Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamauchi A et al. | Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. | 2014 | J. Immunol. Methods | pmid:24370750 |
| Zebrowska A et al. | Mediators of mast cells in bullous pemphigoid and dermatitis herpetiformis. | 2014 | Mediators Inflamm. | pmid:25400334 |
| Sahu RP et al. | Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. | 2014 | Cancer Res. | pmid:25304264 |
| Wu H et al. | Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. | 2014 | PLoS ONE | pmid:24671173 |
| Kaplanis M et al. | Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor. | 2014 | J. Inorg. Biochem. | pmid:24632342 |
| Mallet de Lima CD et al. | Central role of PAFR signalling in ExoU-induced NF-κB activation. | 2014 | Cell. Microbiol. | pmid:24612488 |
| Moschos MM et al. | In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration. | 2014 | Cutan Ocul Toxicol | pmid:24147947 |
| Abdulnour RE et al. | Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25369934 |
| Chou YI et al. | Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions. | 2014 | Biomarkers | pmid:25391885 |
| Rivera J et al. | Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. | 2014 | J. Biol. Chem. | pmid:24478317 |
| Kim KJ et al. | Platelet-activating factor enhances tumour metastasis via the reactive oxygen species-dependent protein kinase casein kinase 2-mediated nuclear factor-κB activation. | 2014 | Immunology | pmid:24628121 |
| Frazer CA | Heparin-induced thrombocytopenia. | 2013 Nov-Dec | Medsurg Nurs | pmid:24600938 |
| Muñoz-Cano R et al. | Platelet-activating factor nasal challenge induces nasal congestion and reduces nasal volume in both healthy volunteers and allergic rhinitis patients. | 2013 Mar-Apr | Am J Rhinol Allergy | pmid:23562190 |
| Archer SL and Roudebush WE | Enhancement of sperm motility using pentoxifylline and platelet-activating factor. | 2013 | Methods Mol. Biol. | pmid:22992918 |
| Flasiński M et al. | Interactions between single-chained ether phospholipids and sphingomyelin in mixed monolayers at the air/water interface-Grazing incidence X-ray diffraction and Brewster angle microscopy studies. | 2013 | Colloids Surf B Biointerfaces | pmid:23777791 |
| Grotta MB et al. | Obesity increases eosinophil activity in asthmatic children and adolescents. | 2013 | BMC Pulm Med | pmid:23773659 |
| Zhou Z et al. | Chemical constituents of Callicarpa nudiflora and their anti-platelet aggregation activity. | 2013 | Fitoterapia | pmid:23669034 |
| Wang TM et al. | Alkyl and phenolic glycosides from Saussurea stella. | 2013 | Fitoterapia | pmid:23567860 |
| Herndon B et al. | Urease and Helicobacter spp. antigens in pulmonary granuloma. | 2013 | J. Comp. Pathol. | pmid:22901429 |
| Nasopoulou C et al. | Hen egg yolk lipid fractions with antiatherogenic properties. | 2013 | Anim. Sci. J. | pmid:23480708 |
| Sato A et al. | An endothelin-3-related synthetic biotinylated pentapeptide as a novel inhibitor of platelet-activating factor. | 2013 | Eur. J. Pharmacol. | pmid:23792041 |
| Ayaz G et al. | The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor levels and coronary artery disease risk in Turkish population. | 2013 | Gene | pmid:23816407 |
| Yamazaki Y et al. | A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice. | 2013 | Biochem. Pharmacol. | pmid:23817078 |
| Xia SH et al. | Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. | 2013 | World J. Gastroenterol. | pmid:23840141 |
| Hirayama F | Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment. | 2013 | Br. J. Haematol. | pmid:23215650 |
| Harleton E et al. | Ability to induce atrial fibrillation in the peri-operative period is associated with phosphorylation-dependent inhibition of TWIK protein-related acid-sensitive potassium channel 1 (TASK-1). | 2013 | J. Biol. Chem. | pmid:23229553 |
| Detopoulou P et al. | Platelet activating factor in heart failure: potential role in disease progression and novel target for therapy. | 2013 | Curr Heart Fail Rep | pmid:23389700 |
| Wang HL et al. | Differential inhibitory effects of 2-azafluorenones on PI-PLC activation but not on PC-PLC- or PC-PLD-activation induced by histamine, PAF, PMA or A23187 in C6 glioma cells. | 2013 | Chin J Physiol | pmid:23347011 |
| Motoyama N et al. | Pain-releasing action of platelet-activating factor (PAF) antagonists in neuropathic pain animal models and the mechanisms of action. | 2013 | Eur J Pain | pmid:23355413 |
| Tsoupras AB et al. | Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor. | 2013 | J. Inorg. Biochem. | pmid:23318288 |
| Krause K et al. | Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation. | 2013 | Allergy | pmid:23320562 |
| Vanstreels L and Merk HF | [Value of in-vitro diagnostic tools after anaphylaxis]. | 2013 | Hautarzt | pmid:23385619 |
| Sato A and Ebina K | Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. | 2013 | Inflamm. Res. | pmid:23370722 |
| Singh P et al. | Platelet-activating factor (PAF)-antagonists of natural origin. | 2013 | Fitoterapia | pmid:23160091 |
| Costa M et al. | Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. | 2013 | Stem Cell Res | pmid:23164599 |
| Sirangelo I et al. | Amyloid toxicity and platelet-activating factor signaling. | 2013 | J. Cell. Physiol. | pmid:23169529 |
| Xu B et al. | Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers. | 2013 | Br. J. Cancer | pmid:23949154 |
| Alevizos M et al. | Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. | 2013 | Ann. Allergy Asthma Immunol. | pmid:24267366 |
| Cui H et al. | Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. | 2013 | J. Allergy Clin. Immunol. | pmid:24021572 |
| Flasiński M et al. | Cholesterol as a factor regulating the influence of natural (PAF and lysoPAF) vs synthetic (ED) ether lipids on model lipid membranes. | 2013 | Biochim. Biophys. Acta | pmid:23906729 |
| Lv XX et al. | Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. | 2013 | PLoS ONE | pmid:23869224 |
| Maziero AM et al. | Inhibition of human platelet aggregation by eosinophils. | 2013 | Life Sci. | pmid:23871985 |
| Borthakur A et al. | Lactobacillus acidophilus alleviates platelet-activating factor-induced inflammatory responses in human intestinal epithelial cells. | 2013 | PLoS ONE | pmid:24130731 |
| Predescu S et al. | Platelet activating factor-induced ceramide micro-domains drive endothelial NOS activation and contribute to barrier dysfunction. | 2013 | PLoS ONE | pmid:24086643 |
| Sahu RP et al. | Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. | 2013 | J. Immunol. | pmid:23355733 |
| Berman B and Cockerell CJ | Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. | 2013 | J. Am. Acad. Dermatol. | pmid:23228301 |
| Frost BL and Caplan MS | Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. | 2013 | Semin. Pediatr. Surg. | pmid:23611612 |
| Guerrero AT et al. | The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23187752 |
| Shi YM et al. | Lancolides, antiplatelet aggregation nortriterpenoids with tricyclo[6.3.0.0(2,11)]undecane-bridged system from Schisandra lancifolia. | 2013 | Org. Lett. | pmid:24059675 |
| Kang JW et al. | Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans. | 2013 | Phytother Res | pmid:23296979 |