Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Gastritis D005756 27 associated lipids
Fibrosis D005355 23 associated lipids
Fever D005334 35 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Extravasation of Diagnostic and Therapeutic Materials D005119 3 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Epilepsy D004827 35 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Encephalitis D004660 15 associated lipids
Edema D004487 152 associated lipids
Ear Diseases D004427 7 associated lipids
Dyslexia D004410 3 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Dictyocaulus Infections D004022 1 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Death, Sudden D003645 12 associated lipids
Cystitis D003556 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Coronary Disease D003327 70 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Contracture D003286 3 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Conjunctivitis D003231 7 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Colonic Diseases D003108 5 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Colitis D003092 69 associated lipids
Cluster Headache D003027 4 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Cholestasis D002779 23 associated lipids
Cholecystitis D002764 8 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Brain Ischemia D002545 89 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Burns, Inhalation D002059 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Kochanek PM et al. Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption. 1990 Adv. Exp. Med. Biol. pmid:2096640
Camussi G et al. Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions. 1990 Adv. Exp. Med. Biol. pmid:2096695
Paubert-Braquet M et al. Platelet-activating factor amplifies tumour necrosis factor-induced superoxide generation by human neutrophils. 1990 Adv. Exp. Med. Biol. pmid:2173875
Rabinovici R et al. PAF and TNF alpha interactions in the pathophysiology of septic shock. 1991 Adv. Exp. Med. Biol. pmid:1818486
Jin N et al. Platelet activating factor causes relaxation of isolated pulmonary artery and aorta. 1991 Adv. Exp. Med. Biol. pmid:1803920
Shimizu T and Mutoh H Structure and regulation of platelet activating factor receptor gene. 1997 Adv. Exp. Med. Biol. pmid:9321953
Mori M et al. Localization of platelet-activating factor receptor in the rat brain. 1997 Adv. Exp. Med. Biol. pmid:9321976
Baltas G et al. Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease. 1996 Adv. Exp. Med. Biol. pmid:9131139
Ye RD et al. Stimulation of NF-kappa B activation and gene expression by platelet-activating factor. 1996 Adv. Exp. Med. Biol. pmid:9131140
Shukla SD Tyrosine kinase activation by PAF leads to downstream gene expression. 1996 Adv. Exp. Med. Biol. pmid:9131141
Morooka S and Natsume Y Effect of SM-12502 on disseminated intravascular coagulation (DIC) in tumor-bearing rats. 1996 Adv. Exp. Med. Biol. pmid:9131147
Sanchez Crespo M et al. Platelet-activating factor is an effector of rapid reactions and an inductor of late responses in immune-mediated injury. 1996 Adv. Exp. Med. Biol. pmid:9131148
Saito K PAF response to inflammatory and non-inflammatory stimuli. 1996 Adv. Exp. Med. Biol. pmid:9131150
Silver D et al. Role of platelet-activating factor in skeletal muscle ischemia-reperfusion injury. 1996 Adv. Exp. Med. Biol. pmid:9131151
Lopes-Martins RA et al. Platelet-activating factor. A possible role in the modulation of the vasomotor tone and blood pressure. 1996 Adv. Exp. Med. Biol. pmid:9131152
Ohkuni H et al. Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. 1997 Adv. Exp. Med. Biol. pmid:9331745
Goldman R et al. Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. 1999 Adv. Exp. Med. Biol. pmid:10667361
Kosar-Hashemi B et al. Glyceryl ether monooxygenase [EC 1.14.16.5]: stoichiometry and inhibition. 1993 Adv. Exp. Med. Biol. pmid:8304231
Winkler JD et al. Inhibitors of arachidonate metabolism and effects on PAF production. 1996 Adv. Exp. Med. Biol. pmid:9131119
Armant DR Intracellular Ca2+ signaling and preimplantation development. 2015 Adv. Exp. Med. Biol. pmid:25956298