Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Kang LP et al. | Steroidal saponins from Tribulus terrestris. | 2014 | Phytochemistry | pmid:25172515 |
Wu KZ et al. | Establishment of the method for screening the potential targets and effective components of huatuo reconstruction pill. | 2014 | Interdiscip Sci | pmid:25172450 |
Nitoda E et al. | Correlation of platelet activating factor and age-related macular degeneration. | 2014 | Expert Opin. Ther. Targets | pmid:25077601 |
Sirangelo I et al. | Platelet-activating factor mediates the cytotoxicity induced by W7FW14F apomyoglobin amyloid aggregates in neuroblastoma cells. | 2014 | J. Cell. Biochem. | pmid:25053109 |
Reyes-Quiroz ME et al. | Platelet-activating factor downregulates the expression of liver X receptor-α and its target genes in human neutrophils. | 2014 | FEBS J. | pmid:24289152 |
Semini G et al. | Inositol-C2-PAF down-regulates components of the antigen presentation machinery in a 2D-model of epidermal inflammation. | 2014 | Biochem. Pharmacol. | pmid:24291779 |
Gazos-Lopes F et al. | Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi. | 2014 | PLoS Negl Trop Dis | pmid:25101628 |
Morimoto R et al. | Rapid production of platelet-activating factor is induced by protein kinase Cα-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein. | 2014 | J. Biol. Chem. | pmid:24742674 |
Summers C et al. | Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. | 2014 | Thorax | pmid:24706039 |
Yang Y et al. | Basophil activation through ASGM1 stimulation triggers PAF release and anaphylaxis-like shock in mice. | 2014 | Eur. J. Immunol. | pmid:24777913 |