Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Malone B et al. | Inactivation of platelet activating factor by rabbit platelets. Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to a tetraenoic acylated product. | 1985 | J. Biol. Chem. | pmid:3918041 |
| Zukowska-Grojec Z et al. | The adrenergic system and the cardiovascular effects of platelet activating factor (1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) in SHR and WKY rats. | 1985 | Clin Exp Hypertens A | pmid:2994912 |
| Shen TY et al. | The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. | 1985 | Int J Tissue React | pmid:2997065 |
| Sánchez Crespo M et al. | Synthesis of platelet-activating factor from human polymorphonuclear leukocytes: regulation and pharmacological approaches. | 1985 | Int J Tissue React | pmid:2997066 |
| Proll MA et al. | Phosphatidate and monooleylphosphatidate inhibition of fibroblast adenylate cyclase is mediated by the inhibitory coupling protein, Ni. | 1985 | Mol. Pharmacol. | pmid:2997592 |
| MacIntyre DE et al. | Endogenous and pharmacological mechanisms for the regulation of human platelet cytosolic free Ca2+. | 1985 | Nouv Rev Fr Hematol | pmid:2997706 |
| Lachachi H et al. | Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2998370 |
| Hwang SB et al. | trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. | 1985 | J. Biol. Chem. | pmid:2999126 |
| Wal F et al. | PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. | 1985 | Thromb. Haemost. | pmid:3992525 |
| Khan SN et al. | Response to platelet-activating factor of platelets from patients with multiple sclerosis. | 1985 | Acta Neurol. Scand. | pmid:3993327 |
| Tamargo J et al. | Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles. | 1985 | Eur. J. Pharmacol. | pmid:3996472 |
| Terashita Z et al. | Is platelet activating factor (PAF) a mediator of endotoxin shock? | 1985 | Eur. J. Pharmacol. | pmid:3996473 |
| O'Neill C et al. | Maternal blood platelet physiology and luteal-phase endocrinology as a means of monitoring pre- and postimplantation embryo viability following in vitro fertilization. | 1985 | J In Vitro Fert Embryo Transf | pmid:4020241 |
| Heymans F et al. | Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . | 1985 | J. Med. Chem. | pmid:4020830 |
| Brain SD and Williams TJ | Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. | 1985 | Br. J. Pharmacol. | pmid:2416378 |
| Touqui L et al. | 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. | 1985 | Biochim. Biophys. Acta | pmid:3967037 |
| Weber N and Benning H | Ether glycerolipids: novel substrates for studying specificity of enzymes involved in glycerolipid biosynthesis in higher plants. | 1985 | Eur. J. Biochem. | pmid:3967662 |
| O'Neill C | Partial characterization of the embryo-derived platelet-activating factor in mice. | 1985 | J. Reprod. Fertil. | pmid:4067921 |
| Mallet AI and Cunningham FM | Structural identification of platelet activating factor in psoriatic scale. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3970690 |
| Valone FH | Inhibition of binding of the platelet-activating factor AGEPC to platelets by the AGEPC analog rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate (CV-3988). | 1985 | Biochem. Biophys. Res. Commun. | pmid:3970703 |
| Camussi G and Brentjens JR | Inhalation of horseradish peroxidase by rabbits with specific IgE antibodies results in release into the circulation of platelet-activating factor and in lung lesions. | 1985 | Clin. Immunol. Immunopathol. | pmid:3971603 |
| Ardaillou N et al. | Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells. | 1985 | Am. J. Physiol. | pmid:3918460 |
| Parente L et al. | The release of lyso-PAF from guinea-pig lungs. | 1985 | Eur. J. Pharmacol. | pmid:4029263 |
| Lee TC | Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes. | 1985 | J. Biol. Chem. | pmid:4030776 |
| Wissner A et al. | Analogues of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone. | 1985 | J. Med. Chem. | pmid:4032422 |
| Pritchard PH et al. | The degradation of platelet-activating factor in the plasma of a patient with familial high density lipoprotein deficiency (Tangier disease). | 1985 | Blood | pmid:4063532 |
| Wissner A et al. | Analogues of platelet activating factor. 3. Replacement of the phosphate moiety with a sulfonylbismethylene group. | 1985 | J. Med. Chem. | pmid:4032438 |
| Wimberly HC et al. | Functional and biochemical characterization of immunologically derived equine platelet-activating factor. | 1985 | Vet. Pathol. | pmid:4035942 |
| MacIntyre DE et al. | Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets. | 1985 | FEBS Lett. | pmid:2981715 |
| Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular albumin. | 1985 | Arch. Biochem. Biophys. | pmid:4037794 |
| Surles JR et al. | Facile synthesis of platelet-activating factor and racemic analogues containing unsaturation in the sn-1-alkyl chain. | 1985 | J. Med. Chem. | pmid:4038418 |
| Hanahan DJ et al. | A novel approach to structure proof of glyceryl ether-containing glycerophospholipids. Base-catalyzed methanolysis of platelet-activating factor (AGEPC) at 60 degrees C. | 1985 | J. Lipid Res. | pmid:4067422 |
| Pedersen AK and FitzGerald GA | Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing. | 1985 | Clin. Pharmacol. Ther. | pmid:3917387 |
| Sugiura T et al. | Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2935146 |
| Hallam TJ et al. | Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. | 1985 | Biochem. J. | pmid:4091795 |
| Fouque F and Vargaftig BB | Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine. | 1985 | J Pharmacol | pmid:4094442 |
| Oda M et al. | Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187. | 1985 | J. Immunol. | pmid:3917470 |
| Bergelson LD et al. | Influence of platelet activation factor and prostaglandins on cholesterol esterification in human plasma. | 1985 | FEBS Lett. | pmid:4043408 |
| Kilpatrick JM and Virella G | Inhibition of platelet-activating factor by rabbit C-reactive protein. | 1985 | Clin. Immunol. Immunopathol. | pmid:4042435 |
| Monnens L et al. | Platelet aggregating factor in the epidemic form of hemolytic-uremic syndrome in childhood. | 1985 | Clin. Nephrol. | pmid:4042442 |
| O'Flaherty JT | Neutrophil degranulation: evidence pertaining to its mediation by the combined effects of leukotriene B4, platelet-activating factor, and 5-HETE. | 1985 | J. Cell. Physiol. | pmid:2981891 |
| Khan SN et al. | Desaggregation of PAF-acether-aggregated platelets by verapamil and TMB-8 with reversal of phosphorylation of 40K and 20K proteins. | 1985 | Eur. J. Pharmacol. | pmid:3920056 |
| Wasserman SI | The mast cell and theophylline in asthma. | 1985 | Am. J. Med. | pmid:3002176 |
| Bushfield M et al. | Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP. | 1985 | Biochem. J. | pmid:3002327 |
| Grandel KE et al. | Association of platelet-activating factor with primary acquired cold urticaria. | 1985 | N. Engl. J. Med. | pmid:2410790 |
| Bussolino F et al. | Alkyl-ether phosphoglycerides influence calcium fluxes into human endothelial cells. | 1985 | J. Immunol. | pmid:2411812 |
| Johnson HM and Torres BA | Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2412225 |
| Fjellner B and Hägermark O | Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. | 1985 | Acta Derm. Venereol. | pmid:2416164 |
| Avdonin PV and Altukhova IP | [Blocking with phorbol ester, a protein kinase C activator, of receptor-dependent platelet calcium channels]. | 1985 | Biokhimiia | pmid:2416359 |
| Avdonin PV et al. | [Mechanism of increase in Ca2+ level in platelet cytoplasm induced by aggregating factors]. | 1985 | Biokhimiia | pmid:3000463 |