninio E | Plasma PAF-acetylhydrolase: an unfulfilled promise? | 2006 | Biochim. Biophys. Acta | pmid:16807087 |
| Cheng L et al. | Acid-induced release of platelet-activating factor by human esophageal mucosa induces inflammatory mediators in circular smooth muscle. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16807360 |
| Fragopoulou E et al. | Platelet-activating factor (PAF) increase intracellular lipid accumulation by increasing both LDL and scavenger receptors in human mesangial cells. | 2006 | J. Lab. Clin. Med. | pmid:16750665 |
| Melnikova VO et al. | Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis. | 2006 | J. Biol. Chem. | pmid:16306050 |
| Waschke J et al. | Activation of Rac-1 and Cdc42 stabilizes the microvascular endothelial barrier. | 2006 | Histochem. Cell Biol. | pmid:16195887 |
| Kushikata T et al. | Platelet activating factor and its metabolite promote sleep in rabbits. | 2006 | Neurosci. Lett. | pmid:16263215 |