Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| O'Flaherty JT et al. | Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents. | 1981 | Am. J. Pathol. | pmid:6274199 |
| McManus LM et al. | Human platelet stimulation by acetyl glyceryl ether phosphorylcholine. | 1981 | J. Clin. Invest. | pmid:7204562 |
| Mencia-Huerta JM et al. | Is platelet-activating factor (PAF-acether) synthesis by murine peritoneal cells (PC) a two-step process? | 1981 | Agents Actions | pmid:7053072 |
| Camussi G et al. | Release of platelet-activating factor (PAF) and histamine. II. The cellular origin of human PAF: monocytes, polymorphonuclear neutrophils and basophils. | 1981 | Immunology | pmid:6161885 |
| Benveniste J | Platelet-activating factor (PAF-acether): present status. | 1981 | Agents Actions | pmid:6176101 |
| Metcalfe DD et al. | The mast cell. | 1981 | Crit. Rev. Immunol. | pmid:6178551 |
| Satouchi K et al. | Modification of the polar head group of acetyl glyceryl ether phosphorylcholine and subsequent effects upon platelet activation. | 1981 | J. Biol. Chem. | pmid:7217088 |
| O'Flaherty JT et al. | 1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants. | 1981 | Am. J. Pathol. | pmid:7223864 |
| Hanahan DJ et al. | Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7236259 |
| Cox CP et al. | The presence of platelet-activating factor (PAF) in normal human mixed saliva. | 1981 | J. Immunol. | pmid:7240750 |
| O'Donnell MC et al. | Platelet activating factor: an inhibitor of neutrophil activation? | 1981 | Clin. Exp. Immunol. | pmid:7249391 |
| Findlay SR et al. | Contraction of guinea pig ileal smooth muscle by acetyl glyceryl ether phosphorylcholine. | 1981 | Am. J. Physiol. | pmid:7282914 |
| Demopoulos CA et al. | Intravascular pathobiology of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF). I. Intravenous infusion in guinea pigs. | 1981 | Immunol. Lett. | pmid:7287060 |
| Halonen M et al. | Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. | 1981 | Am. Rev. Respir. Dis. | pmid:7294504 |
| Pinckard RN et al. | Acetyl glyceryl ether phosphorylcholine: platelet-activating factor. | 1981 | Int. Arch. Allergy Appl. Immunol. | pmid:7309256 |
| Czarnetzki BM and Muramatsu T | Saturated and unsaturated 1-O-alkyl-2-O-acetoyl-sn-glycero-3-phosphocholines derived from ratfish liver oil: effect on human leukocyte migration. | 1981 | Chem. Phys. Lipids | pmid:7318048 |
| Czarnetzki BM and Benveniste J | Effect of 1-O-octadecyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF-acether) on leukocytes I. Analysis of the in vitro migration of human neutrophils. | 1981 | Chem. Phys. Lipids | pmid:7318049 |
| Bonnet J et al. | Platelet-activating factor acether (PAF-acether) involvement in acute inflammatory and pain processes. | 1981 | Agents Actions | pmid:7340441 |
| Denjean A et al. | Bronchoconstriction induced by intratracheal administration of platelet-activating factor (PAF-acether) in baboons. | 1981 | Agents Actions | pmid:7340444 |
| Marcus AJ et al. | Effects of acetyl glyceryl ether phosphorylcholine on human platelet function in vitro. | 1981 | Blood | pmid:6457658 |
| Deguchi K et al. | [Blood platelet aggregation]. | 1981 | Nippon Rinsho | pmid:6461781 |
| O'Flaherty JT et al. | Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. | 1981 | Am. J. Pathol. | pmid:6271016 |
| Lee TC et al. | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) stimulates calcium influx in rabbit platelets. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6797422 |
| Vargaftig BB and Ferreira SH | Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors. | 1981 | Braz. J. Med. Biol. Res. | pmid:6802210 |
| Perret BA et al. | Binding of bovine factor VIII-coated colloidal gold particles to receptors on platelet membranes. | 1981 | Agents Actions | pmid:6803540 |
| Furlan M et al. | Binding of colloidal gold granules, coated with bovine factor VIII, to human platelet membranes. | 1981 | Br. J. Haematol. | pmid:6786321 |
