Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Yamada M et al. | Possible participation of intracellular platelet-activating factor in tumor necrosis factor-alpha production by rat peritoneal macrophages. | 1999 | Eur. J. Pharmacol. | pmid:10422778 |
Bocheński J et al. | Role of thromboxane A2 and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats. | 1999 | J. Physiol. Pharmacol. | pmid:10424723 |
Asano K et al. | Cellular source(s) of platelet-activating-factor acetylhydrolase activity in plasma. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425216 |
Rodrigues CR et al. | Proposal of a new PAF pharmacophoric map by the AM1 method. | 1999 | Eur J Pharm Sci | pmid:10425381 |
Ambrosio G and Tritto I | Reperfusion injury: experimental evidence and clinical implications. | 1999 | Am. Heart J. | pmid:10426862 |
Maggirwar SB et al. | HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity. | 1999 | J. Neurochem. | pmid:10428053 |
Fiotti N et al. | Atherosclerosis and inflammation. Patterns of cytokine regulation in patients with peripheral arterial disease. | 1999 | Atherosclerosis | pmid:10428295 |
Schifitto G et al. | Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium. | 1999 | Neurology | pmid:10430432 |
Tanaka R et al. | Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy. | 1999 | Am. J. Kidney Dis. | pmid:10430976 |
Zouki C et al. | Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ET(A) receptors and platelet-activating factor. | 1999 | Br. J. Pharmacol. | pmid:10433505 |