| Chap H et al. | Biosynthetic labelling of platelet activating factor from radioactive acetate by stimulated platelets. | 1981 | Nature | pmid:7453828 |
| Stimler NP et al. | Anaphylactic actions of platelet-activating factor. | 1981 | Am. J. Pathol. | pmid:6975043 |
| Benveniste J et al. | Platelet-activating factor (PAF-acether): molecular aspects of its release and pharmacological actions. | 1981 | Int. Arch. Allergy Appl. Immunol. | pmid:7030966 |
| Czarnetzki BM and Benveniste J | Effect of synthetic PAF-acether on human neutrophil function. | 1981 | Agents Actions | pmid:7041568 |
| Camussi G et al. | Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: the inhibitory effect of prostacyclin (PGI2). | 1981 | Agents Actions | pmid:7041569 |
| Karpatkin S et al. | Role of platelets in tumor cell metastases. | 1981 | Ann. N. Y. Acad. Sci. | pmid:6943955 |
| Henson PM and Betz SJ | Neutrophil and platelet interactions in "allergic" and inflammatory reactions: a role for acetyl glyceryl ether phosphorylcholine (platelet-activating factor). | 1981 | Kroc Found Ser | pmid:6947075 |
| Brown JE and Thuy LP | The binding of bovine platelet aggregating factor to human platelets. | 1981 Apr 1-15 | Thromb. Res. | pmid:7292446 |
| Camussi G et al. | Immune-induced leucopenia. A role for the aggregation of polymorphonuclear neutrophils in systemic lupus erythematosus (SLE). | 1981 Jul-Sep | Minerva Nefrol | pmid:7329598 |
| Camussi G et al. | In vitro spasmogenic effect of platelet-activating factor on rabbit lung tissue. | 1981 Jul-Sep | Panminerva Med | pmid:7335369 |
| De Clerck F and David JL | Pharmacological control of platelet and red blood cell function in the microcirculation. | 1981 Nov-Dec | J. Cardiovasc. Pharmacol. | pmid:6173539 |
| Wykle RL et al. | Platelet activating factor (1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine). Activity of analogs lacking oxygen at the 2-position. | 1982 | FEBS Lett. | pmid:7084476 |
| Sánchez-Crespo M et al. | Vascular actions of synthetic PAF-acether (a synthetic platelet-activating factor) in the rat: evidence for a platelet independent mechanism. | 1982 | Immunopharmacology | pmid:7085259 |
| Mueller HW et al. | Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids. | 1982 | Lipids | pmid:7087685 |
| Haslam RJ and Vanderwel M | Inhibition of platelet adenylate cyclase by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (platelet-activating factor). | 1982 | J. Biol. Chem. | pmid:6177688 |
| Page CP et al. | Platelet activation in asthma. | 1982 | N. Engl. J. Med. | pmid:7088080 |
| Vargaftig BB et al. | Degranulation of rabbit platelets with PAF-acether: a new procedure for unravelling the mode of action of platelet-activating substances. | 1982 | Thromb. Haemost. | pmid:7135345 |
| Sancho J et al. | The effect of the injection of a synthetic platelet-activating factor (PAF-acether) on the fate of IgG aggregates in mice. | 1982 | Immunology | pmid:7141463 |
| Sybertz EJ et al. | Studies on the interactions of acetyl glycerol ether phosphoryl choline with the sympathetic nervous system in rats. | 1982 | J. Pharmacol. Exp. Ther. | pmid:7143227 |
| Lüscher EF | The role of blood cells and of the vessel wall in the induction of intravascular coagulation. | 1982 | Klin. Wochenschr. | pmid:6750223 |
| Basran GS et al. | Cromoglycate (DSCG) inhibits responses to platelet-activating factor (PAF-acether) in man: an alternative mode of action for DSCG in asthma? | 1982 | Eur. J. Pharmacol. | pmid:6819153 |
| Shaw JO and Lyons RM | Requirements for different Ca2+ pools in the activation of rabbit platelets. I. release reaction and protein phosphorylation. | 1982 | Biochim. Biophys. Acta | pmid:6800409 |
| Aderka D et al. | Morphological platelet anomalies in thrombotic thrombocytopenic purpura. | 1982 | Acta Haematol. | pmid:6801893 |
| Hartung HP et al. | Stimulation of the oxidative burst in macrophages with platelet activating factor (PAF-acether). | 1982 | Agents Actions Suppl. | pmid:6960648 |